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HPG: Nuevo avance en la inactivación de virus con catequina de té verde (EGCg)
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News provided by

HPG Co., Ltd.

Feb 15, 2022, 21:32 ET

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TOKIO, 16 de febrero de 2022 /PRNewswire/ -- HPG Co., Ltd. (Chuo-ku, Tokio) ha desarrollado con éxito una tecnología de formulación soluble en agua de catequina EGCg (galato de epigalocatequina) altamente concentrada con excelente estabilidad de almacenamiento e inició procedimientos para una solicitud de patente para la tecnología para estabilizar el producto en una alta concentración en solución acuosa.

La catequina EGCg del té verde tiene efectos inactivadores contra los virus. Sin embargo, tiene un fuerte efecto antioxidante y es altamente susceptible al deterioro oxidativo y carece de estabilidad durante el almacenamiento. La nueva formulación supera este problema al estabilizar una alta concentración en agua y evita que el virus ingrese a las células al unirse a proteínas virales contra varios virus que mutan repetidamente, como la influenza y los nuevos coronavirus. Está estabilizado a una alta concentración de 10.000 ppm y la concentración se puede ajustar fácilmente por dilución. Todos los componentes son aditivos alimentarios comestibles y pueden ser tomados por personas de todas las edades para el cuidado bucal.

Además, casi no se daña el sabor, el aroma o el color original de los productos existentes debido a la astringencia, el amargor o la decoloración peculiares de la catequina EGCg, y el producto se puede utilizar en una variedad de campos. Dado que es altamente efectivo contra bacterias y virus, puede usarse como sustituto de los desinfectantes de manos a base de alcohol en la cocina, la manipulación de alimentos y como medida preventiva contra la gripe humana y aviar y porcina.

- Efecto de inactivación del componente sobre varios virus de la gripe.

Este componente inhibió la adsorción de partículas de virus en las células o el proceso de entrada contra cuatro cepas de virus de gripe A y B. El ensayo de reducción de placa in vitro se realizó utilizando células MDCK (riñón canino de Madin-Darby) y se demostró que el galato de epigalocatequina (EGCg), una catequina del té verde, tiene un efecto antiviral al inhibir la adsorción del galato de epigalocatequina en las células durante el proceso de replicación del virus.

Métodos y resultados:
https://kyodonewsprwire.jp/prwfile/release/M106999/202202026950/_prw_PA3fl_Mn8vh4H6.pdf

- Efecto de inactivación del componente sobre el nuevo coronavirus y el virus del SARS

Detalles:
https://kyodonewsprwire.jp/prwfile/release/M106999/202202026950/_prw_PA2fl_rSucAig1.pdf

Se ha confirmado que EGCg a una baja concentración de 10 ppm tiene cierto efecto inhibitorio sobre el coronavirus humano (HCoV-229E), que es un pariente cercano del SARS-CoV-2 y causa síntomas de resfriado en humanos, a través de los efectos sinérgicos de inactivación directa e inhibición de la adsorción.

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