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New NCCN Guidelines Analyze Evidence for Cancer Type Found Almost Exclusively in Children
  • USA - English

NCCN Logo (C)NCCN(R) 2018. All rights reserved.

News provided by

National Comprehensive Cancer Network

Feb 17, 2021, 08:35 ET

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National Comprehensive Cancer Network publishes first-ever complete medical guidelines for a pediatric solid tumor, so children everywhere receive the best care based on the latest research.

NCCN Guidelines for Wilms Tumor shares information for earlier, safer diagnosis and treatment in effort to reduce disparities; doctors warn of late diagnosis as a possible impact from the COVID-19 pandemic.

PLYMOUTH MEETING, Pa., Feb. 17, 2021 /PRNewswire/ -- The National Comprehensive Cancer Network® (NCCN®) today published its first-ever treatment guidelines for children with a solid tumor cancer type in the United States. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Wilms Tumor (Nephroblastoma) contain evidence-based expert consensus recommendations for how to maximize benefits and minimize side effects for managing a rare type of kidney cancer that typically occurs in children age eight years or younger. These guidelines contain crucial information, particularly for care providers who treat a full spectrum of pediatric tumors, hematologic malignancies, and other blood disorders (such as sickle cell), due to the relative infrequency of all of these conditions. The guidelines also include important diagnostic information for primary care pediatricians to help ensure this cancer is caught early enough to benefit from high curability rates, and managed in a way that reduces side effects.

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NCCN Guidelines for Wilms Tumor available at NCCN.org.
NCCN Guidelines for Wilms Tumor available at NCCN.org.

"Wilms tumor is rare, but highly treatable," says Daniel M. Green, MD, of St. Jude Children's Research Hospital, Vice-Chair of the NCCN Guidelines® Panel for Wilms Tumor. "It's important that we make sure these guidelines and knowledge of the signs and symptoms of Wilms tumor reach primary care physicians and pediatricians so they can help catch it early and save lives."

"Keeping up with all of the current literature for the broad array of children's oncologic and hematologic malignancies can be daunting. The NCCN Guidelines for Wilms Tumor provide compiled, annotated, and vetted recommendations for diagnosis, treatment, and follow up—in keeping with NCCN's goals for streamlining and improving care so that patients can live better lives," said Elizabeth Mullen, MD, of Dana-Farber/Boston Children's Cancer and Blood Disorders Center, another Member of the NCCN Guidelines Panel for Wilms Tumor. "People say Wilms is a 'good cancer' because it has a 90 percent cure rate but that still means too many children don't survive. I won't feel okay until we get that cure rate to 100 percent—with optimization of long-term wellness, fertility, and psycho-social wellbeing."

"The treatment of Wilms tumor is guided by the results of a series of sequential clinical trials that started back in the 1960s," explained Frank M. Balis, MD, Professor of Pediatrics, Louis and Amelia Canuso Family Endowed Chair for Clinical Research in Oncology, Children's Hospital of Philadelphia/Abramson Cancer Center at the University of Pennsylvania, who chairs the NCCN Guidelines Panel for Wilms Tumor. "Treatment approaches have been refined through these clinical trials, making treatment selection more and more complex and nuanced. Management should be determined by clinical and biological risk factors, the presence of unilateral (single kidney) versus bilateral (both kidneys) disease, and patient response to treatment. The NCCN Guidelines for Wilms Tumor present clinicians with the latest evidence for the management of children with Wilms tumor based on their individual clinical and molecular profile."

Wilms tumor accounts for five percent of all childhood cancers and typically occurs between ages one to five. Children often have abdominal swelling and/or a mass with or without other symptoms; however, they often appear healthy, which can delay diagnosis. Wilms tends to be more common among African-American children and is often caught in more advanced disease stages for this population.1,2 In rare cases, children with a number of genetic predisposition syndromes may get Wilms tumor; therefore, these children should be screened for Wilms tumor.

"One of the most common ways that Wilms tumor is diagnosed in a child is through detection of an otherwise asymptomatic abdominal mass during a routine well child care exam with their pediatrician," explained Dr. Mullen. "Now that some parents and guardians have had to delay these appointments, or hold them virtually due to the COVID-19 pandemic, there is concern about the potential of an increase in higher-stage diagnoses."

The guidelines also contain a warning for primary care physicians to be gentle if they feel a mass in the kidney area, especially if the children appear to be otherwise healthy. Wilms tumor(s) can rupture if touched with too much force, causing the cancer to spread within the abdomen or elsewhere.

NCCN Guidelines are considered the gold standard for clinical direction and policy in cancer management and are the most thorough and frequently updated clinical practice guidelines for any area of medicine. The evidence-based recommendations are formulated by a multidisciplinary panel of subject-specific experts from across the 30 leading cancer centers that comprise NCCN. The organization recently published guidelines for three of the most-common pediatric blood cancers: Pediatric Acute Lymphoblastic Leukemia (ALL), Pediatric Aggressive Mature B-Cell Lymphomas, and Pediatric Hodgkin Lymphoma. The NCCN Guidelines for Pediatric ALL have also been translated into Chinese, French, Indonesian, Japanese, Portuguese, Russian, and Spanish.

All NCCN Guidelines can be downloaded and printed for free at NCCN.org or via the Virtual Library of NCCN Guidelines® App for mobile or tablet.

About the National Comprehensive Cancer Network
The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information and follow NCCN on Facebook @NCCNorg, Instagram @NCCNorg, and Twitter @NCCN.


1 Breslow N, Olshan A, Beckwith JB et al. Epidemiology of Wilms' tumor. Med Pediatr Oncol. 1993; 21: 172-181.

2 Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2017, based on November 2019 SEER data submission, posted to the SEER web site, April 2020. Bethesda, MD: National Cancer Institute; 2020

Media Contact:
Rachel Darwin
267-622-6624
[email protected]

SOURCE National Comprehensive Cancer Network

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