TALLAHASSEE, Fla., Jan. 9, 2015 /PRNewswire/ -- Prevacus, Inc. today announces the appointment of Nobel Laureate Bruce Beutler to its Medical Advisory Board.
Professor Beutler is Director of the Center for the Genetics of Host Defense at the University of Texas Southwestern Medical Center in Dallas. He is recognized for his pioneering molecular and genetic studies of inflammation and innate immunity. He was the first to isolate mouse tumor necrosis factor-alpha (TNF), and to demonstrate its role in inflammation. Professor Beutler has published over 175 articles and is the recipient of numerous awards including the Shaw Prize, the Balzan Prize for Innate Immunity and the William B. Coley Award. In 2011, Professor Beutler shared the Nobel Prize in Physiology or Medicine for "discoveries concerning the activation of innate immunity."
Dr. VanLandingham, Founder of Prevacus, Inc. is proud to have a researcher of Dr. Beutler's stature on the Prevacus Medical Advisory Board and looks forward to his wise guidance in developing PRV-002 for the treatment of mTBI.
About Prevacus, Inc.
Prevacus, Inc. is a biopharmaceutical company developing drug candidates with the potential to advance treatment in the fields of traumatic brain injury and other neurological disorders. The Company's first development candidate (PRV-002) represents a breakthrough strategy for treating concussion (mild traumatic brain injury or mTBI).
A concussion is a type of traumatic brain injury (TBI) caused by a traumatic force to the head or upper body causing the brain to shake inside the skull. The injury is defined as a concussion when it causes a change in mental status such as amnesia, disorientation, mental fogginess, confusion, nausea/vomiting, blurred vision or loss of consciousness. There are 21 symptoms demonstrated to be associated with concussion. Loss of consciousness does not indicate injury severity. Because no two concussions are exactly alike, and symptoms are not always definite, the injury's severity, effects and recovery are sometimes difficult to determine.
PRV-002 is a fully synthetic non-naturally occurring neurosteroid administered through the nasal cavity. PRV-002 carries with it equivalent, if not superior, neuroprotective effects compared to related neurosteroids. Animal models of concussion demonstrated that PRV-002 reduces the behavioral pathology associated with brain injury symptoms such as memory impairment, anxiety, and motor/sensory performance. Additionally, PRV-002 is lipophilic and can easily cross the blood-brain barrier to rapidly eliminate swelling, oxidative stress and inflammation in the brain.
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SOURCE Prevacus, Inc.