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Progentec Announces Launch of Novel Test That Anticipates Onset of Lupus-Related Flares

aiSLE™ DX Flare Risk Index laboratory test can indicate likelihood of SLE disease flares in subsequent 12 weeks

Progentec Logo (PRNewsfoto/Progentec Diagnostics, Inc.)

News provided by

Progentec Diagnostics, Inc.

Sep 15, 2020, 11:47 ET

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OKLAHOMA CITY, Sept. 15, 2020 /PRNewswire/ -- Progentec, a leader in the development of diagnostic and digital technologies that support the proactive management of autoimmune diseases, today announces the launch of a novel blood test that can assess the likelihood of a systemic lupus erythematosus ("SLE" or more commonly "lupus") patient experiencing an immunologic disease flare in the ensuing 12 weeks. This new technology gives rheumatologists a new tool to improve the quality of care for the estimated 1.5 million Americans affected by this autoimmune disease.

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Laboratory technician and manager Daniele DeFreese works in Progentec's Oklahoma City-based laboratory.
Laboratory technician and manager Daniele DeFreese works in Progentec's Oklahoma City-based laboratory.

The aiSLE™ DX Flare Risk Index uses a set of blood-based biomarkers that are measurably altered before the onset of flare symptoms in patients with systemic lupus erythematosus. The odds ratio (OR) indicates that a SLE patient with a positive aiSLE™ DX Flare Risk Index score is nearly five times more likely to experience a flare than a patient with a negative score.

"The study of biomarkers continues to be an increasingly invaluable and precise tool in the diagnosis and treatment of disease, and our novel test for assessing the likelihood of lupus-related flares holds great promise for helping rheumatologists manage the often painful and debilitating symptoms of lupus," said Mohan Purushothaman, Ph.D., president, chairman and CEO of Oklahoma City-based Progentec. "This novel test quantifies in practical, numeric terms the risk that a patient will begin experiencing a flare within the ensuing three months – important, actionable knowledge that can be applied to a patient's treatment regimen."

The aiSLE™ DX Flare Risk Index uses the ELLA™ testing platform. As part of the development of the test, a total of 52 soluble immune mediators, including cytokines and chemokines, were examined in study participants for baseline and follow-up plasma levels. An algorithm using weighted levels of this immune panel was used to calculate a flare risk score, which reflects the risk of a study participant developing a disease-related flare within 12 weeks following the initial testing. aiSLE™ DX Flare Risk Index provides a risk score for the patient in addition to the individual biomarker readings. Subsequent patient samples and studies from the Centers of Excellence have demonstrated the ability to reduce the number of informative mediators to 11. 

"The management of lupus symptoms has traditionally involved a regimen of reactive protocols," said Chaim Putterman, MD, Professor of Medicine and Microbiology & Immunology at the Albert Einstein College of Medicine and a member of Progentec's Scientific Advisory Board. "A test that assesses the likely risk of the onset of a flare is one of the first proactive measures available to the rheumatological community. The empirical data derived from such a test potentially has tremendous value in helping devise the right treatment and care for lupus patients."

Proactive treatment strategies based on the aiSLE™ DX Flare Risk Index result may help clinicians and patients reduce the negative impacts of lupus flares, which include organ damage, hospitalizations, and reductions in patient quality of life.

To learn more about the development of the aiSLE™ DX Flare Risk Index and to begin using it at your practice, visit the Progentec website: www.progentec.com/aisle-dx

About Progentec Diagnostics, Inc.
Progentec is committed to improving access and health outcomes for patients with autoimmune diseases by combining clinically validated diagnostic interventions with state-of-the-art digital technologies. Through collaborations with research institutions and health practitioners around the world, Progentec is working to reduce mortality and morbidity while improving care management and service delivery for chronic health conditions.

Forward-Looking Statements:
Statements contained herein that are not historical facts are forward-looking statements that represent management's beliefs and assumptions as of the date of this news release based on currently available information. Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, it cannot assure that these expectations will prove to be correct. Such statements involve risks and uncertainties that could cause actual results to differ materially from those expressed in any forward-looking statements.

Contact: Brett Adelman
405.216.4818, Ext. 105
[email protected]

SOURCE Progentec Diagnostics, Inc.

Related Links

http://www.progentec.com

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