MOBILion Systems to Present Advanced Proteomics Capabilities with New PAMAF Operating Mode at US HUPO 2025

CHADDS FORD, Pa., Feb. 13, 2025 /PRNewswire/ -- MOBILion Systems, Inc., a leader in separation science innovation, today announced its participation in the 21st Annual US HUPO Conference, taking place February 22-26, 2025, in Philadelphia, PA. MOBILion will showcase its new Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF) operating mode through multiple scientific presentations, demonstrating increased speed and sensitivity of LC-MS analysis for proteomics applications.

"Our PAMAF operating mode enables researchers to make more accurate analytical measurements and achieve deeper proteome characterization, supporting scientific discovery in critical areas of human health research," said Melissa Sherman, Ph.D., CEO of MOBILion Systems. "By replacing quadrupole isolation with high-resolution ion mobility separation, PAMAF generates fragmentation data with 10x higher signal-to-noise and 5x faster speeds than conventional systems.  With essentially 100 percent ion utilization, PAMAF is particularly valuable for sample-limited workflows, including single-cell proteomics applications. MOBILion's participation at US HUPO 2025 reflects our commitment to advancing proteomics research through innovative separation science."

Researchers will give presentations demonstrating how PAMAF's capabilities extend beyond traditional LC-MS approaches, highlighting how it reduces chimeric spectra to improve protein quantification and post-translational modification analysis.

An educational breakfast seminar will feature Prof. Birgit Schilling, from The Buck Institute for Research on Aging, presenting research on succinylation levels in a sirtuin-5 knockout mouse model for chronic kidney disease (CKD). Using MOBILion's PAMAF mode, Prof. Schilling's team identified hundreds of differentially regulated succinylation sites that may contribute to phenotypic protection against kidney diseases.

Scientific Program Details:

Oral Presentation (Tuesday, February 25, Session #11 - Emerging Opportunities in Proteomics, 1:40 PM - 3:00 PM):

• Abandoning the Quadrupole for MS Fragmentation Analysis: Towards 1,000 Hz Speeds with 100% Ion Utilization Using High Resolution Ion Mobility Precursor Isolation - Daniel DeBord, Ph.D., Chief Technology Officer at MOBILion

Poster Session 1 (Monday, February 24, 4:30 PM – 6:00 PM):

• P01.45LB: Characterization of Key Performance Figures of Merit for PAMAF in Proteomics Applications

Poster Session 2 (Tuesday, February 25, 4:30 PM – 6:00 PM):

• P05.26LB: Leveraging HRIM for Dual-purpose Feature Definition and Alignment: Validation of Proteomics Workflows for PAMAF Data
  
  
• P08.08LB: A Novel All-Ion Parallel Reaction Monitoring (AI-PRM) methodology for Enhanced Sensitivity and Speed in High Throughput Targeted Proteomics Analysis

Educational Breakfast Seminar (Wednesday, February 26, 7:15 AM - 8:15 AM):

• High Resolution Ion Mobility for Next Generation Proteomics Analysis - Danel DeBord, Ph.D.
• Detection of Upregulated Succinylated Peptides from Sirtuin 5 Knockout Mice - Birgit Schilling, Ph.D.

MOBILion is exhibiting at booth number 18 and inviting attendees to learn how MOBILion's PAMAF operation mode is shaping the future of proteomics.

About MOBILion Systems, Inc.
MOBILion Systems is Revealing What Others Leave Unseen®, leading the way in next-generation separation science. We develop advanced tools that more deeply, accurately and efficiently characterize complex samples, driving innovation across the pharmaceutical, food testing, proteomics, and environmental safety industries. Our technology integrates with mass spectrometry, enabling workflows that unravel the most complex analyses, redefining the possibilities of molecular characterization. Learn more at www.mobilionsystems.com.

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SOURCE MOBILion Systems