BCMA Targeted Therapies, 2017-2030: Even Though Big Pharmaceutical Companies Dominate the Current Space, Several Start-Ups/Small Companies Have Emerged - Research and Markets

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Apr 13, 2017, 15:45 ET

DUBLIN, Apr. 13, 2017 /PRNewswire/ --

Research and Markets has announced the addition of the "BCMA Targeted Therapies, 2017-2030" report to their offering.

The "BCMA Targeted Therapies, 2017-2030" report features an extensive study on the current market landscape of B-cell maturation antigen (BCMA) targeted therapies and offers a comprehensive discussion on the future potential of this market. With no commercial products, the market is still in its infancy.However, industry experts have pinned significant hopes on the novel technologies being developed by start-ups/small companies and the research being conducted at academic institutes.

B-cell maturation antigen (BCMA), an important biomarker of the B-cells, has emerged as a promising therapeutic target for the treatment of multiple myeloma and other hematological malignancies. The antigen is universally expressed on the surface of multiple myeloma cells. The research focus shifted towards BCMA targeted therapies in 2004, when the role of BCMA was first indicated in the progression of multiple myeloma. It is the second most common type (13%) of all hematological malignancies.

Results of preclinical and clinical studies have demonstrated the potential benefits of this class of therapies; the major highlight being their attractive safety profile. As more molecules undergo clinical validation and eventually get commercialized, we believe the overall interest will continue to rise. In fact, our promising outlook is backed by a strong belief that this novel class of therapies is likely to cater to the current unmet need where the existing treatment modalities are not efficient. The upside could be higher; however, it depends on a favorable market environment, reimbursement practices and regulatory regimes.

The prime target indication of these novel molecules is B-cell malignancies, specifically multiple myeloma. BCMA-specific therapies are anticipated to emerge as viable treatment options for such indications. Post initial research on such therapies, many players have entered into collaborations with other stakeholders to fund the clinical and commercial development of their products. Some clinical stage products that have emerged out of such collaborations include bb2121 (bluebird bio/Celgene) and BCMA-CART (Novartis/Abramson Cancer Center of the University of Pennsylvania).

The pipeline currently comprises of 23 molecules that are under development for the treatment of a variety of B-cell malignancies. One of the key objectives of this report was to understand the evolution of the current market and to quantify the opportunities laid down by the innovative BCMA targeted programs of both small and big pharma companies.

Key Topics Covered:

1. PREFACE
1.1. Chapter Overview
1.2. Research Methodology
1.3. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. The B-Cell Maturation Antigen
3.3. Drug Classes for BCMA Targeted Therapies
3.4. BCMA Targeted Therapies and Research Landscape
3.5. Emergence of BCMA as a Therapeutic Target for the Treatment of Multiple Myeloma
3.6. BCMA Related Targets: A Case Study

4. MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Development Pipeline
4.3. Distribution by Phase of Development
4.4. Distribution by Type of Molecule
4.5. Distribution by Type of Developer
4.6. Distribution by Indication
4.7. Geographical Landscape
4.8. Developer Landscape

5. DRUG PROFILES: CLINICAL MOLECULES
5.1. Chapter Overview
5.2. bb2121 (bluebird bio, Celgene)
5.3. CART-BCMA (Novartis, Abramson Cancer Center of the University of Pennsylvania)
5.4. Anti-BCMA CAR-T (National Cancer Institute)
5.5. Anti-BCMA CAR-T (Southwest Hospital, China)
5.6. GSK2857916/J6M0-mcMMAF (GSK, Seattle Genetics)
5.7. AMG 420/BI 836909 (Amgen, Boehringer Ingelheim)
5.8. BCMA Targeted Therapies: Clinical Development Analysis

6. VENTURE CAPITAL INTEREST
6.1. Chapter Overview
6.2. BCMA Targeted Therapies: List of Funding Instances
6.3. Funding Instances: Distribution by Year
6.4. Funding Instances: Distribution by Type of Model
6.5. Leading Players: Distribution by Number of Funding Instances
6.6. Most Active Venture Capital Firms/Investors

7. RECENT COLLABORATIONS
7.1. Chapter Overview
7.2. Partnership Models/Agreements
7.3. BCMA Targeted Therapies: Recent Collaborations
7.4. Recent Collaborations: Distribution by Year
7.5. Recent Collaborations: Distribution by Type of Model
7.6. Recent Collaborations: Distribution by Type of Molecule
7.7. Recent Collaborations: Most Active Companies

8. MARKET FORECAST
8.1. Chapter Overview
8.2. Scope and Limitation
8.3. Forecast Methodology
8.4. Overall BCMA Targeted Therapeutics Market
8.5. BCMA Targeted Therapeutics Market: Drug Specific Forecasts

9. CONCLUSION
9.1. BCMA has Emerged as a Potential Antigen for the Treatment of Multiple Myeloma
9.2. Led by a Number of Technological Advances, CAR- T Therapies are the Current Flag-Bearer
9.3. Even Though Big Pharmaceutical Companies Dominate the Current Space, Several Start-Ups/Small Companies Have Emerged
9.4. Growing Partnerships and Venture Capital Support are Indicative of the Future Potential
9.5. Once Approved, BCMA Targeted Therapies are Poised to Achieve an Accelerated Growth

10. APPENDIX 1: TABULATED DATA

11. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

ABN AMRO
ADC Therapeutics
ARCH Venture Partners
AbbVie
Abramson Cancer Center of the University of Pennsylvania
Acorn Campus Ventures
Adimab
Aduro Biotech
Advanced Technology Ventures
Aeris Capital
Affimed
Alaska Permanent Fund
Alexo Therapeutics
Alta Partners
Amgen
Aquilo Capital Management
Atlante Biotech
Autolus
BankInvest Biomedical Venture
Baylor College of Medicine
Bezos Expeditions
BioMedInvest
Bluebird bio
Boehringer Ingelheim
Bristol-Myers Squibb
California Institute for Biomedical Research
California Institute for Regenerative Medicine
Cancer Institute, University College London
Celgene
Cellectis
Commercial Street Capital
Cowen and Company
Credit Suisse Securities
Dana-Farber Cancer Institute
Deerfield Partners
Diamond Capital Company
Discover Growth Fund
Domain Associates
Easton Capital
Edmond de Rothschild Investment Partners
EngMab
Eureka Therapeutics
FirstVentury Equity
Five Prime Therapeutics
Forbion Capital Partners
French Muscular Dystrophy Association (AFM)
Genzyme Ventures
GlaxoSmithKline (GSK)
Harbinger Venture Capital
Health Canada
Healthcap Venture Capital
Heidelberg Pharma
Hercules Technology Growth Capital
Idinvest Partners
Immune Pharmaceuticals
Institute of Molecular and Cell Biology
JP Morgan Bay Area Equity Fund
Janssen Biotech
Janssen Pharmaceuticals
Jefferies
Johnson & Johnson
Juno Therapeutics
Kite Pharma
Kleiner Perkins Caufield & Byers
Life Sciences Partners
Majuven
Malin Corporation
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
McMaster University
MedImmune
Memorial Sloan Kettering Cancer Center (MSKCC)
Merlin Nexus
Methodist Hospital, Houston
Micromet
Millennium Pharmaceuticals
National Cancer Institute (NCI)
Novartis
Novartis Institute for Biomedical Research
Novartis-Penn Center for Advanced Cellular Therapeutics
Novo Nordisk
Odyssee Venture
Onyx Pharmaceuticals
OrbiMed
Pfizer
Pontifax
Poseida Therapeutics
RA Capital
Ramius Capital Group
Ridgeback Capital Management
Riverbank Capital
Seattle Genetics
Shire
Singapore BioInnovations
Southwest Hospital of the Third Military Medical University, China
Stifel
Suma Venture
Sutro Biopharma
Takeda Pharmaceutical
Techno Venture Management Capital
Texas Children's Hospital
Texas Pacific Group
The Scripps Research Institute
The University of Texas MD Anderson Cancer Center
The Wellcome Trust
Third Rock Ventures
Transposagen Biopharmaceuticals
Triumvira Immunologics
University of Munich
VenBio
Venrock
Versant Ventures
WILEX
Wuhan Bio-Raid Biotechnology
Yuan Capital

For more information about this report visit http://www.researchandmarkets.com/research/4js9bg/bcma_targeted

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