CorePlus Puerto Rico Publishes Groundbreaking Study on Implementing 100% Quality Control in Cervical Cytology Using Whole Slide Imaging and Artificial Intelligence

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CorePlus Servicios Clinicos y Patologicos, LLC

May 27, 2025, 19:13 ET

CAROLINA, Puerto Rico, May 27, 2025 /PRNewswire/ -- CorePlus, a leading precision pathology organization in Puerto Rico, has announced the publication of a landmark study validating the use of artificial intelligence (AI) and whole slide imaging (WSI) as a 100% quality control (QC) tool in cervical cytology workflows. The study was published in the prestigious peer-reviewed journal Cancer Cytopathology, underscoring its scientific rigor and clinical relevance.

Revolutionizing Cytology with AI and Digital Pathology

A depiction of a neural network, which was used to train the Techcyte SureView™ algorithm and is used to find cells within a
whole slide image. Objects are used to teach the algorithm features for identification on the scans. Those features are then learned and applied
to predict representative images to the end user. — A depiction of a neural network, which was used to train the Techcyte SureView™ algorithm and is used to find cells within a whole slide image. Objects are used to teach the algorithm features for identification on the scans. Those features are then learned and applied to predict representative images to the end user.

Techcyte SureView™ user interface from a previous version (V3) of the system that was used within this study. The user
interface shows the categories of objects for user classification on the left. Objects in each category are shown in the center as a gallery and a
view of the entire whole slide image is shown in the larger image. — Techcyte SureView™ user interface from a previous version (V3) of the system that was used within this study. The user interface shows the categories of objects for user classification on the left. Objects in each category are shown in the center as a gallery and a view of the entire whole slide image is shown in the larger image.

As digital pathology continues to advance into the field of cytopathology, laboratories are exploring alternatives to traditional manual microscopy screening. CorePlus evaluated the performance of the Techcyte SureView™ system—specifically designed for digital cytopathology—on 1,442 digitized slides from ThinPrep® and SurePath™ cervical cytology samples.

The slides were scanned using the 3DHISTECH P1000 DX scanner under both dry and water immersion scanning profiles. A board-certified cytopathologist reviewed AI-identified objects of interest and compared them to results obtained through traditional light microscopy.

Outstanding Results and Operational Efficiency

The study demonstrated that the SureView™ system using the water immersion profile significantly outperformed both dry scanning and manual microscopy in detecting squamous and glandular abnormalities. Key performance metrics included:

97% accuracy
82% sensitivity
99% specificity
98% negative predictive value
86% positive predictive value

In addition to its high diagnostic performance, the AI-assisted system considerably reduced review times and improved overall workflow efficiency.

A New Standard for Quality Control in Cervical Cytology

Following successful validation, CorePlus has fully integrated the Techcyte SureView™ system as a 100% QC tool in its laboratory operations. This marks a major step forward in adopting digital and AI technologies to enhance diagnostic accuracy, laboratory efficiency, and patient care.

"We have been able to achieve an unprecedented level of consistency and confidence in cervical cytology screening, every PAP Counts!" Mariano de Socarraz, Founder and Chief Executive Officer at CorePlus. "Our team is proud to contribute to the advancement of digital pathology and demonstrate its real-world clinical impact."

For access to the complete published study please visit: Implementing 100% quality control in a cervical cytology workflow using whole slide images and artificial intelligence provided by the Techcyte SureView™ System - Rivera Rolon - 2025 - Cancer Cytopathology - Wiley Online Library

About CorePlus

CorePlus is a state-of-the-art precision pathology organization based in Puerto Rico, committed to diagnostic excellence through innovation and technology. With a patient-centered approach and quality-driven processes, CorePlus is at the forefront of adopting artificial intelligence algorithms as decision support tools for our pathologists offering unprecedented accuracy and efficiency.

About Cancer Cytopathology

Cancer Cytopathology is a peer-reviewed medical journal published by the American Cancer Society. Internationally recognized, it focuses on the science and practice of cancer cytopathology. The journal publishes innovative research, clinical studies, and expert reviews aimed at improving diagnostic accuracy and outcomes in cancer management. The publication of the CorePlus study in Cancer Cytopathology highlights its significant contribution to the advancement of digital cytopathology in cancer diagnostics and quality control.

About Techcyte

Founded in 2013, Techcyte is transforming the practice of pathology with a unified pathology platform that digitizes lab workflows and offers AI tools that improve the efficiency and accuracy of diagnostic testing.

Our mission is to positively impact the health of humans, animals, and the environment through the use of artificial intelligence.

We do that by partnering with best-in-class labs, whole slide scanner manufacturers, AI vendors, diagnostic companies, hardware manufacturers, and solution providers. Together, we aim to deliver a unified clinical and anatomic pathology platform to labs and clinics around the world.

Visit www.techcyte.com for more information.

About Epredia

Epredia, a global leader in precision cancer diagnostics and subsidiary of PHC Holdings Corporation (TSE: 6523) offers a unique array of end-to-end instruments for pathology workflows including tissue processors, microtomes, embedding stations, and a range of 3DHistech developed whole slide scanners from the single slide Pannoramic Desk II to the Pannoramic 1000 scanner. These scanners offer a single slide to 1000 slide capacity and a throughput of up to 85 slides per hour, including overnight scanning.

Visit www.epredia.com for more information.

SOURCE CorePlus Servicios Clinicos y Patologicos, LLC