NEW YORK, Sept. 8, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global Molecular Cytogenetics Industry
http://www.reportlinker.com/p0611064/Global-Molecular-Cytogenetics-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics
This report analyzes the worldwide markets for Molecular Cytogenetics in US$ Million by the following technologies: Fluorescence In Situ Hybridization (FISH), and Array-based Technology. The report provides separate comprehensive analytics for the North America, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 24 companies including many key and niche players such as Abbott Molecular Inc., Affymetrix, Inc., Applied Spectral Imaging, BI Biological Industries, Bluegnome, ltd., ChromTrax, CytoTest, Inc., Cytognomix, Inc., Illumina, Inc., Inter Medico, Kreatech Diagnostics, Life Technologies Corporation, Oxford Gene Technology, PerkinElmer, Inc., Roche NimbleGen, Inc., and SciGene Corporation. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1
Study Reliability and Reporting Limitations 1
Disclaimers 2
Data Interpretation & Reporting Level 3
Quantitative Techniques & Analytics 3
Product Definitions and Scope of Study 3
Definitions 4
Fluorescence In Situ Hybridization 4
Select FISH Procedures in Use 4
3D-FISH 4
Cellular Compartment Analysis of Temporal Activity 4
Combined Binary Ratio-FISH 4
Cryo-FISH 5
Immuno-FISH 5
Quantum Dot-Conjugates-FISH 5
Array-based Technology 5
Microarrays in Comparative Genomic Hybridization 5
2. INDUSTRY OVERVIEW 7
Advances in Molecular Biology Techniques Broaden the Scope of
Cytogenetics 7
FISH: The Leading Technology in Biomedical Research 7
Molecular Cytogenetics to Advance Gene-Level Disease
Management in Oncology 8
Diverse Applications of FISH Technology in Oncology 9
Array Based Technologies To Drive Significant Market Growth 9
Transition from FISH to Array Based Technologies: A Major Trend 9
Array-based CGH to Emerge as First Line Test for Clinical
Diagnosis of Chromosomal Anomalies 10
Market Outlook 10
Molecular Cytogenetics Find Increasing Penetration in
Clinical Pathological Testing 10
Enhanced AP LIS a Must to Keep Pace with Advancing Molecular
Cytogenetic Testing 11
Impact of Shifting Focus of Biopharmaceuticals from Research
to Development on Microarray Technology 11
Next-Gen Sequencing to Challenge Microarray Technology in the
Distant Future 11
3. TECHNOLOGY OVERVIEW 13
A Preface to Cytogenetics 13
Basic Terms and Definitions in Molecular Biology 13
DNA and RNA 13
RNA (Ribose nucleic acid) 14
Chromosomes 14
Gene 15
Genotype 15
Phenotype 15
Haplotype 15
Karyotyping 15
Karyotype 15
Nick 16
Probe 16
Reporter Molecule 16
Copy Number 16
Copy Number Variation 16
Analysis of Copy Numbers Variations 16
Chromosomal Abnormalities in Human Beings 16
An Overview of Select Chromosomal Anomalies 17
Insertions 17
Deletions 17
Duplication 17
Rearrangement 18
Select Human Diseases/Abnormalities Arising due to
Translocations 18
Molecular Cytogenetics: Definition and Scope 19
Application of Molecular Cytogenetics 19
Insight into Molecular Cytogenetics Techniques 19
Fluorescence In Situ Hybridization (FISH) 19
What is In Situ Hybridization? 19
How is FISH Better than Conventional Techniques? 21
Fluorescence In Situ Hybridization: The Process 21
Probe Types and Application 22
Types of Probes 22
Common Methods of Probe Preparation 23
Nick Translation and Polymerase Chain Reaction (PCR) 23
Applications of FISH 23
Types of FISH 23
3D-FISH 23
ACM-FISH or Multicolor FISH 24
ArmFISH 24
Catalyzed Reporter Deposition-FISH 24
Cellular Compartment Analysis of Temporal Activity 24
Cytochalasin-B -FISH 25
Combined Binary Ratio-FISH 25
Chromosome Orientation And Direction FISH 25
Combinatorial Oligonucleotide -FISH 25
Comet-FISH 26
Cryo-FISH 26
Double-Fusion -FISH 26
DNA Breakage Detection -FISH 27
e-FISH 27
Fiber-FISH 27
Flow-FISH 27
Fusion-Signal FISH 27
Halo-FISH 28
Harlequin-FISH 28
Immuno-FISH 28
Locked Nucleic Acids-FISH 28
M-FISH 29
Multilocus-FISH 29
Premature Chromosome Condensation-FISH 29
Peptide Nucleic Acids-FISH 30
Novel FISH Technology to Detect Plague Bacillus 30
Quantitative-FISH 30
Quantum Dot-Conjugates-FISH 31
Rainbow-FISH 31
Reverse-FISH 31
Recognition of Individual Genes-FISH 31
Expression-FISH 32
RxFISH 32
Split-Signal FISH 32
Telomere-FISH/ Tissue-FISH/ Tyramide-FISH (T-FISH) 32
Zoo-FISH 32
Spectral Karyotyping (SKY) Technique 33
Mouse FISH - a New Development 33
Comparative Genomic Hybridization 34
CGH: The Process 34
CGH: Applications In Clinical Cytogenetics 34
Benefits of CGH Analysis in Clinical Genetics 34
Limitations of CGH 35
Advent of Microarray Technology 35
What are Microarrays? 35
Microarrays in Gene Expression Analysis 35
Microarrays in Comparative Genomic Hybridization 36
Principle Underlying aCGH 36
Low Resolution and High Resolution aCGH 37
ACGH: The Process 37
aCGH: Potential Uses and Limitations 37
Potential Advantages of aCGH could be summarized as below 37
Limitations of aCGH 38
Analytical and Post-analytical Limitations 38
Interpretation of Results 38
Applications of aCGH 38
A Review of Molecular Biology Techniques in Cytogenetics 39
4. RECENT INDUSTRY ACTIVITY 41
Agilent and Kreatech Enter into New License and Supply Deal 41
Clarient to Commercialize CombiMatrix's Genomic Profile Tests
for Cancer 41
Kreatech Inks License Agreement with Veridex to Use Repeat-
Free™ Technology 41
PerkinElmer to Acquire Signature Genomic Laboratories 42
Illumina to Submit Micro-Array based iscan Technology to the
US FDA through Pre-IDE Process 42
Invitrogen Announces Merger with Applied Biosystems 42
LabCorp to Use GeneChip Technology of Affymetrix 43
Dako Denmark Receives FDA Approval for TOP2A FISH pharmDx Device 43
Abbott Partners with Roche, OSI and Genentech 43
5. PRODUCT LAUNCHES 44
BlueGnome Rolls Out CytoChip Cancer 44
PerkinElmer Introduces Prenatal BACs-on-Beads™ Assay in Europe 44
Agilent Introduces New SNP Probes for SurePrint G3 Human CGH
Platform 44
Affymetrix Launches Two Novel Microarrays for Cytogenetics 45
Roche Applied Science Introduces NimbleGen CGX 45
Gastrocor Launches GastroFISH 46
Roche NimbleGen Introduces New Probe Arrays 46
Ambry Genetics Launches Whole-Genome Chromosomal Microarray
Analysis 46
London Genetics Introduces New Molecular Cytogenetics Service 46
OGT Introduces Genomic DNA Labeling Kit 47
Oxford Gene Technology Introduces New Sample Tracking DNA
Labeling Kits 47
BlueGnome Introduces 24sure™ 47
6. FOCUS ON SELECT PLAYERS 48
Abbott Molecular Inc. (US) 48
Affymetrix, Inc. (US) 48
Applied Spectral Imaging (US) 49
BI Biological Industries (Israel) 49
Bluegnome, ltd. (UK) 49
ChromTrax (US) 50
CytoTest, Inc. (UK) 50
Cytognomix, Inc. (Canada) 52
Illumina, Inc. (US) 52
Inter Medico (Canada) 52
Kreatech Diagnostics (The Netherlands) 53
Life Technologies Corporation (US) 53
Oxford Gene Technology (UK) 54
PerkinElmer, Inc. (US) 54
Roche NimbleGen, Inc. (US) 55
SciGene Corporation (US) 55
7. GLOBAL MARKET PERSPECTIVE 56
Table 1: World Recent Past Current & Future Analysis for
Molecular Cytogenetics Technologies by Geographic Region -
North America, Europe, and Rest of World Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2009 through 2017 (includes corresponding Graph/Chart) 56
Table 2: World Historic Review for Molecular Cytogenetics
Technologies by Geographic Region - North America, Europe, and
Rest of World Independently Analyzed with Annual Sales Figures
in US$ Thousand for Years 2003 through 2008 (includes
corresponding Graph/Chart) 57
Table 3: World 15-Year Perspective for Molecular Cytogenetics
Technologies by Geographic Region - Percentage Breakdown of
Dollar Sales for North America, Europe, and Rest of World for
Years 2003, 2010 & 2017 (includes corresponding Graph/Chart) 57
By Technology 58
Table 4: World Recent Past Current & Future Analysis for
Fluorescence In Situ Hybridization by Geographic Region -
North America, Europe, and Rest of World Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2009 through 2017 (includes corresponding Graph/Chart) 58
Table 5: World Historic Review for Fluorescence In Situ
Hybridization by Geographic Region - North America, Europe,
and Rest of World Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2003 through 2008 (includes
corresponding Graph/Chart) 59
Table 6: World 15-Year Perspective for Fluorescence In Situ
Hybridization by Geographic Region - Percentage Breakdown of
Dollar Sales for North America, Europe, and Rest of World for
Years 2003, 2010 & 2017 2010 & 2017 (includes corresponding
Graph/Chart) 59
Table 7: World Recent Past Current & Future Analysis for
Array-Based Technology by Geographic Region - North America,
Europe, and Rest of World Independently Analyzed with Annual
Sales Figures in US$ Thousand for Years 2009 through 2017
(includes corresponding Graph/Chart) 60
Table 8: World Historic Review for Array-Based Technology by
Geographic Region - North America, Europe, and Rest of World
Independently Analyzed with Annual Sales Figures in US$
Thousand for Years 2003 through 2008 (includes corresponding
Graph/Chart) 61
Table 9: World 15-Year Perspective for Array-Based Technology
by Geographic Region - Percentage Breakdown of Dollar Sales
for North America, Europe, and Rest of World for Years 2003,
2010 & 2017 (includes corresponding Graph/Chart) 61
8. NORTH AMERICA 62
A.Market Analysis 62
Market Trends 62
aCGH to Predominate the Technological Front in Molecular
Cytogenetics in Future 62
Revised ACMG Guidelines to Accelerate Use of aCGH Over
FISH in the US 62
The Clinical Sector: A Potential Market Opportunity for
Array-based Technologies 62
FISH in the Cancer Diagnostics Scenario in the US 62
Market Restraints 63
Immunohistochemical (IHC) Tests: The Most Recommended
Diagnostic Test for Cancers 63
Factors Limiting the Growth of FISH Technology in Cancer
Diagnostics 63
FISH in Diagnosis of Bladder Carcinoma 63
FISH in Breast Cancer Diagnosis 63
Table 10: Overview of Prices of Testing Products based
Various Technologies 64
Table 11: Medicare Reimbursement Provided for HER-2/Neu 64
Strategic Corporate Developments 65
Product Launches 68
Focus on Select Major Players 69
Abbott Molecular Inc. 69
Affymetrix, Inc. 70
Applied Spectral Imaging 70
ChromTrax 70
Cytognomix, Inc. 71
Illumina, Inc. 71
Inter Medico 72
Life Technologies Corporation 72
PerkinElmer, Inc. 73
Roche NimbleGen, Inc. 73
SciGene Corporation 74
B.Market Analytics 74
Table 12: North American Recent Past Current & Future
Analysis for Molecular Cytogenetics by Technology
(Fluorescence In Situ Hybridization and Array-based
Technology) Independently Analyzed with Annual Sales Figures
in US$ Thousand for Years 2009 through 2017 (includes
corresponding Graph/Chart) 74
Table 13: North American Historic Review for Molecular
Cytogenetics by Technology Type Fluorescence In Situ
Hybridization and Array-based Technology Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2003 through 2008 (includes corresponding Graph/Chart) 75
Table 14: North American 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescence In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 75
9. EUROPE 76
A.Market Analysis 76
Product Launch 76
B.Market Analytics 77
Table 15: European Recent Past Current & Future Analysis for
Molecular Cytogenetics Market by Region- France, Germany,
Italy, UK, and Rest of Europe Independently Analyzed with
Annual Sales Figures in US$ Thousand for Years 2009 through
2017 (includes corresponding Graph/Chart) 77
Table 16: European Historic Review for Molecular
Cytogenetics Market by Region- France, Germany, Italy, UK,
and Rest of Europe Independently Analyzed with Annual Sales
Figures in US$ Thousand for Years 2003 through 2008
(includes corresponding Graph/Chart) 78
Table 17: European 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for France, Germany, Italy, UK, and Rest of
Europe for Years 2003, 2010 & 2017 (includes corresponding
Graph/Chart) 79
9a. FRANCE 80
Market Analysis 80
Table 18: French Recent Past Current & Future Analysis for
Molecular Cytogenetics Market by Technology (Fluorescent In
Situ Hybridization and Array-based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2009 through 2017 (includes corresponding Graph/Chart) 80
Table 19: French Historic Review for Molecular Cytogenetics
Market by Technology (Fluorescent In Situ Hybridization and
Array-based Technology) Independently Analyzed with Annual
Sales Figures in US$ Thousand for Years 2003 through 2008
(includes corresponding Graph/Chart) 81
Table 20: French 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescent In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 81
9b. GERMANY 82
Market Analysis 82
Table 21: German Recent Past Current & Future Analysis for
Molecular Cytogenetics Market by Technology (Fluorescent In
Situ Hybridization and Array-based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2009 through 2017 (includes corresponding Graph/Chart) 82
Table 22: German Historic Review for Molecular Cytogenetics
Market by Technology (Fluorescent In Situ Hybridization and
Array-based Technology) Independently Analyzed with Annual
Sales Figures in US$ Thousand for Years 2003 through 2008
(includes corresponding Graph/Chart) 83
Table 23: German 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescent In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 83
9c. ITALY 84
Market Analysis 84
Table 24: Italian Recent Past Current & Future Analysis for
Molecular Cytogenetics Market by Technology (Fluorescent In
Situ Hybridization and Array-based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2009 through 2017 (includes corresponding Graph/Chart) 84
Table 25: Italian Historic Review for Molecular Cytogenetics
Market by Technology (Fluorescent In Situ Hybridization and
Array-based Technology) Independently Analyzed with Annual
Sales Figures in US$ Thousand for Years 2003 through 2008
(includes corresponding Graph/Chart) 85
Table 26: Italian 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescent In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 85
9d. THE UNITED KINGDOM 86
A.Market Analysis 86
Product Launches 86
Focus on Select Major Players 88
BlueGnome, Ltd. 88
CytoTest, Inc. 88
Oxford Gene Technology 89
B.Market Analytics 90
Table 27: The United Kingdom Recent Past Current & Future
Analysis for Molecular Cytogenetics Market by Technology
(Fluorescent In Situ Hybridization and Array-based
Technology) Independently Analyzed with Annual Sales Figures
in US$ Thousand for Years 2009 through 2017 (includes
corresponding Graph/Chart) 90
Table 28: The United Kingdom Historic Review for Molecular
Cytogenetics Market by Technology (Fluorescent In Situ
Hybridization and Array-based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2003 through 2008 (includes corresponding Graph/Chart) 91
Table 29: The United Kingdom 15-Year Perspective for
Molecular Cytogenetics Market by Technology - Percentage
Breakdown of Dollar Sales for Fluorescent In Situ
Hybridization and Array-based Technology for Years 2003,
2010 & 2017 (includes corresponding Graph/Chart) 91
9e. REST OF EUROPE 92
A.Market Analysis 92
Strategic Corporate Developments 92
Focus on Select Major Players 93
Kreatech Diagnostics 93
Roche Diagnostics, Corp. 93
B.Market Analytics 94
Table 30: Rest of European Recent Past Current & Future
Analysis for Molecular Cytogenetics Market by Technology
(Fluorescent In Situ Hybridization and Array-based
Technology) Independently Analyzed with Annual Sales Figures
in US$ Thousand for Years 2009 through 2017 (includes
corresponding Graph/Chart) 94
Table 31: Rest of European Historic Review for Molecular
Cytogenetics Market by Technology (Fluorescent In Situ
Hybridization and Array-based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2003 through 2008 (includes corresponding Graph/Chart) 95
Table 32: Rest of European 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescent In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 95
10. REST OF WORLD 96
A.Market Analysis 96
China: A Potential Market for FISH Technology in Clinical
Diagnostics 96
Table 33: Penetration of FISH in Chinese Hospitals
(2008-2012) (includes corresponding Graph/Chart) 96
Table 34: Penetration of FISH in Tier-1 Chinese Hospitals
(2008-2012) (includes corresponding Graph/Chart) 97
Table 35: Penetration of FISH in Tier-2 Chinese Hospitals
(2008-2012) 97
Table 36: Overview of Select FISH Products Offered by
Abbott and CMED: A Comparison (in RMB) (includes
corresponding Graph/Chart) 97
An Insight into the Indian Microarray Market 98
Focus on Select Major Player 98
BI Biological Industries 98
B.Market Analytics 99
Table 37: Rest of World Recent Past Current & Future
Analysis for Molecular Cytogenetics Market by Technology
(Fluorescence In Situ Hybridization and Array-based
Technology) Independently Analyzed with Annual Sales Figures
in US$ Thousand for Years 2009 through 2017 (includes
corresponding Graph/Chart) 99
Table 38: Rest of World Historic Review for Molecular
Cytogenetics Market by Technology (Fluorescence In Situ
Hybridization and Array- based Technology) Independently
Analyzed with Annual Sales Figures in US$ Thousand for Years
2003 through 2008 (includes corresponding Graph/Chart) 100
Table 39: Rest of World 15-Year Perspective for Molecular
Cytogenetics Market by Technology - Percentage Breakdown of
Dollar Sales for Fluorescent In Situ Hybridization and
Array-based Technology for Years 2003, 2010 & 2017 (includes
corresponding Graph/Chart) 100
COMPETITIVE LANDSCAPE
Total Companies Profiled: 24
------------------------------------------
Region/Country Players
------------------------------------------
The United States 15
Canada 2
Europe 6
Germany 1
The United Kingdom 2
Rest of Europe 3
Middle-East 1
------------------------------------------
To order this report:
Genomics Industry: Global Molecular Cytogenetics Industry
Genomics Business News
Check our Industry Analysis and Insights
Nicolas Bombourg
Reportlinker
Email: [email protected]
US: (805)652-2626
Intl: +1 805-652-2626
SOURCE Reportlinker
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