THORNE SETS A HIGHER STANDARD FOR SCIENCE-BACKED WELLNESS WITH NEW CREATINE + ALPHA-GPC CONSUMER RESEARCH SUPPORTING MENTAL AND PHYSICAL PERFORMANCE

New consumer study of Thorne's finished formulation showed improvements in cognitive test scores and participant-reported outcomes, reinforcing the company's leadership in rigorous research, clinically informed innovation, and uncompromising quality

SUMMERVILLE, S.C., Sept. 29, 2026 /PRNewswire/ -- Thorne, the leader in science-backed health and wellness solutions, today announced results from a new consumer study evaluating its Creatine + Alpha-GPC. The findings demonstrated improvements across objectively measured cognitive performance and participant-reported focus, mental clarity, motivation, energy and endurance expanding the evidence supporting the product's role in both mental and physical performance.

The 30-day, open-label study evaluated 105 healthy, physically and mentally active adults using Thorne's Creatine + Alpha-GPC formulation, which combines 5 grams of creatine monohydrate with 600 milligrams of alpha-glycerylphosphorylcholine (Alpha-GPC). The product is also NSF Certified for Sport®, providing independent third-party testing providing athletes with an additional level of assurance through testing for banned substances. In addition to evaluating participants' experiences with the product, the study incorporated a validated cognitive assessment to objectively measure changes in cognitive performance.

"At Thorne, research is not a final checkpoint – it is the foundation of how we develop products," said Ken Rowe, Chief R&D Officer at Thorne. "From evidence-based ingredients and purposeful dosing to rigorous evaluation of our finished formulations, every step is designed to give consumers confidence in what they are taking. That rigor has defined Thorne for more than 40 years, and it will continue to set the standard for how we innovate, validate our products, and earn trust."

Measurable Cognitive Performance and Early Perceived Benefits
After 30 days, more than 60% of participants improved across multiple areas of cognitive performance measured through a validated cognitive assessment.

Participants also reported noticing benefits early in the study:

• Across the four outcomes (focus, clarity, performance and mood) an average of 71% of participants showed an improvement, with the mean time-to-benefit of 2 days.
• 79% experienced a noticeable benefit in focus, clarity, performance or mood during the first week

Mental performance benefits continued to strengthen throughout the study. After four weeks, users reported significant shifts in various measures from baseline, reporting an average increase of:

• 96% in improved motivation
• 89% in improved focus
• 78% in improved mental clarity
• 74% reported that the product helped improve attention

Support for Physical Energy, Endurance, and Exercise
The study also demonstrated participant-reported improvements across several measures of physical performance. After four weeks:

• 83% reported improved energy
• 82% reported improved endurance
• 80% reported improved mental focus during exercise
• 77% reported improved physical energy during exercise
• 71% reported that the product helped improve their ability to work out
• 70% reported that the product helped improve recovery time following physical activity

Participants also reported a strong overall product experience. Ninety percent said they would recommend the product to friends or family for supporting mental and physical performance, and 89% expressed interest in continuing to use it.

Research as a Continuing Commitment
The study reflects a broader research commitment that extends across Thorne's portfolio. To date in 2026, Thorne has completed five clinical and consumer studies, with another 16 studies underway or in planning across the remaining pipeline. Looking ahead, Thorne's preliminary 2027 research pipeline includes more than 30 planned clinical and consumer studies, subject to final prioritization, funding, and scheduling.

For more than four decades, Thorne has invested in research, clinical partnerships, and rigorous quality systems to develop products grounded in science and supported by evidence. This includes studying finished formulations – not only individual ingredients – to better understand the experiences and outcomes consumers can expect from the products they use.

That research commitment is supported by the broader Thorne Standard – thoughtful ingredient selection, purposeful formulation, extensive testing, and stringent manufacturing and quality controls.

"This study gives us a more complete picture of how the formula performs by pairing a validated cognitive assessment with participants' real-world experiences," said Dr. Amanda Frick, ND, LAc – SVP of Medical, Clinical, and Scientific Affairs at Thorne. "The improvements observed across cognitive performance, focus, mental clarity, energy and endurance reinforce the potential of thoughtfully combining creatine and Alpha-GPC to support both mind and body."

To learn more about Thorne's Creatine + Alpha-GPC, visit here.

Study Disclaimer: Results are based on a 30-day, open-label consumer study involving 105 healthy, physically and mentally active adults. The study included participant-reported outcomes and a validated objective cognitive assessment. Individual results may vary.

About Thorne®:
Thorne is the leader in science-backed health and wellness solutions built to connect the science of performance with the science of people. As the top recommended clinical brand by health-care practitioners, Thorne offers a comprehensive range of nutritional supplements and innovative technology tools including Taia™ – Thorne's AI-powered wellness advisor – empowering individuals to take control of their health and wellness journey with confidence. Founded in 1984, Thorne develops products with high-quality ingredients, guided by clinical research and an in-house team of doctors, researchers, and scientists to ensure every formula meets rigorous standards for purity, potency, and efficacy. Thorne maintains a vertically integrated model, setting the industry standard for supplement manufacturing at its own facility in South Carolina. Trusted by tens of thousands of health-care professionals, thousands of professional athletes, 100+ professional sports teams and multiple U.S. National Teams, and over seven million consumers, Thorne is a trusted partner bringing scientific rigor to everyday health and wellness. For more information, visit Thorne.com.

SOURCE Thorne