GNC Leads Pioneering Study on Diet Trends Among GLP-1 Users Revealing Key Nutritional Gaps

While GLP-1s have been an effective weight loss tool, the first clinical nutrition study shows they can lead to low protein and essential nutrient intake

PITTSBURGH, June 17, 2025 /PRNewswire/ -- GNC, the leading global health and wellness retailer, continues its dedication to support individuals using GLP-1 agonists in new groundbreaking scientific research revealing the first-ever real-world nutritional analysis of GLP-1 users. In an industry increasingly driven by trends, GNC is setting itself apart through research by doing what no one else has — conducting real-world research to understand the true nutritional needs of GLP-1 users. The study highlights critical evidence of everyday eating habits among GLP-1 users and the unintended nutritional deficiencies by decreasing food intake and changing dietary habits.

"We set out last year to develop a product tailored to the unique needs of GLP-1 users," said Dr. Brittany Johnson, PHD, RDN, Senior Manager, Scientific Affairs and Principal Investigator. "However, we quickly realized there simply wasn't enough evidence to inform a formula based on our scientific standards. That's why our team decided to start at the foundation and understand exactly what nutritional inadequacies exist in this population."

The novel research findings can help shape clinical practice guidance, supplement formulations, and education efforts to support the long-term success and safety of GLP-1 therapy, based on the population, not assumptions or speculation.

The study conducted by senior researchers at GNC, "Investigating Nutrient Intake During Use of Glucagon-like Peptide-1 Receptor Agonist: A Cross-Sectional Study," accepted for peer-reviewed publication in Frontiers, involved 69 GLP-1 users over a three-day period, completing surveys and a detailed food log. Participant nutrient intake data was compared to the Dietary Reference Intakes (DRIs) using rigorous statistical analysis and demonstrated that participants did not meet vital nutrient intake through their diets and were significantly below recommended protein consumption.

Key Findings of the Study:

• Poor diet quality overall: Participants did not meet USDA MyPlate servings for fruits, vegetables, grains, or dairy and demonstrated overconsumption of calories from fat and saturated fat.
• Low protein: While total caloric intake from protein was sufficient, the intake per body weight was below recommended levels.
• Nutrient deficiencies: Significant shortages were noted in the consumption of fiber, calcium, iron, magnesium, potassium, choline, and vitamins A, C, D, and E.

"Science is the foundation for everything we do at GNC. Recognizing the lack of clinical nutritional research among GLP-1 users, we set out to examine their real-world dietary intake and habits to help understand the true nutritional needs," said Rachel Jones, MS, RDN, EVP Chief Merchandising & Science Officer. "The results of our study provide critical evidence to guide the next generation of support for the growing population of GLP-1 users — whether through education, clinical nutrition advice or dietary supplements."

The clinical research, conducted according to academic standards, is the latest step in the brand's unwavering support among users in the weight management category. In 2024, GNC became the first major retailer to launch a GLP-1 support program with a dedicated selection of products designed to help semaglutide users manage common side effects and challenges associated with their treatment. Recognizing that patient-centered nutritional guidance is essential to optimize health outcomes and prevent unintended health consequences, GNC is at the forefront of investing in scientific research to reinforce the importance of evidence-based solutions in the industry, establishing a standard for credibility and consumer trust.

The full publication will be available via open access: Frontiers | Investigating Nutrient Intake During Use of Glucagon-like Peptide-1 Receptor Agonist: A Cross-Sectional Study.

To learn more about GNC visit GNC.com.

About GNC
GNC is a leading global health and wellness brand that provides customers with a wide variety of science-based products and solution services to live well. The brand touches consumers worldwide by providing its products and services through company-owned retail locations, domestic and international franchise locations, digital commerce, and strong wholesale and retail partnerships across the globe. GNC's diversified, multi-channel business model has worldwide reach and a well-recognized, trusted brand. By combining exceptional innovation, product development capabilities, and an extensive global distribution network, GNC manages a best-in-class product portfolio. www.gnc.com.

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SOURCE GNC