An Encouraging Turn in the Study - Report on Cara Therapeutics Inc.

Jul 31, 2015, 09:20 ET from

NEW YORK, July 31, 2015 /PRNewswire/ --

ACI Association has initiated research coverage on Cara Therapeutics Inc. (NASDAQ: CARA). Select highlights from the internally released reports are being made available to the general public (included below), with access to the entirety of the research available to new members.

Today, membership is open to readers on a complementary basis at the following URL:

Highlights from our CARA Report include:

  • Cara Therapeutics announces statistically significant results - On July 23, 2015, Cara Therapeutics, Inc. announced that the topline results from its Phase 2 trial of its lead kappa opioid agonist, CR845, for the treatment of moderate to severe uremic pruritus (UP) were statistically significant.
  • The Phase 2 Trial - The Phase 2 Trial conducted by the Company was a double-blind, randomized, placebo-controlled trial devised to evaluate the efficacy of I.V. CR845 compared to placebo in reducing the intensity of itch in dialysis patients over a two-week dosing period. For the trial, Cara Therapeutics enrolled 65 dialysis patients at multiple sites in the United States. According to the Company, the primary endpoint of the Phase 2 trial was the change from baseline of the average worst itching during the second week of treatment, as was recorded on a visual analog scale (VAS).
  • Management Views - Derek Chalmers, Ph.D., D.Sc., the CEO and President of Cara Therapeutics said that the results demonstrated the potential of Cara's lead candidate CR845 to address an additional indication of significant unmet need beyond its lead I.V. CR845 program in acute pain. Joseph Stauffer, D.O., M.B.A., the Chief Medical Officer of the Company said that the management was excited by the topline results in uremic pruritus, as they show that I.V. CR845 holds significant clinical potential in what seems as an indication of significant unmet need for dialysis patients. Dr. James Tumlin, Professor, Department of Medicine, University of Tennessee and a Principal Investigator on the trial said that with no approved therapy and the limited efficacy of current options, CR845 provides an opportunity to relieve the pain and discomfort of this persistent clinical problem among ESRD patients.

To find out how this influences our rating on Cara Therapeutics, Inc. read the full report in its entirety here:


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