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Setria® Glutathione Featured in RHYTHM's New NAD+ Supplement Launch


News provided by

Kyowa Hakko U.S.A

Oct 15, 2026, 16:22 ET

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Cardiologist-Formulated Formula Pairs NMN with a Full 500 mg Dose of Setria® to Address a Top Consumer Search Term Most NAD+ Brands Ignore

NEW YORK, Oct. 15, 2026 /PRNewswire/ -- Kyowa Hakko USA today announced that RHYTHM NMN, a new delayed-release NAD+ supplement from The Rhythm Line™, features Setria® Glutathione at a full 500 mg per serving, a dose the brand's co-founder, a practicing cardiologist, considered essential to the formula.

Meet RHYTHM NMN: cardiologist-formulated with a full 500 mg of Setria® Glutathione. Now on Amazon and therhythmline.com.
Meet RHYTHM NMN: cardiologist-formulated with a full 500 mg of Setria® Glutathione. Now on Amazon and therhythmline.com.
Built for daily consistency. Take RHYTHM NMN with Setria® Glutathione every day. Subscribe and Save so you never run out.
Built for daily consistency. Take RHYTHM NMN with Setria® Glutathione every day. Subscribe and Save so you never run out.
Nothing hidden. Nothing random. Every ingredient disclosed, including 500 mg of Setria® Glutathione. If it’s in RHYTHM, there’s a reason.
Nothing hidden. Nothing random. Every ingredient disclosed, including 500 mg of Setria® Glutathione. If it’s in RHYTHM, there’s a reason.

RHYTHM combines seven ingredients in a single delayed-release capsule, with each ingredient chosen for a specific role in supporting energy and cellular health*. While most NAD+ supplements focus on a single active ingredient, RHYTHM pairs NMN with a full dose of Setria® Glutathione, placing glutathione, a top consumer search term that few NAD+ brands currently address, at the center of the formula alongside CoQ10, PQQ, trans-resveratrol, vitamin D3, and BioPerine®. The brand discloses every ingredient and its exact amount on the label, with no proprietary blends.

"Setria® is one of the most extensively studied forms of glutathione on the market, and we are glad to see a brand like RHYTHM include it at a clinically meaningful dose rather than as a minor addition," said Katie Emerson, PhD(c), RD, CISSN, Senior Manager of Scientific Affairs at Kyowa Hakko USA. "Glutathione plays a central role in the body's cellular defense system, and RHYTHM's formula reflects a growing recognition among formulators that the ingredient deserves a real dose, not just a mention on the label."

"Most supplements are built by marketing teams," said Nick Signore, Co-Founder of The Rhythm Line. "RHYTHM was built with a cardiologist, and one of the first decisions was that glutathione belonged in the formula at a real dose. Setria was the only form we'd put our name next to."

Kyowa Hakko Bio Co., Ltd., manufactures Setria® Glutathione through a patented fermentation process that yields a high-purity, high-quality ingredient. It is non-GMO, vegetarian and allergen-free, and Kyowa Hakko's clinical research program has studied its role in cellular defense, healthy aging and antioxidant support.

Each two-capsule serving of RHYTHM delivers 500 mg of NMN, 500 mg of Setria® L-glutathione (reduced), 100 mg of CoQ10 (ubiquinone), 10 mg of PQQ, 10 mg of trans-resveratrol, 50 mcg of vitamin D3, and 5 mg of BioPerine® in a DRcaps® delayed-release capsule. RHYTHM is manufactured in the United States in a cGMP facility, and the company publishes third-party test results from Eurofins for potency, purity, and heavy metals on its website.

RHYTHM NMN is now available on Amazon here and at therhythmline.com in 60-capsule bottles (30 servings) for $69, with launch pricing on Amazon and a subscription option for repeat orders.

About Kyowa Hakko USA

Kyowa Hakko USA is the North & South American office of Kyowa Hakko Bio Co., Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food and beverage products. Kyowa is the maker of branded ingredients, including Cognizin®, Eyemuse® Lacticaseibacillus paracasei KW3110, Pantesin® Pantethine, Setria® Glutathione, and L-Alanyl-L-Glutamine. For more information, visit www.kyowa-usa.com.

About Setria®

Setria® Glutathione, manufactured by Kyowa Hakko Bio Co., Ltd., is a clinically studied and patented form of glutathione that, when taken orally, has been shown to increase the body's reserves, which may be depleted by lifestyle choices, stress, or natural aging. Called the "master antioxidant," glutathione helps protect cells in the body from the damaging effects of oxidative stress and toxins. Setria® Glutathione is manufactured through a patented fermentation process to yield high purity and high quality, and is non-GMO, vegetarian, and allergen-free. For more information, visit www.setriaglutathione.com.

About RHYTHM

RHYTHM is a cardiologist-formulated NAD+ supplement from The Rhythm Line, designed for people who experience the afternoon energy crash and want an alternative to caffeine. The product combines seven ingredients in a single delayed-release capsule, with each ingredient selected for a specific role in the formula. RHYTHM is manufactured in the United States in a cGMP facility and independently tested by Eurofins for potency, purity, and heavy metals, with results published on the company's website. RHYTHM NMN is now available on Amazon here and at therhythmline.com.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

SOURCE Kyowa Hakko U.S.A

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