Opened, Reclosed, and Still Reduced: Spoke Sciences Completes 12-Month Stability Study of IsoCaps™ Water-Soluble Ubiquinol

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Oct 20, 2026, 08:57 ET

BAINBRIDGE ISLAND, Wash., Oct. 20, 2026 /PRNewswire/ -- Spoke Sciences, developer of the patent-pending IsoCaps™ ingredient delivery platform, today announced completion of its long-term stability assessment of IsoCaps™ COQ200: a 10% (100 mg/mL) water-soluble ubiquinol. After a full year of refrigerated storage in a bulk container that was opened, sampled and reclosed at every timepoint, COQ200 measured 97.4 mg/g ubiquinol — with 95.8% of total CoQ10 still in the active, reduced form.

Ubiquinol is the form of CoQ10 the body uses directly. It is strongly fat-soluble and oxidizes back to ubiquinone on contact with air, which is why it has largely been confined to softgel capsules. COQ200 is designed to change that: a dispersion that mixes into water-based systems like any other ingredient, at a dose that matters, while remaining activated.

"Most stability studies are designed to pamper the ingredient. We designed ours for the worst-case scenario," said Kim Zubris, Ph.D., Chief Science Officer of Spoke Sciences. "We made and bottled COQ200 under ambient conditions with no nitrogen blanket, then opened the bottle without added precautions every time we pulled a sample — the way a formulation bench or a co-packer's line works. A year later, 96% of what's in that bottle is still ubiquinol. That tells you the protection is built into the dispersion, not the packaging."

BUILT FOR THE FORMULATOR

COQ200 is added to the water phase with simple stirring and can be added before pasteurization. It is stable below pH 4, which suits seltzers, teas, juices and other acidic systems, and every component is generally recognized as safe (GRAS) or otherwise approved for food use. COQ200 has been screened in energy drinks, vitamin waters, prebiotic beverages, flavored seltzers, and meal-replacement beverages.

"The first question from every formulator has been, 'Great — but does it last?' Now we can hand them twelve months of data and let the numbers do the talking," said Brad Douglass, Ph.D., Chief Strategy Officer of Spoke Sciences. "That means ubiquinol can finally leave the softgel and move into the shot, the seltzer and the RTD tea, with a stability story built on real data. At SupplySide Global we will be sitting down with the brands, contract manufacturers, and distributors who intend to take drinkable ubiquinol to market."

ABOUT SPOKE SCIENCES

Spoke Sciences is an ingredient-technology company that makes oil-loving actives behave in water. Its patent-pending IsoCaps™ platform turns lipophilic ingredients — including CoQ10, ubiquinol and fat-soluble vitamins — into water-dispersible liquid and powder ingredients that carry into beverages, shots, supplements and topicals at meaningful doses, with the stability data to back them. Learn more at www.spokesciences.com.

MEDIA CONTACT
Spoke Sciences is attending SupplySide Global, Mandalay Bay, Las Vegas, October 28–30, 2026.
Brad Douglass, Ph.D. • Chief Strategy Officer • [email protected] • (310) 309-7238

SOURCE Spoke Ingredient Sciences, Inc.