Global Markets for Reagents for Chromatography -- Focus on Supercritical Fluid Chromatography

NEW YORK, Oct. 11, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Markets for Reagents for Chromatography -- Focus on Supercritical Fluid Chromatography

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INTRODUCTION

STUDY OBJECTIVES

The purpose of this study, conducted by BCC, is to offer a synopsis of the current characteristics of the global market for chromatography reagents in order to forecast its future. The key intent is to provide an extensive analysis of the current market and the future trends for the chromatography reagents market. The report offers analysis on the market size, market leaders, and factors affecting the market of chromatography reagents from the perspective of its end users, which includes the pharma and biotech, food and beverages, environmental agencies and other sectors.

This report investigates current and future strategies within the chromatography techniques and reagents market. The report takes a close look at the market's inventiveness, its setbacks and future needs. The comparisons, usage and the advantages and disadvantages of different types of chromatography products and reagents are also covered in this report.

A comprehensive analysis of chromatography reagents sales is given, broken down by regions—North America, Europe and emerging markets. Sales figures are forecast for the five-year period from 2012 through 2017.

REASONS FOR DOING THIS STUDY

Chromatography techniques and reagents are being used extensively in pharmaceutical and biotechnology industries in the development of pure drug compounds. The primary usage of chromatography techniques is for quality assurance of drug products wherein chromatography separation techniques can, in some cases, assure up to 99.9% purity level and can reveal the impurities to 0.1% or even smaller. These separations or analysis techniques use chromatography reagents for the measurement of the drug purity, which has led to the growing market of the reagents. The study thus focuses on the usage of these reagents in various industries across the global markets.

Most of the techniques of chromatography and their reagents are discussed in this report. The fast-changing scenarios and developmental landscape of various technologies in the market justify focusing on this segment. Along with the end users—pharmaceutical and biotech, food and beverage, environmental agencies and other industries—merger and acquisition and collaborations of companies are also covered in this report. This study also discusses the strengths and weaknesses of each reagent type/technology in light of new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND ITS AUDIENCE

This study contributes to knowledge and understanding of market growth and setbacks for chromatography reagents from the manufacturer and end user perspectives. Pharmaceutical, biochemical, chemical, petrochemical, food and beverage industries, clinics, forensics and environmental agencies will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study comprises the markets of reagents of chromatography along with various chromatography techniques. BCC analyzes each market; the different types of chromatographic techniques and reagents; the regulatory aspects; the end users of the chromatographic reagents and market projections, its market leaders and market share. The study also offers details of technological refinements including the latest trends and developments.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this study. BCC carried out a comprehensive literature search that included technical newsletters, journals, technical blogs and research papers as well as many other sources. The data were collected through interviews and correspondence with various pharmaceutical, biotechnical, food and beverage and environment experts. Projections were based on estimates such as the current number of end users, potential end users, likely unit prices, rates of consumption and market trends.

INFORMATION SOURCES

BCC surveyed various companies within the industry to obtain data for this study. They were reputed manufacturers and end users of chromatographic reagents in pharmaceutical, chemical, biotechnology, food & beverages and other relevant industries. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature, technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were done. In addition, data were compiled from current financial, trade and governmental sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has more than 14 years of industry experience. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems, Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 1

STUDY OBJECTIVES 1

REASONS FOR DOING THIS STUDY 1

CONTRIBUTIONS OF THE STUDY AND ITS AUDIENCE 1

SCOPE OF THE STUDY 2

METHODOLOGY 2

INFORMATION SOURCES 2

ABOUT THE AUTHOR 2

RELATED BCC RESEARCH REPORTS 2

BCC ON-LINE SERVICES 3

DISCLAIMER 3

CHAPTER 2 SUMMARY 5

SUMMARY TABLE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 6

SUMMARY FIGURE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES

OF CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 6

CHAPTER 3 OVERVIEW 9

DEFINITIONS 9

REAGENTS FOR CHROMATOGRAPHY 9

TYPES OF REAGENTS 10

Silylation Reagents 10

TABLE 1 ADVANTAGES AND DISADVANTAGES OF SILYLATION 10

TABLE 2 SILYLATION REAGENTS 10

Alkylation Reagents 11

TABLE 3 ADVANTAGES AND DISADVANTAGES OF ALKYLATION 11

TABLE 4 ALKYLATING REAGENTS 12

Acylation Reagents 12

TABLE 5 ADVANTAGES AND DISADVANTAGES OF ACYLATION 12

TABLE 6 ACYLATING REAGENTS 12

Ion-Pairing Reagents 13

TABLE 7 ADVANTAGES AND DISADVANTAGES OF ION-PAIRING CHROMATOGRAPHY 13

TABLE 8 ION-PAIRING REAGENTS 14

Solvents 14

TABLE 9 EXAMPLES OF SOLVENTS USED IN CHROMATOGRAPHY 14

Buffers 14

TABLE 10 BUFFERS USED IN CHROMATOGRAPHY 15

Adsorbents 15

TABLE 11 ADSORBENTS USED IN GAS-SOLID AND LIQUID-SOLID CHROMATOGRAPHY 15

CLASSIFICATION OF CHROMATOGRAPHY 16

TYPES OF CHROMATOGRAPHY WITH THE USE REAGENTS AND THEIR APPLICATIONS 16

GAS CHROMATOGRAPHY (GC) 16

TABLE 12 ADVANTAGES AND DISADVANTAGES OF GAS CHROMATOGRAPHY 16

Reagents Used in Gas Chromatography 17

TABLE 13 REAGENTS USED IN GAS CHROMATOGRAPHY 17

Applications of Gas Chromatography 17

TABLE 14 APPLICATIONS OF GAS CHROMATOGRAPHY 17

LIQUID CHROMATOGRAPHY (LC) 18

Paper Chromatography (PC) 18

TABLE 15 ADVANTAGES AND DISADVANTAGES OF PAPER CHROMATOGRAPHY 18

Applications of Paper Chromatography 19

Thin Layer Chromatography (TLC) 19

TABLE 16 ADVANTAGES AND DISADVANTAGES OF THIN LAYER CHROMATOGRAPHY 19

TABLE 17 REAGENTS USED IN THIN LAYER CHROMATOGRAPHY 19

Applications of Thin Layer Chromatography 20

High-Performance Liquid Chromatography (HPLC) 20

Ultra High-Performance Liquid Chromatography (UHPLC) 20

Fast Protein Liquid Chromatography (FPLC) 20

TABLE 18 ADVANTAGES AND DISADVANTAGES OF HIGH-PERFORMANCE LIQUID

CHROMATOGRAPHY 20

Reagents used in HPLC 21

TABLE 19 REAGENTS USED IN HPLC CHROMATOGRAPHY 21

Applications of HPLC 21

TABLE 20 APPLICATIONS OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 21

SORPTION CHROMATOGRAPHY 21

Adsorption Chromatography 21

TABLE 21 ADVANTAGES AND DISADVANTAGES OF ADSORPTION CHROMATOGRAPHY 22

Reagents Used in Adsorption Chromatography 22

TABLE 22 REAGENTS USED IN ADSORPTION CHROMATOGRAPHY 22

Applications of Adsorption Chromatography 22

Partition Chromatography 22

Reverse Phase Partition Chromatography 23

Normal Phase Partition Chromatography 23

TABLE 23 ADVANTAGES AND DISADVANTAGES OF PARTITION CHROMATOGRAPHY 23

Reagents used in Partition Chromatography 23

Applications of Adsorption Chromatography 23

SIZE EXCLUSION CHROMATOGRAPHY 23

TABLE 24 ADVANTAGES AND DISADVANTAGES OF SIZE EXCLUSION CHROMATOGRAPHY 24

Reagents Used in Size Exclusion Chromatography 24

Applications of Size Exclusion Chromatography 24

ION EXCHANGE CHROMATOGRAPHY 24

Cation Exchange 24

Anion exchange 24

TABLE 25 ADVANTAGES AND DISADVANTAGES OF ION EXCHANGE CHROMATOGRAPHY 25

Reagents Used in Ion Exchange Chromatography 25

TABLE 26 REAGENTS USED IN ION EXCHANGE CHROMATOGRAPHY 25

Applications of Ion Exchange Chromatography 25

ION PAIR CHROMATOGRAPHY 25

TABLE 27 ADVANTAGES AND DISADVANTAGES OF ION PAIR CHROMATOGRAPHY 26

Reagents Used in Ion Pair Chromatography 26

TABLE 28 REAGENTS USED IN ION PAIR CHROMATOGRAPHY 26

Applications of Ion Pair Chromatography 26

AFFINITY CHROMATOGRAPHY 26

TABLE 29 ADVANTAGES AND DISADVANTAGES OF AFFINITY CHROMATOGRAPHY 26

Reagents Used in Affinity Chromatography 27

TABLE 30 REAGENTS USED IN AFFINITY CHROMATOGRAPHY 27

Applications of Affinity Chromatography 27

COLUMN CHROMATOGRAPHY 27

TABLE 31 ADVANTAGES AND DISADVANTAGES OF COLUMN CHROMATOGRAPHY 27

Reagents Used in Column Chromatography 28

TABLE 32 REAGENTS USED IN COLUMN CHROMATOGRAPHY 28

Applications of Column Chromatography 28

OPEN BED OR PLANAR CHROMATOGRAPHY 28

TABLE 33 ADVANTAGES AND DISADVANTAGES OF OPEN BED OR PLANAR

CHROMATOGRAPHY 28

Reagents Used in Open Bed or Planar Chromatography 29

TABLE 34 REAGENTS USED IN PLANAR CHROMATOGRAPHY 29

Applications of Open Bed or Planar Chromatography 29

SIMULATED MOVING BED CHROMATOGRAPHY (SMB) 29

TABLE 35 ADVANTAGES AND DISADVANTAGES OF SIMULATED MOVING BED

CHROMATOGRAPHY 30

Reagents Used in SMB Chromatography 30

TABLE 36 REAGENTS USED IN SMB CHROMATOGRAPHY 30

Applications of SMB Chromatography 30

TABLE 37 APPLICATIONS OF SMB CHROMATOGRAPHY 30

SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) 30

TABLE 38 ADVANTAGES AND DISADVANTAGES OF SUPERCRITICAL FLUID

CHROMATOGRAPHY 31

Reagents Used in Supercritical Fluid Chromatography 31

TABLE 39 REAGENTS USED IN SFC CHROMATOGRAPHY 31

TABLE 40 CRITICAL PROPERTIES OF COMMONLY USED SCFS (SUPERCRITICAL FLUID

SOLVENTS) 31

Applications of Supercritical Fluid Chromatography 32

CAPILLARY ELECTROPHORESIS 32

TABLE 41 ADVANTAGES AND DISADVANTAGES OF CAPILLARY ELECTROPHORESIS 32

Reagents Used in Capillary Electrophoresis 32

TABLE 42 REAGENTS USED IN CAPILLARY ELECTROPHORESIS 33

Applications of Capillary Electrophoresis 33

TABLE 43 APPLICATIONS OF CAPILLARY ELECTROPHORESIS 33

CHAPTER 4 REGULATORY ASPECTS 35

INTRODUCTION 35

TABLE 44 CLASSES OF SOLVENTS AS PER FDA 36

ACETONE 37

CHLOROFORM 37

BENZENE 37

METHANOL 37

PHENOL 37

PYRIDINE 38

TOLUENE 38

1,2,3-TRICHLOROPROPANE 38

METHYLENE CHLORIDE 38

2 -BUTANONE 39

CHAPTER 5 NEW DEVELOPMENTS 41

CHAPTER 6 GLOBAL MARKETS 45

MARKETS BY TECHNOLOGY 45

MARKET OVERVIEW 45

MARKET REVENUE 46

TABLE 45 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 46

FIGURE 1 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 46

MARKET SHARE 47

TABLE 46 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 47

FIGURE 2 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48

MARKETS BY TYPES OF REAGENTS 48

MARKET OVERVIEW 49

MARKET REVENUE 50

TABLE 47 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,

THROUGH 2017 ($ MILLIONS) 50

FIGURE 3 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,

2010-2017 ($ MILLIONS) 50

MARKET SHARE 51

TABLE 48 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN

CHROMATOGRAPHY, 2011 (%) 51

FIGURE 4 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN

CHROMATOGRAPHY, 2011 (%) 52

MARKET BY REGION 52

MARKET OVERVIEW 53

MARKET REVENUE FOR SOLVENTS 54

TABLE 49 SALES OF SOLVENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 54

FIGURE 5 SALES OF SOLVENTS USED IN CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 54

MARKET REVENUE FOR CHEMICALS 55

TABLE 50 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 55

FIGURE 6 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 55

MARKET REVENUE FOR GASES 55

TABLE 51 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($

MILLIONS) 56

FIGURE 7 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 56

MARKET REVENUE FOR ADSORBENTS 56

TABLE 52 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH

2017 ($ MILLIONS) 57

FIGURE 8 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 57

MARKET REVENUE FOR MEMBRANES 57

TABLE 53 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, THROUGH

2017 ($ MILLIONS) 58

FIGURE 9 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 58

MARKET REVENUE FOR CAPILLARIES 58

TABLE 54 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, THROUGH

2017 ($ MILLIONS) 59

FIGURE 10 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 59

MARKET REVENUE FOR PLATES 59

TABLE 55 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($

MILLIONS) 60

FIGURE 11 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 60

MARKET REVENUE FOR FLUIDS 60

TABLE 56 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID

CHROMATOGRAPHY BY REGION, THROUGH 2017 ($ MILLIONS) 61

FIGURE 12 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID

CHROMATOGRAPHY BY REGION, 2010-2017 ($ MILLIONS) 61

MARKET SHARE 61

TABLE 57 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED

IN CHROMATOGRAPHY, 2011 (%) 62

FIGURE 13 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS

USED IN CHROMATOGRAPHY, 2011 (%) 62

MARKET BY INDUSTRIAL END USERS 62

PHARMACEUTICAL AND BIOTECHNOLOGY 63

Market Overview 63

TABLE 58 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN

PHARMACEUTICAL INDUSTRY, THROUGH 2017 ($ MILLIONS) 64

FIGURE 14 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN

PHARMACEUTICAL INDUSTRY, 2010-2017 ($ MILLIONS) 64

Market Share 65

TABLE 59 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 65

FIGURE 15 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 66

FOOD AND BEVERAGE 66

Market Overview 67

TABLE 60 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN THE FOOD

AND BEVERAGE INDUSTRY, THROUGH 2017 ($ MILLIONS) 67

FIGURE 16 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN FOOD AND

BEVERAGE INDUSTRY, 2010-2017 ($ MILLIONS) 68

Market Share 68

TABLE 61 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69

FIGURE 17 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69

ENVIRONMENTAL AGENCIES 69

Market Overview 70

TABLE 62 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN

ENVIRONMENTAL AGENCIES, THROUGH 2017 ($ MILLIONS) 70

FIGURE 18 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN

ENVIRONMENTAL AGENCIES, 2010-2017 ($ MILLIONS) 71

Market Share 72

TABLE 63 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72

FIGURE 19 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72

OTHERS 73

Market Overview 73

TABLE 64 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER

INDUSTRIES, THROUGH 2017 ($ MILLIONS) 74

FIGURE 20 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER

INDUSTRIES, 2010-2017 ($ MILLIONS) 74

Market Share 75

TABLE 65 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75

FIGURE 21 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75

CHAPTER 7 SUPERCRITICAL FLUID CHROMATOGRAPHY REAGENTS - MARKET ANALYSIS 77

MARKET BY REAGENTS 77

MARKET OVERVIEW 77

MARKET REVENUE 78

TABLE 66 SALES OF SUPERCRITICAL FLUIDS, THROUGH 2017 ($ MILLIONS) 78

FIGURE 22 SALES OF SUPERCRITICAL FLUIDS, 2010-2017 ($ MILLIONS) 78

MARKET BY REGION 78

TABLE 67 SALES OF SUPERCRITICAL FLUIDS BY REGION, THROUGH 2017 ($ MILLIONS) 79

FIGURE 23 SALES OF SUPERCRITICAL FLUIDS BY REGION, 2010-2017 ($ MILLIONS) 79

MARKET SHARE 79

TABLE 68 MARKET SHARE OF SUPERCRITICAL REAGENTS BY REGION, 2011 (%) 80

FIGURE 24 MARKET SHARE OF SUPERCRITICAL REAGENTS BY REGION, 2011 (%) 80

MARKET BY END USERS 80

PHARMACEUTICAL AND RESEARCH INDUSTRY 81

ENVIRONMENTAL AND BIOLOGICAL ANALYSIS 81

TABLE 69 REVENUE OF SUPERCRITICAL FLUIDS BY END USERS, THROUGH 2017 ($

MILLIONS) 82

FIGURE 25 REVENUE OF SUPERCRITICAL FLUIDS BY END USERS, 2010-2017 ($ MILLIONS) 82

MARKET SHARE 82

TABLE 70 MARKET SHARE OF SUPERCRITICAL FLUIDS BY END USERS, 2011 (%) 83

FIGURE 26 MARKET SHARE OF SUPER CRITICAL FLUIDS BY END USERS, 2011 (%) 83

MARKET LEADERS AND THEIR SHARES 83

TABLE 71 SHARES OF MANUFACTURERS/DISTRIBUTORS FOR REAGENTS IN

SUPERCRITICAL FLUID CHROMATOGRAPHY, 2011 (%) 83

FIGURE 27 SHARES OF MANUFACTURERS/DISTRIBUTORS FOR REAGENTS IN

SUPERCRITICAL FLUID CHROMATOGRAPHY, 2011 (%) 84

CHAPTER 8 PATENT ANALYSIS 86

PATENTS BY YEAR 86

TABLE 72 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 86

FIGURE 28 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 86

PATENTS BY TYPE OF REAGENTS 87

TABLE 73 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF

PATENTS) 87

FIGURE 29 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF

PATENTS) 87

PATENTS BY TYPE OF CHROMATOGRAPHY 88

TABLE 74 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 88

FIGURE 30 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 89

PATENTS BY COUNTRY 89

TABLE 75 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,

2008–2012 90

FIGURE 31 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,

2008-2012 90

TABLE 76 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS 2008-2012

(NO./%) 91

FIGURE 32 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS, 2008-2012

(%) 91

PATENTS BY COMPANY 92

TABLE 77 NUMBER OF U.S. PATENTS BY COMPANY FOR CHROMATOGRAPHY REAGENTS,

2008-2012 92

PATENTS BY ASSIGNEE 93

TABLE 78 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS, 2008-2012 94

FIGURE 33 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS 2008-2012 94

CHAPTER 9 CURRENT SITUATION 96

CONSUMERS OF CHROMATOGRAPHY REAGENTS 96

PHARMACEUTICAL INDUSTRY 96

Drug Discovery 96

Drug Development 97

Purification and Isolation 97

Manufacturing and Quality Assurance/Quality Control (QA/QC) 97

Biopharmaceuticals 98

ENVIRONMENTAL AGENCIES 98

FOOD AND BEVERAGE 98

FOOD LABORATORIES 99

NUTRACEUTICAL INDUSTRY 99

CLINICS AND FORENSICS 100

MERGERS AND ACQUISITIONS/LATEST DEVELOPMENTS 100

FACTORS GOVERNING THE CHROMATOGRAPHY REAGENTS MARKET 102

INCREASE FOCUS ON PROTEIN PURIFICATION 102

INCREASED R&D EXPENDITURE 102

CURRENT MARKET DRIVERS 103

CHAPTER 10 COMPANY PROFILES 106

AGILENT TECHNOLOGIES 106

AVANTOR PERFORMANCE MATERIALS 106

BECKMAN COULTER, INC 107

BIO-RAD LABORATORIES, INC. 107

DANAHER CORPORATION 108

DIONEX CORPORATION 108

GE HEALTHCARE LIFE SCIENCES 109

HELENA LABORATORIES 109

HICHROM LIMITED 110

HOEFER INC. 110

LONZA GROUP LTD. 111

MILLIPORE CORPORATION 111

NACALAI TESQUE 112

REGIS TECHNOLOGIES 112

SEBIA 113

SERVA ELECTROPHORESIS GMBH 113

SIGMA-ALDRICH CORPORATION 114

THERMO FISHER SCIENTIFIC INC. 115

TOSOH BIOSCIENCES LLC 115

VWR INTERNATIONAL 116

W. R. GRACE & CO. 116

CHAPTER 11 APPENDIX I - ABBREVIATIONS 119

LIST OF TABLES

SUMMARY TABLE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 6

TABLE 1 ADVANTAGES AND DISADVANTAGES OF SILYLATION 10

TABLE 2 SILYLATION REAGENTS 10

TABLE 3 ADVANTAGES AND DISADVANTAGES OF ALKYLATION 11

TABLE 4 ALKYLATING REAGENTS 12

TABLE 5 ADVANTAGES AND DISADVANTAGES OF ACYLATION 12

TABLE 6 ACYLATING REAGENTS 12

TABLE 7 ADVANTAGES AND DISADVANTAGES OF ION-PAIRING CHROMATOGRAPHY 13

TABLE 8 ION-PAIRING REAGENTS 14

TABLE 9 EXAMPLES OF SOLVENTS USED IN CHROMATOGRAPHY 14

TABLE 10 BUFFERS USED IN CHROMATOGRAPHY 15

TABLE 11 ADSORBENTS USED IN GAS-SOLID AND LIQUID-SOLID CHROMATOGRAPHY 15

TABLE 12 ADVANTAGES AND DISADVANTAGES OF GAS CHROMATOGRAPHY 16

TABLE 13 REAGENTS USED IN GAS CHROMATOGRAPHY 17

TABLE 14 APPLICATIONS OF GAS CHROMATOGRAPHY 17

TABLE 15 ADVANTAGES AND DISADVANTAGES OF PAPER CHROMATOGRAPHY 18

TABLE 16 ADVANTAGES AND DISADVANTAGES OF THIN LAYER CHROMATOGRAPHY 19

TABLE 17 REAGENTS USED IN THIN LAYER CHROMATOGRAPHY 19

TABLE 18 ADVANTAGES AND DISADVANTAGES OF HIGH-PERFORMANCE LIQUID

CHROMATOGRAPHY 20

TABLE 19 REAGENTS USED IN HPLC CHROMATOGRAPHY 21

TABLE 20 APPLICATIONS OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 21

TABLE 21 ADVANTAGES AND DISADVANTAGES OF ADSORPTION CHROMATOGRAPHY 22

TABLE 22 REAGENTS USED IN ADSORPTION CHROMATOGRAPHY 22

TABLE 23 ADVANTAGES AND DISADVANTAGES OF PARTITION CHROMATOGRAPHY 23

TABLE 24 ADVANTAGES AND DISADVANTAGES OF SIZE EXCLUSION CHROMATOGRAPHY 24

TABLE 25 ADVANTAGES AND DISADVANTAGES OF ION EXCHANGE CHROMATOGRAPHY 25

TABLE 26 REAGENTS USED IN ION EXCHANGE CHROMATOGRAPHY 25

TABLE 27 ADVANTAGES AND DISADVANTAGES OF ION PAIR CHROMATOGRAPHY 26

TABLE 28 REAGENTS USED IN ION PAIR CHROMATOGRAPHY 26

TABLE 29 ADVANTAGES AND DISADVANTAGES OF AFFINITY CHROMATOGRAPHY 26

TABLE 30 REAGENTS USED IN AFFINITY CHROMATOGRAPHY 27

TABLE 31 ADVANTAGES AND DISADVANTAGES OF COLUMN CHROMATOGRAPHY 27

TABLE 32 REAGENTS USED IN COLUMN CHROMATOGRAPHY 28

TABLE 33 ADVANTAGES AND DISADVANTAGES OF OPEN BED OR PLANAR

CHROMATOGRAPHY 28

TABLE 34 REAGENTS USED IN PLANAR CHROMATOGRAPHY 29

TABLE 35 ADVANTAGES AND DISADVANTAGES OF SIMULATED MOVING BED

CHROMATOGRAPHY 30

TABLE 36 REAGENTS USED IN SMB CHROMATOGRAPHY 30

TABLE 37 APPLICATIONS OF SMB CHROMATOGRAPHY 30

TABLE 38 ADVANTAGES AND DISADVANTAGES OF SUPERCRITICAL FLUID

CHROMATOGRAPHY 31

TABLE 39 REAGENTS USED IN SFC CHROMATOGRAPHY 31

TABLE 40 CRITICAL PROPERTIES OF COMMONLY USED SCFS (SUPERCRITICAL FLUID

SOLVENTS) 31

TABLE 41 ADVANTAGES AND DISADVANTAGES OF CAPILLARY ELECTROPHORESIS 32

TABLE 42 REAGENTS USED IN CAPILLARY ELECTROPHORESIS 33

TABLE 43 APPLICATIONS OF CAPILLARY ELECTROPHORESIS 33

TABLE 44 CLASSES OF SOLVENTS AS PER FDA 36

TABLE 45 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 46

TABLE 46 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 47

TABLE 47 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,

THROUGH 2017 ($ MILLIONS) 50

TABLE 48 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN

CHROMATOGRAPHY, 2011 (%) 51

TABLE 49 SALES OF SOLVENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($

MILLIONS) 54

TABLE 50 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 55

TABLE 51 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($

MILLIONS) 56

TABLE 52 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 57

TABLE 53 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 58

TABLE 54 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017

($ MILLIONS) 59

TABLE 55 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($

MILLIONS) 60

TABLE 56 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID

CHROMATOGRAPHY BY REGION, THROUGH 2017 ($ MILLIONS) 61

TABLE 57 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED

IN CHROMATOGRAPHY, 2011 (%) 62

TABLE 58 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN

PHARMACEUTICAL INDUSTRY, THROUGH 2017 ($ MILLIONS) 64

TABLE 59 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY TECHNOLOGY)

IN PHARMACEUTICAL COMPANIES, 2011 (%) 65

TABLE 60 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN THE FOOD

AND BEVERAGE INDUSTRY, THROUGH 2017 ($ MILLIONS) 67

TABLE 61 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69

TABLE 62 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN

ENVIRONMENTAL AGENCIES, THROUGH 2017 ($ MILLIONS) 70

TABLE 63 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72

TABLE 64 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER

INDUSTRIES, THROUGH 2017 ($ MILLIONS) 74

TABLE 65 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75

TABLE 66 SALES OF SUPERCRITICAL FLUIDS, THROUGH 2017 ($ MILLIONS) 78

TABLE 67 SALES OF SUPERCRITICAL FLUIDS BY REGION, THROUGH 2017 ($ MILLIONS) 79

TABLE 68 MARKET SHARE OF SUPERCRITICAL REAGENTS BY REGION, 2011 (%) 80

TABLE 69 REVENUE OF SUPERCRITICAL FLUIDS BY END USERS, THROUGH 2017 ($

MILLIONS) 82

TABLE 70 MARKET SHARE OF SUPERCRITICAL FLUIDS BY END USERS, 2011 (%) 83

TABLE 71 SHARES OF MANUFACTURERS/DISTRIBUTORS FOR REAGENTS IN SUPERCRITICAL

FLUID CHROMATOGRAPHY, 2011 (%) 83

TABLE 72 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 86

TABLE 73 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF

PATENTS) 87

TABLE 74 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 88

TABLE 75 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,

2008–2012 90

TABLE 76 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS 2008-2012

(NO./%) 91

TABLE 77 NUMBER OF U.S. PATENTS BY COMPANY FOR CHROMATOGRAPHY REAGENTS,

2008-2012 92

TABLE 78 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS, 2008-2012 94

LIST OF FIGURES

SUMMARY FIGURE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 6

FIGURE 1 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF

CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 46

FIGURE 2 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48

FIGURE 3 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,

2010-2017 ($ MILLIONS) 50

FIGURE 4 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN

CHROMATOGRAPHY, 2011 (%) 52

FIGURE 5 SALES OF SOLVENTS USED IN CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 54

FIGURE 6 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 55

FIGURE 7 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 56

FIGURE 8 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 57

FIGURE 9 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 58

FIGURE 10 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 59

FIGURE 11 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($

MILLIONS) 60

FIGURE 12 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID

CHROMATOGRAPHY BY REGION, 2010-2017 ($ MILLIONS) 61

FIGURE 13 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED

IN CHROMATOGRAPHY, 2011 (%) 62

FIGURE 14 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN

PHARMACEUTICAL INDUSTRY, 2010-2017 ($ MILLIONS) 64

FIGURE 15 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 66

FIGURE 16 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN FOOD AND

BEVERAGE INDUSTRY, 2010-2017 ($ MILLIONS) 68

FIGURE 17 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69

FIGURE 18 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN

ENVIRONMENTAL AGENCIES, 2010-2017 ($ MILLIONS) 71

FIGURE 19 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72

FIGURE 20 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER

INDUSTRIES, 2010-2017 ($ MILLIONS) 74

FIGURE 21 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY

TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75

FIGURE 22 SALES OF SUPERCRITICAL FLUIDS, 2010-2017 ($ MILLIONS) 78

FIGURE 23 SALES OF SUPERCRITICAL FLUIDS BY REGION, 2010-2017 ($ MILLIONS) 79

FIGURE 24 MARKET SHARE OF SUPERCRITICAL REAGENTS BY REGION, 2011 (%) 80

FIGURE 25 REVENUE OF SUPERCRITICAL FLUIDS BY END USERS, 2010-2017 ($ MILLIONS) 82

FIGURE 26 MARKET SHARE OF SUPER CRITICAL FLUIDS BY END USERS, 2011 (%) 83

FIGURE 27 SHARES OF MANUFACTURERS/DISTRIBUTORS FOR REAGENTS IN

SUPERCRITICAL FLUID CHROMATOGRAPHY, 2011 (%) 84

FIGURE 28 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 86

FIGURE 29 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF

PATENTS) 87

FIGURE 30 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 89

FIGURE 31 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,

2008-2012 90

FIGURE 32 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS, 2008-2012 (%) 91

FIGURE 33 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS 2008-2012 94

To order this report:

Diagnostics Industry: Global Markets for Reagents for Chromatography -- Focus on Supercritical Fluid Chromatography

__________________________

Contact Nicolas: [email protected]

US: (805)-652-2626

Intl: +1 805-652-2626

SOURCE Reportlinker