Gene Therapy Deal-Making Trends Report 2018: Focus on Deals from 2012 to 2017

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Mar 29, 2018, 04:15 ET

DUBLIN, March 29, 2018 /PRNewswire/ --

The "Gene Therapy Deal-Making Trends, 2012-17" report has been added to ResearchAndMarkets.com's offering.

A robust deal-making market has enabled gene therapy drug development to be advanced and adequately funded through alliances and financings, and in many cases has provided exits for investors through acquisitions. The volume of deals in each of these transaction types has experienced some fluctuation during 2012-17, but generally is on an upward trend as companies aim to capitalize on a market that has been reinvigorated with the strong scientific and commercial argument for cell and gene therapies, particularly chimeric antigen receptor T-cell (CAR-T) therapies.

Among acquisitions, there was virtually an even split between targets focused on in vivo gene therapies, or "gene" therapies, and those concentrating on ex vivo "cell and gene" therapies. However, large pharmaceutical buyers were more likely to acquire in vivo therapy developers, reflective more of the disease focus of the target company rather than the overall gene therapy development strategies of the acquirers. Alliances, too, did not show a preference for one approach over the other, but gene therapy companies were more active in aggregate financing than cell and gene therapy players, possibly an effect of the emergence only within the last few years of start-ups founded around CAR-T and other cell and gene therapies.

The broad field of gene therapy may be broken down into two main categories: gene therapy, which mainly involves the in vivo administration of genes, packaged into viral or non-viral vectors, directly into cells inside of the body; or cell and gene therapy, which comprises the ex vivo genetic modification of cells. Certain datasets within the report are split in this manner.

Key Topics Covered:

1 EXECUTIVE SUMMARY

2 GENE THERAPY DEAL-MAKING ACROSS THE INDUSTRY

Deal volume is generally increasing, supported by alliances
Outlier transactions, especially in acquisitions, have contributed to peaks in gene therapy values in certain years

3 GENE THERAPY ACQUISITIONS

There has been a steady increase in the volume of gene therapy acquisitions
Acquisitions have reached multibillion-dollar values, thanks to outlier transactions
Both gene therapies, and cell and gene therapies, are the subjects of acquisitions
Besides oncology, another active therapy area target in acquisitions is blood diseases
Bibliography

4 GENE THERAPY ALLIANCES

Aggregate value for alliances has reached $30bn
As time goes on, upfront payments represent a lower proportion of total deal value
The top 10 deals captured a large part of the total value
Over time, cell and gene therapies have become more of a focus in partnerships
Oncology gene therapies are subject of the most alliances
Bellicum, a CAR-T developer, is the most active gene therapy in-licenser
Bibliography

5 GENE THERAPY FINANCINGS

Companies working in gene therapy have raised $14bn through various financing types
Gene therapy developers were more active in financing
Cell and gene therapy companies lead the top 10 grossing IPOs
Gene editing was well represented in top 10 gene therapy venture rounds
Bibliography

6 DEAL-MAKING CASE STUDIES IN GENE THERAPY

Pfizer commits to gene therapy with Bamboo Therapeutics
CAR-T is worth billions to Gilead
Biogen and the University of Pennsylvania form a lucrative industry/academic partnership
Vertex turns to gene editing as another way to extend its cystic fibrosis franchise
Bibliography

7 APPENDIX

Companies Mentioned

Pfizer
Vertex
Biogen
Bamboo Therapeutics
Gilead

For more information about this report visit https://www.researchandmarkets.com/research/53cwc3/gene_therapy?w=5

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SOURCE Research and Markets