Simdax (levosimendan; Orion/Tenax Therapeutics) is a calcium-sensitizing agent indicated for the treatment of acute decompensated heart failure (ADHF) in situations where conventional therapy is not sufficient. It acts by binding to cardiac troponin C in a calcium-dependent manner. Its pharmacological effects include increased cardiac contractility mediated by calcium sensitization of troponin C, vasodilation based on the opening of potassium channels in the vasculature, and cardioprotection due to the opening of mitochondrial potassium channels in the cardiomyocytes.
Key Topics Covered:
1 Product Profiles
Simdax: Acute decompensated heart failure (ADHF)
List of Figures Figure 1: Simdax for ADHF - SWOT analysis Figure 2: The author's drug asment summary of Simdax for ADHF Figure 3: The author's drug assessment summary of Simdax for ADHF
List of Tables Table 1: Simdax drug profile Table 2: Simdax Phase III data in ADHF