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Ebola vaccine trial begins in Sierra Leone

6,000 health and other frontline workers will receive vaccine in five districts of the country


News provided by

Centers for Disease Control and Prevention (CDC)

Apr 14, 2015, 10:49 ET

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ATLANTA, April 14, 2015 /PRNewswire-USNewswire/ -- The Centers for Disease Control and Prevention (CDC), in partnership with the Sierra Leone College of Medicine and Allied Health Sciences (COMAHS) and the Sierra Leone Ministry of Health and Sanitation (MoHS), is now enrolling and vaccinating volunteers for the Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE). This study will assess the safety and efficacy of the rVSV-ZEBOV candidate Ebola vaccine among health and other frontline workers.

"A safe and effective vaccine would be a very important tool to stop Ebola in the future, and the frontline workers who are volunteering to participate are making a decision that could benefit health care professionals and communities wherever Ebola is a risk," said CDC Director Tom Frieden, M.D., M.P.H.  "We hope this vaccine will be proven effective but in the meantime we must continue doing everything necessary to stop this epidemic —find every case, isolate and treat, safely and respectfully bury the dead, and find every single contact."

STRIVE will enroll about 6,000 health and other frontline workers. It will be conducted in Western Area Urban district, which includes Freetown, Western Area Rural district, and certain chiefdoms in Bombali, Port Loko, and Tonkolili districts. These study locations were selected because they have been heavily affected by the Ebola outbreak in the past few months.

"We are happy to be partnering with MoHS and CDC on this important study, which may help to prevent future cases of Ebola," said Mohamed Samai, M.B., Ch.B., Ph.D., acting Provost of COMAHS and the study's principal investigator. "It brings me hope and pride that my country can take from this devastating epidemic something that may benefit people around the world."

When participants enroll in the study, they will be assigned randomly to one of two timeframes for vaccination – either immediately or about six months later. All study participants will receive the vaccine and be followed closely for six months. The study will evaluate if and how well the vaccine worked by comparing rates of Ebola virus disease in those who are vaccinated to those who have not yet received the vaccine.

The rVSV-ZEBOV candidate vaccine uses a vesicular stomatitis virus carrying a non-infectious Ebola virus gene. The vaccine cannot cause Ebola virus disease but can potentially stimulate an immune response to protect against the disease. The vaccine was developed by the Public Health Agency of Canada's National Microbiology Laboratory and licensed to NewLink Genetics. In 2014, NewLink Genetics entered into a licensing and collaboration agreement with Merck to research, develop, manufacture, and distribute the rVSV-ZEBOV candidate vaccine. The vaccine has, and continues to be, studied in hundreds of people (as of March 26, 2015, more than 800 people) in Africa, Canada, Europe, and the United States. Results from early studies to date of the vaccine show an acceptable safety profile and indicate that the rVSV-ZEBOV candidate vaccine produces an immune response. The Biomedical Advanced Research and Development Authority is supporting the development and manufacturing of the vaccine and is assisting CDC in conducting the clinical trial in Sierra Leone using BARDA's Clinical Study Network.

"We don't know whether this vaccine will be the Ebola prevention tool we're all eager for, but we hope that what we learn from STRIVE will help us save lives during this and future Ebola outbreaks," said Anne Schuchat, M.D., director of CDC's National Center for Immunization and Respiratory Diseases.

Because it is not yet clear how much protection, if any, the rVSV-ZEBOV candidate vaccine may offer, health and other frontline workers who receive the vaccine should continue to take full preventive actions to protect themselves from Ebola, including proper training, focused protocols and procedures, and use of all recommended personal protective equipment.

Learn more about STRIVE at www.cdc.gov/vhf/ebola/strive/.

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

CDC works 24/7 saving lives, protecting people from health threats, and saving money through prevention. Whether these threats are global or domestic, chronic or acute, curable or preventable, natural disaster or deliberate attack, CDC is the nation's health protection agency.

SOURCE Centers for Disease Control and Prevention (CDC)

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