Enteris BioPharma's Formulation Technology Enables Oral Delivery of Cara Therapeutics' CR845 Peptide in Phase 2 Trial in Osteoarthritis

Cara Therapeutics' Trial Will Evaluate Safety, Pharmacokinetics and Effectiveness of Four Tablet Strengths Dosed Over Two Weeks in Osteoarthritis Patients

Aug 20, 2015, 10:24 ET from Enteris BioPharma, Inc.

BOONTON, N.J., Aug. 20, 2015 /PRNewswire/ -- Enteris BioPharma, Inc., an industry leader in oral peptide delivery, congratulates Cara Therapeutics (Nasdaq: CARA) on the dosing of the first patients in a Phase 2 trial of an oral tablet formulation of its peripherally selective kappa opioid agonist, CR845, for the treatment of osteoarthritis (OA). Cara's tablet formulation of CR845 utilizes Enteris' proprietary oral delivery technology.

The Phase 2 trial is a singleblind, randomized, multiple ascending dose trial designed to evaluate the safety, pharmacokinetics and effectiveness of oral CR845 tablets dosed over a two-week treatment period in OA patients experiencing moderate-to-severe pain.

Brian Zietsman, President and CFO of Enteris BioPharma, commented: "We congratulate Cara Therapeutics on the dosing of the first patients in its Phase 2 study of oral CR845. As Cara Therapeutics seeks to expand the clinical development of CR845 beyond the treatment of acute pain in an institutional setting, oral delivery of CR845 will be the key to unlock this opportunity."

Derek Chalmers, Ph.D., D.Sc., President and Chief Executive Officer of Cara Therapeutics, remarked, "In our estimation, oral CR845 has the potential to address a significant market opportunity in the treatment of acute and chronic pain for which there continues to be a very large unmet need for safer, alternatives to narcotic opioids."

About Cara Therapeutics Cara Therapeutics is a clinical-stage biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pain and pruritus by selectively targeting kappa opioid receptors. Cara is developing a novel and proprietary class of product candidates that target the body's peripheral nervous system and have demonstrated efficacy in patients with moderate-to-severe pain without inducing many of the undesirable side effects typically associated with currently available pain therapeutics.

About Enteris BioPharma Enteris BioPharma, Inc. is a privately held, New Jersey-based biotechnology company offering innovative formulation solutions built around its proprietary drug delivery technologies. Enteris' proprietary oral delivery technology has been the subject of numerous feasibility studies and active development programs, several of which are in late stage clinical development. For more information on Enteris BioPharma and its proprietary oral delivery technology, please visit http://www.EnterisBioPharma.com.

For Enteris BioPharma:   Tim Saxon    Vice President Business Development    973.453.3515    tsaxon@enterisbiopharma.com

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SOURCE Enteris BioPharma, Inc.