American College of Medical Genetics and Genomics Releases Policy Statement on Genomic Sequencing

Mar 29, 2012, 18:45 ET from American College of Medical Genetics and Genomics

BETHESDA, Md., March 29, 2012 /PRNewswire-USNewswire/ -- The American College of Medical Genetics and Genomics (ACMG) has released an important new Policy Statement on Genomic Sequencing.  Released at the ACMG Annual Meeting in Charlotte, N.C., on March 28, the Policy Statement titled "Points to Consider in the Clinical Application of Genomic Sequencing" outlines general principles that are recommended as genome-scale DNA sequencing begins to be applied in the care of patients. These new guidelines should help guide clinicians as they use such testing and address:

-The categories of patients and types of clinical situations for which such testing will likely be the most helpful

-What patients need to know about genomic sequencing before it is performed

-Principles that guide the use of information from genomic sequencing to improve patient care and medical decision-making

ACMG President Wayne Grody, M.D., Ph.D., FACMG said upon the Statement's release, "The transition from traditional targeted gene testing to genome-wide analysis constitutes a genuine sea change in medicine, offering vastly enhanced diagnostic power along with unprecedented challenges in test interpretation and reporting. This policy represents the first professional guidance for appropriate integration of this new technology into clinical practice."

"Genomic sequencing is now transitioning from the research laboratory into the clinic and will have a transformative effect on healthcare," said Bruce R. Korf, M.D., Ph.D., FACMG, one of the authors of the new Policy Statement and past-president of the ACMG.  "This statement by the American College of Medical Genetics and Genomics will help set the context for clinical genomic sequencing to insure maximum value and quality or our patients and the public."

In defining the need for this document, ACMG said in the Policy Statement, "Major advances in DNA sequencing technology have made it possible to do large-scale sequencing, up to and including whole genome sequencing, in an effort to identify a gene mutation that may provide a diagnosis for a patient with an abnormal phenotype. This strategy offers potential advantages over classic approaches in which genes are analyzed individually, often over a long period of time and at substantial expense.  As a result, there is considerable interest in offering genomic sequencing-based tests on a clinical basis. This document outlines points to consider in the clinical application of genomic sequencing to the detection of germ-line mutations. It is expected that this document will require revision as this rapidly changing field evolves."

One of the main conclusions/recommendations of the Policy Statement is that genomic sequencing data must be integrated in the context of the medical and family history of the individual patient to guide medical decision-making.  This should be done by a health provider who is familiar with the enormously complex and voluminous data that is obtained from genomic sequencing.

The full policy statement is available on ACMG's homepage at

Available Topic Expert(s): For information on the listed expert(s), click appropriate link.
Michael S. Watson



SOURCE American College of Medical Genetics and Genomics