Current therapies for disease management for Psoriatic Arthritis include conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), injectable immuno-suppressants and oral small molecule therapies. Of these, intravenous and subcutaneous therapies targeting tumor necrosis factor (anti-TNFs) have been the gold standard of care for almost 20 years. However, other mechanisms of action have gained traction in recent years. Over the forecast period, market growth is expected to be driven primarily by the approval and launch of five pipeline therapies. However, this growth will likely be curtailed by the erosion of branded agents sales by biosimilars and generics in the second half of the forecast period.
The greatest drivers of growth in the global PsA market include the launch of five new pipeline therapies during the forecast period and a steadily climbing diagnosed prevalence in many 7MM countries.
The main barriers to growth in the PsA market include low diagnostic and treatment rates as well as low patient compliance and persistence.
Among the late-stage pipeline products, two are injectable anti-interleukin therapies and three are oral Janus Kinase (JAK) inhibitors.
The most important unmet needs in the PsA market are increased access to therapies as well as therapies that can target the multiple disease domains.
KEY QUESTIONS ANSWERED
Which unmet needs are limiting the treatment of PsA in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan)?
What strategies can the pharmaceutical industry employ to increase treatment rates for PsA? How should these strategies differ across different geographical markets?
What effect will the launch of biosimilars and generics have on the sales of branded agents? What can drug manufacturers do in order to ensure the success of their biosimilars?
What are the main R&D trends in the PsA market and which companies are leading the way? Are there major differences in the mechanisms of action used by therapies in late-stage versus early-stage clinical development?
Overview of PsA including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.
Topline PsA market revenue, annual cost of therapy, and major pipeline product sales in the forecast period.
Key topics covered include current treatment and pipeline therapies, unmet needs and opportunities, and the drivers and barriers affecting PsA therapeutics sales in the 7MM.
Pipeline analysis: Comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late-stage pipeline drugs.
Analysis of the current and future market competition in the global PsA therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Key Topics Covered:
1.1 List of Tables 1.2 List of Figures
2 Psoriatic Arthritis: Executive Summary 2.1 PsA Market to Experience Moderate Growth from 2018-2028 2.2 Oral Therapeutics Dominate the Late-Stage PsA Pipeline 2.3 Opportunities Remain for More Cost-Effective and Targeted Treatments 2.4 Convenient and Affordable Pipeline Agents Poised to Perform Well in a Crowded PsA Market 2.5 What Do Physicians Think?
8 Unmet Needs and Opportunity Assessment 8.1 Overview 8.2 Increased Clinician Awareness of PsA 8.3 Earlier and More Accurate PsA Diagnoses 8.4 Improved Drug Safety and Efficacy Across All Disease Domains 8.5 Improved Access to Therapies
9 Pipeline Assessment 9.1 Overview 9.1.1 IL-17 Inhibitors 9.1.2 IL-23 Inhibitors 9.1.3 JAK Inhibitors 9.2 Promising Drugs in Clinical Development 9.3 Other Drugs in Development
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