Granulomatosis with Polyangiitis Market to Grow at an Impressive CAGR of 27.03% During the Study Period [2018-2030], Asserts DelveInsight

LAS VEGAS, Feb. 7, 2022 /PRNewswire/ -- DelveInsight's "Granulomatosis with Polyangiitis Market" report provides a thorough comprehension of the Granulomatosis with Polyangiitis historical and forecasted epidemiology and the Granulomatosis with Polyangiitis market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Granulomatosis with Polyangiitis market report also proffers an analysis of the current Granulomatosis with Polyangiitis treatment algorithm/practice, market drivers, market barriers, and unmet medical needs. 

Some of the necessary takeaways from the Granulomatosis with Polyangiitis Market Research Report 

• Several key pharmaceutical companies, including Biogen Idec, Genentech, ChemoCentryx, InflaRx GmbH, Bristol-Myers Squibb, GlaxoSmithKline, and others, are developing novel products to improve the Granulomatosis with Polyangiitis treatment outlook. 
• Rituximab (RTX) is the only drug approved in the United States, Europe, and Japan to treat Granulomatosis with Polyangiitis at present. 
• The approval of the emerging gene therapies will be a milestone for Granulomatosis with Polyangiitis patients.
• Granulomatosis with Polyangiitis market to observe growth since there has been a rise in disease awareness, registry establishment, and increasing investment in R&D and technological advancements. Nevertheless, Granulomatosis with Polyangiitis market growth is hampered by the poor understanding of the disease's pathophysiology, lack of efficient biomarkers for identification, and difficulty in developing animal models. 
• The launch of promising agents for the treatment of Granulomatosis with Polyangiitis can help address the unmet needs of patients with GPA and also provide proof of concept for future therapies.

For further information on Market Impact by Therapies, visit: Granulomatosis with Polyangiitis Drugs Market Analysis 

Granulomatosis with Polyangiitis (GPA) is a multisystem autoimmune condition associated with anti-neutrophil cytoplasm antibodies. 

DelveInsight estimates that the total Granulomatosis with Polyangiitis incident cases were 7,580 cases in the 7MM in 2018. 

The Granulomatosis with Polyangiitis Market Analysis Report provides historical as well as forecasted epidemiological analysis segmented into: 

• Granulomatosis With Polyangiitis Incident cases 
• Gender-specific Cases of Granulomatosis With Polyangiitis 
• Age-specific Cases of Granulomatosis With Polyangiitis

Get a complete epidemiological segmentation breakdown @ Granulomatosis with Polyangiitis Epidemiological Analysis 

Granulomatosis with Polyangiitis Treatment Market 

Granulomatosis with Polyangiitis prognosis was poor mainly because of renal failure and GI (gastrointestinal)/alveolar bleedings. With the introduction of cyclophosphamide therapy (CYC), and subsequently, approval of Rituximab (RTX) in both adults and pediatric patients, prognosis has significantly improved. Because of its toxicity, its use is limited to short-term induction therapy of severe flares, followed by maintenance therapy with other, in general, better-tolerated immune-suppressant agents, like AZA (azathioprine), MFM (mycophenolate mofetil), or MTX (methotrexate). However, these therapies are associated with significant adverse effects. 

RTX is an alternative for cyclophosphamide to induce remission and may also be the first choice for relapsing patients and those refractory to cyclophosphamide. RTX is also preferred for use in women of childbearing age. Currently, three RTX biosimilar are approved, i.e., Ruxience (by Pfizer), Riabni (by Amgen), and Truxima (by Teva). RTX has demonstrated efficacy in maintaining remission and preventing future relapses in several retrospective studies. However, it is also associated with significant side effects such as a considerable risk of hypogammaglobulinemia, infection, lymphopenia, and neutropenia. It is important to note that none of the currently used therapies is specific to the fundamental auto-immune activation of neutrophils by PR3-ANCA. Also, RTX depletes circulating B lymphocytes without specifically targeting those producing Antineutrophil Cytoplasmic Antibodies (ANCA). 

There is an ongoing need to reduce the toxicity of treatment for Granulomatosis with Polyangiitis and increase the efficacy of maintenance therapy in preventing relapse. Currently, only a few pipeline products are in the late stage of clinical development. The key players are Avacopan (ChemoCentryx), Vilobelimab (InflaRx GmbH), Belimumab (GlaxoSmithKline), and Abatacept (Bristol-Myers Squibb), and others.

Granulomatosis with Polyangiitis management requires a multidisciplinary approach to treat the disease, prevent relapse, and manage long-term cardiovascular risk, organ damage, and side effects of therapy. Although treatments have been refined due to large multicenter randomized controlled trials in Adeno-Associated Virus (AAV); however, there are unmet needs to resolve granulomatous inflammation more rapidly, to reduce steroid exposure, and to improve the efficacy of remission maintenance strategies in the indication. The launch of promising agents for treating Granulomatosis with Polyangiitis can fulfill patients' unmet needs and provide proof of concept for future therapies.

Granulomatosis with Polyangiitis Market Dynamics 

Granulomatosis with Polyangiitis market to expand because of the development of biological therapeutics and small molecules that target specific cell types, cytokines, and immunological pathways, which have enabled more rational drug targeting in inflammatory diseases. The clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in Granulomatosis with Polyangiitis patients. Also, the biomarker and mechanistic studies conducted in Granulomatosis with Polyangiitis treatment trials have provided better awareness of the heterogeneity and differences of disease phenotypes with prognostic implications. Moreover, there has been an improved understanding of the currently available medicines, hence the development of new drugs for this disease. In addition to that, there is a lack of competitors, which provide unique opportunities to Pharma players to bring unique innovation first in Granulomatosis with Polyangiitis market.

However, growth of the Granulomatosis with Polyangiitis market may be hindered due to no single animal model that has reproduced both the vasculitis and granulomatous features of Granulomatosis with Polyangiitis. Also, there are no diagnostic criteria. The disease remains difficult to diagnose due to the generalized symptomatic presentation of Granulomatosis with Polyangiitis patients. Moreover, Granulomatosis with Polyangiitis is still a severe disease with a high risk of relapse. People with Granulomatosis with Polyangiitis need regular check-ups. The medications used to treat Granulomatosis with Polyangiitis have potentially serious side effects, such as lowering your body's ability to fight infection, cardiovascular diseases, cerebrovascular diseases, glucose intolerance, and potential bone loss (osteoporosis), among others.

Scope of the Granulomatosis with Polyangiitis Market Insight Report 

• Geography Covered: The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. 
• Study Period: 3-year historical and 10-year forecasted analysis (2018-2030).
• Granulomatosis with Polyangiitis Markets Segmentation: By Geographies and By Granulomatosis with Polyangiitis Therapies (Historical and Forecasted, Current and Upcoming) 
• Dominant Market Companies investigating its candidates for Granulomatosis with Polyangiitis: Biogen Idec, Genentech, ChemoCentryx, InflaRx GmbH, Bristol-Myers Squibb, GlaxoSmithKline, and several others. 
• Analysis: Comparative and conjoint analysis of emerging therapies. 
• Case Studies
• KOL's Views
• Analyst's View

Request for a Webex demo of the report @ Granulomatosis with Polyangiitis Therapeutics Market

Table of Contents 

Browse full report with detailed TOC with charts, figures, tables @ Granulomatosis with Polyangiitis Diagnostics Market Report

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SOURCE DelveInsight Business Research, LLP