Biocept Awarded US Patent for proprietary Primer-Switch Mutation Detection and Amplification Improvement Platform Used to Detect Rare Cell Mutations, Including Cancer Biomarkers
Expands Company's patent portfolio and marks another step in pursuit of worldwide intellectual property protection for proprietary Primer-Switch technology used to detect rare events such as cancer biomarkers found in tissue and liquid biopsies
SAN DIEGO, Aug. 18, 2020 /PRNewswire/ -- Biocept, Inc. (NASDAQ: BIOC), a leading commercial provider of liquid biopsy tests designed to provide physicians with clinically actionable information to improve the outcomes of patients, announces that it has been granted US Patent number: 10,745,749, entitled METHODS FOR DETECTING NUCLEIC ACID SEQUENCE VARIANTS. The patent provides intellectual property protection for Primer-Switch technology, which is useful for the detection of rare cell mutations using circulating tumor DNA (ctDNA) analysis through real-time PCR and associated analysis methods, including next-generation sequencing (NGS).
The issuance of this patent expands Biocept's intellectual property protection for the detection of rare mutations, including cancer biomarkers found in tissue, blood and cerebrospinal fluid. This is the second issued patent for the Primer-Switch technology, and is another step in Biocept's pursuit of worldwide patent protection for this technology. The Primer-Switch technology provides another method for specifically enriching patient specimens for oncogene mutations of interest. Additionally, the Primer-Switch technology can be used to enhance the performance and specificity of the PCR method, which is the most widely used amplification approach used in diagnostic assays.
"Our Primer-Switch methodology has the potential to find rare mutations in PCR reactions, especially where the detection of rare genetic events is needed, or in cases where more precise PCR amplification reactions are desired or required," said Michael Nall, Biocept's President and CEO. "This technology builds upon our ability to detect rare genetic events in addition to our Switch-Blocker technology, which we routinely use in our ctDNA Target Selector™ assays. This is another tool in our toolkit for methods to inform on biomarkers found in tissue, blood and cerebrospinal fluid to aid physician decision making in the treatment of their patients with cancer."
About Biocept Biocept, Inc. is a molecular diagnostics company with commercialized assays for lung, breast, gastric, colorectal and prostate cancers, and melanoma. The Company uses its proprietary liquid biopsy technology to provide physicians with clinically actionable information for treating and monitoring patients diagnosed with cancer. The Company's patented Target Selector™ liquid biopsy technology platform captures and analyzes tumor-associated molecular markers in both circulating tumor cells (CTCs) and in circulating tumor DNA (ctDNA). With thousands of tests performed, the platform has demonstrated the ability to identify cancer mutations and alterations to inform physicians about a patient's disease and therapeutic options. In addition, Biocept recently added COVID-19 testing to support efforts to fight the pandemic. For additional information, please visit www.biocept.com.
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