Positive Results from Phase II Clinical Trial of OHR-102 - Report on Ohr Pharmaceutical

Jul 20, 2015, 09:00 ET from www.aciassociation.com

NEW YORK, July 20, 2015 /PRNewswire/ --

ACI Association has initiated research coverage on Ohr Pharmaceutical, Inc. (NASDAQ: OHRP). Select highlights from the internally released reports are being made available to the general public (included below), with access to the entirety of the research available to new members.

Today, membership is open to readers on a complementary basis at the following URL: http://www.aciassociation.com/?c=OHRP

Highlights from our OHRP Report include:

  • Final Result of Phase II Clinical Study - On July 13, 2015, the ophthalmology research and development company Ohr Pharmaceutical, Inc. announced the outcome of Phase II investigator sponsored clinical trial of OHR-102 (0.2% Squalamine lactate ophthalmic solution). The Company informed that the final result of the trial, which was conducted in patients with macular edema secondary to branch (BRVO) and central retinal vein occlusion (CRVO), was positive. The study demonstrated that OHR-102 combination therapy enhances visual recovery in macular edema secondary to retinal vein occlusion.
  • Data Presentation - The data was presented by a retina specialist John Wroblewski at retina specialist on July 11 at the 2015 Annual Meeting of the American Society of Retina Specialists (ASRS) in Vienna, Austria. This data included the final analysis of patients that, following a 10 week initial combination treatment period, were randomized to receive either continued OHR-102 + Lucentis PRN therapy or only Lucentis monotherapy PRN through week 38.
  • Study Design - The Company stated that for the 38 week, investigator sponsored, Phase II clinical trial, 20 treatment naïve patients were enrolled with macular edema due to retinal vein occlusion. While all the patients received OHR-102 topically for the first 10 weeks of treatment, two injections of Lucentis were injected to them at week 2 and week 6. In the later stage of the study, patients were randomized 1:1 at week 10 to either continue administering OHR-102 eye drops or discontinue drops for the remainder of the study. Retreatment with Lucentis injections were administered monthly as needed (PRN) through week 38 based on OCT criteria. 
  • Combination Therapy versus only Lucentis - The data demonstrated that the patients who continued to receive a combination of topical OHR-102 BID plus Lucentis®, following an initial 10 week combination therapy treatment period, achieved greater visual acuity gains than the control group who received Lucentis alone. After the initial combination therapy phase, the mean gain in visual acuity from week 10 to week 38 was +7.4 letters for patients who continued treatment with OHR-102 + Lucentis PRN compared with +3.1 letters in those receiving Lucentis PRN alone. At week 38, 80% of patients in the OHR-102 + Lucentis treated group had a gain in visual acuity, compared with 50% of patients treated with Lucentis alone. Additionally, at week 38, none of the patients in the OHR-102 + Lucentis treated group lost any vision.

To find out how this influences our rating on Ohr Pharmaceutical, Inc., read the full report in its entirety here: http://www.aciassociation.com/?c=OHRP

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