Microfluidics: Technologies and Global Markets

Jan 30, 2013, 05:13 ET from Reportlinker

NEW YORK, Jan. 30, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Microfluidics: Technologies and Global Markets

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REPORT SCOPE INTRODUCTION

Microfluidics is a set of technologies that deal with the movement of small amounts of fluid. The field has been developing for more than two decades, but most of the early development, while intense, was in isolated modules. More recently, scientists have been putting the pieces together into systems, leading to new applications and rapid market growth.

STUDY GOALS AND OBJECTIVES

This report covers the major markets and applications for microfluidics-based products and technologies. The current state of the market as defined is assessed, and projections for growth and advancements in technology along with market trends are detailed.

The major objectives of this report are:

• To provide a thorough evaluation of the technical and business environment surrounding the emerging microfluidic systems market.

• To review the technologies, the related sub-technologies and alternative technologies in light of the emerging needs of the relevant markets.

• To examine the current and potential applications of microfluidic technologies and assess their importance in the context of emerging market paradigms.

• To describe the spectrum of microfluidics-related products currently on the market and in development.

• To provide an overview of the current microfluidics market in terms of scale and competitive structure.

• To assess the future of the microfluidics market in terms of growth potential for various product and application segments.

• To examine the trends that will shape the future of microfluidics technologies and markets, and to examine their impacts.

REASONS FOR DOING THE STUDY BCC published its last survey of the microfluidics industry in 2006. Since then, microfluidics products and applications on the market and under development have grown and diversified rapidly.

In addition to the resulting business opportunities, microfluidics is a key enabler of micro-synthesis, micro-separations and labs-on-a-chip. It is expected that microfluidics will continue to revolutionize the fields of chemistry and biology, speed the development of new drugs and methods for administering them, and improve the cost/performance ratio of computers and other electronic devices, to name but a few of the possibilities. Thus, BCC believes that the time is right to re-examine this important market.

INTENDED AUDIENCE The report is intended especially for entrepreneurs, investors, venture capitalists and other readers with a need to know where the microfluidics market is headed in the next five years. Other readers who should find the report particularly valuable include MEMS marketing executives and government officials associated with the National Nanotechnology Initiative and other state-level programs to promote the development of the nanotechnology injury. The report's findings and conclusions should also be of interest to the broader nanotechnology community.SCOPE AND FORMAT This report addresses the global market for microfluidics devices and applications, from 2011 (base year) through 2017. Microfluidic devices are defined, in general terms, as devices that handle very small (e.g., micro- or nanoliter) volumes of fluids.

The study format includes the following major elements:• Executive summary.• Definitions.• Microfluidic components and systems.• Microfluidic fabrication technologies• Major end-user markets and applications.• Global microfluidic market trends, 2011–2017.• Industry structure, market shares and ownership trends.• Factors that will influence the long-term development of microfluidic technologies.

METHODOLOGY AND INFORMATION SOURCES

Projecting the market for emerging technologies such as microfluidic technologies, whose commercial potential has not yet been proven, is a challenging task. This report uses a multi-phase approach to identify the technologies with the greatest commercial potential and quantify the market for these applications, as described below.In the first phase of the analysis, we identified a "long list" of microfluidic technologies (including technologies that are still under development) and mapped them against potential applications and end-user industries, such as life sciences research, drug discovery and medical diagnostics.In the second phase, we eliminated those technologies that appear to have little likelihood of making it into commercial production in the next five years, through a literature review and statements by industry sources. The result of phase two was a "short list" of technologies and applications with the greatest near- to mid-term commercial potential.The third phase focused on quantifying the potential market for each short-listed technology and application and identifying the main prerequisites for commercial success. Various methodologies and data sources were used to develop the market projections, including trend line projections, input-output analysis and estimates of future demand from industry sources.

AUTHOR'S CREDENTIALS

This report is partially based on an earlier (2004) report prepared by Maura Lane, a BCC analyst with over 15 years of experience conducting technology and market assessments in the chemical, pharmaceutical and biotechnology industries. The analyst responsible for updating the report is Andrew McWilliams, a partner in the Boston-based international technology and marketing consulting firm, 43rd Parallel LLC. Mr. McWilliams is the author of a number of other BCC studies, including a previous (2006) update of Ms. Lane's report, as well as a number of other microfluidics-related studies such as SMC051C Microelectromechanical Systems (MEMS) Technology: Current and Future Markets; NAN035A Nanosensors; IAS027B MEMS: Biosensors and Nanosensors; and HLC016D Microelectronic Medical Implants: Products, Technologies and Opportunities.

REPORT HIGHLIGHTS

This report provides:• An overview for the global market for microfluidic technologies, which deal with the movement of small amounts of fluids• Analyses of global market trends, with data from 2011 and 2012, and projections of compound annual growth rates (CAGRs) through 2017• A thorough evaluation of the technical and business environment surrounding the emerging microfluidic systems market• Examination of the current and potential applications of the technologies and an assessment of their importance in the context of emerging market paradigms• The trends that will shape the future of microfluidic technologies and markets, and their impact• A patent analysis for new and emerging technologies• Comprehensive company profiles of major players in the industry.

TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 1

STUDY GOALS AND OBJECTIVES 1REASONS FOR DOING THE STUDY 1INTENDED AUDIENCE 2SCOPE AND FORMAT 2METHODOLOGY AND INFORMATION SOURCES 2AUTHOR'S CREDENTIALS 3RELATED BCC PUBLICATIONS 3BCC ON-LINE SERVICES 3DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES,THROUGH 2017 ($ MILLIONS) 6SUMMARY FIGURE GLOBAL MARKET FOR MICROFLUIDIC TECHNOLOGIES, 2011–2017 ($MILLIONS) 6

CHAPTER 3 OVERVIEW 9

DEFINITIONS 9MICROFLUIDICS 9MEMS 9BASIC CONCEPTS IN MICROFLUIDICS 9GENERAL 9WHAT IS A MICROFLUIDIC DEVICE? 10BASIC PRINCIPLES OF MICROFLUIDICS 11Pressure Driven Flow 11Electrokinetic Flow 11Passive Fluid Control Technology 11FIGURE 1 PASSIVE MICROFLUIDIC VALVE 12Chemical Control 12Hydrogels 12Colloidal Microspheres 13FINITE ELEMENT MODELING IN FLUID MECHANICS 13The Utility of Modeling 13Phase Phenomena 14TABLE 1 DESIGN OF MICROFLUIDIC DEVICES: PHASE PHENOMENA CONSIDERATIONS 14Heat Removal 14Bimetallic Actuation 15SURFACE CHEMISTRY 15Substrate Factors 15Surface Coatings 16Hydrophilic Material 16FIGURE 2 THE HYDROPHILIC EFFECT IN MICROFLUIDIC CONDUITS 16Hydrophobic Material 16FIGURE 3 THE HYDROPHOBIC EFFECT IN MICROFLUIDIC CONDUITS 16Surface Finish 17DIFFUSION BONDING 18"MICROJAWS" FOR GENETIC ENGINEERING AND THERAPEUTICS 18TABLE 2 DESIGN OF MICROFLUIDIC DEVICES: ACTUATION PRINCIPLES ANDAPPLICATIONS 19MICROFLUIDIC COMPONENTS 19TYPES OF MICROFLUIDIC COMPONENTS 19Microchannels 19Micropumps 20Mechanical Micropumps 20Piezoelectric Pumps 20Pneumatic Pumps 20Thermopneumatic Pumps 20Electrostatic Pumps 21Non-mechanical Pumps 21Capillary Pumps 21Electrohydrodynamic Pumps 21Electrokinetic Pumps 21Magneto-hydrodynamic Pumps 21Phase Difference Pumps 22Micronozzles 22Microvalves 22Passive Microvalves 22Active Microvalves 22Micromixers 23Active Mixers 23SAW Mixers 23Magneto-hydrodynamic Mixers 23Passive Mixers 23Microreactors 23MICROFLUIDIC SYSTEMS 24FABRICATION OF MICROFLUIDIC COMPONENTS AND SYSTEMS 24SENSORS 24ACTUATORS 25MICROSTRUCTURES 25MICROSYSTEMS 25Construction 26MICROMACHINING 26Photolithography 27Thin Films 27Wet Etching 27Dry Etching 28Surface Micromachining 28Laser Micromachining 29LIGA 29HexSil 29Photopolymerization Process 29FEATURES OF MICROSYSTEMS 30HYBRID MICROSYSTEMS 30BioMEMS 31CORIOLIS MASS FLOW TECHNOLOGY 31MATERIALS OF CONSTRUCTION 32Silicon 32PDMS and Silicone Elastomers 32Polyimide 33TABLE 3 FABRICATION TECHNIQUES FOR MICROFLUIDIC DEVICES 33RELATED TECHNOLOGY CONSIDERATIONS 33EDM 34Fluidic Driving Force 34MAJOR END-USER MARKETS 35HIGH-THROUGHPUT SCREENING (HTS) AND COMPOUND PROFILING 35DIAGNOSTIC AND POINT-OF-CARE (POC) 35INKJET PRINTING 35CHEMICAL ANALYSIS 35DRUG DELIVERY/MEDICAL 36PROTEOMICS 36DEFENSE AND PUBLIC SAFETY 36

CHAPTER 4 MICROFLUIDIC MARKET BY END-USER SEGMENTS 38

OVERVIEW 38TABLE 4 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, THROUGH2017 ($ MILLIONS) 38FIGURE 4 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, 2011–2017 ($MILLIONS) 39HIGH-THROUGHPUT SCREENING AND COMPOUND PROFILING 40INTRODUCTION 40APPLICATIONS 40DNA Analysis 40Assays 41Compound Libraries 41Lab Automation 41MARKET FORECAST 42TABLE 5 GLOBAL MARKET FOR MICROFLUIDIC DEVICES IN HTS/COMPOUND SCREENING,THROUGH 2017 ($ MILLIONS) 42MAJOR MANUFACTURERS AND MARKET SHARES 42TABLE 6 HTS/COMPOUND PROFILING COMPANIES, GLOBAL MARKET SHARE, 2011 (%) 43FIGURE 5 HTS/COMPOUND PROFILING COMPANIES, GLOBAL MARKET SHARE, 2011 (%) 43Tecan 43Caliper Life Sciences 44Gamidor Diagnostics Ltd. 44CLINICAL DIAGNOSTICS/POC TESTING 45OVERVIEW 45Acceptance of Technology 45APPLICATIONS 46Animal Healthcare Applications 46MARKET FORECAST 47TABLE 7 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS IN POC DIAGNOSTICDEVICES, THROUGH 2017 ($ MILLIONS) 47MAJOR MANUFACTURERS AND MARKET SHARES 48FIGURE 6 MICROFLUIDICS-BASED POC DIAGNOSTIC TEST MARKET SHARES, 2011 (%) 48Abaxis 49Abbott Laboratories 49Alere Inc. 50Gyros AB 50HandyLab (now Becton Dickinson & Co.) 51Maxwell Sensors 51INKJET PRINTING 52OVERVIEW 52APPLICATIONS 52Inkjet Printer Applications 52New Applications of Inkjet Technology 53Biochip Production 53Flat Panel Displays 53Printable Electronics 54Other Applications 54MARKET FORECAST 54TABLE 8 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET HEADS BY APPLICATION,THROUGH 2017 ($ MILLIONS) 54Inkjet Printers 55TABLE 9 MARKET FORECAST FOR DISPOSABLE INKJET CARTRIDGE SHIPMENTS, THROUGH2017 (MILLION UNITS) 55TABLE 10 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET PRINTER HEADS,THROUGH 2017 ($ MILLIONS) 56Biochip Production Equipment 56TABLE 11 GLOBAL MARKET FORECAST FOR BIOCHIP SHIPMENTS, THROUGH 2017 ($BILLIONS) 56TABLE 12 GLOBAL MARKET FOR MICROFLUIDIC MEMS USED IN BIOCHIP PRODUCTION,THROUGH 2017 ($ MILLIONS) 57Flat Panel Display Fabrication 57TABLE 13 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN FLAT PANELDISPLAY PRODUCTION, THROUGH 2017 ($ MILLIONS) 58Printed Organic Electronics 58TABLE 14 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN PRODUCTIONOF OTHER PRINTABLE ORGANIC ELECTRONICS, THROUGH 2017 ($ MILLIONS) 58MANUFACTURERS AND MARKET SHARES 58FIGURE 7 GLOBAL MICROFLUIDIC INKJET MARKET SHARES, 2011 (%) 59Hewlett-Packard Co. 59Seiko Epson Corp. 60Agilent Technologies Inc. 60Litrex Corp. 61CHEMICAL ANALYSIS AND SYNTHESIS 61OVERVIEW 61APPLICATIONS 62Chemical Analysis 62Micro-Total Analysis Systems 62Chemical Synthesis 62MARKET FORECAST 63TABLE 15 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SYSTEMS, THROUGH 2017 ($MILLIONS) 63Chemical Analysis 63TABLE 16 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SENSORS, THROUGH 2017 ($MILLIONS/%) 64Chemical Synthesis 64MANUFACTURERS 64Ehrfeld Mikrotechnik BTS GmbH 65CompactGTL PLC 65Global Hydrogen Inc. 65DRUG DELIVERY/MEDICAL APPLICATIONS 65OVERVIEW 65APPLICATIONS 66MARKET FORECAST 66TABLE 17 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DRUG PUMPS, THROUGH 2017($ MILLIONS/%) 66MANUFACTURERS AND MARKET SHARES 66FIGURE 8 IMPLANTABLE DRUG PUMP MARKET SHARES, 2011 (PERCENTAGE OF TOTALSEGMENT SALES) 66ISSYS 67Debiotech SA 68PROTEOMICS 68OVERVIEW 68APPLICATIONS 69High-Pressure Liquid Chromatography 69Tabletop Nano-LC Systems 69Chip-Based Systems 70Microfluidic Chip-based Immunoassays 70"Rotating Chip" Immunoassay 70MARKET FORECAST 71TABLE 18 GLOBAL MARKET FORECAST FOR MICROFLUIDIC PROTEOMICS SYSTEMS,THROUGH 2017 ($ MILLIONS) 71MANUFACTURERS AND MARKET SHARES 71FIGURE 9 MICROFLUIDIC DEVICES FOR PROTEOMICS APPLICATIONS, MARKET SHARES,2011 (%) 71Bio-Rad Laboratories 72Advion Inc. 72Agilent Technologies Inc. 72Dionex Corp. 73Gyros AB 73Life Technologies Corp. 73Biacore Life Sciences 73DEFENSE AND PUBLIC SAFETY 74OVERVIEW 74APPLICATIONS 74MARKET FORECAST 74TABLE 19 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN CBW SENSORS,THROUGH 2017 ($ MILLIONS) 75OTHER 75DISPENSING 75Applications 75Positive-Displacement Pumps 76Pin Arrays 76Aerosol Systems 76Market Forecast 77TABLE 20 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DISPENSING DEVICES,THROUGH 2017 ($ MILLIONS) 77NEW APPLICATIONS 77Electronic Cooling 77Fuel Cells 78Food Quality Testing 78

CHAPTER 5 MICROFLUIDICS COMPANIES 80

TABLE 21 MICROFLUIDICS COMPANIES 80AGILENT TECHNOLOGIES 82CALIPER LIFE SCIENCES 83LABCHIP SYSTEM 83CEPHEID 84SMARTCYCLER 84EKSIGENT TECHNOLOGIES 85NANOLC 85EKPUMP 85FIGURE 10 PRINCIPLE OF EKPUMP 86NANOFLOW 86FLUIDIGM 87GAMIDOR DIAGNOSTICS LTD. 87GYROS MICROLABS 88HEWLETT-PACKARD 88INTELLIGENT MICRO PATTERNING LLC 89INTELLISENSE SOFTWARE 90MICRALYNE INC. 90MICROFLUIDIC TOOLKIT 91MICROCHIPS 91MICROFLUIDIC SYSTEMS INC. 92MICRONICS 92ORCHID CELLMARK 93SRU BIOSYSTEMS 93TECAN 93

CHAPTER 6 MICROFLUIDICS DEALS 96

INTELLECTUAL PROPERTY CONSIDERATIONS 96RECENT DEALS 97TABLE 22 SELECTED MICROFLUIDICS-RELATED DEALS, 1999-2011 97NOTABLE DEALS BY YEAR 1011999 1012000 1022001 1032002 1072006 1072008 1082009 1082010 1082011 108

CHAPTER 7 PATENT LANDSCAPE (DEVELOPMENTS SINCE 1999) 111

INTRODUCTION 111TRENDS BY COUNTRY 111TRENDS BY ASSIGNEE 111FIGURE 11 SHARES OF U.S. PATENTS BY ASSIGNEE, JAN. 1, 1999 THROUGH NOV. 30, 2012(%) 111TABLE 23 COMPANIES AND INSTITUTIONS WITH THE GREATEST NUMBER OFNANOFLUIDICS-RELATED PATENTS, JAN. 1, 1999 THROUGH NOV. 30, 2012 112TRENDS BY EMPHASIS: PRODUCTION VERSUS APPLICATION 112FIGURE 12 SHARES OF PATENTS ISSUED BY EMPHASIS, JAN. 1, 1999 THROUGH NOV. 30,2012 (%) 113

CHAPTER 8 CHALLENGES AND TRENDS IN THE MICROFLUIDICS INDUSTRY 115

TECHNICAL CHALLENGES AND DEVELOPMENTS 115MICROFLUIDICS AND NANOTECHNOLOGY 117LIST OF TABLES SUMMARY TABLE GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES,

THROUGH 2017 ($ MILLIONS) 6

TABLE 1 DESIGN OF MICROFLUIDIC DEVICES: PHASE PHENOMENA CONSIDERATIONS 14

TABLE 2 DESIGN OF MICROFLUIDIC DEVICES: ACTUATION PRINCIPLES AND APPLICATIONS 19

TABLE 3 FABRICATION TECHNIQUES FOR MICROFLUIDIC DEVICES 33

TABLE 4 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, THROUGH 2017

($ MILLIONS) 38

TABLE 5 GLOBAL MARKET FOR MICROFLUIDIC DEVICES IN HTS/COMPOUND SCREENING,

THROUGH 2017 ($ MILLIONS) 42

TABLE 6 HTS/COMPOUND PROFILING COMPANIES, GLOBAL MARKET SHARE, 2011 (%) 43

TABLE 7 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS IN POC DIAGNOSTIC

DEVICES, THROUGH 2017 ($ MILLIONS) 47

TABLE 8 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET HEADS BY APPLICATION,

THROUGH 2017 ($ MILLIONS) 54

TABLE 9 MARKET FORECAST FOR DISPOSABLE INKJET CARTRIDGE SHIPMENTS, THROUGH

2017 (MILLION UNITS) 55

TABLE 10 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET PRINTER HEADS,

THROUGH 2017 ($ MILLIONS) 56

TABLE 11 GLOBAL MARKET FORECAST FOR BIOCHIP SHIPMENTS, THROUGH 2017 ($

BILLIONS) 56

TABLE 12 GLOBAL MARKET FOR MICROFLUIDIC MEMS USED IN BIOCHIP PRODUCTION,

THROUGH 2017 ($ MILLIONS) 57

TABLE 13 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN FLAT PANEL

DISPLAY PRODUCTION, THROUGH 2017 ($ MILLIONS) 58

TABLE 14 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN PRODUCTION OF

OTHER PRINTABLE ORGANIC ELECTRONICS, THROUGH 2017 ($ MILLIONS) 58

TABLE 15 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SYSTEMS, THROUGH 2017 ($

MILLIONS) 63

TABLE 16 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SENSORS, THROUGH 2017 ($

MILLIONS/%) 64

TABLE 17 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DRUG PUMPS, THROUGH 2017 ($

MILLIONS/%) 66

TABLE 18 GLOBAL MARKET FORECAST FOR MICROFLUIDIC PROTEOMICS SYSTEMS,

THROUGH 2017 ($ MILLIONS) 71

TABLE 19 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN CBW SENSORS,

THROUGH 2017 ($ MILLIONS) 75

TABLE 20 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DISPENSING DEVICES,

THROUGH 2017 ($ MILLIONS) 77

TABLE 21 MICROFLUIDICS COMPANIES 80

TABLE 22 SELECTED MICROFLUIDICS-RELATED DEALS, 1999-2011 97

TABLE 23 COMPANIES AND INSTITUTIONS WITH THE GREATEST NUMBER OF

NANOFLUIDICS-RELATED PATENTS, JAN. 1, 1999 THROUGH NOV. 30, 2012 112

LIST OF FIGURES SUMMARY FIGURE GLOBAL MARKET FOR MICROFLUIDIC TECHNOLOGIES, 2011–2017 ($

MILLIONS) 6

FIGURE 1 PASSIVE MICROFLUIDIC VALVE 12

FIGURE 2 THE HYDROPHILIC EFFECT IN MICROFLUIDIC CONDUITS 16

FIGURE 3 THE HYDROPHOBIC EFFECT IN MICROFLUIDIC CONDUITS 16

FIGURE 4 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, 2011–2017 ($

MILLIONS) 39

FIGURE 5 HTS/COMPOUND PROFILING COMPANIES, GLOBAL MARKET SHARE, 2011 (%) 43

FIGURE 6 MICROFLUIDICS-BASED POC DIAGNOSTIC TEST MARKET SHARES, 2011 (%) 48

FIGURE 7 GLOBAL MICROFLUIDIC INKJET MARKET SHARES, 2011 (%) 59

FIGURE 8 IMPLANTABLE DRUG PUMP MARKET SHARES, 2011 (PERCENTAGE OF TOTAL

SEGMENT SALES) 66

FIGURE 9 MICROFLUIDIC DEVICES FOR PROTEOMICS APPLICATIONS, MARKET SHARES,

2011 (%) 71

FIGURE 10 PRINCIPLE OF EKPUMP 86

FIGURE 11 SHARES OF U.S. PATENTS BY ASSIGNEE, JAN. 1, 1999 THROUGH NOV. 30, 2012 (%) 111

FIGURE 12 SHARES OF PATENTS ISSUED BY EMPHASIS, JAN. 1, 1999 THROUGH NOV. 30,

2012 (%) 113

To order this report:Biotechnology Industry: Microfluidics: Technologies and Global Markets

Nicolas Bombourg
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