Frontier Pharma: Type 2 Diabetes Mellitus - Therapies Targeting GPCRs and Protein Kinases Dominate Pipeline, with Strong Repositioning Opportunities into Associated Areas, Including Obesity and Cardiovascular Disease
NEW YORK, August 9, 2018 /PRNewswire/ -- Frontier Pharma: Type 2 Diabetes Mellitus - Therapies Targeting GPCRs and Protein Kinases Dominate Pipeline, with Strong Repositioning Opportunities into Associated Areas, Including Obesity and Cardiovascular Disease
Read the full report: https://www.reportlinker.com/p05385770
Summary
Type 2 diabetes mellitus (T2DM) is a major metabolic disease and one of the leading causes of death worldwide. The prevalence is on the rise, alongside increases in obesity due to lifestyle changes in the 21st century. Type 2 diabetes is characterized by insulin resistance leading to dysregulation of glucose control and chronic hyperglycemia.
This leads to several co-morbidities and complications, some of which are associated with damage to blood vessels as a result of elevated blood glucose levels. The disease is progressive: patients' standard of living deteriorate over time and the symptoms worsen, meaning more complex treatment regimens are required over time. The complexity of the treatment means there is a high diversity of marketed products. In recent years new drug types have been great commercial successes and reached blockbuster status. This alongside the financial cost of type 2 diabetes to healthcare providers has led to significant investment in R&D on therapeutics in this area.
The demand for T2DM therapeutics has resulted in a large and competitive market landscape, with a number of drugs competing with one another for different market segments, across multiple lines of therapy. Since the mid-2000s a number of new drug classes have entered the market including glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors and sodium-glucose linked transporter-2 (SGLT-2) inhibitors. These drug classes have proved to be highly commercially successful.
The T2DM pipeline is large with more than 560 products in active development, which accounts for almost a third of the metabolic disorders pipeline. This pipeline is dominated by products acting on G protein coupled receptors (GPCR) and protein kinases.
First-in-class products have the greatest potential in terms of development and commercial prospects. Among the pipeline products, 152 are first-in-class, which act on 95 distinct first-in-class targets. In line with the overall pipeline, first-in-class innovation is dominated by products acting on GPCRS and protein kinases. Additionally, there is a strong representation of first-in-class products at the Preclinical development stage.
The report "Frontier Pharma: Type 2 Diabetes Mellitus - Therapies Targeting GPCRs and Protein Kinases Dominate Pipeline, with Strong Repositioning Opportunities into Associated Areas, Including Obesity and Cardiovascular Disease" enables you to -
- Appreciate the current clinical and commercial landscapes by considering disease pathogenesis, etiology, epidemiology, symptoms, and diagnosis and treatment options.
- Identify leading products and key unmet needs within the market.
- Recognize innovative pipeline trends by analyzing therapies by stage of development, molecule type and molecular target.
- Assess the therapeutic potential of first-in-class targets. Using proprietary matrix assessments, first-in-class targets in the pipeline have been assessed and ranked according to clinical potential. Individual matrix assessments are provided for targets identified in the pipeline for T2DM. Promising early-stage first-in-class targets are reviewed in greater detail.
- Consider first-in-class pipeline products with no prior involvement in licensing and co-development deals that may represent potential investment opportunities.
Scope
- Requirement for new types of therapeutics to add to already complex treatment algorithms for severe T2DM
- What are the most important etiological risk factors and pathophysiological processes implicated in T2DM?
- What is the current treatment algorithm?
- How effective are current therapies for these indications, and how does this impact prognosis? What are the side effects associated with these treatments?
- The T2DM pipeline is dominated by G-protein-coupled receptors (GPCRs) and protein kinases
- Which molecule types and molecular targets are most prominent in the T2DM pipeline?
- Which first-in-class targets are most promising?
- How does the level of first-in-class innovation change within different target classes?
- How does first-in-class target diversity differ by stage of development and molecular target class?
- The deals landscape is active and dominated by products that target GPCRS and protein kinases
- Which molecular types/molecular target groups attract the highest deal values?
- How has deal activity fluctuated over the past decade?
- Which first-in-class pipeline products have no prior involvement in licensing or co-development deals?
Reasons to buy
- Appreciate the current clinical and commercial landscapes by considering disease pathogenesis, etiology, epidemiology, symptoms, and diagnosis and treatment options.
- Identify leading products and key unmet needs within the market.
- Recognize innovative pipeline trends by analyzing therapies by stage of development, molecule type and molecular target.
- Assess the therapeutic potential of first-in-class targets. Using proprietary matrix assessments, first-in-class targets in the pipeline have been assessed and ranked according to clinical potential. Individual matrix assessments are provided for targets identified in the pipeline for T2DM. Promising early-stage first-in-class targets are reviewed in greater detail.
- Consider first-in-class pipeline products with no prior involvement in licensing and co-development deals that may represent potential investment opportunities.
Read the full report: https://www.reportlinker.com/p05385770
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