Global Markets for Media, Sera and Reagents in Biotechnology -- Focus on Emerging Markets
NEW YORK, June 4, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global Markets for Media, Sera and Reagents in Biotechnology -- Focus on Emerging Marketshttp://www.reportlinker.com/p0870808/Global-Markets-for-Media-Sera-and-Reagents-in-Biotechnology----Focus-on-Emerging-Markets.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic
INTRODUCTION
STUDY OBJECTIVESThis report explores present and future strategies within the media and sera market, including reagents used in biotechnology. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The types of cell cultures and the products from cell culture technology are also presented in this report. The advantages and disadvantages for the use of various types of media are also covered in this report.
A detailed analysis of the cell culture industry structure has been conducted. This includes the biotechnology reagents, media and the sera used. Revenues are broken down by global region. Sales figures are estimated for the five-year period from 2011 through 2016.
Applications for the cell culture industry—media, sera and reagents used in biotechnology—are also discussed in the report, with an emphasis on the usage in the research, production and contract segments. The report also covers significant patents in each segment.
REASONS FOR DOING THIS STUDY
Demand for cell culture products, namely media, sera and reagents, is increasing, with the increasing demand for biopharmaceuticals. Cell culture, a crucial component of the life sciences industry, has witnessed major development during the past three decades. R&D spending, along with increasing competition, patent expiries, new technologies and an international marketplace are moving the cell culture process in a new direction. As cell culture technologies evolved, a number of disciplines such as cell biology, genetic engineering, protein chemistry, genomics and chemical engineering have been successfully incorporated into the cell culture field.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of the different types of media used in light of the new technologies, growing competition and changing customer needs.
INTENDED AUDIENCE SCOPE OF THE STUDY METHODOLOGY INFORMATION SOURCES ABOUT THE AUTHOR Shalini S. Dewan India IndiaThe lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit.
TABLE OF CONTENTSCHAPTER ONE: INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 4
CHAPTER TWO: EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY 5
SUMMARY TABLE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET,
THROUGH 2016 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL REVENUES FROM MEDIA, SERA AND
REAGENTS USED IN THE BIOTECHNOLOGY MARKET, 2009-2016
($ MILLIONS) 6
EXECUTIVE SUMMARY (CONTINUED) 7
CHAPTER THREE: OVERVIEW 8
DEFINITIONS 8
HISTORY 8
TABLE 1 HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT 9
TABLE 1 (CONTINUED) 10
TYPES OF CELL CULTURES 10
PRIMARY CULTURES 10
TABLE 2 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL
CULTURE 11
SECONDARY CELL CULTURE 11
CONTINUOUS CELL CULTURE 11
TABLE 3 ADVANTAGES AND DISADVANTAGES OF CONTINUOUS
CELL CULTURE 12
MORPHOLOGY OF CELLS IN CULTURE 12
FIBROBLASTIC CELLS 12
EPITHELIAL-LIKE CELLS 12
LYMPHOBLAST-LIKE CELLS 12
BASIC SYSTEMS FOR CELL CULTURE 12
TABLE 4 ADHERENT CULTURE VS SUSPENSION CULTURE 13
CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES 13
CHARACTERISTICS OF IMMORTALIZED CELL LINES 14
FACTORS AFFECTING CELL CULTURE 14
APPLICATIONS OF CELL CULTURE 15
MODEL SYSTEM 15
CANCER RESEARCH 15
VIROLOGY 15
TABLE 5 CULTURE MEDIA USED FOR THE PRODUCTION OF
VACCINES 16
TABLE 5 (CONTINUED) 17
GENETICALLY ENGINEERED PROTEINS 17
TABLE 6 POTENTIAL SOURCES OF CELL CULTURE ADDITIVES 18
Recombinant Thrombolytic Agents 19
TABLE 7 RECOMBINANT THROMBOLYTIC AGENTS 19
Recombinant Coagulation Factor 19
TABLE 8 RECOMBINANT COAGULATION FACTOR 20
Cytokines 20
Hematopoietic Growth Factors 21
Human Growth Hormones 22
Monoclonal Antibodies 22
TISSUE AND ORGAN REPLACEMENT 22
GENETIC COUNSELING 23
GENE THERAPY 23
PROBLEMS DURING CELL CULTURE 23
TOXICITY 23
MICROBIAL CONTAMINATION 23
Cross-Contamination 24
BASIC REQUIREMENTS OF CELL CULTURE 24
CELL CULTURE MEDIA 24
Basic Constituents of Media 24
Inorganic Salts 24
TABLE 9 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS 25
Buffering Systems 25
Energy Source 26
Amino Acids 26
Vitamins 26
Proteins and Peptides 27
Fatty Acids and Lipids 27
Trace Elements 27
Antibiotics 28
TABLE 10 COMMONLY USED ANTIBIOTICS IN CELL CULTURES 28
Serum 29
Types of Cell Culture Media 29
Serum-Containing Media 29
TABLE 11 ADVANTAGES AND DISADVANTAGES OF SERUMCONTAINING
MEDIA 30
Serum-free Media 30
TABLE 12 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE
MEDIA 31
Chemically Defined Media 31
Amino Acids 31
Carbohydrates 32
Inorganic Salts 32
Vitamins 32
Protein-Free Media 32
Selection of Cell Culture Media 33
Serum-Free Media: Reasons for Preference 33
Supplements for Serum-Free Media 33
Hormones 34
Transferrin 34
Lipids 34
Hydrolysates 35
SERUM 35
Role of Serum in Cell Culture 35
Serum Components 36
Growth Factors 36
Albumin 36
Protease Inhibitors 36
TABLE 13 NORMAL RANGE OF CONCENTRATION OF SERUM
CONSTITUENTS 36
TABLE 13 (CONTINUED) 37
Sources of Serum 37
Fetal Bovine Serum 37
Calf Serum 37
Calf Serum, Donor (Bovine) 37
Calf Serum, Newborn (Bovine) 37
Other Animal Sera 38
Chicken Serum 38
Dog Serum 38
Donor Donkey Serum 38
Donor Goat Serum 38
Donor Rat Serum 38
Rat Serum 38
Feline Serum 38
Guinea Pig Serum 39
Monkey Serum 39
Mouse Serum 39
Porcine Serum 39
Rabbit Serum 39
Sheep Serum 39
Horse Serum 39
Potential Problems with Serum 40
Serum Selection 40
CELL CULTURE REAGENTS 41
Amino Acids and Vitamins 41
Antibiotics and Antimycotics 41
Buffers 41
Cell Dissociation Agents 42
Growth Supplements 42
REGULATORY ASPECTS 42
APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS 43
TABLE 14 APPROVALS OF BIOLOGICAL LICENSE APPLICATIONS,
2010 TO AUG 2011 43
TABLE 14 (CONTINUED) 44
ADMINISTRATIVE ACTIONS: BIOLOGICS 44
TABLE 15 ADMINISTRATIVE ACTIONS: BIOLOGICS, 2007 TO AUG
2011 44
TABLE 15 (CONTINUED) 45
TABLE 16 PRODUCT RECALLS, 2007 TO AUG 2011 46
TABLE 16 (CONTINUED) 47
TABLE 16 (CONTINUED) 48
LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 LEADING MANUFACTURERS OF MEDIA 48
TABLE 17 (CONTINUED) 49
TABLE 17 (CONTINUED) 50
TABLE 17 (CONTINUED) 51
TABLE 17 (CONTINUED) 52
TABLE 17 (CONTINUED) 53
TABLE 17 (CONTINUED) 54
TABLE 18 LEADING MANUFACTURERS OF SERA 54
TABLE 18 (CONTINUED) 55
TABLE 18 (CONTINUED) 56
TABLE 19 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE
MODIFIERS 57
TABLE 19 (CONTINUED) 58
TABLE 19 (CONTINUED) 59
TABLE 19 (CONTINUED) 60
TABLE 20 LEADING MANUFACTURERS OF CELL DISSOCIATION
REAGENTS 60
TABLE 20 (CONTINUED) 61
TABLE 21 LEADING MANUFACTURERS OF ANTIBIOTICS AND
ANTIMYCOTICS USED IN CELL CULTURE 62
TABLE 21 (CONTINUED) 63
TABLE 22 LEADING MANUFACTURERS OF OTHER REAGENTS 63
TABLE 22 (CONTINUED) 64
TABLE 22 (CONTINUED) 65
NEW DEVELOPMENTS 66
TABLE 23 NEW DEVELOPMENTS IN THE CELL CULTURE
INDUSTRY SINCE 2008 67
TABLE 23 (CONTINUED) 68
NEW DEVELOPMENTS IN APPLICATIONS 68
NEW DEVELOPMENTS IN APPLICATIONS (CONTINUED) 69
TABLE 24 NEW DEVELOPMENTS IN APPLICATION OF CELL
CULTURE 70
TABLE 24 (CONTINUED) 71
CHAPTER FOUR: GLOBAL MARKETS 72
GLOBAL MARKETS 72
GLOBAL MARKETS (CONTINUED) 73
TABLE 25 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 74
FIGURE 1 GLOBAL MARKET FOR CELL CULTURE PRODUCTS,
2009-2016 ($ MILLIONS) 74
MEDIA 75
MARKET REVENUE 76
TABLE 26 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, THROUGH 2016 ($ MILLIONS) 76
FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN
BIOTECHNOLOGY BY REGION, 2009-2016 ($ MILLIONS) 77
MARKET SHARES 77
TABLE 27 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 77
FIGURE 3 GLOBAL BIOTECHNOLOGY MEDIA MARKET SHARES BY
REGION, 2010 (%) 78
SERUM-FREE MEDIA AND SERUM-REQUIRING MEDIA 78
Serum-Free Media Market Revenue 79
TABLE 28 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 79
FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA BY REGION,
2009-2016 ($ MILLIONS) 79
Serum-Requiring Media Market Revenue 80
TABLE 29 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, THROUGH 2016 ($ MILLIONS) 80
FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA BY
REGION, 2009-2016 ($ MILLIONS) 81
POWDERED MEDIA AND LIQUID MEDIA 81
Powdered Media Market Revenue 82
TABLE 30 GLOBAL MARKET FOR POWDERED MEDIA, THROUGH
2016 ($ MILLIONS) 82
FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA, 2009-2016 ($
MILLIONS) 82
Liquid Media Market Revenue 83
TABLE 31 GLOBAL MARKET FOR LIQUID MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 83
FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA BY REGION, 2009-
2016 ($ MILLIONS) 83
CLASSICAL AND SPECIALTY MEDIA 84
Classical Media Market Revenue 84
TABLE 32 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 85
FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA BY REGION,
2009–2016 ($ MILLIONS) 85
Specialty Media Market Revenue 86
TABLE 33 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
THROUGH 2016 ($ MILLIONS) 86
FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA BY REGION,
2009-2016 ($ MILLIONS) 86
SERA 87
MARKET REVENUE 88
TABLE 34 GLOBAL MARKET FOR SERA BY REGION, THROUGH
2016 ($ MILLIONS) 88
FIGURE 10 GLOBAL MARKET FOR SERA BY REGION, 2009–2016 ($
MILLIONS) 88
MARKET SHARES 89
TABLE 35 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2010 (%) 89
BOVINE SERA OR FETAL BOVINE SERA 90
TABLE 36 GLOBAL MARKET FOR BOVINE SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 90
FIGURE 12 GLOBAL MARKET FOR BOVINE SERA BY REGION, 2009–
2016 ($ MILLIONS) 91
OTHER SERA 91
TABLE 37 GLOBAL MARKET FOR OTHER SERA BY REGION,
THROUGH 2016 ($ MILLIONS) 92
FIGURE 13 GLOBAL MARKET FOR OTHER SERA BY REGION, 2009-
2016 ($ MILLIONS) 92
REAGENTS 93
MARKET OVERVIEW 94
MARKET REVENUE 95
TABLE 38 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, THROUGH 2016 ($ MILLIONS) 95
FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY
REGION, 2009-2016 ($ MILLIONS) 96
MARKET SHARES 96
TABLE 39 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 96
FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES
BY REGION, 2010 (%) 97
BIOLOGICAL RESPONSE MODIFIERS 97
TABLE 40 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 97
FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 98
Growth Factors 98
TABLE 41 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
THROUGH 2016 ($ MILLIONS) 99
FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS BY REGION,
2009- 2016 ($ MILLIONS) 99
Cytokines 99
TABLE 42 GLOBAL MARKET FOR CYTOKINES BY REGION,
THROUGH 2016 ($ MILLIONS) 100
FIGURE 18 GLOBAL MARKET FOR CYTOKINES BY REGION, 2009-
2016 ($ MILLIONS) 100
Other Biological Response Modifiers 100
TABLE 43 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, THROUGH 2016 ($ MILLIONS) 101
FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE
MODIFIERS BY REGION, 2009-2016 ($ MILLIONS) 101
CELL DISSOCIATION REAGENTS 102
TABLE 44 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS
BY REGION, THROUGH 2016 ($ MILLIONS) 102
FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION
REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102
OTHERS 103
TABLE 45 GLOBAL MARKET FOR OTHERS BY REGION, THROUGH
2016 ($ MILLIONS) 103
FIGURE 21 GLOBAL MARKET FOR OTHERS BY REGION, 2009-2016
($ MILLIONS) 104
CHAPTER FIVE: EMERGING MARKETS/REST OF THE WORLD
MARKET 105
TABLE 46 EMERGING MARKETS FOR CELL CULTURE PRODUCTS,
THROUGH 2016 ($ MILLIONS) 105
FIGURE 22 EMERGING MARKETS FOR CELL CULTURE
PRODUCTS, 2009-2016 ($ MILLIONS) 106
MEDIA 106
MARKET OVERVIEW 107
Market Revenue 107
TABLE 47 EMERGING MARKETS FOR CELL CULTURE MEDIA,
THROUGH 2016 ($ MILLIONS) 108
FIGURE 23 EMERGING MARKETS FOR CELL CULTURE MEDIA,
2009-2016 ($ MILLIONS) 108
SERUM-FREE AND SERUM-REQUIRING MEDIA 109
Market Revenue 109
TABLE 48 EMERGING MARKETS FOR SERUM-REQUIRING AND
SERUM-FREE MEDIA, THROUGH 2016 ($ MILLIONS) 109
FIGURE 24 EMERGING MARKETS FOR SERUM-REQUIRING AND
SERUM-FREE MEDIA, THROUGH 2016 ($ MILLIONS) 110
POWDERED AND LIQUID MEDIA 110
Market Revenue 110
TABLE 49 EMERGING MARKETS FOR POWDERED AND LIQUID
MEDIA, THROUGH 2016 ($ MILLIONS) 111
FIGURE 25 EMERGING MARKETS FOR POWDERED AND LIQUID
MEDIA, 2009-2016 ($ MILLIONS) 111
CLASSICAL MEDIA AND SPECIALTY MEDIA 111
Market Revenue 112
TABLE 50 EMERGING MARKETS FOR CLASSICAL AND SPECIALTY
MEDIA, THROUGH 2016 ($ MILLIONS) 112
FIGURE 26 EMERGING MARKETS FOR CLASSICAL AND
SPECIALTY MEDIA, 2009 2016 ($ MILLIONS) 112
SERA 113
MARKET OVERVIEW 113
MARKET REVENUE 113
TABLE 51 EMERGING MARKETS FOR BOVINE AND OTHER SERA,
THROUGH 2016 ($ MILLIONS) 114
FIGURE 27 EMERGING MARKETS FOR BOVINE AND OTHER SERA,
2009-2016 ($ MILLIONS) 114
REAGENTS 114
MARKET OVERVIEW 115
MARKET REVENUE 115
TABLE 52 EMERGING MARKETS FOR CELL CULTURE REAGENTS,
THROUGH 2016 ($ MILLIONS) 116
FIGURE 28 EMERGING MARKETS FOR CELL CULTURE
REAGENTS, 2009-2016 ($ MILLIONS) 116
BIOLOGICAL RESPONSE MODIFIERS 117
Market Revenue 117
TABLE 53 EMERGING MARKETS FOR BIOLOGICAL RESPONSE
MODIFIERS, THROUGH 2016 ($ MILLIONS) 117
FIGURE 29 EMERGING MARKETS FOR BIOLOGICAL RESPONSE
MODIFIERS, 2009-2016 ($ MILLIONS) 118
MARKET LEADERS IN THE EMERGING MARKETS 118
MEDIA 118
Serum-Free Media 118
TABLE 54 MARKET SHARES OF SERUM FREE MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 119
FIGURE 30 MARKET SHARES OF SERUM FREE MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 119
Serum-Requiring/Containing Media 119
TABLE 55 MARKET SHARES OF SERUM-CONTAINING MEDIA IN
THE EMERGING MARKETS BY COMPANY, 2010 (%) 120
FIGURE 31 MARKET SHARES OF SERUM CONTAINING MEDIA IN
THE EMERGING MARKETS BY COMPANY, 2010 (%) 120
Powdered Media 121
TABLE 56 MARKET SHARES OF POWDERED MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 121
FIGURE 32 MARKET SHARES OF POWDERED MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 121
Liquid Media 122
TABLE 57 MARKET SHARES OF LIQUID MEDIA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 122
FIGURE 33 MARKET SHARES OF LIQUID MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 122
Classical Media 123
TABLE 58 MARKET SHARES OF CLASSICAL MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 123
FIGURE 34 MARKET SHARES OF CLASSICAL MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 123
Specialty Media 124
TABLE 59 MARKET SHARES OF SPECIALTY MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 124
FIGURE 35 MARKET SHARES OF SPECIALTY MEDIA IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 124
SERA 125
Bovine Sera 125
TABLE 60 MARKET SHARES OF BOVINE SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 125
FIGURE 36 MARKET SHARES OF BOVINE SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 125
Other Sera 126
TABLE 61 MARKET SHARES OF OTHER SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 126
FIGURE 37 MARKET SHARES OF OTHER SERA IN THE EMERGING
MARKETS BY COMPANY, 2010 (%) 126
REAGENTS 127
Biological Response Modifiers 127
TABLE 62 MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
(%) 127
FIGURE 38 MARKET SHARES OF BIOLOGICAL RESPONSE
MODIFIERS IN THE EMERGING MARKETS BY COMPANY, 2010
(%) 128
Cell Dissociation Reagents 128
TABLE 63 MARKET SHARES OF CELL DISSOCIATION REAGENTS
IN THE EMERGING MARKETS BY COMPANY, 2010 (%) 128
FIGURE 39 MARKET SHARES OF CELL DISSOCIATION REAGENTS
IN THE EMERGING MARKETS BY COMPANY, 2010 (%) 129
Other Reagents 129
TABLE 64 MARKET SHARES OF OTHER REAGENTS IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 130
FIGURE 40 MARKET SHARES OF OTHER REAGENTS IN THE
EMERGING MARKETS BY COMPANY, 2010 (%) 130
CHAPTER SIX: END USERS 131
MARKET SHARE OF APPLICATIONS 131
TABLE 65 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES
BY END USER, 2010 (%) 132
FIGURE 41 GLOBAL MEDIA, SERA AND REAGENT MARKET
SHARES BY END USER, 2010 (%) 132
RESEARCH SEGMENT 132
RESEARCH SEGMENT (CONTINUED) 133
RESEARCH SEGMENT (CONTINUED) 134
MARKET REVENUE 135
TABLE 66 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, THROUGH 2016 ($ MILLIONS) 135
FIGURE 42 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE RESEARCH SEGMENT, 2009-2016 ($ MILLIONS) 136
PRODUCTION SEGMENT 136
PRODUCTION SEGMENT (CONTINUED) 137
MARKET REVENUE 138
TABLE 67 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, THROUGH 2016 ($ MILLIONS) 138
FIGURE 43 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE PRODUCTION SEGMENT, 2009-2016 ($ MILLIONS) 139
CONTRACT SEGMENT 139
CONTRACT SEGMENT (CONTINUED) 140
MARKET REVENUE 141
TABLE 68 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, THROUGH 2016 ($ MILLIONS) 142
FIGURE 44 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE CONTRACT SEGMENT, 2009-2016 ($ MILLIONS) 142
OTHERS SEGMENT 142
MARKET REVENUE 143
TABLE 69 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, THROUGH 2016 ($ MILLIONS) 144
FIGURE 45 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN
THE OTHERS SEGMENT, 2009-2016 ($ MILLIONS) 144
CHAPTER SEVEN: PATENT ANALYSIS 145
PATENTS BY YEAR 145
TABLE 70 NUMBER OF U S PATENTS ISSUED BY YEAR, 2007 TO
OCT 2011 146
FIGURE 46 U S PATENTS ISSUED BY YEAR, 2007 TO OCT 2011 (%) 146
PATENTS BY TYPE 146
TABLE 71 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007–2011 147
FIGURE 47 PATENTS BY TYPE FOR MEDIA, SERA AND REAGENTS
USED IN BIOTECHNOLOGY, 2007–2011 (NO OF PATENTS) 147
PATENTS BY COMPANY 147
TABLE 72 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS IN BIOTECHNOLOGY BY COMPANY, 2007 TO OCT
2011 (NO ) 148
PATENTS BY COUNTRY 149
TABLE 73 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY, 2007 TO
OCT 2011 (NO ) 149
TABLE 74 SHARES OF U S PATENTS ISSUED FOR MEDIA, SERA
AND REAGENTS USED IN BIOTECHNOLOGY BY COUNTRY,
2007–OCT 2011 (%) 150
PATENTS BY ASSIGNEE 150
TABLE 75 U S PATENTS ISSUED FOR MEDIA, SERA AND
REAGENTS USED IN BIOTECHNOLOGY BY TYPE OF END USER,
2007 TO OCT 2011 (NO ) 150
CHAPTER EIGHT: THE CURRENT SITUATION 151
REGIONAL MARKETS 151
UNITED STATES 151
EUROPE 152
ASIA 152
EMERGING MARKETS 153
TRENDS AND ISSUES IN THE CELL CULTURE MARKET 153
GLOBAL ECONOMY 153
INCREASED RESEARCH AND DEVELOPMENT BUDGET 153
TABLE 76 R&D BUDGETS OF TOP 10 COMPANIES IN 2009 AND 2010
($ BILLIONS) 154
GROWING DEMAND AND RICH PIPELINE OF
BIOTHERAPEUTICS 154
RESEARCH ON THERAPEUTIC VACCINES 155
BIOMEDICAL RESEARCH 156
STEM CELL RESEARCH 156
GOVERNMENT POLICIES ON RESEARCH 156
INNOVATIONS 157
ETHICAL AND ANIMAL WELFARE ISSUES 157
REGULATORY ISSUES 158
USE OF HUMAN BLOOD ALTERNATIVES 158
MERGERS, ACQUISITIONS AND ALLIANCES 159
SHIFT TOWARD CONTRACT MANUFACTURING 159
CHAPTER NINE: COMPANY PROFILES 160
ADVANCED BIOTECHNOLOGIES INC 160
AFFYMETRIX 160
AMRESCO LLC 161
ATHENA ENVIRONMENTAL SCIENCES INC 161
ATLANTA BIOLOGICALS INC 162
BD BIOSCIENCES 163
BIORECLAMATION INC 163
BOVOGEN BIOLOGICALS PTY LTD 164
CELL APPLICATIONS INC 164
CELL CULTURE TECHNOLOGIES GMBH 165
CLONTECH LABORATORIES INC 166
EQUITECH-BIO INC 166
GEMINI BIO-PRODUCTS 167
GENEX INDIA BIOSCIENCES PVT LTD 167
HIMEDIA LABORATORIES 168
INVITROGEN CORP 168
IRVINE SCIENTIFIC 169
J R SCIENTIFIC INC 170
LONZA 170
MEDIATECH INC 171
MEDOX BIOTECH INDIA PVT LTD 171
MILLIPORE CORP 172
MP BIOMEDICALS 173
PAA LABORATORIES 174
PEPROTECH INC 174
PROMOCELL GMBH 175
QUALITY BIOLOGICAL INC 175
R&D SYSTEMS 176
ROCHE APPLIED SCIENCES 177
SERA LABORATORIES INTERNATIONAL LTD 177
SERACARE LIFE SCIENCES INC 178
SIGMA-ALDRICH 178
STEMCELL TECHNOLOGIES 179
STEMCELLS INC 179
THERMO FISHER SCIENTIFIC INC 180
TICO EUROPE 181
VALLEY BIOMEDICAL PRODUCTS AND SERVICES INC 182
APPENDIX: ABBREVIATIONS 183
ABBREVIATIONS 183
ABBREVIATIONS(CONTINUED) 184
ABBREVIATIONS (CONTINUED) 185
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