Reportlinker Adds Cell Therapy - Technologies, Markets and Companies
NEW YORK, June 3 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Cell Therapy - Technologies, Markets and Companies
http://www.reportlinker.com/p0203537/Cell-Therapy---Technologies-Markets-and-Companies.html
Summary
This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.
Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.
Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.
Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.
Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.
The cell-based markets was analyzed for 2009, and projected to 2019. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.
The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 270 of these are profiled in part II of the report along with tabulation of 253 alliances. Of these companies, 150 are involved in stem cells. Profiles of 66 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 47 Tables and 11 Figures. The bibliography contains 1,000 selected references, which are cited in the text.
TABLE OF CONTENTS
0.Executive Summary21
1.Introduction to Cell Therapy25
Introduction25
Historical landmarks of cell therapy25
Interrelationship of cell therapy technologies27
Cells and organ transplantation27
Cells and protein/gene therapy28
Cell therapy and regenerative medicine29
Cells therapy and tissue engineering29
Therapy based on cells involved in disease30
Advantages of therapeutic use of cells30
Use of cells for improving drug delivery31
2.Cell Therapy Technologies33
Introduction33
Cell types used for therapy33
Sources of cells33
Xenografts34
Cell lines34
Immortalized cells34
Blood component therapy34
Therapeutic apheresis34
Leukoreduction35
Platelet therapy35
Basic technologies for cell therapy36
Cell culture36
Observation of stem cell growth and viability36
Companies involved in cell culture37
Cell sorting38
Flow cytometry38
A dielectrophoretic system for cell separation39
Molecular beacons for specific detection and isolation of stem cells39
Multitarget magnetic activated cell sorter40
Nanocytometry40
Companies supplying cell sorters40
Dynabead technology for cell sorting41
ALDESORTER system for isolation of stem cells41
Adult stem cell sorting by identification of surface markers42
Cell analysis42
Preservation of cells43
Innovations in cryopreservation43
Packaging of cells43
Selective expansion of T cells for immunotherapy44
Cloning and cell therapy44
Techniques for cell manipulation45
Cell-based drug discovery45
Cells as vehicles for drug delivery48
RBCs as drug delivery vehicles48
Drug delivery systems for cell therapy48
Intravenous delivery of stem cells48
Pharmacologically active microcarriers49
Devices for delivery of cell therapy49
Artificial cells50
Applications of artificial cells50
Cell encapsulation51
Diffusion capsule for cells51
Encapsulated cell biodelivery52
Therapeutic applications of encapsulated cells52
Nitric oxide delivery by encapsulated cells53
Implantation of microencapulated genetically modified cells54
Ferrofluid microcapsules for tracking with MRI54
Companies involved in encapsulated cell technology55
Electroporation55
Gene therapy56
Cell-mediated gene therapy56
Fibroblasts56
Chondrocyte57
Skeletal muscle cells57
Vascular smooth muscle cells58
Keratinocytes58
Hepatocytes59
Lymphocytes59
Mammalian artificial chromosomes59
In vivo tracking of cells59
Molecular imaging for tracking cells60
MRI technologies for tracking cells60
Superparamagnetic iron oxide nanoparticles as MRI contrast agents61
Visualization of gene expression in vivo by MRI61
Role of nanobiotechnology in development of cell therapy61
Cell transplantation for development of organs62
Cells transplantation and tolerance62
Strategies to improve tolerance of transplanted cells63
Encapsulation to prevent immune rejection63
Prevention of rejection of xenotransplants63
Expansion of allospecific regulatory T cells64
Removal and replacement of pathogenic cells of the body64
Therapeutic leukocytapheresis64
3.Stem Cells66
Introduction66
Biology of stem cells67
Embryonic stem cells67
Growth and differentiation of ESCs67
Regulation of stem cell self-renewal and differentiation68
Role of Pax3 in stem cell differentiation68
ESCs and signaling pathways69
Genetic signature of of stem cells69
Epigenetics of hESCs69
Chromatin as gene regulator for ESC development70
Mechanism of differentiation of ESCs70
Chemical regulation of stem cell differentiation71
Comparison of development of human and mouse ESCs71
In vitro differentiation of hESCs71
Global transcription in pluripotent ESCs72
Signaling pathways and transcription factors in ESCs72
Stem cells in the pituitary gland72
hESCs in stead of oocytes for reprogramming human somatic nuclei73
Mechanism of regulation of stem cells for regeneration of body tissues73
Role of microenvironments in the regulation of stem cells73
Regulation and regeneration of intestinal stem cells74
Parthenogenesis and human stem cells74
Uniparental ESCs75
Bone marrow stem cells75
Hematopoietic stem cells75
Role of HSCs in the immune system77
Derivation of HSCs from ESCs78
Mesenchymal stem cells78
Multipotent adult progenitor cells79
Side population (SP) stem cells80
Differentiation of adult stem cells80
Growth and differentiation of HSCs81
Signaling pathways in the growth and differentiation of HSCs81
Mathematical modeling of differentiation of HSCs82
Role of prions in self renewal of HSCs82
Sources of stem cells82
Sources of of human embryonic stem cells82
Nuclear transfer to obtain hESCs83
Direct derivation of hESCs from embryos without nuclear transfer84
Alternative methods of obtaining hESCs84
Establishing hESC lines without destruction of embryo84
Altered nuclear transfer85
Small embryonic-like stem cells86
Advantages and disadvantages of ESCs for transplantation86
Use of ESC cultures as an alternative source of tissue for transplantation87
Spermatogonial stem cells87
Amniotic fluid as a source of stem cells88
Generation of iPS cells from AF cells89
Placenta as source of stem cells89
Amnion-derived multipotent progenitor cells89
Placenta as a source of HSCs90
Umbilical cord as a source of MSCs90
Umbilical cord blood as source of neonatal stem cells90
Cryopreservation of UCB stem cells91
UCB as source of MSCs92
Applications of UCB92
Advantages of UCB92
Limitations of the use of UCB93
Licensing and patent disputes involving UCB94
Infections following UCB transplants94
Unanswered questions about UCB transplantation95
Companies involved in UCB banking95
UCB banking in the UK96
US national UCB banking system97
Future prospects of UCB as a source of stem cells98
Induced pluripotent stem cells derived from human somatic cells98
Characteristics of iPSCs99
DNA methylation patterns of iPS cells99
iPSCs derived from blood100
iPSCs derived from skin100
Use of retroviral vectors for generation of iPSCs100
Use of non-integrating viral vectors for generation of iPSCs100
Clinical relevance of iPSCs101
Sources of adult human stem cells102
Adipose tissue as a source of stem cells103
Transforming adult adipose stem cells into other cells103
iPSCs derived from adult human adipose stem cells103
Skin as a source of stem cells104
Controlling the maturation of embryonic skin stem cells104
Epidermal neural crest stem cells104
Follicle stem cells105
Mesenchymal stem cells in skin105
Regulation of stem cells in hair follicles105
Skin-derived precursor cells106
Stem cells in teeth106
Peripheral blood stem cells107
Spleen as a source of adult stem cells107
Search for master stem cells108
Vascular cell platform to self-renew adult HSC108
Adult stem cells vs embryonic stem cells108
Transdifferentiation potential of adult stem cells109
Neural crest stem cells from adult hair follicles110
Stem cells obtained from blood in adults111
VENT cells111
Stem cell banking111
Stem cell technologies112
Analysis of stem cell growth and differentiation112
Tracking self-renewal and expansion of transplanted muscle stem cells112
Stem cell biomarkers112
Endoglin as a functional biomarker of HSCs113
STEMPRO? EZChek? for analysis of biomarkers of hESCs113
SSEA-4 as biomarker of MSCs113
p75NTR as a biomarker to isolate adipose tissue-derived stem cells113
Neural stem cell biomarker114
Protein expression profile as biomarker of stem cells114
Real-time PCR for quantification of protein biomarkers114
Study of stem cell pathways115
Study of stem cell genes115
Gene inactivation to study hESCs116
RNAi to study gene inactivation in hESCs116
Study of ESC development by inducible RNAi117
Targeting Induced Local Lesions in Genomes117
Homologous recombination of ESCs117
Immortalization of hESCs by telomerase117
Gene modification in genomes of hESCs and hiPSCs using zinc-finger nuclease118
miRNA and stem cells118
Role of miRNAs in gene regulation during stem cell differentiation119
Influence of miRNA on stem cell formation and maintenance119
Transcriptional regulators of ESCs control miRNA gene expression120
Stem cells and cloning120
Cell nuclear replacement and cloning120
Nuclear transfer and ESCs120
Cloning from differentiated cells122
Cloning mice from adult stem cells122
Creating interspecies stem cells123
Cloned cells for transplantation medicine123
Claims of cloning of hESCs123
Cytogenetics of embryonic stem cells125
Engraftment, mobilization and expansion of stem cells125
Adipogenesis induced by adipose tissue-derived stem cells126
Antisense approach for preservation and expansion of stem cells126
Chemoattraction of neuronal stem cells through GABA receptor127
Enhancement of HSC engraftment by calcium-sensing receptor127
Enhancement of stem cell differentiation by Homspera128
Ex vivo expansion of human HSCs in culture128
Ex vivo expansion of MSCs129
Expansion of HSCs in culture by inhibiting aldehyde dehydrogenase129
Expansion of adult stem cells by activation of Oct4129
Expansion of transduced HSCs in vivo130
Mobilization of HSCs by growth factors130
Mobilization of stem cells by cytokines/chemokines131
Mobilization of adult human HSCs by use of inhibitors131
Mobilization of stem cells by HYC750132
Mobilization of stem cells by hyperbaric oxygen132
Mobilization by adenoviral vectors expressing angiogenic factors133
Selective mobilization of progenitor cells from bone marrow133
Selective Amplification133
Stem cell mobilization by acetylcholine receptor agonists134
Use of parathyroid hormone to increase HSC mobilzation134
Expansion of stem cells in vivo by Notch receptor ligands134
Technologies for inducing differentiation of stem cells134
Use of lineage selection to induce differentiation of hESCs134
Growth factor-induced differentiation of MAPCs135
Neurotrophin-mediated survival and differentiation of hESCs135
Generation of RBCs from hematopoietic stem cells135
Generation of multiple types of WBCs from hESCs and iPSCs136
Use of RNAi to expand the plasticity of autologous adult stem cells136
Use of carbohydrate molecules to induce differentiation of stem cells136
Mechanical strain to induce MSC differentiation137
Limitations of the currently available stem cell lines in the US137
Contaminating material in stem cell culture and measures to eliminate it138
Stem cell separation139
Stem cell culture139
Conversion of stem cells to functioning adipocytes140
Mass production of ESCs140
Promoting survival of dissociated hESCs141
Analysis and characterization of stem cells141
Havesting and identification of EPCs141
Labeling of stem cells142
Quantum dots for labeling stem cells142
Imaging and tracking of stem cells in vivo142
Quantum dot imaging for ESCs142
Perfluorocarbon nanoparticles to track therapeutic cells in vivo143
Project for imaging in stem cell therapy research143
Applications of stem cells143
Controlling the maintenance process of hematopoietic stem cells144
Self renewal and proliferation of HSCs144
Aging and rejuvenation of HSCs144
Peripheral blood stem cell transplantation145
Complications of PBSC transplantation in children145
Stem cell transplantation for radiation sickness145
Stem cells and human reproduction146
Expansion of spermatogonial stem cells146
Conversion of ESCs into spermatogonial stem cells146
Conversion of stem cells to oocytes146
ESCs for treatment of infertility in women147
Cloning human embryos from oocytes matured in the laboratory147
In utero stem cell transplantation148
Innovations in delivery of stem cells149
Immunological aspects of hESC transplantation149
Immunosuppression to prevent rejection of hESC transplants149
Histocompatibility of hESCs150
Strategies for promoting immune tolerance of hESCs150
Stem cells for organ vascularization151
Activation of EphB4 to enhance angiogenesis by EPCs151
Advantages and limitations of clinical applications of MSCs152
Biofusion by genetically engineering stem cells152
Stem cell gene therapy153
Combination of gene therapy with nuclear transfer153
Gene delivery to stem cells by artificial chromosome expression153
Genetic manipulation of ESCs153
Genetic engineering of human stem cells for enhancing angiogenesis154
HSCs for gene therapy154
Helper-dependent adenoviral vectors for gene transfer in ESCs155
Lentiviral vectors for in vivo gene transfer to stem cells155
Linker based sperm-mediated gene transfer technology155
Mesenchymal stem cells for gene therapy156
Microporation for transfection of MSCs156
Regulation of gene expression for SC-based gene therapy156
Stem cells and in utero gene therapy157
Therapeutic applications for hematopoietic stem cell gene transfer157
The future of hematopoietic stem cell gene therapy157
Stem cell pharmaceutics157
Cardiomyocytes derived from hESCs158
Engineered stem cells for drug delivery to the brain158
ESCs as source of models for drug discovery159
Hepatocytes derived from hESCs159
Pharmaceutical manipulation of stem cells160
Role of stem cells in therapeutic effects of drugs162
Stem cells for drug discovery162
Stem cell activation for regeneration by using glucocortoids163
Toxicology and drug safety studies using ESCs163
Future challenges for stem cell technologies165
Study of the molecular mechanism of cell differentiation166
MBD3-deficient ESC line166
In vivo study of human hemopoietic stem cells166
Stem cell biology and cancer167
Research into plasticity of stem cells from adults168
Stem cells and aging168
Activation of bone marrow stem cells into therapeutic cells169
Role of nitric oxide in stem cell mobilization and differentiation169
Stem cell genes170
Gene expression in hESCs170
The casanova gene in zebrafish170
Nanog gene171
Stem cell proteomics172
hESC phosphoproteome172
Proteomic studies of mesenchymal stem cells173
Proteomic profiling of neural stem cells173
Proteome Biology of Stem Cells Initiative173
Genomic alterations in cultured hESCs174
Hybrid embryos/cybrids for stem cell research174
Generation of patient-specific pluripotent stem cells175
Markers for characterizing hESC lines175
Switch of stem-cell function from activators to repressors176
Stem cell research at academic centers176
International Regulome Consortium177
Companies involved in stem cell technologies178
Concluding remarks about stem cells183
Challenges and future prospects of stem cell research183
4.Clinical Applications of Cell Therapy186
Introduction186
Cell therapy for hematological disorders186
Transplantation of autologous hematopoietic stem cells186
Hemophilias186
Ex vivo cell/gene therapy of hemophilia B186
Cell/gene therapy of hemophilia A187
Hematopoietic stem cell therapy for thrombocytopenia188
Stem cell transplant for sickle cell anemia188
Treatment of chronic acquired anemias189
Implantation of genetically engineered HSCs to deliver rhEpo189
Drugs acting on stem cells for treatment of anemia189
Stem cell therapy of hemoglobinopathies190
Stem cells for treatment of immunoglobulin-light chain amyloidosis190
Future prospects of cell therapy of hematological disorders190
Cell therapy for immunological disorders191
Role of dendritic cells in the immune system191
Modifying immune responses of DCs by vaccination with lipiodol-siRNA mixtures191
Stem cell therapy of chronic granulomatous disease192
Stem cell therapy of X-linked severe combined immunodeficiency192
Stem cell therapy of autoimmune disorders193
Treatment of Crohn's disease with stem cells193
Treatment of rheumatoid arthritis with stem cells193
Stem cell transplants for scleroderma194
Role of T-Cells in immunological disorders194
Autologous T-cells from adult stem cells195
Cell therapy for graft vs host disease195
Cell therapy for viral infections196
T-cell therapy for CMV196
T-cell therapy for HIV infection197
T-cell immunity by Overlapping Peptide-pulsed Autologous Cells197
Anti-HIV ribozyme delivered in hematopoietic progenitor cells198
Dendritic-cell targeted DNA vaccine for HIV198
Cell therapy of lysosomal storage diseases198
Niemann-Pick disease199
Gaucher's disease199
Fabry's disease200
Cell therapy for diabetes mellitus200
Limitations of current treatment201
Limitations of insulin therapy for diabetes mellitus201
Limitations of pancreatic transplantation201
Islet cell transplantation202
Autologous pancreatic islet cell transplantation in chronic pancreatitis202
Clinical trials of pancreatic islet cell transplants for diabetes202
Drawbacks of islet cell therapy203
Use of an antioxidant peptide to improve islet cell transplantation203
Cdk-6 and cyclin D1 enhance human beta cell replication and function204
A device for delivery of therapeutic cells in diabetes204
Monitoring of islet cell transplants with MRI204
Concluding remarks about allogeneic islet transplantation for diabetes205
Encapsulation of insulin producing cells205
Encapsulated porcine pancreatic islet cells for pancreas205
Encapsulated insulinoma cells206
Magnetocapsule enables imaging/tracking of islet cell transplants206
Islet precursor cells207
Dedifferentiation of ? cells to promote regeneration207
Xenotransplantation of embryonic pancreatic tissue208
Non-pancreatic tissues for generation of insulin-producing cells208
Exploiting maternal microchimerism to treat diabetes in the child208
Bio-artificial substitutes for pancreas209
Role of stem cells in the treatment of diabetes209
Pancreatic stem cells209
Embryonic stem cells for diabetes210
Isolation of islet progenitor cells211
Expansion of pancreatic progenitor cells in vitro211
Human neural progenitor cells converted into insulin-producing cells211
Insulin-producing cells derived from UCB stem cells212
Stem cell injection into portal vein of diabetic patients212
HSC transplantation to supplement immunosuppressant therapy212
Dendritic cell-based therapy for type 1 diabetes213
Gene therapy in diabetes213
Viral vectors for gene therapy of diabetes213
Genetically engineered dendritic cells214
Genetically altered liver cells214
Genetically modified stem cells215
Companies developing cell therapy for diabetes215
Concluding remarks about cell and gene therapy of diabetes216
Cell therapy of gastrointestinal disorders217
Inflammatory bowel disease217
Cell therapy for liver disorders217
Types of cells and methods of delivery for hepatic disorders218
Bioartificial liver218
Limitations of bioartificial liver219
Stem cells for hepatic disorders219
Deriving hepatocytes from commercially available hMSCs220
Implantation of hepatic cells derived from hMSCs of adipose tissue221
MSC derived molecules for reversing hepatic failure221
Cell-based gene therapy for liver disorders221
Transplantation of genetically modified fibroblasts222
Transplantation of genetically modified hepatocytes222
Intraperitoneal hepatocyte transplantation222
Genetically modified hematopoietic stem cells222
Clinical applications223
Future prospects of cell-based therapy of hepatic disorders223
Cell therapy of renal disorders224
Bioartificial kidney224
Bone marrow stem cells for renal disease224
Human stem cells to prevent end stage renal disease225
Role of stem cells in renal repair225
Cell-based repair for vascular access failure in renal disease225
Mesangial cell therapy226
Cell therapy for pulmonary disorders226
Delivery of cell therapy for pumonary disorders226
Intratracheal injection of cells for pulmonary hypoplasia226
Role of stem cells in pulmonary disorders227
Lung tissue regeneration from stem cells227
Role of stem cells in construction of the Cyberlung227
Respiratory epithelial cells derived from UCB stem cells228
Respiratory epithelial cells derived from hESCs228
Lung tissue engineering with adipose stromal cells228
Cell-based tissue-engineering of airway229
Pulmonary disorders that are treatable by stem cells229
Acute lung injury and ARDS treated with MSCs230
Bronchopulmonary dysplasia treated with MSCs231
Cystic fibrosis treatment with genetically engineered MSCs231
Pulmonary arterial hypertension treatment with EPCs231
Cell therapy for disorders of bones and joints232
Repair of fractures and bone defects232
Adult stem cells for bone grafting233
Cell therapy for osteonecrosis233
ESCs for bone repair234
Intrauterine use of MSCs for osteogenesis imperfecta234
In vivo bone engineering as an alternative to cell transplantation234
MSCs for repair of bone defects234
MSCs for repair of bone fractures237
Osteocel238
Stem cells for repairing skull defects238
Stem cell-based bone tissue engineering238
Osteoarthritis and other injuries to the joints239
Mosaicplasty240
Autologous cultured chondrocytes240
Autologous intervertebral disc chondrocyte transplantation241
Cartilage repair by genetically modified fibroblasts expressing TGF-?242
Generation of cartilage from stem cells242
Role of cell therapy in repair of knee cartilage injuries244
Role of cells in the repair of anterior cruciate ligament injury245
Autologous tenocyte implantation in rotator cuff injury repair246
Platelet injection for tennis elbow246
Cell therapy of rheumatoid arthritis247
Cell therapy for diseases of the eye247
Cell therapy for corneal repair247
Stem cell therapy for limbal stem cell deficiency249
Cell therapy for regeneration249
Stem cells for regeneration249
Stem cells for regenerating organs250
Umbilical cord blood for regeneration251
Promotion of regeneration by Wnt/beta-catenin signaling251
Role of stem cells in regeneration of esophageal epithelium252
Cell therapy for regeneration of muscle wasting252
MSCs for regeneration of ovaries following radiotherapy damage253
Wound healing: skin and soft tissue repair253
Cells to form skin substitutes for healing ulcers253
CellSpray for wound repair254
Cell therapy for burns255
Closure of incisions with laser guns and cells255
Follicular stem cells for skin and wound repair256
Genetically engineered cells for wound repair256
Regeneration of skin by adipose-derived stem cells256
Repair of aging skin by injecting autologous fibroblasts257
Role of cells in tissue engineering and reconstructive surgery257
Stem cells for tissue repair257
Scaffolds for tissue engineering258
Improving vascularization of engineered tissues258
Enhancing vascularization by combining cell and gene therapy258
Choosing cells for tissue engineering259
ESCs vs adult SCs for tissue engineering259
Use of adult MSCs for tissue engineering260
Nanobiotechnology applied to cells for tissue engineering260
Stem cells for tissue engineering of various organs261
Engineering of healthy living teeth from stem cells261
Adipose tissue-derived stem cells for breast reconstruction262
Improving tissue engineering of bone by MSCs262
Intra-uterine repair of congenital defects using amniotic fluid MSCs263
Cell-based tissue engineering in genitourinary system263
Urinary incontinence263
Tissue engineering of urinary bladder264
Label retaining urothelial cells for bladder repair265
Repair of the pelvic floor with stem cells from the uterus265
Reconstruction of vagina from stem cells265
Facial skin regeneration by stem cells as an alternative to face transplant266
Cell therapy for rejuvenation266
Cell therapy for performance enhancement in sports266
Application of stem cells in veterinary medicine267
Use of stem cells to repair tendon injuries267
Stem cells for spinal cord injury in dogs267
5.Cell Therapy for Cardiovascular Disorders269
Introduction to cardiovascular disorders269
Limitations of current therapies for myocardial ischemic disease269
Types of cell therapy for cardiovascular disorders269
Cell-mediated immune modulation for chronic heart disease270
Human cardiovascular progenitor cells271
Inducing the proliferation of cardiomyocytes271
Role of the SDF-1-CXCR4 axis in stem cell therapies for myocardial ischemia272
Role of splenic myocytes in repair of the injured heart272
Small molecules to enhance myocardial repair by stem cells272
Cell therapy for atherosclerotic coronary artery disease273
MyoCell™ (Bioheart)273
Cardiac stem cells274
Cardiomyocytes derived from epicardium274
Methods of delivery of cells to the heart275
Cellular cardiomyoplasty275
IGF-1 delivery by nanofibers to improve cell therapy for MI275
Non-invasive delivery of cells to the heart by Morph®guide catheter276
Cell therapy for cardiac revascularization276
Transplantation of cardiac progenitor cells for revascularization of myocardium276
Stem cells to prevent restenosis after coronary angioplasty276
Role of cells in cardiac tissue repair277
Transplantation of myoblasts for myocardial infarction277
Patching myocardial infarction with fibroblast culture278
Cardiac repair with myoendothelial cells from skeletal muscle278
Myocardial tissue engineering279
Role of stem cells in repair of the heart280
Role of stem cells in cardiac regeneration following injury280
Cardiomyocytes derived from adult skin cells280
Cardiomyocytes derived from ESCs280
Studies to identify subsets of progenitor cells suitable for cardiac repair281
Technologies for preparation of stem cells for cardiovascular therapy282
Pravastatin for expansion of endogenous progenitor and stem cells282
Cytokine preconditioning of human fetal liver CD133+ SCs282
Expansion of adult cardiac stem cells for transplantation283
Role of ESCs in repair of the heart283
ESC transplantation for tumor-free repair of the heart284
Transplantation of stem cells for acute myocardial infarction284
Autologous bone marrow-derived stem cell therapeutics285
Autologous bone marrow-derived mesenchymal precursor stem cells285
Transplantation of cord blood stem cells285
Transplantation of hESCs285
Transplantation of HSCs286
Transplantation of autologous angiogenic cell precursors287
Transplantation of adipose-derived stem cells287
Intracoronary infusion of bone marrow-derived cells for AMI288
Intracoronary infusion of mobilized peripheral blood stem cells288
Transplantation of endothelial cells289
Transplantation of cardiomyocytes differentiated from hESCs289
Stem cell therapy for cardiac regeneration289
Regeneration of the chronic myocardial infarcts by HSC therapy290
Human mesenchymal stem cells for cardiac regeneration290
In vivo tracking of MSCs transplanted in the heart291
MSCs for hibernating myocardium291
Simultaneous transplantation of MSCs and skeletal myoblasts292
Transplantation of genetically modified cells292
Transplantation of genetically modified MSCs292
Transplantation of cells secreting vascular endothelial growth factor292
Transplantation of genetically modified bone marrow stem cells293
Cell transplantation for congestive heart failure293
Myoblasts for treatment of congestive heart failure293
Injection of adult stem cells for congestive heart failure293
AngioCell gene therapy for congestive heart failure294
Stem cell therapy for dilated cardiac myopathy295
Role of cell therapy in cardiac arrhythmias295
Atrioventricular conduction block296
Genetically engineered cells as biological pacemakers296
Ventricular tachycardia297
Prevention of myoblast-induced arrhythmias by genetic engineering297
ESCs for correction of congenital heart defects297
Cardiac progenitors cells for treatment of heart disease298
Autologus stem cells for chronic myocardial ischemia298
Role of cells in cardiovascular tissue engineering299
Construction of blood vessels with cells299
Targeted delivery of endothelial progenitor cells labeled with nanoparticles300
Fetal cardiomyocytes seeding in tissue-engineered cardiac grafts300
UCB progenitor cells for engineering heart valves300
Cell therapy for peripheral vascular disease300
ALD-301301
Cell/gene therapy for PVD301
Colony stimulating factors for enhancing peripheral blood stem cells301
Intramuscular autologous bone marrow cells302
Vascular Repair Cell302
Clinical trials of cell therapy in cardiovascular disease302
Mechanism of the benefit of cell therapy for heart disease305
A critical evaluation of cell therapy for heart disease305
Publications of clinical trials of cell therapy for CVD305
Current status of cell therapy for cardiovascular disease306
Future directions for cell therapy of CVD306
Prospects of adult stem cell therapy for repair of heart306
Regeneration of cardiomyocytes without use of cardiac stem cells307
6.Cell Therapy for Cancer308
Introduction308
Cell therapy technologies for cancer308
Cellular immunotherapy for cancer309
Treatments for cancer by ex vivo mobilization of immune cells309
Granulocytes as anticancer agents310
Neutrophil granulocytes in antibody-based immunotherapy of cancer310
Cancer vaccines311
Autologous tumor cell vaccines311
BIOVAXID311
OncoVAX311
Tumor cells treated with dinitrophenyl312
Vaccines that simultaneously target different cancer antigens312
Gene modified cancer cells vaccines312
GVAX cancer vaccines312
K562/GM-CSF313
Active immunotherapy based on antigen specific to the tumor313
The use of dendritic cells for cancer vaccination314
Autologous dendritic cells loaded ex vivo with telomerase mRNA314
Dendritic/tumor cell fusion314
Genetically modified dendritic cells315
In vivo manipulation of dendritic cells315
Preclinical and clinical studies with DC vaccines315
Vaccines based on dendritic cell-derived exosomes316
Limitations of DC vaccines for cancer316
Future developments to enhance clinical efficacy of DC vaccines316
Lymphocyte-based cancer therapies318
Adoptive immunotherapy318
Rescue of CD8+ T cells for use in tumor immunotherapy319
Expansion of antigen-specific cytotoxic T lymphocytes319
Genetically targeted T cells for treating B cell malignancies320
Tumor infiltrating lymphocytes320
Genetic engineering of tumor cells321
Hybrid cell vaccination321
Stem cell-based anticancer therapies322
Stem cell transplantation in cancer322
Peripheral blood stem cell transplantation322
Stem cell transplantation for hematological malignancies324
Complications of stem cell transplants in cancer325
Long-term results of HSC transplantation326
Prediction of T-cell reconstitution after HSC transplantation.327
HSC transplantation followed by GM-CSF-secreting cell vaccines327
Role of MSCs in cancer328
Nonmyeloablative allogeneic hematopoietic stem cell transplantation328
Umbilical cord blood transplant for leukemia329
hESC-derived NK cells for treatment of cancer329
ESC vaccine for prevention of lung cancer330
Genetic modification of stem cells for cancer therapy330
Genetic modification of hematopoietic stem cells330
Use of hematopoietic stem cells to deliver suicide genes to tumors330
Delivery of anticancer agents by genetically engineered MSCs331
Mesenchymal progenitor cells for delivery of oncolytic adenoviruses331
Genetically modified NSCs for treatment of neuroblastoma332
Innovations in cell-based therapy of cancer332
Use of immortalized cells332
Cancer therapy based on natural killer cells332
Mesothelin as a target for cancer immunotherapy333
Nanomagnets for targeted cell-based cancer gene therapy333
Implantation of genetically modified encapsulated cells for anticancer therapy334
Antiangiogenesis therapy by implantation of microencapsulated cells334
Recombinant tumor cells secreting fusion protein334
NovaCaps?, for pancreatic c
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