Global qPCR and dPCR Instrumentation Industry

NEW YORK, Dec. 9, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global qPCR and dPCR Instrumentation Industry
http://www.reportlinker.com/p01921269/Global-qPCR-and-dPCR-Instrumentation-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genetically_Modified_Organism,_GMO

This report analyzes the worldwide markets for qPCR and dPCR Instrumentation in US$ Million. The Global market is further analyzed by the following Product Segments and End-Use Markets: Product Segments - qPCR (quantitative Polymerase Chain Reaction), and dPCR (digital Polymerase Chain Reaction); End-Use markets - Educational/Research, Testing Laboratories, and Pharma.

The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East/Africa, and Latin America. Annual estimates and forecasts are provided for the period 2009 through 2018. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs.

The report profiles 49 companies including many key and niche players such as -
Agilent Technologies
Biofire Diagnostics, Inc.
Bio-Rad Laboratories, Inc.
Cepheid
Eppendorf AG
Exiqon A/S
F. Hoffmann-La Roche Ltd.
Fluidigm Corporation
Illumina, Inc.

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-2
Product Definitions and Scope Of Study I-3
Polymerase Chain Reaction I-3
qPCR I-3
dPCR I-4

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Polymerase Chain Reaction: An Integral Part of Gene
Amplification & Quantification II-1
As Real-Time PCR Technology Matures, Saturation is Imminent II-2
Digital PCR Sales to Skyrocket in Near Term II-2
qPCR-dPCR Adoption to Zoom in Japan II-3
Macro-Growth Drivers II-3
Progress in Human Genome Project and Molecular Diagnostics
Domain Spur Demand for the Gene Amplification Technologies II-3
Prospects for Predictive Genetic Diagnostics and Testing Grow
Brighter II-4
Next-Generation Sequencing - A Giant Leap in Genome Sequencing II-5
Increasing Incidence and Prevalence of Cancer: A Grim Reality
Driving Demand for qPCR and dPCR II-5

2. MAJOR TRENDS & ISSUES II-7
PCR Continues to Dominate Amplification Technologies II-7
Cost of PCR instruments and Reagents to Decline II-7
Advancements in Probe Technology Enhance qPCR Sensitivity II-7
qPCR Market to Witness increasing Affinity for Automated and
Robotic Equipment II-8
Factors influencing Selection of Lab Robots II-8
Striking the Right Balance between qPCR and dPCR in Research
Laboratories II-9
qPCR- A Suitable Tool for Gene Expression and Validation II-9
Digital PCR Holds Potential to Take Quantification of Nucleic
Acids to the Next Level II-9
dPCR - A Valuable Tool in Virology Research II-10
High Sensitivity Viral Detection II-11
Creation and Validation of Viral Reference Standards II-11
High-Precision Quantification II-11
New dPCR Systems Threaten to Disrupt qPCR Market II-11
Table 1: Leading dPCR Systems At a Glance II-12

QuantStudio 3D Digital PCR System II-12
BioMark HD system II-13
QX100 droplet digital PCR System II-13
RainDrop Systems II-13
Applications of Droplet dPCR II-13
Lab on Chip/Microfluidic RT-PCR- A Game Changer in the Offing II-14
Two Types of Microfluidic Designs II-14
Advantages of Lab on Chip PCR II-15
Roadblocks in the Path to Development II-15
New Developments in Lab-on-chip PCR II-15
Researchers Continue to Campaign for Adoption and Strict
Compliance with MIQE and SPIDIA Guidelines II-16
Alternate Technologies Pose Threat to Growth of PCR Market II-17
New Isothermal PCR Technology - A Potential Game Changer
Promising Faster PCR II-17

3. COMPETITION II-19
Competitive Landscape II-19
Table 2: Leading Players in Global RT-PCR Instruments Market
(2012): Percentage Breakdown of Value Sales for Life Sciences
Research by Leading Players - Life Technologies, Bio-Rad,
Roche, Agilent, Qiagen and Others (includes corresponding
Graph/Chart) II-19
Select Real-Time PCR Products by Company II-19
Life Technologies Corporation: the Unquestioned Leader in qPCR II-20
Table 3: Life Technologies' Royalty Roll-Off by Year:
2009-2013 (includes corresponding Graph/Chart) II-20
Competition Heats Up in dPCR Market II-20
Manufacturers Step-Up Online Exposure II-21
Multiple Factors to Sustain Consolidation Trend in PCR Industry II-21
Staving off Competitive Pressure II-21
Accelerated Commercialization of Products II-21
Market Leaders Gear Up to Offer Integrated and Multi-
technology Solutions II-22
Manufacturers Target Expansion of Distribution Reach and
Global Footprint II-22

4. END-USE MARKET ANALYSIS II-23
Application Areas of PCR II-23
Medical and Diagnostics II-23
PCR Plays a Vital Role in the Diagnosis of Infectious Diseases II-23
Detection of Antimicrobial Resistance II-24
PCR-Based Nucleic Acid Amplification for Detection of
Antimicrobial Agents II-24
Forensic and Paternity Testing II-25
Food Safety II-25
Detection and Quantification of Food Pathogens II-25
Detection of Beneficial and Non-Pathogenic Microbes II-26
Study of Microbial Responses to Environment II-26
Microbial Risk Assessment II-26
qPCR Application in Food Microbiology: Study of Select
Micro-Organisms By Target Gene and Food Substrate II-26
PCR Technique in Identification of GMOs II-27
Research & Academics II-28
SYBR Dye and Taqman Techniques Popular in Research Publications II-28

5. PRODUCT OVERVIEW II-29
Introduction to Polymerase Chain Reaction II-29
Reagents and Components Required for PCR II-30
Reaction Steps II-30
Denaturation II-30
Annealing II-30
Extension II-30
Real-Time PCR or Quantitative PCR (qPCR) II-31
qPCR Instrumentation II-31
Evolution II-31
Working of qPCR Instruments II-32
Thermal Control II-32
Fluorimetry II-32
DNA Detection Methods II-33
Fluorescence Measurement II-33
Asymmetrical dsDNA dyes II-33
Quantification II-33

High-Throughput qPCR II-34
Comparison of Working of Conventional PCR versus qPCR II-34
Drawbacks in Core PCR II-35
Advantages of qPCR II-35
Disadvantages of qPCR II-36
End-Use Applications of qPCR II-36
Factors Influencing Purchase Decisions of qPCR Systems II-37
qPCR Consumables, Accessories and Software II-37
Digital PCR II-37
Development of dPCR II-38
Working Principle II-38
Droplet dPCR II-38
Applications of dPCR II-39
Advantages of dPCR II-39

6. INSIGHT INTO GLOBAL SPENDING ON LIFE SCIENCES RESEARCH II-40
Sequestration Bites Deep into US Research Funds II-40
Table 4: NIH Annual Appropriations in Current and Inflation
Adjusted Figures, and Total No. of Research Projects Grants
(2008-2013) (includes corresponding Graph/Chart) II-40

Table 5: NCI Research Spending in US$ Millions on Major Types
of Cancers Listed in Decreasing Order of Prevalence (2010,
2011 & 2012) (includes corresponding Graph/Chart) II-41
New MoPath Codes for Reimbursement for Medical Diagnostics Tests II-42
Japan Falling Back in Race on Account of Economic Woes II-42
Table 6: Human Frontier Science Program Budget for 2014 by
Country: Contribution in US$ Million for Japan, United
States, European Union, and Others (includes corresponding

Graph/Chart) II-42
Fiscal Prudence to Undermine Research Programs II-43
Table 7: European Research Council (ERC) Funding for Life
Sciences by Country (2008-2013): Breakdown of Number of
Starting Grants Allocated for United Kingdom, Germany,
France, Israel, Switzerland, Netherlands, Sweden, Spain,
Belgium, Austria, and Others (includes corresponding
Graph/Chart) II-44

Table 8: European Research Council (ERC) Funding for Life
Sciences by Country (2008-2013): Breakdown of Number of
Advance Grants Allocated for United Kingdom, Germany, France,
Switzerland, Netherlands, Italy, Israel, Spain, Sweden,
Belgium, and Others (includes corresponding Graph/Chart) II-45
Asia Pacific - The New Global Hub for Life Sciences Research II-46

7. PRODUCT INNOVATIONS/ INTRODUCTIONS II-47
Life Technologies Launches QuantStudio 3D Digital PCR System II-47
LGC Introduces Updated 1536-Well PCR Plate for Genomics
Applications II-47
Exiqon Unveils Toxicology Focus microRNA PCR Panel II-47
Exiqon Introduces LNA™ LongRNA GapmeR Products II-48
Life Technologies and Quidel Secure US FDA Approval for
Marketing RT-PCR Instruments II-48
Life Technologies Obtains US FDA Approval for 3500 Dx Genetic
Analyzers and SeCore® HLA Typing Kit II-48
Bio-Rad Unveils iTaq Universal Supermixes II-49

Nextreme Thermal Solutions Introduces New-Generation Reference
Design for Compact PCR Thermal Cycler II-49
Sigma Life Science Introduces KiCqStart Primers II-50
Bio-Rad Rolls Out CFX96 Touch Deep Well PCR Detection System II-50
Roche Introduces Light Cycler 96 System II-50
Fluidigm Rolls Out New Integrated Fluidic Circuits II-51
Promega Unveils GoTaq Master Mixes Range II-51
Illumina Unveils Real-Time PCR Reagent Portfolio II-52
Integromics® Introduces OmicsOffice® Platform II-52
Ingenuity Systems and Life Technologies Unveil Ingenuity
iReport for Real-Time PCR II-53
Life Technologies Introduces QuantStudio™ Dx Real-Time PCR
Instrument II-53
RainDance Technologies Introduces RainDrop™ Digital PCR Platform II-54
Life Technologies Unveils QuantStudio 3D Digital PCR System
Chip-Based Instrument II-54
Integromics® Unveils RealTime StatMiner® 4.3 on TIBCO® Spotfire® II-54
Bio-Rad Laboratories Unveils CFX Qualification Plate II-54
Bio-Rad Laboratories Introduces CFX96 Touch Deep Well™ RT-PCR
Detection System II-55
Exiqon Unveils miRCURY™ RNA Isolation Kit-Biofluids II-55

Bio-Rad Laboratories Launches One-Step RT-ddPCR Kit II-55
Accelero® Bioanalytics Announces Addition of RT-qPCR System of
Applied Biosystems II-55
Roche Introduces New LightCycler® Nano Instrument in US II-56
Life Technologies Unveils Flagship Applied Biosystems
QuantStudio™ 12K Flex Real-Time PCR system II-56
Life Technologies Launches VetMAX™-Gold SIV Detection Real-
Time PCR Kit II-57
Life Technologies Introduces Diagnostics Platforms in Japan II-57
Fluidigm Launches New BioMark™ HD Real-Time PCR System II-57
Thermo Fisher Scientific Introduces Thermo Scientific PikoReal
Real-Time PCR Systems II-57

Exiqon Introduces Focus microRNA PCR Panels II-58
Bio-Rad Unveils New Color Touch Screens for Select Bio-Rad
1000 PCR Systems II-59
Asuragen Introduces ARQ IS Calibrator Panels II-59
Biometra Announces Launch of TProfessional TRIO Featuring New
Thermocycler Technology II-59
Bio-Rad Laboratories Introduces MIQE qPCR App on Apple App Store II-60
Bio-Rad Laboratories Launches CFX Connect RT-PCR Detection System II-60
Bio-Rad Laboratories Launches iScript Advanced cDNA Synthesis Kit II-60
Fluidigm Introduces SNPtype Assays, DELTAgene Assays and
Access Array Target-specific Primers II-60
InstantLabs® Expands Presence in Middle East by Installing
Hunter Accelerated-PCR® Systems II-61
Life Technologies Launches Kit for Digital PCR on OpenArray®
Real-Time qPCR System II-61
Analytik Jena Introduces New Real-Time PCR Systems II-61
Promega Introduces New PromegaGoTaq® 2-Step RT-qPCR Reagent
System II-62
Illumina Introduces Eco Real-Time PCR System II-62
Life Technologies Introduces ViiA 7 Real-Time PCR System II-62
Agilent Technologies Introduces Brilliant III Ultra-Fast QPCR

and QRT-PCR Master Mix Kits II-63
Bio-Rad Launches CFX Automation System for CFX96 and CFX384
Real-Time PCR Detection Systems II-63

8. RECENT INDUSTRY ACTIVITY II-64
Quotient Bioresearch Divests Bioanalytical Sciences Business
to LGC II-64
Thermo Fisher Scientific Inks Definitive Agreement to Take
Over Life Technologies II-64
QIAGEN and WaferGen Bio-systems Ink Co-Marketing Agreement II-65
Biodesign Institute® Enters into Partnership with Life
Technologies II-65

WaferGen Bio-systems Enters into Partnership with Salk
Institute to Establish nano-qPCR Core Laboratory II-65
TATAA Biocenter Extends Product Line II-66
Integrated DNA Technologies to Showcase Novel Multiplex qPCR
Assays II-66
Illumina and VWR International Sign Agreement II-66
Integrated DNA Technologies Collaborates with RainDance
Technologies II-66
Life Technologies Takes Over Compendia Bioscience II-67
Luminex Takes Over GenturaDx II-67
Life Technologies Takes Over Pinpoint Genomics II-68
Idaho Technology Announces Corporate Rebranding to BioFire
Diagnostics II-68

Exosome Diagnostics and Life Technologies Ink Agreement II-68
Abbott Inks Partnership Agreement with Astellas Pharma Global
Development for Executing Clinical Trial on TransVax™ Vaccine II-68
Accelero Bioanalytics and Synlab Clinical Trial Enter into
Collaboration II-69
Immunexpress Group, Biocartis and Debiopharm Ink Agreement to
Develop and Commercialize SeptiCyte® Triage Assay II-69
Accelero Bioanalytics Collaborates with LPT Laboratory II-70
Bio-Rad Laboratories Takes Over QuantaLife II-70
AlphaHelix Merges with Techtum Lab II-70
Applied Biosystems Obtains FDA Clearance for 7500 Fast Dx
Real-Time PCR Instrument II-71
Fluidigm Selects Research Instruments as Distributor in
Thailand and Singapore II-71
Life Technologies and Quidel Ink Agreement II-71
Roche Applied Science and IT-IS Life Sciences Ink Worldwide
Exclusive OEM Agreement II-71
Roche Inks Co-Exclusive Distribution Contract with Lonza for
Commercializing MycoTOOL Mycoplasma PCR Assays II-72
WaferGen Biosystems Enters into Agreement with NuGEN
Technologies for Integrated Workflows for Gene Expression II-72
Thermo Fisher Scientific Snaps up Fermentas International II-72
Thermo Fisher Scientific Acquires Finnzymes II-73
Illumina Acquires Helixis II-73
Fluidigm Partners with SABiosciences II-73

9. FOCUS ON SELECT GLOBAL PLAYERS II-74
Agilent Technologies (US) II-74
Biofire Diagnostics, Inc. (US) II-74
Bio-Rad Laboratories, Inc. (US) II-75
Cepheid (US) II-76
Eppendorf AG (Germany) II-76
Exiqon A/S (Denmark) II-77
F. Hoffmann-La Roche Ltd. (Switzerland) II-77
Fluidigm Corporation (US) II-78

Illumina, Inc. (US) II-79
Life Technologies Corporation (US) II-79
Promega Corporation (US) II-80
RainDance Technologies, Inc. (US) II-81
QIAGEN N.V. (Netherlands) II-81
Takara Bio, Inc. (Japan) II-82
Thermo Fisher Scientific (US) II-82

10. GLOBAL MARKET PERSPECTIVE II-84
Table 9: World Recent Past, Current & Future Analysis for qPCR
and dPCR Instrumentation by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific, Middle East & Africa and Latin
America Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for the Years 2009 through 2018
(includes corresponding Graph/Chart) II-84

Table 10: World 10-Year Perspective for qPCR and dPCR
Instrumentation by Geographic Region - Percentage Breakdown of
Revenues for US, Canada, Japan, Europe, Asia-Pacific, Middle
East & Africa and Latin America Markets for the Years 2009,
2013 & 2018 (includes corresponding Graph/Chart) II-85

Table 11: World Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation by Product Segment - qPCR and
dPCR Markets Independently Analyzed with Annual Revenue
Figures in US$ Million for the Years 2009 through 2018
(includes corresponding Graph/Chart) II-86

Table 12: World 10-Year Perspective for qPCR and dPCR
Instrumentation by Product Segment - Percentage Breakdown of
Revenues for qPCR and dPCR Markets for the Years 2009, 2013 &
2018 (includes corresponding Graph/Chart) II-87

Table 13: World Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation by End-Use Segment -
Educational/Research, Testing Laboratories and Pharma Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for the Years 2009 through 2018 (includes
corresponding Graph/Chart) II-88

Table 14: World 10-Year Perspective for qPCR and dPCR
Instrumentation by End-Use Segment - Percentage Breakdown of
Revenues for Educational/Research, Testing Laboratories and
Pharma Markets for the Years 2009, 2013 & 2018 (includes
corresponding Graph/Chart) II-89

III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Current and Future Analysis III-1
Real-Time PCR Market in North America: A Primer III-1
Key Factors (Ranked in Order) in Buyer Selection of Real-
Time/qPCR Platforms III-1
qPCR and dPCR Instrumentation in the US: An Overview III-1
Competition III-2
Product Launches III-2
Strategic Corporate Developments III-14
Key Players III-20
B.Market Analytics III-27
Table 15: US Recent Past, Current & Future Analysis for qPCR
and dPCR Instrumentation Market Analyzed with Annual Revenue
Figures in US$ Million for the Years 2009 through 2018
(includes corresponding Graph/Chart) III-27

2. CANADA III-28
A.Market Analysis III-28
Current and Future Analysis III-28
Strategic Corporate Development III-28
Funglyn biotech, inc. - a key player III-28
B.Market Analytics III-29
Table 16: Canadian Recent Past, Current & Future Analysis
for qPCR and dPCR Instrumentation Market Analyzed with
Annual Revenue Figures in US$ Million for the Years 2009
through 2018 (includes corresponding Graph/Chart) III-29

3. JAPAN III-30
A.Market Analysis III-30
Current and Future Analysis III-30
Product Launch III-30
Strategic Corporate Development III-30
Takara bio, inc. - a key player III-31
B.Market Analytics III-32
Table 17: Japanese Recent Past, Current & Future Analysis
for qPCR and dPCR Instrumentation Market Analyzed with
Annual Revenue Figures in US$ Million for the Years 2009
through 2018 (includes corresponding Graph/Chart) III-32

4. EUROPE III-33
A.Market Analysis III-33
Current and Future Analysis III-33
PCR Reagents in Europe: An Overview III-33
Product Launches III-33
Strategic Corporate Development III-34
B.Market Analytics III-35
Table 18: European Recent Past, Current & Future Analysis
for qPCR and dPCR Instrumentation by Geographic Region -
France, Germany, Italy, UK, and Rest of Europe Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for the Years 2009 through 2018 (includes
corresponding Graph/Chart) III-35

Table 19: European 10-Year Perspective for qPCR and dPCR
Instrumentation by Geographic Region - Percentage Breakdown
of Revenues for France, Germany, Italy, UK, and Rest of
Europe Markets for the Years 2009, 2013 & 2018 (includes
corresponding Graph/Chart) III-36

4a. FRANCE III-37
A.Market Analysis III-37
Current and Future Analysis III-37
B.Market Analytics III-37
Table 20: French Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation Market Analyzed with Annual
Revenue Figures in US$ Million for the Years 2009 through
2018 (includes corresponding Graph/Chart) III-37

4b. GERMANY III-38
A.Market Analysis III-38
Current and Future Analysis III-38
Product Launches III-38
Strategic Corporate Developments III-39
Eppendorf Ag - A Key Player III-40
B.Market Analytics III-41
Table 21: German Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation Market Analyzed with Annual
Revenue Figures in US$ Million for the Years 2009 through
2018 (includes corresponding Graph/Chart) III-41

4c. ITALY III-42
A.Market Analysis III-42
Current and Future Analysis III-42
B.Market Analytics III-42
Table 22: Italian Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation Market Analyzed with Annual
Revenue Figures in US$ Million for the Years 2009 through
2018 (includes corresponding Graph/Chart) III-42

4d. THE UNITED KINGDOM III-43
A.Market Analysis III-43
Current and Future Analysis III-43
Strategic Corporate Development III-43
B.Market Analytics III-44
Table 23: UK Recent Past, Current & Future Analysis for qPCR
and dPCR Instrumentation Market Analyzed with Annual Revenue
Figures in US$ Million for the Years 2009 through 2018
(includes corresponding Graph/Chart) III-44

4e. REST OF EUROPE III-45
A.Market Analysis III-45
Current and Future Analysis III-45
Product Launches III-45
Strategic Corporate Developments III-48
Key Players III-50
B.Market Analytics III-52
Table 24: Rest of Europe Recent Past, Current & Future
Analysis for qPCR and dPCR Instrumentation Market Analyzed
with Annual Revenue Figures in US$ Million for the Years
2009 through 2018 (includes corresponding Graph/Chart) III-52

5. ASIA-PACIFIC III-53
A.Market Analysis III-53
Current and Future Analysis III-53
B.Market Analytics III-53
Table 25: Asia-Pacific Recent Past, Current & Future
Analysis for qPCR and dPCR Instrumentation by Geographic
Region - China and Rest of Asia-Pacific Markets
Independently Analyzed with Annual Revenue Figures in US$
Million for the Years 2009 through 2018 (includes
corresponding Graph/Chart) III-53

Table 26: Asia-Pacific 10-Year Perspective for qPCR and dPCR
Instrumentation by Geographic Region - Percentage Breakdown
of Revenues for China and Rest of Asia-Pacific Markets for
the Years 2009, 2013 & 2018 (includes corresponding
Graph/Chart) III-54

5a. CHINA III-55
A.Market Analysis III-55
Current and Future Analysis III-55
B.Market Analytics III-55
Table 27: Chinese Recent Past, Current & Future Analysis for
qPCR and dPCR Instrumentation Market Analyzed with Annual
Revenue Figures in US$ Million for the Years 2009 through
2018 (includes corresponding Graph/Chart) III-55

5b. REST OF ASIA-PACIFIC III-56
A.Market Analysis III-56
Current and Future Analysis III-56
Professional Biotech Pvt. Ltd. - A Key Real Time PCR
Manufacturer in India III-56
B.Market Analytics III-57
Table 28: Rest of Asia-Pacific Recent Past, Current & Future
Analysis for qPCR and dPCR Instrumentation Market Analyzed
with Annual Revenue Figures in US$ Million for the Years
2009 through 2018 (includes corresponding Graph/Chart) III-57

6. MIDDLE EAST & AFRICA III-58
A.Market Analysis III-58
Current and Future Analysis III-58
Product Launch III-58
B.Market Analytics III-59
Table 29: Middle East & Africa Recent Past, Current & Future
Analysis for qPCR and dPCR Instrumentation Market Analyzed
with Annual Revenue Figures in US$ Million for the Years
2009 through 2018 (includes corresponding Graph/Chart) III-59

7. LATIN AMERICA III-60
A.Market Analysis III-60
Current and Future Analysis III-60
B.Market Analytics III-60
Table 30: Latin American Recent Past, Current & Future
Analysis for qPCR and dPCR Instrumentation Market Analyzed
with Annual Revenue Figures in US$ Million for the Years
2009 through 2018 (includes corresponding Graph/Chart) III-60

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 49 (including Divisions/Subsidiaries - 51)

The United States (29)
Canada (1)
Japan (1)
Europe (19)
- Germany (7)
- The United Kingdom (2)
- Spain (1)
- Rest of Europe (9)
Asia-Pacific (Excluding Japan) (1)

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__________________________
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