Ledger Run and ICE Global Consulting Expand Strategic Partnership to Advance Clinical Trial Contracting and Financial Management

Ledger Run deepens commitment to its ClinRun platform and site payments services; ICE Global expands market position as the industry's leading provider of global site contracting and budgeting

RALEIGH, N.C., Sept. 15, 2026 /PRNewswire/ -- Ledger Run, a leader in clinical trial financial management solutions, and ICE Global Consulting, a leader in contract and budget management services, today announced an expansion of their five-year partnership. As part of the expanded relationship, ICE Global will carry forward providing site contracts and budget negotiation and management services, while Ledger Run focuses on advancing its best-in-class ClinRun platform and site payments services to support the end-to-end contract-to-pay process.

The expanded partnership brings together ICE Global's experienced clinical contracting team and Ledger Run's advanced technology to provide continuity for customers while allowing each company to concentrate on its core strengths. ICE Global will work directly with customers on their contracting and budget needs while continuing to leverage the ClinRun technology to support efficient clinical trial contracting and financial operations.

"Deepening our strategic partnership with Ledger Run is a natural alignment for both organizations and a strong catalyst for our continued growth in site contracting services," said Brooke Millman-Ice, CEO of ICE Global Consulting. "Clients gain direct access to a global team with decades of hands-on expertise in site contracts and budgets, seamlessly paired with Ledger Run's advanced, AI-powered financial platform technology. We have experienced its efficiency firsthand and are thrilled to build on this shared momentum."

Ledger Run is laser-focused on its core strength: the ClinRun platform and its site payments services, providing sponsors and contract research organizations (CROs) with both the technology and the expert, hands-on support needed to manage end-to-end financial operations and improve the payment experience for research sites. Ledger Run continues to increase its investment in research and development, releasing platform updates quarterly and infusing AI into key friction points across the payment lifecycle. In its latest ClinRun update, Ledger Run incorporated intelligent automation and expanded flexibility to accelerate payment operations while it continues moving forward on an aggressive product improvement roadmap.

"Agentic technology is ideal to automate low-value payment processing activities, such as cross-referencing invoices and uploading them to multiple systems," said Patrick Mizer, Chief Technology Officer at Ledger Run. "These tasks are still largely manual, time-consuming, and prone to human error plus they pull study staff away from strategic work. Administrative payment processing is the perfect strike zone for AI and will drive our next-generation platform."

For ICE Global, the expanded relationship further strengthens its trusted contracting operations and builds on its experience supporting sponsors, CROs, and other research organizations. By combining experienced contracting professionals with technology-enabled processes, ICE Global will ensure continuity of service while supporting the evolving needs of existing and future customers. Legacy Ledger Run customers will also have access to ICE Global's broader suite of contracting and legal support solutions, providing additional opportunities to support their needs across the clinical development lifecycle.

In addition to increasing financial management efficiency for sponsors and CROs, Ledger Run remains dedicated to improving the site experience by providing greater clarity and faster remittance. "Sponsors are starting to think about site experience as part of their brand, so being able to demonstrate that the payment process is fast and easy becomes a differentiator," added Mizer. "This is especially poignant given the growing disproportionate site-to-trial ratio of approximately four trials to one site – making attracting sites more competitive than ever."

CEO of Hightower Clinical Brad Hightower voiced similar sentiment on a recent episode of his podcast, Note to File. "There is increasingly more chatter at conferences by sponsors who want to know how they can become a sponsor-of-choice for sites – and payment processing is a big part of the criteria. For instance, I am most motivated to work with a sponsor that pays on time and provides the most financial transparency and clarity with the least friction."

"Our contracts and budgets customers will be in experienced hands with ICE Global," concluded John Chinnici, CEO of Ledger Run. "Our expanded relationship provides continuity for customers while enabling both companies to focus on what they do best. I am excited for the possibilities that our dedicated focus and increased investment in technology will deliver for the clinical research industry."

About Ledger Run
Ledger Run is transforming clinical trial business operations through an innovative combination of technology and services. ClinRun, the company's software suite of budgeting, contracting, payments, and forecasting, automates manual tasks, reduces errors, and speeds cycle times, while Ledger Run's site payments services provide expert, hands-on support for sponsors, contract research organizations (CRO), and trial sites. ClinRun is the industry's only unified CTA-to-pay platform and is leveraged by three of the top 10 pharmaceutical companies, two of the top five CROs, and 18,000 sites worldwide. Ledger Run is backed by Blue Star Innovation Partners ("BSIP"), a growth-focused investment firm that partners with healthcare and technology companies in highly regulated industries to drive accelerated growth via its deep operational experience. For more information, contact [email protected] or visit www.LedgerRun.com.

About ICE Global Consulting
ICE Global Consulting, Inc. provides technology-enabled contracting and legal support solutions to the global clinical research industry. ICE Global supports sponsors, CROs and other organizations across the clinical development lifecycle with site contract and budget negotiation and management, commercial contracting, and related contracting services. Through a combination of experienced professionals, scalable processes and technology-enabled solutions, ICE Global helps customers streamline contracting operations and navigate the complexities of global clinical research. www.iceglobalconsulting.com; [email protected]

Media Contact:
Lisa Barbadora, Barbadora INK for Ledger Run
+1 (610) 420-3413
[email protected]

SOURCE Ledger Run