Reportlinker Adds Cell Therapy - Technologies, Markets and Companies

Jun 03, 2010, 11:24 ET from Reportlinker

NEW YORK, June 3 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Cell Therapy - Technologies, Markets and Companies

http://www.reportlinker.com/p0203537/Cell-Therapy---Technologies-Markets-and-Companies.html

Summary

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets was analyzed for 2009, and projected to 2019. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 270 of these are profiled in part II of the report along with tabulation of 253 alliances. Of these companies, 150 are involved in stem cells. Profiles of 66 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 47 Tables and 11 Figures. The bibliography contains 1,000 selected references, which are cited in the text.

TABLE OF CONTENTS

0.Executive Summary21

1.Introduction to Cell Therapy25

Introduction25

Historical landmarks of cell therapy25

Interrelationship of cell therapy technologies27

Cells and organ transplantation27

Cells and protein/gene therapy28

Cell therapy and regenerative medicine29

Cells therapy and tissue engineering29

Therapy based on cells involved in disease30

Advantages of therapeutic use of cells30

Use of cells for improving drug delivery31

2.Cell Therapy Technologies33

Introduction33

Cell types used for therapy33

Sources of cells33

Xenografts34

Cell lines34

Immortalized cells34

Blood component therapy34

Therapeutic apheresis34

Leukoreduction35

Platelet therapy35

Basic technologies for cell therapy36

Cell culture36

Observation of stem cell growth and viability36

Companies involved in cell culture37

Cell sorting38

Flow cytometry38

A dielectrophoretic system for cell separation39

Molecular beacons for specific detection and isolation of stem cells39

Multitarget magnetic activated cell sorter40

Nanocytometry40

Companies supplying cell sorters40

Dynabead technology for cell sorting41

ALDESORTER system for isolation of stem cells41

Adult stem cell sorting by identification of surface markers42

Cell analysis42

Preservation of cells43

Innovations in cryopreservation43

Packaging of cells43

Selective expansion of T cells for immunotherapy44

Cloning and cell therapy44

Techniques for cell manipulation45

Cell-based drug discovery45

Cells as vehicles for drug delivery48

RBCs as drug delivery vehicles48

Drug delivery systems for cell therapy48

Intravenous delivery of stem cells48

Pharmacologically active microcarriers49

Devices for delivery of cell therapy49

Artificial cells50

Applications of artificial cells50

Cell encapsulation51

Diffusion capsule for cells51

Encapsulated cell biodelivery52

Therapeutic applications of encapsulated cells52

Nitric oxide delivery by encapsulated cells53

Implantation of microencapulated genetically modified cells54

Ferrofluid microcapsules for tracking with MRI54

Companies involved in encapsulated cell technology55

Electroporation55

Gene therapy56

Cell-mediated gene therapy56

Fibroblasts56

Chondrocyte57

Skeletal muscle cells57

Vascular smooth muscle cells58

Keratinocytes58

Hepatocytes59

Lymphocytes59

Mammalian artificial chromosomes59

In vivo tracking of cells59

Molecular imaging for tracking cells60

MRI technologies for tracking cells60

Superparamagnetic iron oxide nanoparticles as MRI contrast agents61

Visualization of gene expression in vivo by MRI61

Role of nanobiotechnology in development of cell therapy61

Cell transplantation for development of organs62

Cells transplantation and tolerance62

Strategies to improve tolerance of transplanted cells63

Encapsulation to prevent immune rejection63

Prevention of rejection of xenotransplants63

Expansion of allospecific regulatory T cells64

Removal and replacement of pathogenic cells of the body64

Therapeutic leukocytapheresis64

3.Stem Cells66

Introduction66

Biology of stem cells67

Embryonic stem cells67

Growth and differentiation of ESCs67

Regulation of stem cell self-renewal and differentiation68

Role of Pax3 in stem cell differentiation68

ESCs and signaling pathways69

Genetic signature of of stem cells69

Epigenetics of hESCs69

Chromatin as gene regulator for ESC development70

Mechanism of differentiation of ESCs70

Chemical regulation of stem cell differentiation71

Comparison of development of human and mouse ESCs71

In vitro differentiation of hESCs71

Global transcription in pluripotent ESCs72

Signaling pathways and transcription factors in ESCs72

Stem cells in the pituitary gland72

hESCs in stead of oocytes for reprogramming human somatic nuclei73

Mechanism of regulation of stem cells for regeneration of body tissues73

Role of microenvironments in the regulation of stem cells73

Regulation and regeneration of intestinal stem cells74

Parthenogenesis and human stem cells74

Uniparental ESCs75

Bone marrow stem cells75

Hematopoietic stem cells75

Role of HSCs in the immune system77

Derivation of HSCs from ESCs78

Mesenchymal stem cells78

Multipotent adult progenitor cells79

Side population (SP) stem cells80

Differentiation of adult stem cells80

Growth and differentiation of HSCs81

Signaling pathways in the growth and differentiation of HSCs81

Mathematical modeling of differentiation of HSCs82

Role of prions in self renewal of HSCs82

Sources of stem cells82

Sources of of human embryonic stem cells82

Nuclear transfer to obtain hESCs83

Direct derivation of hESCs from embryos without nuclear transfer84

Alternative methods of obtaining hESCs84

Establishing hESC lines without destruction of embryo84

Altered nuclear transfer85

Small embryonic-like stem cells86

Advantages and disadvantages of ESCs for transplantation86

Use of ESC cultures as an alternative source of tissue for transplantation87

Spermatogonial stem cells87

Amniotic fluid as a source of stem cells88

Generation of iPS cells from AF cells89

Placenta as source of stem cells89

Amnion-derived multipotent progenitor cells89

Placenta as a source of HSCs90

Umbilical cord as a source of MSCs90

Umbilical cord blood as source of neonatal stem cells90

Cryopreservation of UCB stem cells91

UCB as source of MSCs92

Applications of UCB92

Advantages of UCB92

Limitations of the use of UCB93

Licensing and patent disputes involving UCB94

Infections following UCB transplants94

Unanswered questions about UCB transplantation95

Companies involved in UCB banking95

UCB banking in the UK96

US national UCB banking system97

Future prospects of UCB as a source of stem cells98

Induced pluripotent stem cells derived from human somatic cells98

Characteristics of iPSCs99

DNA methylation patterns of iPS cells99

iPSCs derived from blood100

iPSCs derived from skin100

Use of retroviral vectors for generation of iPSCs100

Use of non-integrating viral vectors for generation of iPSCs100

Clinical relevance of iPSCs101

Sources of adult human stem cells102

Adipose tissue as a source of stem cells103

Transforming adult adipose stem cells into other cells103

iPSCs derived from adult human adipose stem cells103

Skin as a source of stem cells104

Controlling the maturation of embryonic skin stem cells104

Epidermal neural crest stem cells104

Follicle stem cells105

Mesenchymal stem cells in skin105

Regulation of stem cells in hair follicles105

Skin-derived precursor cells106

Stem cells in teeth106

Peripheral blood stem cells107

Spleen as a source of adult stem cells107

Search for master stem cells108

Vascular cell platform to self-renew adult HSC108

Adult stem cells vs embryonic stem cells108

Transdifferentiation potential of adult stem cells109

Neural crest stem cells from adult hair follicles110

Stem cells obtained from blood in adults111

VENT cells111

Stem cell banking111

Stem cell technologies112

Analysis of stem cell growth and differentiation112

Tracking self-renewal and expansion of transplanted muscle stem cells112

Stem cell biomarkers112

Endoglin as a functional biomarker of HSCs113

STEMPRO? EZChek? for analysis of biomarkers of hESCs113

SSEA-4 as biomarker of MSCs113

p75NTR as a biomarker to isolate adipose tissue-derived stem cells113

Neural stem cell biomarker114

Protein expression profile as biomarker of stem cells114

Real-time PCR for quantification of protein biomarkers114

Study of stem cell pathways115

Study of stem cell genes115

Gene inactivation to study hESCs116

RNAi to study gene inactivation in hESCs116

Study of ESC development by inducible RNAi117

Targeting Induced Local Lesions in Genomes117

Homologous recombination of ESCs117

Immortalization of hESCs by telomerase117

Gene modification in genomes of hESCs and hiPSCs using zinc-finger nuclease118

miRNA and stem cells118

Role of miRNAs in gene regulation during stem cell differentiation119

Influence of miRNA on stem cell formation and maintenance119

Transcriptional regulators of ESCs control miRNA gene expression120

Stem cells and cloning120

Cell nuclear replacement and cloning120

Nuclear transfer and ESCs120

Cloning from differentiated cells122

Cloning mice from adult stem cells122

Creating interspecies stem cells123

Cloned cells for transplantation medicine123

Claims of cloning of hESCs123

Cytogenetics of embryonic stem cells125

Engraftment, mobilization and expansion of stem cells125

Adipogenesis induced by adipose tissue-derived stem cells126

Antisense approach for preservation and expansion of stem cells126

Chemoattraction of neuronal stem cells through GABA receptor127

Enhancement of HSC engraftment by calcium-sensing receptor127

Enhancement of stem cell differentiation by Homspera128

Ex vivo expansion of human HSCs in culture128

Ex vivo expansion of MSCs129

Expansion of HSCs in culture by inhibiting aldehyde dehydrogenase129

Expansion of adult stem cells by activation of Oct4129

Expansion of transduced HSCs in vivo130

Mobilization of HSCs by growth factors130

Mobilization of stem cells by cytokines/chemokines131

Mobilization of adult human HSCs by use of inhibitors131

Mobilization of stem cells by HYC750132

Mobilization of stem cells by hyperbaric oxygen132

Mobilization by adenoviral vectors expressing angiogenic factors133

Selective mobilization of progenitor cells from bone marrow133

Selective Amplification133

Stem cell mobilization by acetylcholine receptor agonists134

Use of parathyroid hormone to increase HSC mobilzation134

Expansion of stem cells in vivo by Notch receptor ligands134

Technologies for inducing differentiation of stem cells134

Use of lineage selection to induce differentiation of hESCs134

Growth factor-induced differentiation of MAPCs135

Neurotrophin-mediated survival and differentiation of hESCs135

Generation of RBCs from hematopoietic stem cells135

Generation of multiple types of WBCs from hESCs and iPSCs136

Use of RNAi to expand the plasticity of autologous adult stem cells136

Use of carbohydrate molecules to induce differentiation of stem cells136

Mechanical strain to induce MSC differentiation137

Limitations of the currently available stem cell lines in the US137

Contaminating material in stem cell culture and measures to eliminate it138

Stem cell separation139

Stem cell culture139

Conversion of stem cells to functioning adipocytes140

Mass production of ESCs140

Promoting survival of dissociated hESCs141

Analysis and characterization of stem cells141

Havesting and identification of EPCs141

Labeling of stem cells142

Quantum dots for labeling stem cells142

Imaging and tracking of stem cells in vivo142

Quantum dot imaging for ESCs142

Perfluorocarbon nanoparticles to track therapeutic cells in vivo143

Project for imaging in stem cell therapy research143

Applications of stem cells143

Controlling the maintenance process of hematopoietic stem cells144

Self renewal and proliferation of HSCs144

Aging and rejuvenation of HSCs144

Peripheral blood stem cell transplantation145

Complications of PBSC transplantation in children145

Stem cell transplantation for radiation sickness145

Stem cells and human reproduction146

Expansion of spermatogonial stem cells146

Conversion of ESCs into spermatogonial stem cells146

Conversion of stem cells to oocytes146

ESCs for treatment of infertility in women147

Cloning human embryos from oocytes matured in the laboratory147

In utero stem cell transplantation148

Innovations in delivery of stem cells149

Immunological aspects of hESC transplantation149

Immunosuppression to prevent rejection of hESC transplants149

Histocompatibility of hESCs150

Strategies for promoting immune tolerance of hESCs150

Stem cells for organ vascularization151

Activation of EphB4 to enhance angiogenesis by EPCs151

Advantages and limitations of clinical applications of MSCs152

Biofusion by genetically engineering stem cells152

Stem cell gene therapy153

Combination of gene therapy with nuclear transfer153

Gene delivery to stem cells by artificial chromosome expression153

Genetic manipulation of ESCs153

Genetic engineering of human stem cells for enhancing angiogenesis154

HSCs for gene therapy154

Helper-dependent adenoviral vectors for gene transfer in ESCs155

Lentiviral vectors for in vivo gene transfer to stem cells155

Linker based sperm-mediated gene transfer technology155

Mesenchymal stem cells for gene therapy156

Microporation for transfection of MSCs156

Regulation of gene expression for SC-based gene therapy156

Stem cells and in utero gene therapy157

Therapeutic applications for hematopoietic stem cell gene transfer157

The future of hematopoietic stem cell gene therapy157

Stem cell pharmaceutics157

Cardiomyocytes derived from hESCs158

Engineered stem cells for drug delivery to the brain158

ESCs as source of models for drug discovery159

Hepatocytes derived from hESCs159

Pharmaceutical manipulation of stem cells160

Role of stem cells in therapeutic effects of drugs162

Stem cells for drug discovery162

Stem cell activation for regeneration by using glucocortoids163

Toxicology and drug safety studies using ESCs163

Future challenges for stem cell technologies165

Study of the molecular mechanism of cell differentiation166

MBD3-deficient ESC line166

In vivo study of human hemopoietic stem cells166

Stem cell biology and cancer167

Research into plasticity of stem cells from adults168

Stem cells and aging168

Activation of bone marrow stem cells into therapeutic cells169

Role of nitric oxide in stem cell mobilization and differentiation169

Stem cell genes170

Gene expression in hESCs170

The casanova gene in zebrafish170

Nanog gene171

Stem cell proteomics172

hESC phosphoproteome172

Proteomic studies of mesenchymal stem cells173

Proteomic profiling of neural stem cells173

Proteome Biology of Stem Cells Initiative173

Genomic alterations in cultured hESCs174

Hybrid embryos/cybrids for stem cell research174

Generation of patient-specific pluripotent stem cells175

Markers for characterizing hESC lines175

Switch of stem-cell function from activators to repressors176

Stem cell research at academic centers176

International Regulome Consortium177

Companies involved in stem cell technologies178

Concluding remarks about stem cells183

Challenges and future prospects of stem cell research183

4.Clinical Applications of Cell Therapy186

Introduction186

Cell therapy for hematological disorders186

Transplantation of autologous hematopoietic stem cells186

Hemophilias186

Ex vivo cell/gene therapy of hemophilia B186

Cell/gene therapy of hemophilia A187

Hematopoietic stem cell therapy for thrombocytopenia188

Stem cell transplant for sickle cell anemia188

Treatment of chronic acquired anemias189

Implantation of genetically engineered HSCs to deliver rhEpo189

Drugs acting on stem cells for treatment of anemia189

Stem cell therapy of hemoglobinopathies190

Stem cells for treatment of immunoglobulin-light chain amyloidosis190

Future prospects of cell therapy of hematological disorders190

Cell therapy for immunological disorders191

Role of dendritic cells in the immune system191

Modifying immune responses of DCs by vaccination with lipiodol-siRNA mixtures191

Stem cell therapy of chronic granulomatous disease192

Stem cell therapy of X-linked severe combined immunodeficiency192

Stem cell therapy of autoimmune disorders193

Treatment of Crohn's disease with stem cells193

Treatment of rheumatoid arthritis with stem cells193

Stem cell transplants for scleroderma194

Role of T-Cells in immunological disorders194

Autologous T-cells from adult stem cells195

Cell therapy for graft vs host disease195

Cell therapy for viral infections196

T-cell therapy for CMV196

T-cell therapy for HIV infection197

T-cell immunity by Overlapping Peptide-pulsed Autologous Cells197

Anti-HIV ribozyme delivered in hematopoietic progenitor cells198

Dendritic-cell targeted DNA vaccine for HIV198

Cell therapy of lysosomal storage diseases198

Niemann-Pick disease199

Gaucher's disease199

Fabry's disease200

Cell therapy for diabetes mellitus200

Limitations of current treatment201

Limitations of insulin therapy for diabetes mellitus201

Limitations of pancreatic transplantation201

Islet cell transplantation202

Autologous pancreatic islet cell transplantation in chronic pancreatitis202

Clinical trials of pancreatic islet cell transplants for diabetes202

Drawbacks of islet cell therapy203

Use of an antioxidant peptide to improve islet cell transplantation203

Cdk-6 and cyclin D1 enhance human beta cell replication and function204

A device for delivery of therapeutic cells in diabetes204

Monitoring of islet cell transplants with MRI204

Concluding remarks about allogeneic islet transplantation for diabetes205

Encapsulation of insulin producing cells205

Encapsulated porcine pancreatic islet cells for pancreas205

Encapsulated insulinoma cells206

Magnetocapsule enables imaging/tracking of islet cell transplants206

Islet precursor cells207

Dedifferentiation of ? cells to promote regeneration207

Xenotransplantation of embryonic pancreatic tissue208

Non-pancreatic tissues for generation of insulin-producing cells208

Exploiting maternal microchimerism to treat diabetes in the child208

Bio-artificial substitutes for pancreas209

Role of stem cells in the treatment of diabetes209

Pancreatic stem cells209

Embryonic stem cells for diabetes210

Isolation of islet progenitor cells211

Expansion of pancreatic progenitor cells in vitro211

Human neural progenitor cells converted into insulin-producing cells211

Insulin-producing cells derived from UCB stem cells212

Stem cell injection into portal vein of diabetic patients212

HSC transplantation to supplement immunosuppressant therapy212

Dendritic cell-based therapy for type 1 diabetes213

Gene therapy in diabetes213

Viral vectors for gene therapy of diabetes213

Genetically engineered dendritic cells214

Genetically altered liver cells214

Genetically modified stem cells215

Companies developing cell therapy for diabetes215

Concluding remarks about cell and gene therapy of diabetes216

Cell therapy of gastrointestinal disorders217

Inflammatory bowel disease217

Cell therapy for liver disorders217

Types of cells and methods of delivery for hepatic disorders218

Bioartificial liver218

Limitations of bioartificial liver219

Stem cells for hepatic disorders219

Deriving hepatocytes from commercially available hMSCs220

Implantation of hepatic cells derived from hMSCs of adipose tissue221

MSC derived molecules for reversing hepatic failure221

Cell-based gene therapy for liver disorders221

Transplantation of genetically modified fibroblasts222

Transplantation of genetically modified hepatocytes222

Intraperitoneal hepatocyte transplantation222

Genetically modified hematopoietic stem cells222

Clinical applications223

Future prospects of cell-based therapy of hepatic disorders223

Cell therapy of renal disorders224

Bioartificial kidney224

Bone marrow stem cells for renal disease224

Human stem cells to prevent end stage renal disease225

Role of stem cells in renal repair225

Cell-based repair for vascular access failure in renal disease225

Mesangial cell therapy226

Cell therapy for pulmonary disorders226

Delivery of cell therapy for pumonary disorders226

Intratracheal injection of cells for pulmonary hypoplasia226

Role of stem cells in pulmonary disorders227

Lung tissue regeneration from stem cells227

Role of stem cells in construction of the Cyberlung227

Respiratory epithelial cells derived from UCB stem cells228

Respiratory epithelial cells derived from hESCs228

Lung tissue engineering with adipose stromal cells228

Cell-based tissue-engineering of airway229

Pulmonary disorders that are treatable by stem cells229

Acute lung injury and ARDS treated with MSCs230

Bronchopulmonary dysplasia treated with MSCs231

Cystic fibrosis treatment with genetically engineered MSCs231

Pulmonary arterial hypertension treatment with EPCs231

Cell therapy for disorders of bones and joints232

Repair of fractures and bone defects232

Adult stem cells for bone grafting233

Cell therapy for osteonecrosis233

ESCs for bone repair234

Intrauterine use of MSCs for osteogenesis imperfecta234

In vivo bone engineering as an alternative to cell transplantation234

MSCs for repair of bone defects234

MSCs for repair of bone fractures237

Osteocel238

Stem cells for repairing skull defects238

Stem cell-based bone tissue engineering238

Osteoarthritis and other injuries to the joints239

Mosaicplasty240

Autologous cultured chondrocytes240

Autologous intervertebral disc chondrocyte transplantation241

Cartilage repair by genetically modified fibroblasts expressing TGF-?242

Generation of cartilage from stem cells242

Role of cell therapy in repair of knee cartilage injuries244

Role of cells in the repair of anterior cruciate ligament injury245

Autologous tenocyte implantation in rotator cuff injury repair246

Platelet injection for tennis elbow246

Cell therapy of rheumatoid arthritis247

Cell therapy for diseases of the eye247

Cell therapy for corneal repair247

Stem cell therapy for limbal stem cell deficiency249

Cell therapy for regeneration249

Stem cells for regeneration249

Stem cells for regenerating organs250

Umbilical cord blood for regeneration251

Promotion of regeneration by Wnt/beta-catenin signaling251

Role of stem cells in regeneration of esophageal epithelium252

Cell therapy for regeneration of muscle wasting252

MSCs for regeneration of ovaries following radiotherapy damage253

Wound healing: skin and soft tissue repair253

Cells to form skin substitutes for healing ulcers253

CellSpray for wound repair254

Cell therapy for burns255

Closure of incisions with laser guns and cells255

Follicular stem cells for skin and wound repair256

Genetically engineered cells for wound repair256

Regeneration of skin by adipose-derived stem cells256

Repair of aging skin by injecting autologous fibroblasts257

Role of cells in tissue engineering and reconstructive surgery257

Stem cells for tissue repair257

Scaffolds for tissue engineering258

Improving vascularization of engineered tissues258

Enhancing vascularization by combining cell and gene therapy258

Choosing cells for tissue engineering259

ESCs vs adult SCs for tissue engineering259

Use of adult MSCs for tissue engineering260

Nanobiotechnology applied to cells for tissue engineering260

Stem cells for tissue engineering of various organs261

Engineering of healthy living teeth from stem cells261

Adipose tissue-derived stem cells for breast reconstruction262

Improving tissue engineering of bone by MSCs262

Intra-uterine repair of congenital defects using amniotic fluid MSCs263

Cell-based tissue engineering in genitourinary system263

Urinary incontinence263

Tissue engineering of urinary bladder264

Label retaining urothelial cells for bladder repair265

Repair of the pelvic floor with stem cells from the uterus265

Reconstruction of vagina from stem cells265

Facial skin regeneration by stem cells as an alternative to face transplant266

Cell therapy for rejuvenation266

Cell therapy for performance enhancement in sports266

Application of stem cells in veterinary medicine267

Use of stem cells to repair tendon injuries267

Stem cells for spinal cord injury in dogs267

5.Cell Therapy for Cardiovascular Disorders269

Introduction to cardiovascular disorders269

Limitations of current therapies for myocardial ischemic disease269

Types of cell therapy for cardiovascular disorders269

Cell-mediated immune modulation for chronic heart disease270

Human cardiovascular progenitor cells271

Inducing the proliferation of cardiomyocytes271

Role of the SDF-1-CXCR4 axis in stem cell therapies for myocardial ischemia272

Role of splenic myocytes in repair of the injured heart272

Small molecules to enhance myocardial repair by stem cells272

Cell therapy for atherosclerotic coronary artery disease273

MyoCell™ (Bioheart)273

Cardiac stem cells274

Cardiomyocytes derived from epicardium274

Methods of delivery of cells to the heart275

Cellular cardiomyoplasty275

IGF-1 delivery by nanofibers to improve cell therapy for MI275

Non-invasive delivery of cells to the heart by Morph®guide catheter276

Cell therapy for cardiac revascularization276

Transplantation of cardiac progenitor cells for revascularization of myocardium276

Stem cells to prevent restenosis after coronary angioplasty276

Role of cells in cardiac tissue repair277

Transplantation of myoblasts for myocardial infarction277

Patching myocardial infarction with fibroblast culture278

Cardiac repair with myoendothelial cells from skeletal muscle278

Myocardial tissue engineering279

Role of stem cells in repair of the heart280

Role of stem cells in cardiac regeneration following injury280

Cardiomyocytes derived from adult skin cells280

Cardiomyocytes derived from ESCs280

Studies to identify subsets of progenitor cells suitable for cardiac repair281

Technologies for preparation of stem cells for cardiovascular therapy282

Pravastatin for expansion of endogenous progenitor and stem cells282

Cytokine preconditioning of human fetal liver CD133+ SCs282

Expansion of adult cardiac stem cells for transplantation283

Role of ESCs in repair of the heart283

ESC transplantation for tumor-free repair of the heart284

Transplantation of stem cells for acute myocardial infarction284

Autologous bone marrow-derived stem cell therapeutics285

Autologous bone marrow-derived mesenchymal precursor stem cells285

Transplantation of cord blood stem cells285

Transplantation of hESCs285

Transplantation of HSCs286

Transplantation of autologous angiogenic cell precursors287

Transplantation of adipose-derived stem cells287

Intracoronary infusion of bone marrow-derived cells for AMI288

Intracoronary infusion of mobilized peripheral blood stem cells288

Transplantation of endothelial cells289

Transplantation of cardiomyocytes differentiated from hESCs289

Stem cell therapy for cardiac regeneration289

Regeneration of the chronic myocardial infarcts by HSC therapy290

Human mesenchymal stem cells for cardiac regeneration290

In vivo tracking of MSCs transplanted in the heart291

MSCs for hibernating myocardium291

Simultaneous transplantation of MSCs and skeletal myoblasts292

Transplantation of genetically modified cells292

Transplantation of genetically modified MSCs292

Transplantation of cells secreting vascular endothelial growth factor292

Transplantation of genetically modified bone marrow stem cells293

Cell transplantation for congestive heart failure293

Myoblasts for treatment of congestive heart failure293

Injection of adult stem cells for congestive heart failure293

AngioCell gene therapy for congestive heart failure294

Stem cell therapy for dilated cardiac myopathy295

Role of cell therapy in cardiac arrhythmias295

Atrioventricular conduction block296

Genetically engineered cells as biological pacemakers296

Ventricular tachycardia297

Prevention of myoblast-induced arrhythmias by genetic engineering297

ESCs for correction of congenital heart defects297

Cardiac progenitors cells for treatment of heart disease298

Autologus stem cells for chronic myocardial ischemia298

Role of cells in cardiovascular tissue engineering299

Construction of blood vessels with cells299

Targeted delivery of endothelial progenitor cells labeled with nanoparticles300

Fetal cardiomyocytes seeding in tissue-engineered cardiac grafts300

UCB progenitor cells for engineering heart valves300

Cell therapy for peripheral vascular disease300

ALD-301301

Cell/gene therapy for PVD301

Colony stimulating factors for enhancing peripheral blood stem cells301

Intramuscular autologous bone marrow cells302

Vascular Repair Cell302

Clinical trials of cell therapy in cardiovascular disease302

Mechanism of the benefit of cell therapy for heart disease305

A critical evaluation of cell therapy for heart disease305

Publications of clinical trials of cell therapy for CVD305

Current status of cell therapy for cardiovascular disease306

Future directions for cell therapy of CVD306

Prospects of adult stem cell therapy for repair of heart306

Regeneration of cardiomyocytes without use of cardiac stem cells307

6.Cell Therapy for Cancer308

Introduction308

Cell therapy technologies for cancer308

Cellular immunotherapy for cancer309

Treatments for cancer by ex vivo mobilization of immune cells309

Granulocytes as anticancer agents310

Neutrophil granulocytes in antibody-based immunotherapy of cancer310

Cancer vaccines311

Autologous tumor cell vaccines311

BIOVAXID311

OncoVAX311

Tumor cells treated with dinitrophenyl312

Vaccines that simultaneously target different cancer antigens312

Gene modified cancer cells vaccines312

GVAX cancer vaccines312

K562/GM-CSF313

Active immunotherapy based on antigen specific to the tumor313

The use of dendritic cells for cancer vaccination314

Autologous dendritic cells loaded ex vivo with telomerase mRNA314

Dendritic/tumor cell fusion314

Genetically modified dendritic cells315

In vivo manipulation of dendritic cells315

Preclinical and clinical studies with DC vaccines315

Vaccines based on dendritic cell-derived exosomes316

Limitations of DC vaccines for cancer316

Future developments to enhance clinical efficacy of DC vaccines316

Lymphocyte-based cancer therapies318

Adoptive immunotherapy318

Rescue of CD8+ T cells for use in tumor immunotherapy319

Expansion of antigen-specific cytotoxic T lymphocytes319

Genetically targeted T cells for treating B cell malignancies320

Tumor infiltrating lymphocytes320

Genetic engineering of tumor cells321

Hybrid cell vaccination321

Stem cell-based anticancer therapies322

Stem cell transplantation in cancer322

Peripheral blood stem cell transplantation322

Stem cell transplantation for hematological malignancies324

Complications of stem cell transplants in cancer325

Long-term results of HSC transplantation326

Prediction of T-cell reconstitution after HSC transplantation.327

HSC transplantation followed by GM-CSF-secreting cell vaccines327

Role of MSCs in cancer328

Nonmyeloablative allogeneic hematopoietic stem cell transplantation328

Umbilical cord blood transplant for leukemia329

hESC-derived NK cells for treatment of cancer329

ESC vaccine for prevention of lung cancer330

Genetic modification of stem cells for cancer therapy330

Genetic modification of hematopoietic stem cells330

Use of hematopoietic stem cells to deliver suicide genes to tumors330

Delivery of anticancer agents by genetically engineered MSCs331

Mesenchymal progenitor cells for delivery of oncolytic adenoviruses331

Genetically modified NSCs for treatment of neuroblastoma332

Innovations in cell-based therapy of cancer332

Use of immortalized cells332

Cancer therapy based on natural killer cells332

Mesothelin as a target for cancer immunotherapy333

Nanomagnets for targeted cell-based cancer gene therapy333

Implantation of genetically modified encapsulated cells for anticancer therapy334

Antiangiogenesis therapy by implantation of microencapsulated cells334

Recombinant tumor cells secreting fusion protein334

NovaCaps?, for pancreatic c

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