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First Smartphone DNA Test for Chlamydia to Be Presented at 2015 AACC Annual Meeting

Dedicated to achieving better health through laboratory medicine, the American Association for Clinical Chemistry, AACC, brings together more than 50,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of breaking laboratory science. Since 1948, AACC has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit www.aacc.org.

News provided by

AACC

Jul 29, 2015, 10:30 ET

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ATLANTA, July 29, 2015 /PRNewswire-USNewswire/ -- At the 2015 AACC Annual Meeting & Clinical Lab Expo, researchers will present findings that a first-of-its-kind smartphone test for chlamydia can detect the disease with high accuracy, which could reduce the prevalence of this sexually transmitted disease (STD) by making chlamydia screening easier and cheaper.

Most people with chlamydia are not aware of it because the infection often causes no symptoms, but if left untreated, this STD can develop into pelvic inflammatory disease and irreversibly damage a woman's reproductive system. According to the Centers for Disease Control and Prevention, pelvic inflammatory disease affects up to 30% of women with chlamydia, and can cause infertility; debilitating, chronic pelvic pain; and life-threatening ectopic pregnancies. Over the past decade, healthcare providers have been able to expand screening programs for chlamydia thanks to the development of a highly sensitive method known as nucleic acid amplification testing (NAAT). NAATs are too complex, however, to perform in point-of-care settings such as physicians' offices, health fairs, school clinics, or other sexual health outreach venues, and they also have a high per-test cost.

A team of researchers led by Jeff Tza-Huei Wang, PhD, from the Johns Hopkins University BioMEMS Lab, Baltimore, Maryland have developed the first low-cost NAAT platform that can diagnose chlamydia at the point-of-care and that integrates sample preparation, DNA amplification, and data processing all in one coffee mug-sized instrument. Known as mobiLab, this battery-powered device works by using a microfluidics cartridge to detect the DNA of chlamydia bacteria in genital swab samples. The DNA analysis unit is integrated with a smartphone, which enables the user to control the platform and process test data with an app.

MobiLab's developers validated the test's accuracy by comparing its performance with the Gen-Probe Aptima Combo 2 assay, the gold standard test for chlamydia. After analyzing 20 patient samples using both tests, the researchers found that mobiLab and the Gen-Probe test both identified the same 10 positive and 10 negative cases. This demonstrates that mobiLab can be used in place of standard NAATs. Additionally, each microfluidics cartridge it uses costs less than $2, an order of magnitude cheaper than similar commercial cartridges, which can cost close to $10 per test. Altogether, this will make it possible for a greater number of non-traditional healthcare settings to afford and offer chlamydia testing and to screen a wider portion of at-risk women and men with high precision.        

"We now have these pretty accurate, sensitive, and specific molecular assays to detect very few numbers of organisms in biological samples," said Dong Jin Shin, one of the abstract's authors and a PhD student at Johns Hopkins. "But a lot of these technologies are confined to being used in centralized lab settings. If we're able to bring molecular diagnostic technology closer to the clinic and deliver accurate results to clinicians sooner, then we'll be able to improve our standard of care for patients with chlamydia while also saving costs."

Session Information
AACC annual meeting registration is free for members of the media. Reporters can register online here: https://www.xpressreg.net/register/aacc075/media/landing.asp

Session 34103: Technology-Driven Patient Care
Wednesday, July 29
10:30 a.m. – Noon
Room B309
Georgia World Congress Center
Atlanta

About the 2015 AACC Annual Meeting & Clinical Lab Expo
AACC's annual meeting offers 5 days packed with opportunities to learn about exciting science from July 26–30. Plenary sessions feature expert presentations on using tumor DNA in the blood to diagnose and monitor cancer, reducing the risk of heart disease, transparency in healthcare delivery, the latest advances that could lead to a cure for HIV, and new tests and treatment for infection.

At the AACC Clinical Lab Expo, more than 700 exhibitors will fill the show floor of Atlanta's convention center, Georgia World Congress Center, with displays of the latest diagnostic technology, including but not limited to mobile health, molecular diagnostics, mass spectrometry, point-of-care, and automation.

About AACC
Dedicated to achieving better health through laboratory medicine, AACC brings together more than 50,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of progressing laboratory science. Since 1948, AACC has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit www.aacc.org.

Christine DeLong
AACC
Manager, Communications & PR
(p) 202.835.8722
[email protected]

Molly Polen
AACC
Director of Communications & PR
(p) 202.420.7612
(c) 703.598.0472
[email protected]

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SOURCE AACC

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