Global Markets for Chiral Technology -- Focus on Europe
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Global Markets for Chiral Technology -- Focus on Europe http://www.reportlinker.com/p0870810/Global-Markets-for-Chiral-Technology----Focus-on-Europe.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Diagnostics
INTRODUCTION
STUDY OBJECTIVESThis report explores present and future strategies within the chiral market, including the synthesis, separation and analysis of chiral products. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. An overview of chirality, and the chiral products and technologies used in the past and currently are discussed in this report.
A detailed analysis of the structure of the chiral industry has been conducted. This includes chiral synthesis, chiral separation/resolution and chiral analysis. Revenues are broken down by global region from 2009 to 2011 and estimated for the five-year period from 2011 through 2016.
Applications for chiral products and technologies are also discussed in this report, with an emphasis on the usage in the pharmaceutical, biochemical and agrochemical industries. The report also covers significant patents and their allotment in each category.
REASONS FOR DOING THIS STUDY
This study was conducted to provide an update of new developments in the chiral technology market. The current study covers the global market for chiral products, with a specific focus on the U.S. markets, European markets and emerging markets. This study was conducted to provide a detailed market analysis of chiral-enabling products, including the factors influencing this market. New advancements and the need for enantiopure compounds have driven growth within this market. This study looks at most of the systems influenced by these factors.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each system/technology in light of the new technologies, growing competition and changing customer needs.
INTENDED AUDIENCE
This study contributes to the areas of market growth in therapeutic segments through chiral products and technologies from the point of view of manufacturers and users. The pharmaceutical and biopharmaceutical industries, agrochemical industries, physicians, hospitals and research institutes will find this study to be of interest.
SCOPE OF THE STUDY
The scope of this study encompasses the chiral markets with their usage in the pharmaceutical, biotechnical and agrochemical markets. BCC analyzes each market and its applications by its need for chiral products, their regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.
METHODOLOGY
Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.
INFORMATION SOURCES
Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of chiral products. Data were gathered from various industry sources. BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.
ABOUT THE AUTHOR
Shalini S. Dewan holds a master's degree in pharmaceutical chemistry. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC include Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets. The lead consultant for this project was Ms. Ruma Chakravarty, who holds a master's degree in biophysics. She has tremendous experience in market research, quality, process improvement, and lean and six sigma concepts.
TABLE OF CONTENTS
CHAPTER ONE: INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 4
DISCLAIMER 4
CHAPTER TWO: EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY (CONTINUED) 6
SUMMARY TABLE GLOBAL CHIRAL TECHNOLOGY MARKET BY
SEGMENT, THROUGH 2016 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL CHIRAL TECHNOLOGY MARKET BY
SEGMENT, THROUGH 2016 ($ MILLIONS) 7
CHAPTER THREE: OVERVIEW 8
DEFINITIONS 8
GENERAL CHARACTERISTICS OF ISOMERS 9
TYPES OF ISOMERISM 9
FIGURE 1 TYPES OF ISOMERISM 9
STRUCTURAL ISOMERISM 10
Skeletal Isomerism 10
Positional Isomerism 10
Functional Isomerism 10
STEREOISOMERISM 11
Geometric Isomerism 11
FIGURE 2 EXAMPLE 1 OF GEOMETRIC ISOMERISM 11
FIGURE 3 EXAMPLE 2 OF GEOMETRIC ISOMERISM 12
FIGURE 4 EXAMPLE 3 OF GEOMETRIC ISOMERISM 12
Properties of Geometrical Isomers 12
TABLE 1 CIS- VS TRANS-ISOMERS 13
Optical Isomerism 13
Properties of Optical Isomers 14
CHAPTER FOUR: CHIRAL TECHNOLOGY 15
CHIRAL SYNTHESIS 15
METHODS OF CHIRAL SYNTHESIS 15
Chiral Pool Synthesis 15
Asymmetric Induction 16
Chiral Auxiliaries 17
TABLE 2 EVANS-TYPE AUXILIARIES 18
Asymmetric Catalysis 18
Chiral Catalyst 18
Metal Ligand Complexes Derived from Chiral
Ligands 19
Chiral Organocatalysts 20
Biocatalysts 20
Types of Asymmetric Catalytic Oxidation Reactions 21
PRODUCTS FOR CHIRAL SYNTHESIS 22
Chiral Intermediates 22
Chiral Amino Acids 23
Chiral Epoxides and Glycidols 24
Saturated Chiral Propionic Acids 24
TABLE 3 CHIRAL INTERMEDIATES FOR VARIOUS INHIBITORS 25
TABLE 4 CHIRAL INTERMEDIATES FOR PHARMACEUTICAL
PRODUCTS 25
TABLE 4 (CONTINUED) 26
TABLE 4 (CONTINUED) 27
Chiral Catalysts 27
Chiral Acid Catalysts 28
Biocatalysts or Enzymes 28
Chiral Auxiliaries 29
Chiral Reagents 29
CHIRAL SEPARATION OR RESOLUTION 30
RESOLUTION BY CRYSTALLIZATION 30
CHIRAL RESOLVING AGENTS 31
CHIRAL COLUMN CHROMATOGRAPHY 31
KINETIC RESOLUTION 32
TABLE 5 PRODUCTION OF COMPOUNDS BY ENZYMATIC
RESOLUTION 33
IMPORTANCE OF CHIRALITY 33
ADVANTAGES 33
Advantages (Continued) 34
ENANTIOPURE MEDICATION 35
TABLE 6 RACEMIC AND ENANTIOMER DRUGS 36
CHAPTER FIVE: REGULATORY ASPECTS 37
APPROVALS OF CHIRAL DRUGS 37
TABLE 7 FDA APPROVALS OF NEW AND GENERIC CHIRAL DRUGS,
2009 TO OCT 2011 37
TABLE 7 (CONTINUED) 38
TABLE 7 (CONTINUED) 39
TABLE 8 FDA ANDA (ABBREVIATED NEW DRUG
APPLICATION)/GENERICS APPROVALS FOR CHIRAL DRUGS,
2009 TO OCT 2011 39
TABLE 8 (CONTINUED) 40
TABLE 8 (CONTINUED) 41
TABLE 8 (CONTINUED) 42
TABLE 8 (CONTINUED) 43
TABLE 9 NEW DRUG APPLICATIONS FOR CHIRAL DRUGS 43
TABLE 10 SAFETY ALERTS, 2009 THROUGH OCT 2010 43
TABLE 10 (CONTINUED) 44
TABLE 11 RECALLED CHIRAL DRUGS, 2009 TO OCT 2011 44
TABLE 11 (CONTINUED) 45
REGULATORY DEVELOPMENTS OF CHIRAL PRODUCTS 45
CHAPTER SIX: MARKET LEADERS IN CHIRAL PRODUCTS 46
TABLE 12 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
INTERMEDIATES 46
TABLE 12 (CONTINUED) 47
TABLE 12 (CONTINUED) 48
TABLE 12 (CONTINUED) 49
TABLE 12 (CONTINUED) 50
TABLE 12 (CONTINUED) 51
TABLE 12 (CONTINUED) 52
TABLE 13 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
CHEMICAL CATALYSTS 52
TABLE 13 (CONTINUED) 53
TABLE 13 (CONTINUED) 54
TABLE 14 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
BIOCATALYSTS 54
TABLE 14 (CONTINUED) 55
TABLE 15 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
AUXILIARIES 55
TABLE 15 (CONTINUED) 56
TABLE 16 LEADING MANUFACTURERS/SUPPLIERS OF OTHER
SYNTHETIC MATERIAL 56
TABLE 16 (CONTINUED) 57
TABLE 17 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
STATIONARY PHASES AND COLUMNS 57
TABLE 17 (CONTINUED) 58
TABLE 17 (CONTINUED) 59
TABLE 18 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 59
TABLE 19 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
RESOLVING/DERIVATIZING AND CRYSTALLIZING AGENTS 60
TABLE 19 (CONTINUED) 61
TABLE 20 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
ANALYTICAL INSTRUMENTS 61
TABLE 20 (CONTINUED) 62
TABLE 20 (CONTINUED) 63
TABLE 20 (CONTINUED) 64
CHAPTER SEVEN: NEW DEVELOPMENTS 65
TABLE 21 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2011 65
TABLE 21 (CONTINUED) 66
TABLE 21 (CONTINUED) 67
TABLE 22 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2010 68
TABLE 22 (CONTINUED) 69
TABLE 22 (CONTINUED) 70
TABLE 22 (CONTINUED) 71
TABLE 22 (CONTINUED) 72
TABLE 23 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2009 72
TABLE 23 (CONTINUED) 73
TABLE 23 (CONTINUED) 74
TABLE 23 (CONTINUED) 75
TABLE 23 (CONTINUED) 76
TABLE 23 (CONTINUED) 77
CHAPTER EIGHT: GLOBAL MARKET ANALYSIS 78
CHIRAL SYNTHESIS MARKET 78
CHIRAL INTERMEDIATES 79
Market Overview 79
Market Revenues 80
TABLE 24 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY
REGION, THROUGH 2016 ($ MILLIONS) 81
FIGURE 5 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY
REGION, 2009-2016 ($ MILLIONS) 81
CHIRAL CHEMICAL CATALYSTS 82
Market Overview 82
Market Revenues 83
TABLE 25 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS
BY REGION, THROUGH 2016 ($ MILLIONS) 84
FIGURE 6 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS
BY REGION, 2009-2016 ($ MILLIONS) 84
CHIRAL BIOCATALYST 85
Market Overview 85
Market Overview (Continued) 86
Market Revenues 87
TABLE 26 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY
REGION, THROUGH 2016 ($ MILLIONS) 87
FIGURE 7 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY
REGION, 2009-2016 ($ MILLIONS) 88
CHIRAL AUXILIARIES 88
Market Overview 89
Market Revenues 89
TABLE 27 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY
REGION, THROUGH 2016 ($ MILLIONS) 90
FIGURE 8 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY
REGION, 2009-2016 ($ MILLIONS) 90
OTHER SYNTHETIC CHIRAL MATERIALS 91
Market Overview 92
Market Revenues 93
TABLE 28 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL
MATERIALS BY REGION, THROUGH 2016 ($ MILLIONS) 93
FIGURE 9 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL
MATERIALS BY REGION, 2009-2016 ($ MILLIONS) 94
MARKET SHARES OF CHIRAL SYNTHESIS MARKET 94
TABLE 29 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY
REGION, 2010 (%) 94
FIGURE 10 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY
REGION, 2010 (%) 95
CHIRAL SEPARATION MARKET 95
CRYSTALLIZING AGENTS 96
Market Overview 97
Market Revenues 98
TABLE 30 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY
REGION, THROUGH 2016 ($ MILLIONS) 99
FIGURE 11 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY
REGION, 2009-2016 ($ MILLIONS) 99
CHROMATOGRAPHY COLUMNS AND REAGENTS 100
Market Overview 100
Market Revenues 101
TABLE 31 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS
AND REAGENTS BY REGION, THROUGH 2016 ($ MILLIONS) 102
FIGURE 12 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS
AND REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 102
Market Overview 103
Market Revenues 104
TABLE 32 GLOBAL MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS BY REGION, THROUGH 2016 ($
MILLIONS) 104
FIGURE 13 GLOBAL MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS BY REGION, 2009-2016 ($
MILLIONS) 105
ENZYMES IN KINETIC RESOLUTION 105
Market Overview 106
Market Overview (Continued) 107
Market Revenues 107
TABLE 33 GLOBAL MARKET FOR ENZYMES USED IN KINETIC
RESOLUTION BY REGION, THROUGH 2016 ($ MILLIONS) 108
FIGURE 14 GLOBAL MARKET FOR ENZYMES USED IN KINETIC
RESOLUTION BY REGION, 2009-2016 ($ MILLIONS) 108
MARKET SHARES OF CHIRAL SEPARATION MARKET 109
TABLE 34 GLOBAL CHIRAL SEPARATION MARKET SHARES BY
REGION, 2010 (%) 109
FIGURE 15 GLOBAL CHIRAL SEPARATION MARKET SHARES BY
REGION, 2010 (%) 109
CHIRAL ANALYSIS MARKET 110
CHIRAL LIQUID CHROMATOGRAPHY 110
Market Overview 111
Market Revenues 112
TABLE 35 GLOBAL MARKET FOR CHIRAL LIQUID
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 112
FIGURE 16 GLOBAL MARKET FOR CHIRAL LIQUID
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 113
CHIRAL GAS CHROMATOGRAPHY 113
Market Overview 114
Market Revenues 115
TABLE 36 GLOBAL MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 115
FIGURE 17 GLOBAL MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 116
CHIRAL CAPILLARY ELECTROPHORESIS 116
Market Overview 117
Market Revenues 118
TABLE 37 GLOBAL MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 118
FIGURE 18 GLOBAL MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 119
CHIRAL SUPERCRITICAL FLUID CHROMATOGRAPHY 119
Market Overview 120
Market Revenues 120
TABLE 38 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL FLUID
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 121
FIGURE 19 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 121
CHIRAL POLARIMETERS 122
Market Overview 122
Market Revenues 123
TABLE 39 GLOBAL MARKET FOR CHIRAL POLARIMETERS,
THROUGH 2016 ($ MILLIONS) 123
FIGURE 20 GLOBAL MARKET FOR CHIRAL POLARIMETERS, 2009-
2016 ($ MILLIONS) 124
NMR SHIFT REAGENTS 124
Market Overview 125
Market Revenues 126
TABLE 40 GLOBAL MARKET FOR NMR SHIFT REAGENTS,
THROUGH 2016 ($ MILLIONS) 126
FIGURE 21 GLOBAL MARKET FOR NMR SHIFT REAGENTS, 2009-
2016 ($ MILLIONS) 127
OTHERS 127
Market Overview 128
Market Revenues 128
TABLE 41 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS
TECHNIQUES, THROUGH 2016 ($ MILLIONS) 129
FIGURE 22 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS
TECHNIQUES, 2009-2016 ($ MILLIONS) 129
MARKET SHARES OF THE CHIRAL ANALYSIS MARKET 129
TABLE 42 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS
TECHNIQUES BY REGION, 2010 (%) 130
FIGURE 23 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS
TECHNIQUES BY REGION, 2010 (%) 130
CHAPTER NINE: EUROPEAN MARKET ANALYSIS 131
EUROPEAN MARKET FOR CHIRAL TECHNOLOGIES 131
TABLE 43 EUROPEAN MARKET FOR CHIRAL TECHNOLOGIES BY
TECHNOLOGY TYPE, THROUGH 2016 ($ MILLIONS) 131
FIGURE 24 EUROPEAN MARKET FOR CHIRAL TECHNOLOGIES BY
TECHNOLOGY TYPE, 2009-2016 ($ MILLIONS) 132
CHIRAL SYNTHESIS MARKET 132
Market Revenues 133
TABLE 44 EUROPEAN MARKET FOR CHIRAL SYNTHESIS,
THROUGH 2016 ($ MILLIONS) 133
FIGURE 25 EUROPEAN MARKET FOR CHIRAL SYNTHESIS, 2009-
2016 ($ MILLIONS) 134
Chiral Intermediates 134
Market Overview 135
Market Revenue 136
TABLE 45 EUROPEAN MARKET FOR CHIRAL INTERMEDIATES,
THROUGH 2016 ($ MILLIONS) 136
FIGURE 26 EUROPEAN MARKET FOR CHIRAL INTERMEDIATES,
2009-2016 ($ MILLIONS) 136
Chiral Chemical Catalysts 137
Market Overview 137
Market Revenue 138
TABLE 46 EUROPEAN MARKET FOR CHIRAL CHEMICAL
CATALYSTS, THROUGH 2016 ($ MILLIONS) 138
FIGURE 27 EUROPEAN MARKET FOR CHIRAL CHEMICAL
CATALYSTS, 2009-2016 ($ MILLIONS) 139
Chiral Biocatalysts 139
Market Overview 139
Market Overview (Continued) 140
Market Revenue 141
TABLE 47 EUROPEAN MARKET FOR CHIRAL BIOCATALYSTS,
THROUGH 2016 ($ MILLIONS) 141
FIGURE 28 EUROPEAN MARKET FOR CHIRAL BIOCATALYSTS,
THROUGH 2016 ($ MILLIONS) 141
Chiral Auxiliaries 142
Market Overview 142
Market Revenue 143
TABLE 48 EUROPEAN MARKET FOR CHIRAL AUXILIARIES,
THROUGH 2016 ($ MILLIONS) 143
FIGURE 29 EUROPEAN MARKET FOR CHIRAL AUXILIARIES, 2009-
2016 ($ MILLIONS) 143
Other Synthetic Materials 144
Market Overview 144
Market Revenue 145
TABLE 49 EUROPEAN MARKET FOR OTHER SYNTHETIC
MATERIAL, THROUGH 2016 ($ MILLIONS) 145
FIGURE 30 EUROPEAN MARKET FOR OTHER SYNTHETIC
MATERIAL, 2009-2016 ($ MILLIONS) 145
CHIRAL SEPARATION MARKET 146
MARKET REVENUES 146
TABLE 50 EUROPEAN MARKET FOR CHIRAL SEPARATION BY
TYPE, THROUGH 2016 ($ MILLIONS) 147
FIGURE 31 EUROPEAN MARKET FOR CHIRAL SEPARATION BY
TYPE, 2009-2016 ($ MILLIONS) 147
CRYSTALLIZING AGENTS 148
Market Overview 148
Market Revenue 149
TABLE 51 EUROPEAN MARKET FOR CRYSTALLIZING AGENTS,
THROUGH 2016 ($ MILLIONS) 150
FIGURE 32 EUROPEAN MARKET FOR CRYSTALLIZING AGENTS,
2009-2016 ($ MILLIONS) 150
CHROMATOGRAPHY COLUMNS AND REAGENTS 150
Market Overview 151
TABLE 52 EUROPEAN MARKET FOR CHROMATOGRAPHY
COLUMNS AND REAGENTS, THROUGH 2016 ($ MILLIONS) 152
FIGURE 33 EUROPEAN MARKET FOR CHROMATOGRAPHY
COLUMNS AND REAGENTS, THROUGH 2016 ($ MILLIONS) 152
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 152
Market Overview 153
Market Revenue 154
TABLE 53 EUROPEAN MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS, THROUGH 2016 ($ MILLIONS) 154
FIGURE 34 EUROPEAN MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS, 2009-2016 ($ MILLIONS) 155
ENZYMES IN KINETIC RESOLUTION 155
Market Overview 156
Market Revenue 157
TABLE 54 EUROPEAN MARKET FOR KINETIC RESOLUTION,
THROUGH 2016 ($ MILLIONS) 157
FIGURE 35 EUROPEAN MARKET FOR KINETIC RESOLUTION, 2009-
2016 ($ MILLIONS) 157
CHIRAL ANALYSIS MARKET 158
MARKET REVENUES 158
TABLE 55 EUROPEAN MARKET FOR CHIRAL ANALYSIS BY TYPE,
THROUGH 2016 ($ MILLIONS) 158
FIGURE 36 EUROPEAN MARKET FOR CHIRAL ANALYSIS, 2009 2016
($ MILLIONS) 159
CHIRAL LIQUID CHROMATOGRAPHY 159
Market Overview 160
Market Revenue 160
TABLE 56 EUROPEAN MARKET FOR LIQUID CHROMATOGRAPHY,
THROUGH 2016 ($ MILLIONS) 161
FIGURE 37 EUROPEAN MARKET FOR LIQUID CHROMATOGRAPHY,
2009-2016 ($ MILLIONS) 161
CHIRAL GAS CHROMATOGRAPHY 161
Market Overview 162
Market Revenue 163
TABLE 57 EUROPEAN MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 163
FIGURE 38 EUROPEAN MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 164
CHIRAL CAPILLARY ELECTROPHORESIS 164
Market Overview 165
Market Revenue 165
TABLE 58 EUROPEAN MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 166
FIGURE 39 EUROPEAN MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 166
CHIRAL SUPERCRITICAL FLUID CHROMATOGRAPHY 166
Market Overview 167
Market Revenue 167
TABLE 59 EUROPEAN MARKET FOR CHIRAL SUPERCRITICAL
FLUID CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 167
FIGURE 40 EUROPEAN MARKET FOR CHIRAL SUPERCRITICAL
FLUID CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 168
CHIRAL POLARIMETERS 168
Market Overview 168
Market Revenue 169
TABLE 60 EUROPEAN MARKET FOR CHIRAL POLARIMETERS,
THROUGH 2016 ($ MILLIONS) 169
FIGURE 41 EUROPEAN MARKET FOR CHIRAL POLARIMETERS,
2009-2016 ($ MILLIONS) 170
NMR SHIFT REAGENTS 170
TABLE 61 EXAMPLES OF CHIRAL NMR SHIFT REAGENTS 171
Market Overview 171
Market Revenue 171
TABLE 62 EUROPEAN MARKET FOR NMR SHIFT REAGENTS,
THROUGH 2016 ($ MILLIONS) 172
FIGURE 42 EUROPEAN MARKET FOR NMR SHIFT REAGENTS,
2009-2016 ($ MILLIONS) 172
OTHERS 172
Market Overview 173
Market Revenue 173
TABLE 63 EUROPEAN MARKET FOR OTHER CHIRAL ANALYSIS,
THROUGH 2016 ($ MILLIONS) 174
FIGURE 43 EUROPEAN MARKET FOR OTHER CHIRAL ANALYSIS,
THROUGH 2016 ($ MILLIONS) 174
INDUSTRY LEADER MARKET SHARES 174
CHIRAL INTERMEDIATES 174
TABLE 64 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL INTERMEDIATES IN EUROPE, 2010 (%) 175
FIGURE 44 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL INTERMEDIATES IN EUROPE, 2010 (%) 176
CHIRAL CHEMICAL CATALYSTS 176
TABLE 65 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL CHEMICAL CATALYSTS IN EUROPE, 2010 (%) 177
FIGURE 45 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL CHEMICAL CATALYSTS IN EUROPE, 2010 (%) 177
CHIRAL BIOCATALYSTS 178
TABLE 66 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL BIOCATALYSTS IN EUROPE, 2010 (%) 178
FIGURE 46 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL BIOCATALYSTS IN EUROPE, 2010 (%) 179
CHIRAL AUXILIARIES 179
TABLE 67 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL AUXILIARIES IN EUROPE, 2010 (%) 180
FIGURE 47 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL AUXILIARIES IN EUROPE, 2010 (%) 180
OTHER SYNTHETIC MATERIALS 181
TABLE 68 MANUFACTURER/SUPPLIER MARKET SHARES OF
OTHER SYNTHETIC MATERIALS IN EUROPE, 2010 (%) 181
FIGURE 48 MANUFACTURER/SUPPLIER MARKET SHARES OF
OTHER SYNTHETIC MATERIALS IN EUROPE, 2010 (%) 181
CHIRAL COLUMNS AND STATIONARY PHASES 182
TABLE 69 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL COLUMNS AND STATIONARY PHASES IN EUROPE, 2010
(%) 182
FIGURE 49 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL COLUMNS AND STATIONARY PHASES IN EUROPE, 2010
(%) 183
CHIRAL RESOLVING/CRYSTALLIZING AGENTS 183
TABLE 70 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN EUROPE,
2010 (%) 183
FIGURE 50 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN EUROPE,
2010 (%) 184
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 184
TABLE 71 MANUFACTURER/SUPPLIER MARKET SHARES OF
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN
EUROPE, 2010 (%) 184
TABLE 71 (CONTINUED) 185
FIGURE 51 MANUFACTURER/SUPPLIER MARKET SHARES OF
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN
EUROPE, 2010 (%) 185
CHIRAL ANALYSIS INSTRUMENTS 186
TABLE 72 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL ANALYSIS INSTRUMENTS IN EUROPE, 2010 (%) 186
FIGURE 52 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL ANALYSIS INSTRUMENTS IN EUROPE, 2010 (%) 187
CHAPTER TEN: MARKET BY INDUSTRY APPLICATION 188
INTRODUCTION 188
CHIRAL TECHNOLOGY MARKET BY INDUSTRY 188
TABLE 73 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
SALES BY INDUSTRY, 2010 (%) 189
FIGURE 53 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
SALES BY INDUSTRY, 2010 (%) 189
PHARMACEUTICALS 189
Pharmaceuticals (Continued) 190
TABLE 74 CHIRAL DRUGS FROM THERAPEUTIC CLASSES 191
TABLE 75 ENANTIOPURE DRUGS 191
TABLE 75 (CONTINUED) 192
TABLE 75 (CONTINUED) 193
Market Revenue 193
TABLE 76 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY
PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 193
FIGURE 54 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY
PRODUCT TYPE, 2009-2016 ($ MILLIONS) 194
Market Share 194
TABLE 77 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED BY THE PHARMACEUTICAL
INDUSTRY, 2010 (%) 195
FIGURE 55 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
IN THE PHARMACEUTICAL INDUSTRY BY PRODUCT TYPE, 2010
(%) 195
TABLE 78 U S SALES OF TOP 10 CHIRAL DRUGS, 2010 ($
MILLIONS) 196
BIOCHEMICALS 196
Amino Acids 197
Hydroxy Acids 197
Oligonucleotides 197
Peptides 198
Oligosaccharides 198
Vitamins 199
Market Revenues 199
TABLE 79 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE BIOCHEMICAL INDUSTRY, THROUGH 2016
($ MILLIONS) 199
FIGURE 56 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE BIOCHEMICAL INDUSTRY, 2009-2016 ($
MILLIONS) 200
Market Share 200
TABLE 80 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,
2010 (%) 201
FIGURE 57 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,
2010 (%) 201
PESTICIDES/AGROCHEMICAL INDUSTRY 201
Pesticides/Agrochemical … (Continued) 202
TABLE 81 CHIRAL PESTICIDES 203
Pesticides/Agrochemical … (Continued) 204
Market Revenues 205
TABLE 82 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN THE AGROCHEMICAL INDUSTRY, THROUGH 2016
($ MILLIONS) 205
FIGURE 58 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN AGROCHEMICAL INDUSTRY, THROUGH 2016 ($
MILLIONS) 206
Market Share 206
TABLE 83 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE AGROCHEMICAL
INDUSTRY, 2010 (%) 206
FIGURE 59 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE AGROCHEMICAL
INDUSTRY, 2010 (%) 207
OTHER INDUSTRIES 207
Aromas and Fragrances 207
Aromas and Fragrances (Continued) 208
TABLE 84 CHIRAL AROMA COMPOUNDS 209
Liquid Crystals 209
Liquid Crystals (Continued) 210
Polymers 211
Market Revenues 212
TABLE 85 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($
MILLIONS) 212
FIGURE 60 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($
MILLIONS) 213
Market Share 213
TABLE 86 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 214
FIGURE 61 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 214
CHAPTER ELEVEN: PATENT ANALYSIS 215
PATENTS BY YEAR 215
TABLE 87 U S PATENTS FOR CHIRAL PRODUCTS BY YEAR, 2009
TO OCT 2011 (NO ) 216
PATENTS BY TECHNOLOGY 216
TABLE 88 U S PATENTS FOR CHIRAL PRODUCTS BY
TECHNOLOGY, 2009 TO OCT 2011 (NO ) 217
FIGURE 62 U S PATENTS FOR CHIRAL PRODUCTS BY
TECHNOLOGY, 2009 TO OCT 2011 (NO ) 217
PATENTS BY TYPE 217
TABLE 89 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009
TO OCT 2011 (NO ) 218
FIGURE 63 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009
TO OCT 2011 (NO ) 218
TABLE 90 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE, 2009
TO OCT 2011 (NO ) 219
FIGURE 64 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE,
2009 TO OCT 2011 (NO ) 219
TABLE 91 U S PATENTS FOR CHIRAL ANALYSIS, 2009 TO OCT
2011 (NO ) 220
FIGURE 65 U S PATENTS BY TYPE FOR CHIRAL ANALYSIS, 2009
TO OCT 2011 (NO ) 220
PATENTS BY COMPANY 221
TABLE 92 U S PATENTS FOR CHIRAL SYNTHESIS BY COMPANY,
2009 TO OCT 2011 (NO ) 221
TABLE 92 (CONTINUED) 222
TABLE 93 U S PATENTS FOR CHIRAL RESOLUTION BY COMPANY,
2009 TO OCT 2011 (NO ) 223
TABLE 94 U S PATENTS FOR CHIRAL ANALYSIS BY COMPANY,
2009 TO OCT 2011 (NO ) 224
PATENTS BY COUNTRY 224
TABLE 95 U S PATENTS FOR CHIRAL SYNTHESIS BY COUNTRY,
2009 TO OCT 2011 (NO ) 224
TABLE 95 (CONTINUED) 225
TABLE 96 SHARES OF U S CHIRAL SYNTHESIS PATENTS BY
COUNTRY, 2009 TO OCT 2011 (%) 225
TABLE 96 (CONTINUED) 226
TABLE 97 U S PATENTS FOR CHIRAL RESOLUTION/SEPARATION
BY COUNTRY, 2009 TO OCT 2011 (NO ) 226
TABLE 98 SHARES OF U S CHIRAL RESOLUTION/SEPARATION
PATENTS BY COUNTRY, 2009 TO OCT 2011 (%) 227
TABLE 99 U S PATENTS FOR CHIRAL ANALYSIS BY COUNTRY,
2009 TO OCT 2011 (NO ) 227
TABLE 100 SHARES OF U S CHIRAL ANALYSIS PATENTS BY
COUNTRY, 2009 TO OCT 2011 (%) 228
PATENTS BY ASSIGNEE 228
TABLE 101 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE OF
ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 228
TABLE 102 U S PATENTS FOR CHIRAL
RESOLUTION/SEPARATION BY TYPE OF ASSIGNEE/END USER,
2009 TO OCT 2011 (NO ) 229
TABLE 103 U S PATENTS FOR CHIRAL ANALYSIS BY TYPE OF
ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 229
CHAPTER TWELVE: CURRENT CHIRAL MARKET ENVIRONMENT 230
INTRODUCTION 230
MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 231
MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 232
MARKET TRENDS IN CHIRAL RESOLUTION 233
MARKET TRENDS IN CHIRAL ANALYSIS 234
MARKET TRENDS IN CHIRAL … (CONTINUED) 235
MARKET TRENDS IN CHIRAL … (CONTINUED) 236
CHAPTER THIRTEEN: COMPANY PROFILES 237
3B SCIENTIFIC CORP 237
ABA CHEMICALS CORP 237
AESICA PHARMACEUTICALS LTD 238
AGILENT TECHNOLOGIES 238
ALLIED INDUSTRIAL CORP LTD 239
ALMAC GROUP LTD 239
AMPAC FINE CHEMICALS LLC 240
ARCH PHARMALABS LTD 240
ARRAN CHEMICAL CO LTD 241
AVANTIUM TECHNOLOGIES BV 242
AVANTOR PERFORMANCE MATERIALS 242
BACHEM AMERICAS 243
BASF SE 244
BAYER AG 244
BECKMAN COULTER INC 245
BIOCATALYSTS LTD 246
BOULDER SCIENTIFIC CO 246
BRUKER AXS GMBH 247
CAMBREX CORP 248
CARBOSYNTH LTD 249
CHEMTURA CORP 249
CHIRAL BIOSCIENCES LTD 250
CHIRAL MANAGEMENT 250
CHIRAL TECHNOLOGIES INC 251
CHIRAL TECHNOLOGIES EUROPE 251
CHIRALVISION BV 252
CHIROTECH TECHNOLOGY LTD 252
CHONGQING CHIRAL BIOCATALYSIS TECHNOLOGY CO LTD 253
CHROMACOL LTD 253
CHROMTECH GESELLSCHAFT FÜR ANALYTISCHE
MEßTECHNIK MBH 254
CODEXIS INC 254
CORDEN PHARMA SWITZERLAND LLC 255
CYTEC INDUSTRIES INC 256
DAICEL CORP 257
DAINIPPON SUMITOMO PHARMA CO LTD 257
DIONEX CORP 258
DOW CHEMICAL CO 259
DOW PHARMACEUTICAL SCIENCES 259
DSM PHARMACEUTICAL PRODUCTS 260
ENZYTECH CO LTD 261
EVOCATAL GMBH 261
FARBEN-CHEM EUROPE LTD 262
GENENCOR INTERNATIONAL INC 262
GILSON INC 263
JASCO INC 263
JOHNSON MATTHEY PLC 264
KANEKA CORP 265
KEMFINE LTD 266
KOCH MODULAR PROCESS SYSTEMS 266
LANXESS AG 267
LASERCHROM HPLC LABORATORIES LTD 268
LG CHEM EUROPE GMBH 268
LONZA 269
LOUSTON INTERNATIONAL INC 269
MACHEREY-NAGEL GMBH & CO KG 270
MARRESEARCH GMBH 270
MEGA S N C 271
MERCK KGAA 271
NOVASEP 272
NOVOZYMES A/S 273
OUTOTEC OYJ 273
PANALYTICAL INC 274
PDR-CHIRAL LLC 275
PERKINELMER 275
PHENOMENEX INC 276
PROZOMIX LTD 277
RARE EARTH PRODUCTS INC 277
REGIS TECHNOLOGIES INC 278
RHODIA INC USA 278
ROCHE APPLIED SCIENCE 279
ROUSSELET CENTRIFUGATION SA 280
RUDOLPH INSTRUMENTS 280
SHIMADZU CORP 281
SIGMA-ALDRICH 281
SILICYCLE 282
STREM CHEMICALS INC 283
SUPELCO INC 284
SYNQUEST LABORATORIES INC 284
SYNTHETECH INC 285
SYMRISE AG 285
TAKEDA PHARMACEUTICAL CO LTD 286
TCI AMERICA 287
TAKASAGO INTERNATIONAL CORP 288
THERMO FISHER SCIENTIFIC 288
VERENIUM CORP 289
WUXI APPTEC CO LTD 290
YAMAKAWA CHEMICAL 291
YMC AMERICA INC 291
ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD 292
ZIRCHROM SEPARATIONS INC 292
APPENDIX: ABBREVIATIONS 293
ABBREVIATIONS 293
ABBREVIATIONS (CONTINUED) 294
ABBREVIATIONS (CONTINUED) 295
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