ADCs in Oncology Trials: Practical Strategies for Clinical Development Success, Upcoming Webinar Hosted by Xtalks

In this free webinar, gain actionable insights and proven strategies to support more effective navigation of the complexities of antibody-drug conjugate (ADC) clinical development. Attendees will learn about the rapid evolution of ADCs in oncology and how they have revolutionized the cancer treatment landscape. The featured speakers will discuss how to navigate an increasingly competitive landscape and ensure operational excellence in ADC trial delivery. Attendees will gain insight into ADC study design and startup essentials, including how to avoid common protocol design pitfalls, optimize ADC dosing, streamline global startup timelines and strengthen site and investigator relationships. The speakers will also share practical strategies for biomarker-selective patient identification and how to mitigate common ADC safety risks.

TORONTO, Aug. 26, 2025 /PRNewswire/ -- Antibody-drug conjugates (ADCs) are revolutionizing cancer treatment and heralding in a new era of targeted therapies. Although ADCs have been in development since the 1980s, recent advances in antibody engineering, linker stability and payload technologies have reignited interest and investment in this powerful drug class.

Within the past few years, ADCs have surged to the forefront of oncology innovation:

• 14 FDA-approved ADCs are now on the market
• Over 1,100 ADC therapies are in development
• Nearly 3,000 clinical trials are underway globally
• R&D investment has more than doubled since 2020, reaching $10–12 billion annually

Join this webinar to hear from a panel of seasoned clinical operations and medical experts as they share real-world case studies and practical strategies for navigating the complex and competitive ADC clinical trial landscape. Designed for teams planning their first ADC study or optimizing ongoing programs, this session will offer practical insights, lessons learned and actionable insights that can be applied immediately.

Key topics to be discussed:

• The Evolution of ADCs: Paradigm shifts in oncology and the implications for clinical trial design
• Next-Generation ADC Technologies: Advances in antibodies, linkers and payloads
• Regulatory and Protocol Design: Navigating study design and regulatory requirements for proof-of-concept and registrational trials
• Feasibility and Global Study Planning: Standing out in a crowded field while expanding trial footprint
• Biomarker-Driven Recruitment: Assay development, eligibility criteria and identifying the right patients
• Dose Optimization and Cohort Management: Strategies to maximize an ADC's therapeutic window in the Project Optimus era
• Managing ADC-Specific Toxicities: Addressing ocular, neurotoxic and bystander effects
• Overcoming Drug Resistance: Tackling antigen loss and other resistance mechanisms

Register for this webinar to gain valuable insights and takeaways for anticipating and overcoming the unique challenges of ADCs in oncology trials.

Join Andrew Zupnick, PhD, Vice President, Oncology Drug Development, Catalyst Oncology; Udayan Guha, MD, PhD, Chief Medical Officer, NextCure; and Stephanie Kordahi, MS, Senior Director, Clinical Operations, NextCure, for the live webinar on Thursday, September 11, 2025, at 11am EDT (4pm BST/UK).

For more information, or to register for this event, visit ADCs in Oncology Trials: Practical Strategies for Clinical Development Success.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars and digital content to the global life science, food, healthcare and medical device communities. Every year, thousands of industry practitioners (from pharmaceutical, biotechnology, food, healthcare and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps professionals stay current with industry developments, regulations and jobs. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Vera Kovacevic
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