Huntington's Disease Treatment Market to 2023 - Focus on the $1.5 Billion Market with Breakdown of Key Players and Therapeutics

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Nov 09, 2018, 08:15 ET

DUBLIN, Nov. 9, 2018 /PRNewswire/ --

The "Huntington's Disease Treatment Market Size, Share & Trends Analysis Report By Treatment (Symptomatic Therapy, Disease-modifying Therapy), By Major Markets, And Segment Forecasts, 2018 - 2023" report has been added to ResearchAndMarkets.com's offering.

The global huntington's disease treatment market size is expected to be valued at USD 1.5 billion by 2023, registering a CAGR of 38.2% during the forecast period.

The market is largely driven by factors such as rapid uptake of disease-modifying therapies, increased adoption of novel therapeutics, and increase in R&D activities.

Huntington's disease is an inherited neurodegenerative disorder characterized by a combination of motor, cognitive, and psychiatric symptoms. Currently, only two symptom-alleviating therapies are specifically approved for this disorder: Xenazine and Austedo. Off-label medications are used extensively due to lack of approved alternatives.

The pipeline for Huntington's disease is expected to witness rapid developments in the coming years as disease-modifying drugs transform the market landscape. Improved disease understanding has led to significant progress in the development of therapeutic approaches aimed at modifying specific changes linked to the causative mutation. The potential role of RNA antisense technology and stem cell therapy are under active clinical investigation. Wave Life Sciences and Ionis Pharma's antisense oligonucleotides aim to target underlying disease cause and are expected to contribute significantly to market growth.

Further key findings from the report suggest:

Teva is projected to become the market leader, capturing more than 45% of the market in 2023, driven by Austedo's rapid uptake and improved efficacy profile compared to its competitors. Teva's Huntexil is expected to be the only new symptom-alleviating drug to be launched during the forecast period
Raptor's RP103 is expected to face head-to-head competition from Prana Biotech's Phase II drug PBT2 to be the first disease modifying therapy to be launched in the market
Currently, 23 products are under clinical investigation for Huntington's disease, out of which, one is in Phase II/III each, thirteen in Phase II trials, two in Phase Ib/IIa, six in pre-clinical trials, and one in discovery phase
EU5 will remain the second largest market with more than 15% share in 2023, driven by rising disease prevalence, novel drug launches, and increase in R&D activities
Companies are now focusing on development of treatments that can be injected directly in the brain to directly inhibit the formation of mutant HTT protein, instead of targeting the mutant protein
Drugs with novel targets in early-phase development include Stealth Biotherapeutics' SBT-20 (mitochondria-targeted cytoprotective peptide), Cellavita + Azidus Brazil's Cellavita HD (stem cell therapy), Sangamo/ Shire's mHTT ZFP (zinc finger protein), and UniQure's AMT-130 (gene therapy).

Key Topics Covered:

Chapter 1 Research Methodology
1.1. Information procurement
1.2. Information or Data Analysis
1.2.1. Market Formulation & Validation

Chapter 2 Executive Summary

Chapter 3 Disease Primer and Epidemiology
3.1 Disease Primer
3.1.1 Molecular Biology and Genetics of Huntington Disease (HD)
3.1.2 Signs and Symptoms
3.1.3 Biomarkers
3.1.4 Current Prevalence and Incidence Rate for Seven Major Markets (U.S., Japan, EU5)

Chapter 4 Global Huntington's Disease Treatment Market Overview
4.1 Therapeutic Classes for HD
4.2 Market, by Treatment
4.3 Sales Performance, by Treatment (2017 - 2023)
4.3.1 Symptomatic Therapy
4.3.2 Disease - Modifying Therapy
4.4 Market, by Mode of Administration
4.5 Market Size and Forecast (2017 - 2023)
4.6 Market Size and Forecast, by Seven Major Markets (2017 - 2023)
4.7 Market Share Distribution, by Company (2017 - 2023)
4.8 Market Dynamics and Brand Strategies
4.9 Patent Expiry Analysis
4.10 Huntington's Disease Treatment Market: Drivers and Restraints
4.11 M&A, Deal Landscape (2013 - 2018 YTD)
4.12 Pricing and Reimbursement Scenario
4.13 Huntington's Disease Sector SWOT

Chapter 5 Huntington's Disease Treatment Market: Pipeline Intelligence
5.1 Pipeline Landscape
5.1.1 Leading Drugs in Development
5.2 Key R&D Trends
5.2.1 Gene Therapy
5.2.1.1 Antisense Oligonucleotides (ASO)
5.2.1.2 Gene Therapy with miRNAs
5.2.1.3 mRNA Splicing (Splicing Interference)
5.2.1.4 Zinc - Finger DNA Binding Protein (ZFP)
5.2.2 Stem Cell Therapy
5.2.3 Small Molecules
5.3 Pipeline Landscape
5.3.1 Late Stage Pipeline Drugs
5.4 Clinical Profiles of Disruptive Drugs
5.5 Global Pipeline Forecast

Chapter 6 Company Profiles
6.1 Valeant Pharmaceuticals
6.1.1 Company Overview
6.1.2 Product Portfolio - Xenazine (tetrabenazine)
6.1.3 Product Forecast Sales through 2023
6.2 Teva Pharmaceuticals
6.2.1 Company Overview
6.2.2 Product Portfolio - Austedo (deutetrabenazine)
6.2.3 Product Forecast Sales through 2023
6.2.4 Strategic Initiatives
6.2.4.1 Key Company News Flow
6.2.5 Pipeline Analysis and Overview
6.2.5.1 Catalysts and Event Calendar
6.2.6 SWOT
6.3 Ionis Pharmaceuticals
6.3.1 Company Overview
6.3.2 Product Portfolio - IONIS - HTTRx/ RG6042
6.3.3 Product Forecast Sales through 2023
6.3.4 Strategic Initiatives
6.3.4.1 Key Company News Flow
6.3.4.2 Catalysts & Events Calendar
6.3.5 SWOT
6.4 Wave Life Sciences
6.4.1 Company Overview
6.4.2 Product Portfolio - WVE - 120101 and WVE - 120102
6.4.3 Product Forecast Sales through 2023
6.4.4 Strategic Initiatives
6.4.4.1 Key Company News Flow
6.4.4.2 Catalysts & Events Calendar
6.4.5 SWOT
6.5 Horizon Pharma
6.5.1 Company Overview
6.5.2 Product Portfolio - Procysbi (RP103)
6.5.3 Product Forecast Sales through 2023
6.5.4 Strategic Initiatives
6.5.4.1 Key Company News Flow
6.5.5 SWOT
6.6 Prana Biotech
6.6.1 Company Overview
6.6.2 Product Portfolio - PBT2
6.6.3 Product Forecast Sales through 2023
6.6.4 Strategic Initiatives
6.6.4.1 Key Company News Flow
6.6.5 SWOT

Chapter 7 Market Outlook
7.1. What the Future Holds
7.2. The Winners and Losers
7.2.1. Winners
7.2.2. Losers
7.3. Emerging Companies/New Technology Platforms
7.3.1. Vaccinex
7.3.2. UniQure
7.3.3. Stealth BioTherapeutics
7.3.4. Azevan Pharmaceuticals
7.3.5. Voyager Therapeutics
7.3.6. Sangamo/ Shire
7.4. The Road Ahead

For more information about this report visit https://www.researchandmarkets.com/research/k8fqn6/huntingtons?w=5

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