Kyowa Hakko USA: New Narrative Review Highlights the Power of Setria® Glutathione and Citrulline for Better Blood Flow and Performance

The conclusions of the narrative review offer a promising nutritional strategy for athletes, older adults, and individuals seeking cardiovascular support.

NEW YORK, Oct. 2, 2025 /PRNewswire/ -- A newly published review in the Journal of Exercise and Nutrition sheds light on a powerful combination for athletes and active individuals: Kyowa Hakko USA's Setria^® Glutathione and citrulline. The review, titled "Optimizing Nitric Oxide Production for Exercise Performance and Vascular Function: A Narrative Review on the Combination of Glutathione and Citrulline," emphasizes how this pairing supports improved nitric oxide production, which is vital for circulation, vascular health, and exercise performance.

Often called the body's "master antioxidant," glutathione is essential for protecting cells, supporting detoxification, and maintaining immune strength. But beyond baseline wellness, its role in active nutrition and sports performance is gaining new recognition. According to this 2025 review, the synergy between glutathione and citrulline has been shown to amplify nitric oxide pathways, with significant benefits for exercise capacity and vascular health.

The review highlights four human clinical trials demonstrating:

• Improved nitric oxide production and bioavailability
• Enhanced blood flow and vascular function
• Possible benefits for exercise performance and recovery
• The unique role of Setria^® Glutathione in optimizing these outcomes

Glutathione has long been recognized as the body's "master antioxidant," essential for overall health by protecting cells, supporting detoxification, and maintaining a strong immune system. However, according to Katie Emerson, MS, RD, CISSN, its benefits go well beyond basic wellness, as it also plays a role in active nutrition and sports performance. This narrative review highlights four human clinical trials showcasing the benefits of Setria^® glutathione when combined with citrulline. "This is where science meets innovation, and it's a must-read for anyone looking to optimize their health and performance," said Emerson.

The publication further strengthens the growing body of evidence supporting glutathione's role not only in immune and detoxification pathways, but also in advanced sports and vascular nutrition applications.

The full article is available in the Journal of Exercise and Nutrition, ensuring that this valuable information is accessible to all. Read the abstract here.

About the Author:
Katie Emerson, MS, RD, CISSN is a registered dietitian and nutrition professional with specialized expertise in sports nutrition and dietary supplementation. With extensive experience working with collegiate athletes, first responders, and other high-performance populations, Emerson has developed a strong foundation in optimizing health, recovery, and performance through evidence-based nutrition strategies. Currently pursuing a PhD in Health Sciences with a concentration in exercise and human performance, Emerson combines academic research with practical field experience to advance the understanding of how nutrition and supplementation influence performance outcomes. Passionate about bridging science and practice, Emerson continues to contribute to the growing body of knowledge in sports nutrition and human performance as the senior manager of scientific affairs at Kyowa Hakko USA.

About Setria:
Setria^® Glutathione, manufactured by Kyowa Hakko Bio Co., Ltd., is a clinically studied and patented form of glutathione that, when taken orally, has been shown to replenish the body's reserves, which may be depleted as a result of poor lifestyle choices, stress, or natural aging. Called the "master antioxidant," glutathione helps protect cells in the body from the damaging effects of oxidative stress and toxins. Setria^® Glutathione is manufactured through a patented fermentation process to yield high purity and high quality, is non-GMO, vegetarian and allergen-free. For more information, visit http://www.SetriaGlutathione.com.

About Kyowa Hakko USA:
Improving Lives with Health Science
Kyowa Hakko USA serves as the North and South American headquarters for Kyowa Hakko Bio Co., Ltd., a global pioneer in specialty ingredients within Kirin Holdings' Health Science group. Building on over 75 years of fermentation innovation and Kirin's 100+ year legacy of fermentation excellence, Kyowa delivers premium, science-backed branded ingredients to the nutraceutical, pharmaceutical, functional food, beverage and wellness industries. The portfolio features branded solutions like Cognizin^® Citicoline, Setria^® Glutathione, Pantesin^® Pantethine and Eyemuse^™

 Lacticaseibacillus paracasei KW3110. Committed to quality, sustainability, and creating shared value, Kyowa empowers partners to create transformative health solutions, advancing Kirin's vision of improving health and well-being. For more information, visit http://www.kyowa-usa.com/.

SOURCE Kyowa Hakko U.S.A