New Grant Supports Cognitive Risk-Benefit Analysis of Playing Soccer

BRONX, N.Y., Sept. 22, 2022 /PRNewswire/ -- More than 25 million Americans play soccer, the world's most popular sport. Soccer significantly benefits brain health by boosting aerobic capacity and oxygen and blood flow to the brain, but it also has a downside: Recent studies show that highly repetitive heading of the ball is associated with structural brain changes and worse cognitive performance similar to brain damage caused by concussion.

Researchers at Albert Einstein College of Medicine have now received a five-year, $3.4 million grant from the National Institutes of Health (NIH) to assess the tradeoffs between soccer's aerobic brain benefits and the adverse effects from heading in a study employing neuroimaging, exercise testing, and cognitive testing.

"Soccer players and their parents have been rightly warned about the potential risks of heading in soccer, but it leads to mixed messages about the wisdom of playing the sport," said Michael Lipton, M.D., Ph.D., professor of radiology and of psychiatry and behavioral sciences, associate professor in the Dominick P. Purpura Department of Neuroscience, and associate director of Gruss Magnetic Resonance Research Center at Einstein and director of MRI services at Montefiore Health System. "This grant will allow us to determine soccer's tradeoffs with respect to brain health so that people can make informed decisions and we can establish evidence-based guidelines for heading."

Dr. Lipton's previous studies have found that adult amateur soccer players who head more than a thousand times in a year exhibit worse cognitive performance and structural brain changes not found in those who head much less or not at all. Additional findings by Dr. Lipton have shown that heading is worse for women's brains than for men's. "What we want to determine in our new study is whether soccer's benefits mitigate the adverse effects of heading for cognitive performance—and, if so, whether a threshold level of aerobic activity is required to confer protection," he said.

The new study will enroll 280 young men and women—a group including 140 soccer players with high (70) and low (70) exposure to heading, 70 non-collision athletes, and 70 non-athletes.  At the start of the study and again two years later, participants will be tested to measure their aerobic capacity, undergo MRI brain scans to determine their white-matter structure, and will complete detailed surveys and testing to assess their cognitive status. Based on their results, Dr. Lipton and his colleagues will determine whether soccer's aerobic benefits counterbalance the damage sustained from heading. The researchers will also investigate whether genetic factors and gender may explain individual differences in the results.

"We hope that our findings can help people decide whether to engage in soccer heading or in other contact sports, such as football, which have been linked to brain injury," said Dr. Lipton.

The grant, titled "Heading and Soccer: understanding cognitive risks, benefits, and the potential mediating role of white matter," was provided by the National Institute of Neurological Disorders and Stroke, part of the NIH. (R01NS123374) 

About Albert Einstein College of Medicine 
Albert Einstein College of Medicine is one of the nation's premier centers for research, medical education and clinical investigation. During the 2021-22 academic year, Einstein is home to 732 M.D. students, 190 Ph.D. students, 120 students in the combined M.D./Ph.D. program, and approximately 250 postdoctoral research fellows. The College of Medicine has more than 1,900 full-time faculty members located on the main campus and at its clinical affiliates. In 2021, Einstein received more than $185 million in awards from the National Institutes of Health. This includes the funding of major research centers at Einstein in cancer, aging, intellectual development disorders, diabetes, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. For more information, please visit einsteinmed.org, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube. 

SOURCE Albert Einstein College of Medicine