Published recently in US Neurology, the peer-reviewed journal from touchNEUROLOGY, Jake Gold et al, discuss the physiological effects of vitamin D on calcium/phosphorus metabolism, which have been well studied since its discovery in the early 20th century. With recent advances in cellular and molecular biology, its role in maintaining normal brain functions and the protection of neurons via maintenance of cellular homeostasis, immune regulation, modulation of synaptic structure and function are more clearly known. Recently, its deficiency is increasingly implicated in major neurocognitive disorders including Alzheimer's disease, Parkinson's disease, and vascular dementia. Older adults are particularly vulnerable not only because vitamin D deficiency becomes more prevalent with aging, but they also are often complicated with other comorbid illnesses. This new article reviews the role of vitamin D in maintaining normal brain functions, and implications for vitamin D deficiency in cognitive disorders.
Disclosure: Jake Gold, Abdullah Shoaib, Gopinath Gorthy and George T Grossberg have nothing to declare in relation to this article. No funding was received in the publication of this article.
touchNEUROLOGY (a division of Touch Medical Media) publishesUS Neurology, a peer-reviewed, open access, bi-annual journal specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of neurology. The aim of these reviews is to break down the high science from 'data-rich' primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.
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