Illuminate Rx Expands Member Affordability Through Sempre Health Partnership

Manufacturer-funded savings built into the pharmacy benefit help lower member out-of-pocket costs and support medication adherence at no additional cost to plan sponsors

BIRMINGHAM, Ala., Oct. 28, 2026 /PRNewswire/ -- Illuminate Rx, Inc., a low-net-cost pharmacy benefits manager (PBM) and affiliate of RxBenefits, Inc., has partnered with Sempre Health to expand access to manufacturer-funded savings on medications. Designed to bring greater clarity, flexibility, and control to pharmacy benefits, Illuminate Rx is integrating Sempre's affordability solution to give members a simpler way to decrease their prescription costs at the pharmacy counter while improving medication adherence.

The partnership reflects Illuminate Rx's strategic approach to pharmacy benefits: looking beyond traditional PBM levers to find and integrate external sources of value as part of the pharmacy experience. Through Sempre, eligible members can access savings at no additional cost to the employer or member, without having to search for available copay assistance or discount programs independently.

"Our lowest-net-cost philosophy means much more than reducing what the plan pays. It means finding every opportunity to make medications more affordable for the people taking them, too," said Ritu Malhotra, PharmD, President of Illuminate Rx. "This work with Sempre Health helps remove the burden of navigating and monitoring sources of savings, one that shouldn't be on the member in the first place."

Manufacturer copay assistance programs are widely available for certain medications but accessing them can require consumers to know they exist, find them, and enroll. Sempre simplifies that process by using pharmacy claims information to connect with eligible Illuminate Rx members and communicate available savings.

When a member fills a participating medication, Sempre identifies the savings opportunity and proactively reaches out to the member. Then, savings are applied at the pharmacy, bringing down the amount the member pays out of pocket.

"We don't think members should have to become pharmacy benefit experts to get the most value from their coverage," according to Anurati Mathur, Co-founder and CEO of Sempre Health. "PBMs are moving quickly to make point-of-fill affordability a core part of their offerings, and when members save on their medications, those dollars go back to groceries, gas, and rent. Joining forces with Illuminate Rx extends this support to more members nationwide."

As employers manage rising pharmacy costs, their employees feel those same pressures at the pharmacy counter. This is particularly true for those enrolled in high-deductible health plans who may face greater upfront prescription costs. When cost becomes a barrier to filling or staying on a prescription, the impact can extend beyond the pharmacy benefit to members' broader healthcare utilization.

Reducing out-of-pocket costs can help address that challenge by making medications more affordable and encouraging adherence. By detecting savings opportunities from sources outside of PBM formulary, network, and contracting tools, Illuminate Rx can help employers with both objectives. Sempre reports that participating members achieve approximately 45% to 65% estimated savings on out-of-pocket prescription costs and an average 15% to 25% improvement in medication adherence.^[1] 

"As we promised the industry, Illuminate Rx continues to look across the pharmacy ecosystem for opportunities to add on-benefit value," Malhotra said. "Sempre is one example of that strategy in action, and we'll continue searching beyond the traditional PBM sources for chances to deliver lower costs, better outcomes, and an enhanced member experience."

The program will be available to Illuminate Rx members on January 1, 2027.

About Illuminate Rx

Illuminate Rx is a low-net-cost pharmacy benefits manager (PBM) delivering unprecedented clarity to benefits advisors and employers. We go beyond transparency, combining clear visibility into pricing, rebates, and savings; pharmacist-led clinical management that controls spend before it hits the plan; and lowest net cost execution via flexible design and channel optimization to deliver client-aligned results. Backed by RxBenefits, a 30+ year industry leader, Illuminate Rx pairs a modern PBM model with proven infrastructure and service. Learn more at www.illuminate-rx.com.

About Sempre Health

Sempre Health is a digital health technology company dedicated to solving the medication affordability crisis by making essential prescriptions accessible and affordable for millions of patients. Sempre utilizes behavior-based pricing and a proprietary platform to deliver real-time, dynamic discounts directly to members at the point of fill. By successfully aligning incentives across PBMs, health plans, life sciences companies, and patients, Sempre drives significant savings, satisfaction, and adherence. Learn more at www.semprehealth.com.

Media contact
Sarah McLeod
[email protected]

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^[1] Sempre book-of-business data

SOURCE Illuminate Rx