New findings validate clinical utility in Colorectal Cancer Staging
MONTREAL, May 16, 2013 /PRNewswire/ - DiagnoCure Inc. (TSX: CUR) (OTCQX: DGCRF) (the "Corporation"), today announced that results from a large validation study of the PrevistageTM GCC Colorectal Cancer Staging Test have been selected for presentation at the 2013 American Society of Clinical Oncology® (ASCO®) Annual Meeting, taking place in Chicago, Illinois from May 31 to June 4, 2013. The results of the second phase of the VITAR (Validating Indicators To Associate Recurrence Risk) study, which included 463 untreated stage II (T3N0) colon cancer patients from North American and European clinical sites will be presented during this annual meeting. These patients had not been treated with adjuvant chemotherapy mainly because their lymph nodes appeared cancer‐free by examination under the microscope, yet 10% of them had a disease recurrence or died from cancer afterwards.
The presentation titled "Guanylyl cyclase C (GCC) expression in lymph nodes (LNs) as a determinant of recurrence in stage II colon cancer (CC) patients (pts)" (Abstract #3639), will be exhibited on Sunday, June 2, 8:00 AM - 11:45 AM, S Hall A2.
"Our new study supports the prognostic value of our PrevistageTM GCC assay independently of traditional histopathology risk factors. In order to establish a risk of recurrence for the stage II patients, the study focused on the positive LN ratio (LNR), defined as the number of nodes in which cancer cells were identified with the PrevistageTM GCC test, divided by the total number of nodes examined," said Dr Yves Fradet, President and Chief Medical Officer of DiagnoCure. "We believe that PrevistageTM GCC has the potential to improve management of untreated stage II colon cancer."
About Colorectal Cancer and PrevistageTM GCC
Every year in the United States and Canada, 165,000 people are diagnosed with colorectal cancer. Of that number, 69,000 are considered at low risk after surgery. Nonetheless, up to 20% of them suffer recurrence of a more advanced cancer. To date, results of published studies totaling over 1,000 patients have shown that, compared with traditionally-used factors, the GCC biomarker is a better predictor of disease recurrence in early‐stage colorectal cancer patients. PrevistageTM GCC is currently the only colorectal cancer staging test that provides prognostic information based on the tumor burden measured at the molecular level in the lymph nodes. Tumor burden in the lymph nodes has become more widely recognized by treating physicians as a key prognostic factor to determine the risk of recurrence of cancer patients, and hence, to determine which patients might benefit most from adjuvant chemotherapy and which could be safely managed without chemotherapy.
DiagnoCure (TSX: CUR; OTCQX: DGCRF) is a life sciences corporation that develops and commercializes high-value cancer diagnostic tests that increase clinician and patient confidence in making critical treatment decisions. In 2008, the Corporation launched a colorectal cancer staging test through its U.S. CLIA laboratory. PrevistageTM GCC is currently available for licensing. The Corporation has also granted a worldwide exclusive license to Gen-Probe, now a wholly-owned subsidiary of Hologic Inc. operating as Hologic Gen-Probe, for the development and commercialization of a prostate cancer test using PCA3, DiagnoCure's proprietary molecular biomarker. Hologic Gen-Probe's PROGENSA® PCA3 test is commercialized in Europe under CE mark and is approved for commercialization in Canada and the United States. For more information, please visit www.diagnocure.com.
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