WICHITA, Kan., May 6, 2015 /PRNewswire-USNewswire/ -- Pyrroluria (Mauve Factor, Kryptopyrrole) has been studied for well over 40 years[1-6]. Pioneers in Orthomolecular Medicine such as Abram Hoffer, Carl Pfeiffer, Hugh Riordan, Donald Irvine, Arthur Sohler, Humphry Osmond, William Walsh and many others in history, found testing for elevated pyrroles to be very useful in identifying a variety of disorders from mental and behavioral disorders to nutritional deficiencies and other biological disorders. The biological origins of pyrroles are not well known, nor are the specific causes of elevated urinary pyrrole excretion well understood.
A recent study published in the Clinical Medical Reviews and Case Reports by Riordan Clinic Director of Research Dr. Nina Mikirova, takes an in-depth look at the connection between pyrroluria, mental disorders and biological factors. The article titled "Clinical Test of Pyrroles in Psychiatric Disorders: Association with Nutritional, Immunological and Metabolic Markers" is accessible online at http://clinmedlibrary.com/articles/cmrcr/cmrcr-2-027.pdf
During the study, researchers analyzed pyrrole levels in patients with schizophrenia, bipolar disorder, depression, ADHD and compared the data with the results of pyrrole tests for patients with non-mental conditions and healthy volunteers.
Urinary pyrrole concentrations tended to be high in patients with mental illnesses, but elevated levels of pyrroles was not specific to only these patients. The study also revealed evidence of an allergy related component by showing the prevalence of high pyrrole concentrations in patients with elevated histamine levels.
A role of intestinal bacteria, or imbalances in intestinal bacterial metabolism, was also suggested based on the relationship between elevated pyrrole levels and elevations in indicans and urobilinogens.
The data also demonstrated that patients with severely elevated pyrrole levels were also deficient in various nutrients such as zinc, vitamin B3, and vitamin C.
The analysis suggests that pyroluria is relevant to a variety of stress and illness conditions. Abnormal pyrrole excretion appears to also be an indicator of oxidative stress, infection, intoxication, or improper digestion. In conclusion, pyrrole excretion seems to be a component of illness in general and not strictly mental illness.
Moreover, the study concluded that it is possible to reduce pyroluria incidence by using a treatment regimen of supplements including nutrients as zinc, B vitamins, and vitamin C.
About Riordan Clinic
Riordan Clinic is a 501(c)3 not-for-profit organization focused on functional medicine, clinical laboratory testing, health education and research. Since 1975, people worldwide have turned to Riordan Clinic for individualized, solutions-oriented, medical support. For more information about the Riordan Clinic or this release, visit www.RiordanClinic.org.
- Jackson JA, Riordan HD, Neathery S, Riordan NH: Urinary Pyrroles in Health and Disease. Journal of Orthomolecular Medicine, 1997; 12(2): 96-98. http://orthomolecular.org/library/jom/1997/pdf/1997-v12n02-p096.pdf
- Hoffer A: Editorial, A brief history of the discovery of kryptopyrrole: a diagnostic test for a subgroup of the schizophrenias. Journal of Orthomolecular Medicine, 2001; 16(1): 1-2. http://orthomolecular.org/library/jom/2001/pdf/2001-v16n01-p003.pdf
- McGinnis W, Audhya T, Walsh W, Jackson J, McLaren-Howard J, Lewis A, Lauda P, Bibus D, Jurnak F, Lietha R, Hoffer A: Discerning the Mauve Factor, Part 1. Alternative Therapies, 2008, 14(2):40-50 http://www.ncbi.nlm.nih.gov/pubmed/18383989
- McGinnis W, Audhya T, Walsh W, Jackson J, McLaren-Howard J, Lewis A, Lauda P, Bibus D, Jurnak F, Lietha R, Hoffer A: Discerning the Mauve Factor, Part 2. Alternative Therapies, 2008, 14(3):56-62 http://www.ncbi.nlm.nih.gov/pubmed/18383989
- Irvine DG, Bayne W, Miyashita H, et al: Identification of kryptopyrrole in human urine and its relationship to psychosis. Nature, 1969; 224: 811-813. http://www.nature.com/nature/journal/v224/n5221/abs/224811a0.html
- Hoffer A: Editorial - The Discovery of Kryptopyrrole and Its Importance in Diagnosis of Biochemical Imbalances in Schizophrenia and in Criminal Behavior. Journal of Orthomolecular Medicine, 1995; 10(1): 3-7. http://orthomolecular.org/library/jom/1995/pdf/1995-v10n01-p003.pdf
- http://orthomolecular.org/hof/index.shtml and http://orthomolecular.org/history/index.shtml
SOURCE Riordan Clinic