Global Neurostimulation Industry

Jan 12, 2016, 15:35 ET from Reportlinker

NEW YORK, Jan. 12, 2016 /PRNewswire/ -- This report analyzes the worldwide markets for Neurostimulation in US$ by the following Product Segments: Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES). The United States is analyzed both in terms of value (US$) and volume (units) sales. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2014 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 30 companies including many key and niche players such as -

Aleva Neurotherapeutics SA
BioControl Medical
Bioness Inc.
Boston Scientific Corp.
EnteroMedics Inc.



Read the full report: http://www.reportlinker.com/p098270-summary/view-report.html



I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers.............. I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Spinal Cord Stimulation (SCS) I-3 Deep Brain Stimulation (DBS)..............I-4 Sacral Nerve Stimulation (SNS)..............I-4 Vagus Nerve Stimulation (VNS) I-4 Gastric Electric Stimulation (GES) I-5

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW.............. II-1 Market Primer.............. II-1 Major Neurostimulation Therapies and Indications At A Glance II-2 Outlook.............. II-3 Table 1: Global Neurostimulation Market - Product Segments Ranked by CAGR (Value Sales) for 2014-2020: Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) (includes corresponding Graph/Chart).............. II-4 Developed Markets: Traditional Revenue Contributors II-5 Developing Countries Turbo Charge Future Market Growth II-6 Table 2: Global Neurostimulation Market - Geographic Regions Ranked by CAGR (Value Sales) for 2014-2020: Asia-Pacific, Latin America, Rest of World, Europe, Japan, US, and Canada (includes corresponding Graph/Chart) II-6 Spinal Cord Stimulation (SCS): A Rapidly Evolving Market II-6

2. COMPETITIVE SCENARIO.............. II-8 Few Players Dominate Neurostimulation Market II-8 Worldwide Neurostimulation Market: Leading Players by Product Segment.............. II-8 Table 3: Leading Players in the Global Neurostimulation Devices Market (2014): Percentage Share Breakdown of Value Sales for Medtronic, Boston Scientific, St. Jude Medical, Cyberonics and Others (includes corresponding Graph/Chart) II-9 FDA-Approved Products of Leading Players in the Neurostimulation Market..............II-9 Select Neuromodulation Products under Development II-9 Companies Researching Neurostimulator Applications by Indication II-10 Competition in the PNS Space..............II-10

3. GROWTH DRIVERS, TRENDS, & ISSUES..............II-11 New Indications Expand Opportunities for Growth II-11 Growing Awareness and Acceptance Among Physicians II-12 Neuropathic Pain: A Highly Underserved Market II-12 Peripheral Nerve Stimulation (PNS): A Potential Area for Pain Management Devices.............. II-13 Occipital Nerve Stimulation (ONS): An Untapped Market with Potential.............. II-13 Steering Brain Stimulation - An Emerging Concept in DBS II-13 Novel Applications Bode Tremendous Prospects II-14 Obesity Control to Spur Market Growth in Future II-14 Table 4: Obese and Overweight, and Obese Population in the World (2013): Percentage Share Breakdown by Region for US, European Union, and Rest of World (includes corresponding Graph/Chart).............. II-15

Table 5: Global Obesity Population by Region/Country: 2013 (includes corresponding Graph/Chart) II-15 Powering Neurostimulation Devices- The Key to Success II-16 Closed-Loop Functionality Gaining Favor over Open-Loop in Neurostimulation.............. II-16 Device Programmability Gains Precedence in Device Choice II-17 Novel Electrode Configurations Aid in Localization and Side Effect Reduction.............. II-17 Advances in Programming Promise Ease of Treatment II-17 Vagus Nerve Stimulation for Treating Obesity II-18 Trigeminal Nerve Stimulation - A Promising Area II-18 Nanotechnology - The Future of DBS Electrodes II-19 Synergy with Pharma & Biotech Companies Creates New Avenues II-19 Third-Party Reimbursement - A Vital Role to Play II-20 Outsourcing - A Growing Phenomenon II-20 Chip Makers Struggle to Meet Quality Demand II-20 Product Complexity: A Cause of Concern II-20 Concerns Remain Afloat - Affecting Adoption II-21 Hardware-related Infections - A Major Concern II-22 Battery Life - A Bone of Contention for Neurostimulation II-22 Neurostimulation Market Marked by High Entry Barriers II-23

4. MACRO GROWTH DRIVERS FOR NEUROSTIMULATION INDUSTRY II-24 Ballooning Global Population Offers Significant Growth Opportunities.............. II-24 Table 6: Top 25 Countries Worldwide in Terms of Population ( 2010 & 2013) (includes corresponding Graph/Chart) II-24 Aging Global Population: A Major Growth Propeller II-25 Demographic Statistics of Aging Populace: Unfurling the Market Potential..............II-25 Table 7: Aging (65+) Demographics as a Percentage of Total Population for Major Countries: 2000, 2011, and 2020 (includes corresponding Graph/Chart) II-25

Table 8: Global Aging Population (in Thousands) by Age Group: 1975, 2000, 2025, and 2050 (includes corresponding Graph/Chart).............. II-26

Table 9: Global Population Statistics for 65+ Age Group (2014) (includes corresponding Graph/Chart) II-27 Longer Life Expectancy Bolsters Market Growth II-28 Table 10: Life Expectancy for Select Countries in Number of Years (2015E) (includes corresponding Graph/Chart) II-28

Table 11: Global Life Expectancy at Age 60 and 80 Years: 2010-2015; 2020-2025; and 2045-2050 (includes corresponding Graph/Chart).............. II-29 Rising Disposable Incomes Propel Market Growth II-29 Table 12: Annual Disposable Incomes in US$ Thousand for Select Countries (2012) (includes corresponding Graph/Chart) II-30

Table 13: Global Middle Class Population (in Millions) by Geographic Region: 2010, 2020P & 2030P (includes corresponding Graph/Chart)..............II-31 Improving Healthcare Expenditure to Foster Growth II-31 Table 14: Per-Capita Healthcare Expenditure in Select Regions (2013) (includes corresponding Graph/Chart) II-32

Table 15: Healthcare Spending as a Percentage of GDP in Select Countries (2013) (includes corresponding Graph/Chart) II-32

5. TECHNOLOGICAL ADVANCEMENTS IN NEUROSTIMULATION MARKET II-33 RNS Assists Medical Practitioners in Treating Critical Neurological Ailments..............II-33 Investigational DBS Device Inches towards Closed-Loop Functionality.............. II-34 Closed-Loop Stimulation - A Potential Solution for Gait Disturbances in DBS Treated PD Patients II-34 Vagus Nerve Stimulator Offers Safe and Reliable Epilepsy Treatment for Patients..............II-35 AspireSR Neurostimulator Mitigates Requirement of Brain Surgery II-36 AspireSR Neurostimulator Gains Momentum II-36 Medtronic's SCS System Brings Paradigm Shift in Neurostimulators Market..............II-37 Equilia System Provides Cost-Effective Treatment for Cardiovascular Patients..............II-37 Portable Neuromodulation Device to Improve Walking in Multiple Sclerosis Patients.............. II-38 Emerging PNS Technologies to Drive Neuromodulation Device Market II-38 Mainstay ReActive8.............. II-39 SMARTPATCH PNS System from SPR Therapeutics II-39 Neuros Medical's Electrical Nerve Block Technology II-40 I-Patch from Direct Spinal Therapeutics II-40 Valtronic and NDI Medical to Develop Miniature Implantable Pulse Generator.............. II-40 Neuromodulation Device for Obstructive Sleep Apnea Treatment II-41 SetPoint Medical's Vagus Nerve Stimulation Technology II-41 Other Potential Applications for PNS Technology II-42

6. SELECT TARGETED INDICATIONS..............II-43 Parkinson's Disease - The Largest Application Market for DBS II-43 A Note on Incidence and Prevalence of Parkinson's Disease II-44 Table 16: Global Prevalence of Parkinson's Disease (2014): Number of Patients Affected in Thousands for Select Countries/Regions (includes corresponding Graph/Chart) II-44 Research Suggests Greater Benefits of DBS in Parkinson's II-44 Incidence and Prevalence of Essential Tremor II-45 DBS in Dystonia.............. II-45 Clinical Evidence of DBS in Dystonia: An Overview of Results from Select Clinical Studies and Meta-Analyses II-46 Dystonia Patient Selection Criteria for DBS II-47 DBS in OCD.............. II-47 DBS in Epilepsy Treatment..............II-47 Table 17: Global Prevalence of Epilepsy (2014): Number of Patients Affected in Thousands for Select Countries/Regions (includes corresponding Graph/Chart) II-48 DBS in Tourette Syndrome - Research Progress So Far II-49 Clinical Evidence of DBS in Tourette Syndrome: An Overview of Results from Select Clinical Studies and Meta-Analyses II-49 Paucity of Effective Drugs Drives Shift in Psychiatric Disorder Treatment.............. II-50 Multiple Possible Targets Deter Progress of DBS in Depression Treatment.............. II-51 Overview of Select Studies on DBS in Depression Treatment II-52 SCC - A Promising Target for Stimulation in Depression II-53 Eating Disorders - A Note on Potential of DBS II-53 DBS in Obesity - Animal Models Show Promise II-54 Anorexia Treatment - Where Does DBS Stand? II-54 DBS in Dementia Treatment - Animal Studies Bode Well for Efficacy in Humans.............. II-54 Prospects of DBS in Chronic Pain Management II-55 SNS for Incontinence..............II-55 Types of Incontinence and Features/Causes for Incontinence II-56 Table 18: Worldwide Prevalence (%) of Urinary Incontinence in Men and Women (includes corresponding Graph/Chart) II-57

Table 19: Worldwide Prevalence of Stress UI in Women in the Age Group of 15 to 85+ Years by Select Geographic Region: 2013-2020 (includes corresponding Graph/Chart) II-58 Sleep Apnea.............. II-58

7. PRODUCT OVERVIEW.............. II-59 Introduction to Neurostimulator..............II-59 A Historical Note.............. II-59 Neurostimulation Devices by Product Segment II-59 Spinal Cord Stimulation (SCS) II-60 SCS - What it Treats..............II-61 Segmentation by Type of Power Source II-61 Implantable Pulse Generator Systems (IPGs) II-61 Radio Frequency (RF) Systems II-61 Market Assessment for RF Systems II-62 Sacral Nerve Stimulation (SNS)..............II-62 Deep Brain Stimulation (DBS)..............II-63 Vagus Nerve Stimulation (VNS) II-63 Gastric Electric Stimulation (GES) II-64 Stimulation Device - How it Works II-64 Neurostimulation & its Benefits..............II-65 Prospective Application Areas for Neurostimulators - Select Indications.............. II-65 Approved Indications for Spinal Cord Stimulation by Geographic Regions..............II-66 Neurostimulation Devices - Technology & Safety Issues II-66

8. NEUROSTIMULATION DEVICE APPROVALS II-67 St. Jude Medical Wins CE Mark Approval for MR- Conditional Rechargeable Spinal Cord Stimulator II-67 St. Jude Medical Nabs CE Mark for Infinity Deep Brain Stimulation System and Directional DBS Lead II-67 EndoStim Receives CE Mark Approval for EndoStim II II-67 St. Jude Medical Wins Health Canada Approval for Prodigy Spinal Cord Stimulator..............II-67 St. Jude Medical Bags FDA Approval for Brio Neurostimulation System for Parkinson's Disease..............II-67 Medtronic Receives European Approval of Full-Body MR Conditional Deep Brain Stimulation Systems II-67 AdvaStim Gets Neurostimulation Patent II-68 St. Jude Bags EU Regulatory Approval for Prodigy Neurostimulator with Burst Technology II-68 St. Jude Medical Secures FDA Approval for Protégé™ IPG II-68

9. PRODUCT INNOVATIONS/INTRODUCTIONS II-69 NeuroMetrix Introduces Quell™ Wearable Pain Relief Technology II-69 NeuroMetrix Unveils SENSUS Pain Management System II-69 Medtronic Rolls Out Neurostimulation Systems for Chronic Pain II-69

10. RECENT INDUSTRY ACTIVITY..............II-70 St. Jude Medical Snaps Up Spinal Modulation II-70 Allergan Acquires Oculeve..............II-70 Medtronic Takes Over Advanced Uro-Solutions II-70 Sorin and Cyberonics Announces Merger II-70 Greatbatch Spins Off Algostim..............II-70 Medtronic Takes Over Sapiens Steering Brain Stimulation II-70 Kelyniam Global Snaps Up MED-ALLY II-70 AdvaStim Forays into Neuromodulation Device Market II-71 Aurora BioScience Inks Distribution Agreement with Synapse Biomedical.............. II-71 Sorin Group Acquires Neurotech II-71 St Jude Medical and Spinal Modulation Ink Distribution Agreements II-71 Boston Scientific Commences Trial for Neurostimulation Evaluation in Chronic Migraine Treatment II-71 Spinal Modulation Starts Trial for Neurostim Device II-71

11. FOCUS ON SELECT PLAYERS..............II-72 Aleva Neurotherapeutics SA (Switzerland) II-72 BioControl Medical (Israel)..............II-72 Bioness Inc. (USA)..............II-72 Boston Scientific Corp. (USA)..............II-73 EnteroMedics Inc. (USA)..............II-73 LivaNova PLC (UK).............. II-73 Medtronic, Inc. (USA)..............II-74 NeuroPace, Inc. (USA)..............II-74 NeuroSigma, Inc. (USA)..............II-75 Nevro Corp. (USA).............. II-75 SPR Therapeutics, LLC (US)..............II-75 St. Jude Medical, Inc. (USA)..............II-76 Synapse Biomedical, Inc. (USA) II-76

12. GLOBAL MARKET PERSPECTIVE..............II-77 Table 20: World Recent Past, Current & Future Analysis for Neurostimulation Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-77

Table 21: World Historic Review for Neurostimulation Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart)..............II-78

Table 22: World 14-Year Perspective for Neurostimulation Devices by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-79

Table 23: World Recent Past, Current & Future Analysis for Spinal Cord Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-80

Table 24: World Historic Review for Spinal Cord Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart) II-81

Table 25: World 14-Year Perspective for Spinal Cord Stimulators by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-82

Table 26: World Recent Past, Current & Future Analysis for Deep Brain Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-83

Table 27: World Historic Review for Deep Brain Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart) II-84

Table 28: World 14-Year Perspective for Deep Brain Stimulators by Geographic Region - Percentage Breakdown of Value Sales for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-85

Table 29: World Recent Past, Current & Future Analysis for Sacral Nerve Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-86

Table 30: World Historic Review for Sacral Nerve Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart)..............II-87

Table 31: World 14-Year Perspective for Sacral Nerve Stimulators by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-88

Table 32: World Recent Past, Current & Future Analysis for Vagus Nerve Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-89

Table 33: World Historic Review for Vagus Nerve Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart) II-90

Table 34: World 14-Year Perspective for Vagus Nerve Stimulators by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-91

Table 35: World Recent Past, Current & Future Analysis for Gastric Electric Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2014 through 2020 (includes corresponding Graph/Chart)..............II-92

Table 36: World Historic Review for Gastric Electric Stimulators by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for the Years 2007 through 2013 (includes corresponding Graph/Chart)..............II-93

Table 37: World 14-Year Perspective for Gastric Electric Stimulators by Geographic Region - Percentage Breakdown of Revenues for US, Canada, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) II-94

III. MARKET

1. THE UNITED STATES.............. III-1 A.Market Analysis.............. III-1 Overview.............. III-1 Product Segments Ranked by Growth III-2 Table 38: Neurostimulation Market in the US (2014-2020): Product Segments Ranked by Revenue Growth (includes corresponding Graph/Chart) III-2

Table 39: Neurostimulation Market in the US (2014-2020): Product Segments Ranked by Unit Sales Growth (includes corresponding Graph/Chart) III-3 Neurostimulation Indications and Use of Related Devices/ Techniques in the US..............III-3 Potential Growth for Neurostimulation Systems in the US III-4 Spinal Cord Stimulation Products Market III-4 Sacral Nerve Stimulation Products Market III-4 Deep Brain Stimulation Products Market III-5 Aging Baby Boomers Benefit Market Prospects in the US III-6 Table 40: North American Elderly Population by Age Group: 1975, 2000, 2025P, and 2050P (includes corresponding Graph/Chart).............. III-6 Shift Away from Orthopaedic and Cardiovascular Device Markets III-7 Trends in the Embolotherapy Market III-7 Neurovascular Stents Market Attracting Cardiovascular Companies III-8 Migraine Devices - New Frontiers for Neurostimulation III-8 Competitive Landscape..............III-8 Neurostimulation Device Approvals III-9 Product Innovations/Introductions III-9 Strategic Corporate Developments III-10 Select Key Players..............III-11 B.Market Analytics..............III-15 Table 41: US Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-15

Table 42: US Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-16

Table 43: US 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-17

Table 44: US Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in Units for Years 2014 through 2020 (includes corresponding Graph/Chart) III-18

Table 45: US Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in Units for Years 2007 through 2013 (includes corresponding Graph/Chart)..............III-19

Table 46: US 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Unit Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-20

2. CANADA.............. III-21 A.Market Analysis.............. III-21 Outlook.............. III-21 Neurostimulation Device Approval III-21 B.Market Analytics..............III-22 Table 47: Canadian Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-22

Table 48: Canadian Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-23

Table 49: Canadian 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-24

3. JAPAN.............. III-25 Market Analysis.............. III-25 Table 50: Japanese Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-25

Table 51: Japanese Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-26

Table 52: Japanese 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-27

4. EUROPE.............. III-28 A.Market Analysis.............. III-28 Outlook.............. III-28 Increasing Incidence of Neurological Diseases Spur Market Growth.............. III-28 Rising Life Expectancy and the Risk of Injury to Drive Demand across Europe..............III-28 Table 53: Life Expectancy at 65 Years for Select Countries in Europe: 2012 (includes corresponding Graph/Chart) III-29

Table 54: European Country-wise Statistics of 60+ Population as % of Total Population: 2013 (includes corresponding Graph/Chart)..............III-30 Neurostimulation Device Approvals III-31 Strategic Corporate Developments III-32 Select Key Players..............III-32 B.Market Analytics..............III-34 Table 55: European Recent Past, Current & Future Analysis for Neurostimulation Devices by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-34

Table 56: European Historic Analysis for Neurostimulation Devices by Geographic Region - France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-35

Table 57: European 14-Year Perspective for Neurostimulation Devices by Geographic Region - Percentage Breakdown of Value Sales for France, Germany, Italy, UK, Spain, Russia and Rest of Europe Markets for Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-36

Table 58: European Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-37

Table 59: European Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-38

Table 60: European 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-39

5. ASIA-PACIFIC.............. III-40 A.Market Analysis.............. III-40 Outlook.............. III-40 Neurostimulation Devices Market Exhibits Substantial Growth III-40 Strategic Corporate Development III-41 B.Market Analytics..............III-41 Table 61: Asia-Pacific Recent Past, Current & Future Analysis for Neurostimulation Devices by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-41

Table 62: Asia-Pacific Historic Analysis for Neurostimulation Devices by Geographic Region - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-42

Table 63: Asia-Pacific 14-Year Perspective for Neurostimulation Devices by Geographic Region - Percentage Breakdown of Value Sales for China, India and Rest of Asia-Pacific Markets for Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-43

Table 64: Asia-Pacific Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-44

Table 65: Asia-Pacific Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-45

Table 66: Asia-Pacific 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) III-46

6. LATIN AMERICA.............. III-47 Market Analysis.............. III-47 Table 67: Latin American Recent Past, Current & Future Analysis for Neurostimulation Devices by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart) III-47

Table 68: Latin American Historic Analysis for Neurostimulation Devices by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-48

Table 69: Latin American 14-Year Perspective for Neurostimulation Devices by Geographic Region - Percentage Breakdown of Value Sales for Brazil and Rest of Latin America Markets for Years 2007, 2015 & 2020 (includes corresponding Graph/Chart)..............III-49

Table 70: Latin American Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-50

Table 71: Latin American Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-51

Table 72: Latin American 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) III-52

7. REST OF WORLD.............. III-53 A.Market Analysis.............. III-53 Outlook.............. III-53 Business-Friendly Government Policies Fuels Market Growth III-53 BioControl Medical - A Major Israeli Player III-53 B.Market Analytics..............III-54 Table 73: Rest of World Recent Past, Current & Future Analysis for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Revenue Figures in US$ Thousand for Years 2014 through 2020 (includes corresponding Graph/Chart).............. III-54

Table 74: Rest of World Historic Review for Neurostimulation Devices by Product Segment - Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2007 through 2013 (includes corresponding Graph/Chart) III-55

Table 75: Rest of World 14-Year Perspective for Neurostimulation Devices by Product Segment - Percentage Breakdown of Value Sales for Spinal Cord Stimulators (SCS), Deep Brain Stimulators (DBS), Sacral Nerve Stimulators (SNS), Vagus Nerve Stimulators (VNS), and Gastric Electric Stimulators (GES) Markets for the Years 2007, 2015 & 2020 (includes corresponding Graph/Chart) III-56

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 30 (including Divisions/Subsidiaries - 31)

The United States (23) Europe (7) - Germany (2) - The United Kingdom (2) - Rest of Europe (3) Middle East (1)
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