Applying a Holistic Digital Endpoint Strategy in the Development of Congestive Heart Failure Treatments, Upcoming Webinar Hosted by Xtalks

In this free webinar, gain a holistic understanding of how to align cardiac imaging and ECG assessments, along with patient-reported outcome (PRO) strategies to support robust endpoint definitions and regulatory success in congestive heart failure (CHF) trials. Attendees will understand the importance of continuous arrhythmia monitoring, blood pressure tracking and the role of 12-lead ECG in evaluating cardiac function and safety in CHF trials. The featured speakers will discuss the implications of the American Heart Association's (AHA) April guidance on PROs in CHF studies, and how today's trials are integrating these patient-reported outcomes to capture symptom burden and quality of life better. Attendees will learn why reliance on site-based echocardiography may compromise data quality, and how advanced modalities like centralized 3D echo and cardiac MRI can provide additional meaningful data beyond more standard approaches. The speakers will also discuss the essential role of independent clinical adjudication in major adverse cardiovascular events (MACE) studies, ensuring unbiased, high-integrity endpoint classification.

TORONTO, Aug. 27, 2025 /PRNewswire/ -- As the treatment modalities, scope and complexity of clinical trials for congestive heart failure (CHF) drug development increase, so does the need for precision and accuracy in endpoint definitions and assessments. This webinar will provide a comprehensive exploration of how to integrate cardiac imaging, ECG and arrhythmia assessments, along with a meaningful patient report outcome strategy to optimize study outcomes, ensure data integrity and support regulatory success.

Attendees will gain an in-depth understanding of advanced cardiac monitoring techniques, including continuous arrhythmia assessment, blood pressure tracking and the use of 12-lead ECG to characterize cardiac function. The session will also examine recent professional guidelines and trends regarding patient-reported outcomes in heart failure trials and how these can help us to assess and understand symptom burden and quality of life more accurately.

Experts will present the limitations of relying on site-based echocardiography and discuss the advantages of blinded central review. Advanced modalities such as 3D echocardiography and cardiac MRI will also be reviewed. Finally, the discussion will address the critical role of independent clinical adjudication in major adverse cardiovascular events (MACE) studies, underscoring its value in achieving unbiased, regulator-grade endpoint classification.

This webinar is designed to equip clinical development teams with the scientific rationale and operational insights necessary to elevate the quality and impact of CHF clinical trials.

Register for this webinar to learn how a digital endpoint strategy can enhance data quality, support regulatory success and improve outcomes in heart failure trials.

Join experts from Clario, Vic Patel, MD, PhD, VP & Chief Medical Officer, Cardiology; Thomas Moll, PhD, MBA, Senior Scientific Advisor; Judith Narisi, BSN, RN, Senior Medical Scientific Affairs Associate; and Tonya Varcelli, PhD, Director, Scientific and Medical Affairs, CV Imaging, for the live webinar on Tuesday, September 16, 2025, at 11am EDT (4pm BST/UK).

For more information, or to register for this event, visit Applying a Holistic Digital Endpoint Strategy in the Development of Congestive Heart Failure Treatments.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars and digital content to the global life science, food, healthcare and medical device communities. Every year, thousands of industry practitioners (from pharmaceutical, biotechnology, food, healthcare and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps professionals stay current with industry developments, regulations and jobs. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Vera Kovacevic
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