Jak-STAT Signaling Pathway in Oncology Drug Pipeline Update 2015

Jul 20, 2015, 10:15 ET from Reportlinker


NEW YORK, July 20, 2015 /PRNewswire/ -- The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors.


There are today 317 companies plus partners developing 433 Jak-STAT signaling pathway targeting drugs in 1172 developmental projects in cancer. In addition, there are 7 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 137 drugs. Jak-Stat Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 196 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 186 out of the 189 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 41 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.



How May Drug Pipeline Update Be of Use?

* Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.



Drug Pipeline Update at a Glance

Investigators


Includes more than 317 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.



Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.



Drug name & Synonyms

Lists commercial, generic and code names for drugs.



Developmental stage

This Drug Pipeline Update contains 433 Jak-STAT signaling pathway targeting drugs in development, which have a total of 1172 developmental projects in cancer. In addition there are suspended and ceased drugs.



Pipeline Breakdown According to Number of Drugs

Marketed# 104


Pre-registration# 3


Phase III# 39


Phase II# 98


Phase I# 123


Preclinical# 227


No Data# 10


Suspended# 7


Ceased# 137



Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.



Indications


Included Jak-STAT signaling pathway targeting drugs are also in development for 224 other indications, where of 111 are different cancer indications.



Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.



Targets


Mutations


All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 186 out of the 189 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.



Biological Structures


The identity of available biological structures on 160 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3291 structures available today among drug targets.



Identified drugs are linked to more than 196 different targets, divided into 41 classifications of molecular function:


- Antigen binding


- Catalytic activity


- Cell adhesion molecule activity


- Chromatin binding


- Cysteine-type peptidase activity


- Cytokine activity


-


- Deacetylase activity


- DNA binding


- DNA repair protein


- DNA topoisomerase activity


- Extracellular matrix structural constituent


- G-protein coupled receptor activity


- Growth factor activity


- Helicase activity


- Hydrolase activity


- Isomerase activity


- Kinase activity


- Kinase binding


- Kinase regulator activity


- Ligand-dependent nuclear receptor activity


- Lipid kinase activity


- Metallopeptidase activity


- Molecular function unknown


- Oxidoreductase activity


- Protein binding


- Protein serine/threonine kinase activity


- Protein threonine/tyrosine kinase activity


- Protein tyrosine phosphatase activity


- Protein-tyrosine kinase activity


- Receptor activity


- Receptor binding


- Receptor signaling complex scaffold activity


- Receptor signaling protein serine/threonine kinase activity


- Serine-type peptidase activity


- Structural constituent of cytoskeleton


- Transcription factor activity


- Transcription regulator activity


- Translation regulator activity


- Transmembrane receptor activity


- Transmembrane receptor protein tyrosine kinase activity


- Transporter activity



Sub-Cellular Localization


Identified targets are categorized into 26 different primary and alternate sub-cellular localizations:


- Basolateral membrane


- Cell junction


- Cell surface


- Centrosome


- Chromosome


- Clathrin-coated vesicle


- Cytoplasm


- Cytoskeleton


- Cytosol


- Endoplasmic reticulum


- Endosome


- Extracellular


- Golgi apparatus


- Integral to membrane


- Kinetochore


- Lysosome


- Membrane fraction


- Mitochondrial membrane


- Mitochondrion


- Nuclear membrane


- Nucleolus


- Nucleus


- Perinuclear region


- Plasma membrane


- Secreted


- Secretory granule



Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.



Target Expression Profile


Direct links are provided from inside the application to 274 protein expression profiles of 172 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:


- 48 different normal tissue types


- 20 different types of cancer


- 47 cell lines


- 12 samples of primary blood cells



Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.


- BioCarta# 230 Pathways


- KEGG# 167 Pathways


- NCI-Nature# 245 Pathways


- NetPath# 32 Pathways



Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.



Mechanism


In total there are different drug mechanism of action represented in this Drug Pipeline Update.



Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.



Compound


Identified drug compounds are described by:



Compound type, Chemical name, CAS Number and molecular weight



Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.



Drug Profile


Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:



Drug Name & Synonyms

Presentation of drug name and synonyms



Principal Company & Partners

Presentation of principal company and partners



Target and Molecular Function of Target

Described target(s) is/are presented with:


Official Gene Symbol – Chromosome Location – Gene & Protein Name – Molecular Function



Target Localization

Described target(s) is/are presented with primary and alternate localizations.


Target Expression Profiles


Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:


48 different normal tissue types


20 different types of cancer


47 cell lines


12 samples of primary blood cells



Mutation


All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.



Biological Structures


The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.



Targeted Pathways


Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.



Mechanism


Drug mechanism of action



Developmental Projects


Summary field of developmental projects for the drug, including indication, developmental stage and status.


Example:


Cancer, myeloma – Phase II Clinical Trial – Active


Cancer, prostate – Phase III Clinical Trial – Ceased



Drug Description


Short introduction to drug



Compound Data


Compound type, Chemical name, CAS Number and molecular weight



Patent Data


Available patent information related to the drug is presented here.



Fillings and Approvals


Approvals and submissions


Analyst comments



Deals & Licensing


Collaborations and deals


Availability for licensing



Phase IV Data


Available Phase IV development data, developmental history and scientific data.



Phase III Data


Available Phase III development data, developmental history and scientific data.



Phase II Data


Available Phase II development data, developmental history and scientific data.



Phase I Data


Available Phase I development data, developmental history and scientific data.



Phase 0 Data


Available Phase 0 development data, developmental history and scientific data.



Preclinical Data


Available preclinical development data, developmental history and scientific data.



Discovery Data


Available discovery development data, developmental history and scientific data.



Application Features


Search, Find and Filter Panel with Initial Result Presentation


With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.




The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.



Direct linkage from inside the application to related internet resources


- Drug data is linked to search engines like Google and PubMed


- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.


- Direct links to company web pages of companies



Dynamic Report Generator


Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.






System Requirements


- Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online


- Browser Application (Internet Explorer, Firefox, Chrome, Safari)


- Internet access (to access related internet resources)


Read the full report: http://www.reportlinker.com/p01105902-summary/view-report.html

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