2019 Biotechnology Research Review: CRISPR, Spheroids for Drug Development, Luciferase-based High-throughput Screening Assays, and More

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Dec 06, 2019, 09:30 ET

DUBLIN, Dec. 6, 2019 /PRNewswire/ -- The "2019 Biotechnology Research Review" report has been added to ResearchAndMarkets.com's offering.

Several significant developments have aided and accelerated the growth of markets in biotechnology, in the period of review. Notable recent advancements in biotechnology are CRISPR, Spheroids for drug development, Quantitative Cell Based Assay using high content analysis platform and Luciferase based high-throughput screening assay. Such technologies assure the wide adoption of cell line technologies for drug development, simplify the gene editing process making it cost-effective.

Companies operating in cell line market are investing huge amount in setting up manufacturing units with advanced state of art facility and expanded production facilities. At the same time, the genetic sequencing technology is advancing at a great pace especially in the healthcare sector in diagnosis of various cancers.

Gene therapy technology has opened new avenues which places emphasis on curing disease that do not have an effective therapeutic availability. Johnson & Johnson, together with the University of Pennsylvania, is developing a third-generation AAV-based gene therapy for Alzheimer's disease. The goal is to use AAV viral delivery to initiate the expression of therapeutic anti-Alzheimer's antibodies in the brain. Novartis launched Zolgensma for the treatment of spinal muscular atrophy. The research represents a novel way to get biologics into the brain to treat Alzheimer's disease and other neurological diseases. This is expected to pave way for further innovations in AAV-based gene therapy.

The sector continuously faces some challenges related to marketing, paying for innovation, pricing pressures from the government organizations.

Paying for development costs is always most critical part for the manufacturers. In 2019, gene therapies and many cell biology technologies are developed to address the needs of some important diseases and proven to be effective. However, this comes for a high cost. For example, Zolgensma, a viral vector based gene therapy for the treatment of spinal muscular atrophy costs around $5 million. It is important to figure out how to pay for the innovation which is quite challenging.

The pricing and paying for getting the products to market are important challenges. The innovation may take several years from clinical trial phase to get launched in the market. The investors may be disappointed if the company doesn't show expected profits and loses the hope while stock prices fall. This means that companies must carefully manage expectations and maintain balance.

Key Topics Covered

Chapter 1 Foreword

Chapter 2 Cancer Profiling and Pathways: Technologies and Global Markets (Report Code: BIO073C)

Introduction
Study Goals and Objectives
Reasons for Doing This Study
Intended Audience
Scope of the Report
Methodology
Information Sources
Summary and Highlights
Cancer Profiling and Pathways
Introduction to Cancer Profiling Technologies
Biomarkers
Screening Tests
Early Detection and Diagnosis of Cancer
Pathway Profiling
Molecular Profiling
Cancer Profiling
Clinical Utility of Molecular Profiling
Pathological Classification
Cancer Profiling: Future Goals

Chapter 3 Cell Harvesting Market (Report Code: BIO182A)

Introduction
Study Goals and Objectives
Scope of Report
Research Methodology and Information Sources
Geographic Breakdown
Summary and Highlights
Market and Technology Background
Key Market Trends
Increased Healthcare Spending to Promote the Growth of the Market
Manual Cell Harvesting Will Continue to Account for a Significant Share of the Market
North America Will Continue to Account for a Significant Share of the Market
Emphasis on Innovations in 3D Cell Culture Technology
Key Recommendations
Shifting Focus toward Small and Medium-Sized Enterprises (SMEs)
Increased Number of Partnerships and Collaborations Driving Market Growth
Emphasis on Emerging Economies
Bone Marrow is the Major Source of Stem Cells Used in Harvesting Procedures
Factors Restraining Market Growth
High Treatment and Research Costs
Market Breakdown by Type of Harvesting
Automated Cell Harvesting
Manual Cell Harvesting
Market Breakdown by End User
Research Institutes
Biotechnology and Biopharmaceutical Companies
Hospitals and Clinics
Market Breakdown by Application
Bone Marrow
Adipose Tissue
Peripheral Blood
Umbilical Cord

Chapter 4 Exosome Diagnostics and Therapeutics: Global Markets (Report Code: BIO149C)

Introduction
Study Goals and Objectives
Scope of Report
Information Sources
Intended Audience
Summary and Highlights
Market Overview
Exosome Definition and Nomenclature
Exosomes Biogenesis and Processing
Exosome Components
DNA in Exosomes
Proteins in Exosomes
RNA in Exosomes
Exosome Diagnostic Market
Exosome Therapeutic Market
Market Breakdown by End User
Market Breakdown by Region

Chapter 5 Global DNA Read, Write and Edit Market (Report Code: BIO193A)

Introduction
Study Goals and Objectives
Reasons for Doing the Study
Scope of Report
Methodology
Information Sources
Geographical Breakdown
Summary and Highlights
DNA Read, Write and Edit Technologies and Markets
Large-Scale Initiatives and Consortia
Applications of DNA Read, Write and Edit Technologies
DNA Read, Write and Edit Market Driving Forces
Global DNA Read, Write and Edit Markets
DNA Read, Write and Edit Applications
DNA Read, Write and Edit Markets by Region
Gene Editing Market
Industry Growth-Driving Forces

Chapter 6 Global DNA Sequencing: Research, Applied and Clinical Markets (Report Code: BIO045G)

Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Summary and Highlights
Overview of Technology
Sequencing Markets
Sequencing Growth Driving Forces
Sequencing Applications
Sequencing Industry
Market Drivers

Chapter 7 Global Stem Cell and Regenerative Therapy Market: A Research Outlook (Report Code: BIO191A)

Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Summary and Highlights
Introduction to Technology
Stem Cell Research Centers
Stem Cell Production
Customized Therapy
Market Dynamnis
Market Drivers
Market Restraints
Market Breakdown by Product
Global Stem Cell and Regenerative Medicines Market, by Product
Therapeutic Products
Cell Therapies
Tissue Engineering
Gene Therapy
Cell Banking
Tools and Reagents

Chapter 8 Protein Expression: Global Markets (Report Code: BIO165A)

Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources and Methodology
Intended Audience
Geographic Breakdown
Summary and Highlights
Introduction to Technology
Market Definition
Protein Expression Market Overview
Introduction to Protein Expression Systems
Protein Synthesis Machinery
What is Protein Expression?
How Proteins Are Made?
Transcription and Translation
Perfusion Approaches and Supporting Practices (e.g., Continuous Bio Manufacturing and Digital and Model-based Controls)
Post-translational Modification
Cloning Technologies
Constitutive and Inducible Promoters Commonly Used in Recombinant Protein Expression Systems
Production of Recombinant Proteins
Comparison of Expression Systems
Problems Associated with the Production of Protein
Ongoing Clinical Trials for Protein Expression
Global Market for Protein Expression Systems by Type
Global Market for Protein Expression by Products and Services
Global Market for Protein Expression by Application
Global Market for Protein Expression by End User

Chapter 9 Viral Vector and Plasmid DNA: Technologies and Global Markets (Report Code: BIO192A)

Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Summary and Highlights
Introduction to Technology
Gene Therapy
Plasmid Production
Description of Market Trends
Market Dynamics
Market Drivers
Market Restrictions
Opportunity
Market Breakdown by Product Type
Plasmid DNA
Viral Vector
Market Breakdown by End User
Research Institutes
Pharmaceutical and Biopharmaceutical Companies
Market Breakdown by Application
Cancer
Infectious Diseases
CVD
Other Applications
Market Breakdown by Region

For more information about this report visit https://www.researchandmarkets.com/r/w9e51e

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