LONG BEACH, Calif., July 23, 2021 /PRNewswire/ -- The Proceedings of the National Academy of Sciences, one of the world's most cited and comprehensive scientific journals, has released a research article detailing the effectiveness of Anivive's GC376 in preventing the reproduction of SARS-CoV-2, the virus that causes COVID-19.
While vaccines to help prevent COVID-19 are now expansively available in the United States, the need for post-infection treatment options is on the rise.
The PNAS article, "Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection," details a study that shows mice with fatal SARS-CoV-2 infections experienced reduced viral load and improved survival when treated with deuterated variants of GC376, an antiviral medication under development by Anivive Lifesciences.
All coronaviruses, including SARS-CoV-2, contain a protease responsible for replication of the virus. GC376 is a protease inhibitor, designed to block the replication process and stop the virus from spreading.
For the study, mice infected with SARS-CoV-2 that developed lung pathology resembling that of severe COVID-19 in humans were given a series of deuterated variants of GC376 to evaluate the antiviral effect against SARS-CoV-2. Treatment was started 24 hours after infection. Study results show GC376 has excellent therapeutic efficacy as an antiviral agent against SARS-CoV-2.
"We are pleased to see more conclusive evidence that GC376 shows strong activity against the main protease, 3CLpro, in SARS-CoV-2 with a high therapeutic index," said Anivive Chief Medical Officer, David Bruyette. "GC376 continues to demonstrate in vitro and in vivo activity against many human and animal coronaviruses."
Anivive, a biotechnology company focused on pet health, has been developing GC376 since 2018 to treat a deadly cat disease caused by a coronavirus. Feline Infectious Peritonitis is the leading cause of death in kittens and young cats, affecting up to 1 in 300 cats worldwide.
The University of California in Davis conducted field tests for the use of GC376 in cats with FIP. GC376 resulted in a reversal of symptoms within 48 hours with no significant side effects.
GC376 has the potential to be a One Health medicine, providing therapeutic benefits to both pets and people. Anivive has filed a pre-Investigational New Drug request with the Food and Drug Administration to evaluate GC376 as a post-infection treatment of COVID-19 in humans.
"We hope to leverage existing animal work to accelerate the availability of effective COVID-19 therapeutics for humans," said Anivive CEO, Dylan Balsz. "With this additional exciting research in hand, we look forward to discussions with the FDA and advancing toward a clinical trial."
GC376 is a broad-spectrum antiviral medicine under development by Anivive Lifesciences for therapeutic use in animals and humans. A first-in-class small molecule protease inhibitor, GC376 blocks 3CLpro, a protease common to many coronaviruses, with high therapeutic efficacy. Anivive licensed exclusive worldwide patent rights to GC376 from Kansas State University.
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Backed by over $45 million in seed funding, Anivive has gained conditional approval for LAVERDIA™-CA1 (verdinexor), the first oral tablet to treat canine lymphoma and created a specialty sales force dedicated to supporting veterinarians. Anivive's pipeline includes 8+ first-in-class pharmaceuticals, biologics, and vaccines. For more information on how we address unmet needs for pets, visit anivive.com.
SOURCE Anivive Lifesciences Inc.