NEW YORK, June 16 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global G-Protein Coupled Receptors (GPCRs) industry
http://www.reportlinker.com/p0197194/Global-G-Protein-Coupled-Receptors-GPCRs--industry.html
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in US$ Billion. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a six-year historic analysis is provided for these markets. The report profiles 42 companies including 7TM Pharma A/S, Actelion Pharmaceuticals Ltd., Acure Pharma AB, Anchor Therapeutics, Arena Pharmaceuticals, Inc., Addex Pharmaceuticals, Acadia Pharmaceuticals Inc., Cara Therapeutics, Inc., DiscoveRx Corporation, Dimerix Bioscience Pty Ltd., Domain Therapeutics, Euroscreen SA, Millipore Corporation, and Trevena, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
G-PROTEIN COUPLED RECEPTORS (GPCRs) MCP-6269
A GLOBAL MARKET REPORT
CONTENTS
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-3
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
II. EXECUTIVE SUMMARY
1. INDUSTRY OVERVIEW II-1
A Quick Primer II-1
Why GPCRs Are Important? II-1
Illustrative Examples of Currently Available Pharmaceutical
Drugs Targeting GPCRs II-2
Untapped Pharmacological Potential of GPCRs Ignites Interest II-2
Popular Types of GPCRs of Therapeutic Interest Currently
Being Studied Include: II-3
Current Knowledge of GPCR Crystal Structures Just the Tip of
the Iceberg II-4
NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4
Orphan GPCRs: A Promising Area for Drug Discovery II-5
Developments in Screening Technology for GPCRs II-5
Cell Membrane Assays for GPCR Quantitative Analysis II-5
What's in for the Pharmaceutical Industry? II-5
Challenges Aplenty in the GPCR Space II-6
Addressing Orphan GPCRs II-6
Lack of Structural Information II-6
Identification and Classification of Allosteric Sites II-7
2. G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW II-8
GPCR: Gateways to Cell II-8
Classification of GPCRs II-8
Table 1: List of Identified Known and Orphan (Non-Sensory)
GPCRs in Human Genome (includes corresponding Graph/Chart) II-9
Orphan GPCRs and Deorphanization II-9
List of oGPCR-Ligand Pairings Identified By Using Reverse
Pharmacology Approach II-10
Structural Information II-10
Rhodopsin: A Well Studied GPCR II-11
Crystal Structure of Human Beta-2 Adrenergic GPCR II-11
Structure of Human A2A Adenosine Receptor II-11
Significance of GPCR Crystal Structures II-12
GPCR Signaling Pathways II-12
Physiological Roles Performed by GPCRs II-12
Visual Sense II-12
Cell-density Sensing II-12
Regulation of mood and behavior II-12
Smelling Sense II-12
Regulating Immune-System Inflammation and Activity II-13
Automatic Transmission of Nervous System II-13
Receptor - Ligand Interaction II-13
Types of Ligands II-13
Therapeutic Potential of GPCRs II-13
List of Major Disease States and Associated Known GPCRs II-14
Allosteric Modulators and Implication of Allostery in Drug
Discovery II-14
Advantages of Allosteric Modulators II-14
Dimerisation and Role of Dimers in Drug Discovery II-15
Oligomerisation and Role of Oligomers in Drug Discovery II-15
Functional Selectivity II-15
Existing Drug Candidates in GPCR Space II-16
List of Existing GPCR-Based Drugs Available In Market Along
With Their Target Receptor and Indication II-16
Pipeline GPCR Drug Candidates II-16
Ion Channels II-17
Approaches to Drug Discovery in GPCR Space II-17
Structure-Based Drug Discovery II-17
Ligand-Based Drug Discovery II-17
Target-Based Drug Discovery II-17
GPCR Screening and Targeting Technologies II-17
Cell-Based Screening Assays II-18
Virtual Screening II-19
Fragment screening II-19
3. RECENT INDUSTRY ACTIVITY II-20
Medarex Releases Pre-clinical Data for MDX-1338 II-20
Compugen Declares Positive Therapeutic Effects of CGEN-25009 II-20
Addex Releases Clinical Data for ADX10059 II-20
Arana Receives Patent Approval for PMX53 and Related GPCR
Compounds II-20
Epix Pharmaceuticals Receives Patent Approval for PRX-03140
and Related Compounds II-21
Odyssey Thera Receives Patent Approval for Fluorescence-Based
Assays II-21
Cisbio Bioassays Introduces Cellul'erk Assay II-21
DiscoveRx Introduces Products and Services to Assays and
Reagents Portfolio II-21
PerkinElmer Introduces Novel Ion Channel and GPCR Cell Lines II-22
Millipore Launches New AllostericProfilerTM Service II-22
Ligand Pharmaceuticals and Trevena Enter into Agreement II-22
ChanTest Takes Over ACS II-23
PerkinElmer Enters into Collaboration with Sangmyung University II-23
Debiopharm Group Inks Exclusive Agreement with MSM Protein
Technologies II-23
GVK Biosciences and University of Tokyo Sign Agreement II-23
MSM Protein Technologies Enters into Alliance with Merck Serono II-24
Xenome Enters into Agreement with Axxam II-24
DiscoveRx and GlaxoSmithKline Inks Global Agreement II-24
Sygnature Enters into Contract Chemistry Agreement with
Heptares Therapeutics II-24
Enzo Life Sciences Enters into Partnership with BioTek
Instruments II-25
Heptares Therapeutics Enters into Agreement with Novartis
Option Fund II-25
CellAura Enters into Partnership with Cisbio Bioassays II-25
Euroscreen and Novartis Ink Research Collaboration Agreement II-25
Evotec Enters into Co-marketing Agreement with DiscoveRx II-26
Jubilant Biosys Inks Co-marketing Agreement with DiscoveRx II-26
Faust Pharmaceuticals Changes Name to Domain Therapeutics II-26
GSK, MRCT and DiscoveRx Collaborate for Deorphanization of GPCRs II-26
DiscoveRx Inks Agreement with BioFocus II-27
Actelion's S1P1 Receptor Agonist to Enter into Phase II
Clinical Trial II-27
AnaSpec Introduces Two Isoform Specific Antibodies II-27
Millipore Introduces MultiScreen®HTS+ Filter Plates II-27
Faust & Takeda Enter into Research Agreement II-28
Caliper Life Sciences Collaborates with DiscoveRx II-28
Compugen Inks Agreement with Merck Serono II-28
BioFocus and Amgen Extend Drug Discovery Agreement II-28
DiscoveRx Selects Cosmo Bio to Distribute GPCR Profiling
Service across Japan II-28
Euroscreen Extends Agreement with Cephalon II-29
BioFocus DPI Introduces Novel Version of GPCR SARfari II-29
PerkinElmer Takes Over Euroscreen Products II-29
4. FOCUS ON SELECT GLOBAL PLAYERS II-30
7TM Pharma A/S (Denmark) II-30
Actelion Pharmaceuticals Ltd. (Switzerland) II-30
Acure Pharma AB (Sweden) II-30
Anchor Therapeutics (USA) II-31
Arena Pharmaceuticals, Inc. (US) II-31
Addex Pharmaceuticals (Switzerland) II-31
Acadia Pharmaceuticals Inc., (USA) II-32
Cara Therapeutics, Inc. (USA) II-33
DiscoveRx Corporation (USA) II-33
Dimerix Bioscience Pty Ltd (Australia) II-33
Domain Therapeutics (France) II-34
Euroscreen SA (Belgium) II-34
Millipore Corporation (US) II-34
Trevena, Inc. (USA) II-35
5. GLOBAL MARKET PERSPECTIVE II-36
Table 2: World Recent Past, Current & Future Market Analysis
for G-Protein Coupled Receptors (GPCRs) Addressing Drugs With
Annual Sales Figures in US$ Billion for Years 2007 through
2015 (includes corresponding Graph/Chart) II-36
Table 3: World Historic Review for G-Protein Coupled Receptors
(GPCRs) Addressing Drugs With Annual Sales Figures in US$
Billion for Years 2001 through 2006 (includes corresponding
Graph/Chart) II-36
Iii. COMPETITIVE LANDSCAPE
Total Companies Profiled: 42 (including Divisions/Subsidiaries - 43)
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Region/Country Players
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The United States 23
Europe 15
France 2
Germany 1
The United Kingdom 3
Italy 1
Rest of Europe 8
Asia-Pacific (Excluding Japan) 4
Middle-East 1
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To order this report:
Biotechnology Industry: Global G-Protein Coupled Receptors (GPCRs) industry
Check our Company Profile, SWOT and Revenue Analysis!
Nicolas Bombourg |
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Reportlinker |
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