Nuvo Research Announces Scientific Presentation at the Annual Meeting of the American Association of Immunologists

Data Evaluating WF10's Therapeutic Impact on Signs and Symptoms of Experimentally Induced Rheumatoid Arthritis in Mice

MISSISSAUGA, ON, May 16, 2013 /PRNewswire/ - Nuvo Research Inc. (TSX: NRI) a specialty pharmaceutical company dedicated to building a portfolio of products for the topical treatment of pain and the development of its immune modulating drug candidate WF10 today announced that researchers from the Fraunhofer Institute for Cell Therapy and Immunology IZI and Nuvo presented scientific data related to WF10's therapeutic impact on signs and symptoms of experimentally induced rheumatoid arthritis in mice at the 100^th Annual Meeting of The American Association of Immunologists (AAI) in Honolulu, Hawaii, U.S.

Compared to the placebo group, animals treated with WF10 showed a reduction of the degree of symptoms. Based on these results, the investigators concluded that WF10 may present a novel therapeutic approach for patients suffering from rheumatoid arthritis and other inflammatory autoimmune diseases.  Rheumatoid arthritis is a complex chronic autoimmune disease and the most common inflammatory disorder of joints leading to cartilage destruction, bone erosion and deformation of joints.  The initializing causes of rheumatoid arthritis are not fully understood and thus there can be no guarantee that the results observed in this animal model will be reproducible in humans.

"This joint poster presentation is a result of the deep and fruitful cooperation between Nuvo and the prestigious Fraunhofer Institute in Leipzig, Germany," said Dr. Henrich Guntermann, Nuvo's President, Europe and Immunology Group. "With our partners in Leipzig and supported by funding from the Development Bank of Saxony (SAB) and the European Fund for Regional Development (EFRE), we are currently working on multiple research and development projects to further explore WF10's full potential."

About WF10
The immune system provides an essential defense to microorganisms, cancer and substances it sees as foreign and potentially harmful. WF10 focuses on supporting the immune system by targeting the macrophage, a type of white blood cell that coordinates much of the immune system, to regulate normal immune function. In conditions such as allergic rhinitis, the body's immune system inappropriately responds to the presence of foreign allergens. Research suggests that in some cases, WF10 may rebalance improperly functioning immune systems. WF10 is an infusion therapy currently approved only in Thailand under the name IMMUNOKINE for treatment of postradiation chronic inflammatory disease and diabetic foot ulcer.  WF10 is not yet approved for the treatment of rheumatoid arthritis and was used in the reported study on an investigational basis.

About Fraunhofer Institute for Cell Therapy and Immunology IZI
The Fraunhofer Institute for Cell Therapy and Immunology IZI is a member of the Fraunhofer Group for Life Sciences. Its objective is to find solutions for specific problems at the interfaces of medicine, life sciences and engineering. It supports partners active in medicine-related industries and businesses.

About Nuvo Research Inc.
Nuvo is a publicly traded, Canadian specialty pharmaceutical company, headquartered in Mississauga, Ontario.  The Company is building a portfolio of products for the treatment of pain through internal research and development.  The Company's product portfolio includes Pennsaid^®, Pliaglis^® and Synera^®.  Pennsaid, a topical nonsteroidal anti-inflammatory drug (NSAID), is used to treat the signs and symptoms of osteoarthritis of the knee(s).  Pennsaid is sold in the United States by Mallinckrodt Inc., a Covidien company, in Canada by Paladin Labs Inc. and in several European countries. Pliaglis is a topical local anesthetic cream which provides topical local analgesia for superficial dermatological procedures.  The Company has licensed worldwide marketing rights to Pliaglis to Galderma Pharma S.A., a global pharmaceutical company specialized in dermatology.  Synera is a topical patch that combines lidocaine, tetracaine and heat, approved in the United States to provide local dermal analgesia for superficial venous access and superficial dermatological procedures and in Europe, for surface anaesthesia of normal intact skin.  Nuvo currently markets Synera in the United States and its licensing partner, Eurocept International B.V., has initiated a pan-European launch of Synera (under the name Rapydan^®) in several European countries.  The Company is also developing WF10, for the treatment of immune related diseases.

Forward-Looking Statements
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SOURCE Nuvo Research Inc.