Sjogren's Syndrome Market Size to Grow with a Modest CAGR of 13.9% During the Forecast Period of 2017-2030 with 3.2M Diagnosed Prevalent Cases in the 7 Major Markets (US, EU5 & JP) in 2020

LAS VEGAS, Feb. 4, 2021 /PRNewswire/ -- DelveInsight's "Sjogren's Syndrome Market" report provides a complete comprehension of the Sjogren's Syndrome, historical and forecasted epidemiology and the Sjogren's Syndrome market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Sjogren's Syndrome market report also proffers an analysis of recent Sjogren's Syndrome treatment practice/algorithm, market drivers, market barriers and unmet medical needs.

Some of the essential spotlights of Sjogren's Syndrome Market Research Report 

• Several companies such as Resolve Therapeutics, Novartis, MorphoSys, GlaxoSmithKline, Roche, Bristol Myers Squibb, TearSolutions, Incyte Corporation, Galapagos NV, Gilead Sciences, VIELABIO, and several others are working robustly on developing many new therapies for the Sjogren's Syndrome treatment. The mid-stage pipeline is crowded, with several potential therapies with big pharmaceutical companies' imminent attention for Sjogren's Syndrome market space.
• Currently, the Sjogren's Syndrome therapeutic market size is mainly accounted by symptomatic treatment using the local therapies like pilocarpine, cevimeline, topical fluoride, topical cyclosporine, autologous serum eye drops, and, systemic therapies like corticosteroids, hydroxychloroquine, immunosuppressants (Methotrexate (MTX), Cyclosporine A, Azathioprine, Leflunomide, and Mycophenolic acid). Moreover, biological therapy with Rituximab is in extensive use for the US market.
• The recent advances in molecular technology have provided a plethora of novel putative serum, salivary and histologic biomarkers, potentially useful for ameliorating the management of Sjogren's Syndrome patients.
• The current advancements in the classification, defined ESSDAI index, treatment, and diagnostic procedures, and increased prevalence are the major Sjogren's Syndrome market drivers. Additionally, Sjogren's Syndrome market is expected to change with the current market dynamics and emerging therapies, which presently comprises biologics and molecules with novel mechanisms of action.

For additional information on Market Impact by Therapies, visit: Sjogren's Syndrome Market Forecast Analysis 

Sjogren's Syndrome is an autoimmune disorder caused by the lymphocytic infiltration of exocrine glands resulting in glandular dysfunction, preferentially of the salivary and lacrimal glands. The most common Sjogren's Syndrome symptoms are dry eyes and dry mouth. As per DelveInsight estimates, the total cases of Sjogren's Syndrome in the 7MM were found to be 3,179,223 in 2017.

Download Sjogren's Syndrome Market Analysis Infographic 

The Sjogren's Syndrome Market Report provides historical as well as forecasted epidemiological analysis segmented into: 

• Total Diagnosed Prevalent Cases
• Gender-Specific Cases
• Type-Specific Cases
• Severity-Specific Cases

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 Sjogren's Syndrome Treatment Market 

Currently, the Sjogren's Syndrome therapeutic market size is mainly accounted by symptomatic treatment using the local therapies like pilocarpine, cevimeline, topical fluoride, topical cyclosporine, autologous serum eye drops, and, systemic therapies like corticosteroids, hydroxychloroquine, immunosuppressants (Methotrexate (MTX), Cyclosporine A, Azathioprine, Leflunomide, and Mycophenolic acid). Local therapy generally comprises the treatment of sicca symptoms. For the dry-eyes treatment, tear substitution therapy including high-viscosity eye drops and gels, combined with oral mucolytic agents to dissolve mucus, is the mainstay in Sjogren's Syndrome treatment. Drugs with a systemic effect, secretagogues, such as pilocarpine and cevimeline, were approved by the US FDA to treat dry eyes and mouth in Sjogren's Syndrome patients. 

Systemic treatment is indicated when general symptoms cannot be managed with local treatment or adjustment of the patient's lifestyle and organ involvement. The main non-biological drugs that are used for the treatment of Sjogren's Syndrome are corticosteroids and hydroxychloroquine. Corticosteroid treatment is predominantly indicated when severe cutaneous, pulmonary, renal, musculoskeletal, and/or neurological involvement occurs. The long-term use of corticosteroids is associated with adverse effects, including osteoporosis, diabetes, weight gain, and dyslipidemia.

In case of the insufficient effect of corticosteroid therapy or intolerance due to side effects and/or to reduce glucocorticoid dose, adding immunosuppressant or switching off a DMARD (disease-modifying antirheumatic drugs) is considered. 

In the case of therapy-resistant and organ damage, biological therapy is the most promising target-based approach. Rituximab is a monoclonal antibody targeting the CD20 molecule, expressed on the surface of most B cells, comprising pre-B and mature B lymphocytes resulting in B cell depletion. Several studies have shown a favorable effect of rituximab in Sjogren's Syndrome. Because of rituximab treatment, serum BAFF levels raise to stimulate B cell maturation that can be countered by anti-BAFF treatment belimumab to achieve a longer B cell reduction and associated longer treatment effect. However, it has yet to prove the efficacy in the long-term clinical trials. 

In conclusion, the current advancements in the classification, defined ESSDAI index, treatment, and diagnostic procedures and increased prevalence are the major Sjogren's Syndrome market drivers. Additionally, Sjogren's Syndrome market is expected to change with the current market dynamics and emerging therapies, which presently comprises biologics and molecules with novel mechanisms of action. Further, increased diagnosis and analysis of biomarkers may improve the Sjogren's Syndrome treatable pool for the forecast period. 

To meet the current demands of Sjogren's Syndrome patient pool and to counter the unmet needs of the Sjogren's Syndrome therapeutic market, drug developers are gradually shifting their attention toward the disease as a possible indication for new targeted therapies. The launch of various multiple-stage pipeline products will significantly revolutionise the Sjogren's Syndrome market dynamics soon. 

Sjogren's Syndrome Emerging Therapies Along with Key Players 

• RSLV-132: Resolve Therapeutics
• VAY736: Novartis/MorphoSys
• CFZ533: Novartis
• Belimumab: GlaxoSmithKline
• RO5459072: Roche
• LOU-064: Novartis
• Abatacept: Bristol Myers Squibb
• Lacripep: TearSolutions
• Parsaclisib: Incyte Corporation
• Filgotinib: Galapagos NV /Gilead Sciences
• GS-9876: Gilead Sciences
• VIB7734: VIELABIO

And several others. 

Scope of the Sjogren's Syndrome Market Insight  

• Geography Covered: 7MM - The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan.
• Study Period: 3-year historical and 11-year forecasted analysis (2017-2030).
• Sjogren's Syndrome Markets Segmentation: By Geographies and By Sjogren's Syndrome Therapies (Historical and Forecasted, Current and Upcoming)
• Leading Companies investigating its candidates for Sjogren's Syndrome: Resolve Therapeutics, Novartis, MorphoSys, GlaxoSmithKline, Roche, Bristol Myers Squibb, TearSolutions, Incyte Corporation, Galapagos NV, Gilead Sciences, VIELABIO, and several others.
• Analysis: Comparative and conjoint analysis of emerging therapies, Attribute Analysis.
• Case Studies
• KOL's Views
• Analyst's View

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Table of Contents 

Browse detailed TOC with charts, figures, tables @ Sjogren's Syndrome Market Research

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