New research shows how machine learning could revolutionize diagnosis and treatment of multiple myeloma and sepsis

Two breaking studies presented at ADLM 2024

CHICAGO, July 31, 2024 /PRNewswire/ -- Exciting research at the frontier of artificial intelligence and data science in laboratory medicine was presented today at ADLM 2024 (formerly the AACC Annual Scientific Meeting & Clinical Lab Expo). One study leveraged a National Institutes of Health (NIH) research cohort and a machine learning model to predict outcomes for patients with multiple myeloma, and another introduced a model that could help to lower worldwide mortality rates from sepsis.

Advancing precision medicine for multiple myeloma

Diagnosing and monitoring the progression of the blood cancer multiple myeloma involves many factors and is complicated by disparities across demographic groups, as well as imbalanced datasets. To better predict outcomes for patients with multiple myeloma, a team of researchers from the NIH's All of Us Research Program, led by Dr. Thomas Houze, developed machine learning models tailored for different demographic groups diagnosed with multiple myeloma.

The All of Us Research Program is an NIH initiative that seeks to collect and study the health data of 1 million or more people living in the U.S. Because the All of Us database contains a wide range of participants from diverse backgrounds, it is an extremely valuable resource for training a machine learning model to make precise, individualized predictions for patients with a complex disease like multiple myeloma.

When developing their model, the NIH researchers employed the Synthetic Minority Over-Sampling Technique (SMOTE), a machine learning technique used to resolve imbalanced datasets. This ensures that the model makes useful and accurate predictions for smaller groups in the database. Without SMOTE, "the larger datasets would dominate the signal, so you get very good predictions for people of European genetic ancestry, but very poor predictions for people of Asian or African genetic ancestry," Dr. Houze said. "This was something that I thought needed to be done and it's a very recent capability in this field."

Applying SMOTE to the data resulted in significant improvements in prediction accuracy for minority groups within the multiple myeloma patient population, the researchers found, which in turn could improve care for these groups. The technique may also enable precision medicine in areas beyond oncology, according to Dr. Houze.

"Once you get this methodology working with our data, you can apply it to Alzheimer's, cardiovascular disease, mental health, and other areas," Dr. Houze said.

Predicting sepsis risk with machine learning

Sepsis is a major global health concern. It's responsible for approximately 11 million deaths annually, representing the leading cause of hospital readmissions and mortality worldwide. Early diagnosis and appropriate treatment could prevent 80% of sepsis-related deaths, but the majority of sepsis cases occur outside the hospital, making timely detection challenging.

Using data from more than 25,000 sepsis and non-sepsis cases, Dr. Raj Gopalan of BSRM Consulting created a machine learning model to identify a patient's risk of developing sepsis up to 1 week before hospital admission. The model's input parameters include age, gender, and data from routine blood tests such as complete blood counts, differential counts, comprehensive metabolic panels, and lipid panels that were recorded up to 1 week before sepsis diagnosis. The model demonstrated 99% accuracy in predicting sepsis risk, and identified calcium, protein, liver enzymes, hematocrit, white blood cells, and cholesterol as key contributors to sepsis risk prediction.

"Sepsis is difficult to diagnose because the symptoms develop rapidly and it often mimics other infectious conditions," Dr. Gopalan said. "The model can synthesize a vast amount of patient lab test results to make predictions."

Going forward, this model might be used alongside other similar models to make accurate predictions across various health conditions, according to Dr. Gopalan.

"As soon as you receive blood test results, they can be processed through various cancer and chronic disease models — not just one, but 40 or 50 — providing insights into a patient's risk levels. This allows for additional, specific testing to confirm or rule out any risks associated with these conditions," he said.

Session information

ADLM 2024 registration is free for members of the media. Reporters can register online here: https://xpressreg.net/register/adlm0824/media/landing.asp

Abstract B-111: Advancing precision medicine in multiple myeloma: Addressing demographic variabilities and imbalanced data in the NIH All of Us Research Program cohort 

Abstract B-137: Sepsis risk prediction using machine learning (ML) and routine blood markers up to 1 week before emergency admission 

Both abstracts will be presented during:
Scientific poster session
Wednesday, July 31
9:30 a.m. – 5 p.m. (presenting authors in attendance from 1:30 – 2:30 p.m.)

The session will take place in the Poster Hall on the Expo show floor of McCormick Place, Chicago.

About ADLM 2024

ADLM 2024 (formerly the AACC Annual Scientific Meeting & Clinical Lab Expo) offers 5 days packed with opportunities to learn about exciting science from July 28-August 1 in Chicago. Plenary sessions will explore the projected consequences of ending abortion protection, new HIV prevention options, lymphoma biomarkers and therapeutic targets, pharmacogenetic testing in precision health, and the need for clinical trials of laboratory tests.

At the ADLM 2024 Clinical Lab Expo, more than 900 exhibitors will fill the show floor of the McCormick Place Convention Center in Chicago, with displays of the latest diagnostic technology, including but not limited to artificial intelligence, point-of-care, and automation.

About the Association for Diagnostics & Laboratory Medicine (ADLM)

Dedicated to achieving better health through laboratory medicine, ADLM (formerly AACC) brings together more than 70,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of progressing laboratory science. Since 1948, ADLM has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit www.myadlm.org.

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ADLM
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ADLM
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SOURCE Association for Diagnostics & Laboratory Medicine (ADLM)