HONOLULU, Sept. 19, 2017 /PRNewswire/ -- Cardax, Inc. (OTCQB:CDXI) welcomes the findings of a clinical study recently published in the New England Journal of Medicine that validate the crucial role inflammation plays in cardiovascular health. The 10,000 patient, double-blind, placebo-controlled study ("CANTOS") sponsored by Novartis demonstrated, for the first time in history, that an anti‑inflammatory drug reduced major adverse cardiovascular events—independent of cholesterol levels.
The study supports the opportunity Cardax sees for its astaxanthin supplement ZanthoSyn® to manage cardiovascular inflammatory health with substantial safety and cost benefits compared to the agent used in this study.
While this study does not prove that other anti-inflammatory approaches will have similar benefits in cardiovascular health, cardiovascular experts not involved in the trial have pointed to the broad potential application of this study to support the use of other anti-inflammatory agents.
For example, Cleveland Clinic's heart chief, Dr. Steven Nissen, was quoted by the Washington Post as saying, "It (this study) opens up an entirely new vista for the treatment of heart disease, because now everybody on the planet—in the pharmaceutical industry and in research institutions like ours and at the National Institutes of Health—are going to be looking to find anti-inflammatory therapies." (Emphasis added by Cardax.)
We believe that an ideal anti-inflammatory solution for the large cardiovascular health market should provide:
Reduction of CRP, the primary inflammatory measurement in the CANTOS study
Reduction of IL-1ß, a key inflammatory mediator and target of the CANTOS study drug, canakinumab
Reduction of IL-6, a key inflammatory mediator reduced in the CANTOS study
ZanthoSyn®, Cardax's non-pharmaceutical astaxanthin supplement for cardiovascular health, meets all of these criteria:
Safety: Astaxanthin, the active ingredient in ZanthoSyn, has undergone extensive safety testing and is Generally Recognized as Safe ("GRAS") according to FDA regulations—a safety designation traditional anti-inflammatories for cardiovascular health do not have.
Inflammatory Health: More than 1,500 peer-reviewed papers and 50 Phase II type human clinical trials support the use and safety of astaxanthin, the active ingredient in ZanthoSyn. Specifically, astaxanthin has demonstrated statistically significant reduction in:
CRP in humans1
IL-1ß in animals2
IL-6 in animals3
TNF-α, another important mediator of inflammatory health, in humans4
TNF-α equivalent to prednisolone in animals5
Pricing: ZanthoSyn only costs $39.99 per 60 capsule bottle and is widely available through General Nutrition Corporation ("GNC") stores.
ZanthoSyn® 2.0 connects cardiovascular inflammation and longevity:
CDX-085, Cardax's next generation ZanthoSyn astaxanthin supplement, was recently chosen by the National Institutes of Health as a top anti-aging prospect for its impact on FOXO3, an important longevity gene that targets cardiovascular inflammation. This selection resulted from a study at the University of Hawaii demonstrating the ability of CDX-085 to increase FOXO3 activation by 90%. Cardax is developing CDX-085 as an "extra strength" astaxanthin supplement and exploring pharmaceutical applications.
"The CANTOS study confirmed that reducing inflammation improves cardiovascular health, underscoring the basis on which Cardax was founded," said Cardax CEO, David G. Watumull. "We believe that scientifically addressing cardiovascular inflammatory health offers a transformative opportunity, perhaps unmatched in the industry in many years."
Park JS et al., 2010. Nutrition & Metabolism, 7: 18.
Lee SJ et al., 2003. Molecules and Cells, 16(1): 97-105.
Izumi-Nagai K et al., 2008. Investigative Ophthalmology and Visual Science, 49(4): 1679-1683.
Uchiyama A and Okada Y, 2008. Journal of Clinical Biochemistry and Nutrition, 43(Suppl 1): 38-43.
Ohgami K et al., 2003. Investigative Ophthalmology and Visual Science, 44(6): 2694-2701.
About Cardax Cardax devotes substantially all of its efforts to developing and commercializing safe anti-inflammatory dietary supplements and drugs. Cardax is initially focusing on astaxanthin, which is a powerful and safe naturally occurring anti-inflammatory without the side effects of currently marketed anti-inflammatories. The safety and efficacy of Cardax's products have not been directly evaluated in clinical trials or confirmed by the FDA.
About ZanthoSyn® ZanthoSyn is a physician recommended anti-inflammatory supplement for health and longevity that features astaxanthin with optimal absorption and purity. ZanthoSyn is sold online and in GNC stores. ZanthoSyn contains astaxanthin, which is Generally Recognized as Safe (GRAS) according to FDA regulations.
About Astaxanthin Astaxanthin is a clinically studied compound with safe anti-inflammatory activity that supports joint health, cardiovascular health, metabolic health, liver health, and longevity.*
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.