Reportlinker Adds Global Chiral Technology Industry

Mar 21, 2011, 13:36 ET from Reportlinker

NEW YORK, March 21, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Chiral Technology Industry

http://www.reportlinker.com/p090558/Global-Chiral-Technology-Industry.html

This report analyzes the worldwide markets for Chiral Technology in US$ Million, both by Chiral Technology Enabling Products (Intermediates, Analytical, and Others) and by Chiral Technology End Use Markets (Pharmaceuticals, and Agrochemicals). The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a seven-year historic analysis is provided for these markets. The report profiles 38 companies including many key and niche players worldwide such as Albemarle Corporation, BASF AG, Cambrex Corp., Chiral Quest Inc., Dalco ChromTech AB, Daicel Chemical Industries Ltd., Chiral Technologies Worldwide, Chiral Technologies, Inc., Chiral Technologies Europe, DSM Pharmaceutical Products, Johnson Matthey PLC, Regis Technologies Inc., Shasun Chemicals and Drugs Limited, Solvias, Sigma Aldrich Corp, and Suven Life Sciences Ltd. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1

Study Reliability and Reporting Limitations 1

Disclaimers 2

Data Interpretation & Reporting Level 3

Quantitative Techniques & Analytics 3

Product Definitions and Scope of Study 3

Chiral Technology Enabling Products 4

Chiral Intermediates 4

Analytical Products 4

Other Products 4

Chiral Technology End-Use Markets 5

Pharmaceuticals 5

Agrochemicals 5

2. MARKET OVERVIEW 6

Bright Outlook for the Global Chiral Technology Market 6

Analysis by Product Segments and End use Markets 6

Table 1: World Chiral Technology Market by Product Segment

(2009): Percentage Share Breakdown by Value Sales for Chiral

Intermediates, Chiral Analytical Products, and Others

(includes corresponding Graph/Chart) 6

Good Tidings for Chiral Technology 7

Market Drivers 8

Demand for Chiral-based Therapeutic Drugs Augments Growth 8

New Legislations Push Chiral Technology Demand 8

Key Market Trends 8

Organizations Extend Approaches 8

Companies' Association with Universities 9

Trends in Chiral Processes 9

Increasing Reliance on Generic Approaches 9

Predominant Use of Polysaccharides Derivatives as CSPs 9

Automation: Introduction of Instruments Supporting Chiral

Processes, a Growing Trend 9

3. CHIRAL TECHNOLOGY 10

An Insight into Chiral Technology 10

Techniques Used for Achieving Single-Isomers 10

Table 2: World Chiral Technology Market (2002 & 2010):

Percentage Breakdown of Revenues by Techniques- Traditional

Methods, Asymmetric Methods, and Biological Methods (includes

corresponding Graph/Chart) 11

Importance and Advancements 11

4. CHIRAL TECHNOLOGY - AN OVERVIEW 13

Definitions 13

Chiral Technology Enabling Products 13

Chiral Intermediates 13

Analytical Products 13

Other Products 13

Chiral Technology End-Use Markets 14

Pharmaceuticals 14

Agrochemicals 14

Description 14

Functioning of Chiral Molecules 15

Chiral Preparation Process 15

Traditional Methods 15

Biological Methods 16

Asymmetric Methods 16

Chiral Separation 17

Factors Influencing the Efficacy of Chiral Separations 17

Recent Approaches in Chiral Separations 17

Extensive Use of Supercritical Fluid Chromatography (SFC) 17

Chromatography - The Widely Used Method for Separation 18

How it Works? 18

Chiral Mobile Phase Additive (CMPA) 19

Chiral Stationary Phase (CSP) 19

List of Newly Introduced Generic Versions of Derivatized

Amylose and Cellulose Phases 20

Challenges and Novel Concepts in the Development of Chiral

Stationary Phases 20

Novel Concepts 20

Chiral Recognition 21

Protein Chiral Stationary Phases 21

Carbohydrate Columns 21

Pirkle Columns 21

Crystallization 22

Solvent Extraction 22

Kinetic Resolution 23

Capillary Electrophoresis 23

Receptor Based Resolution 23

Miscellaneous Separative Techniques 24

Chiral Synthesis 24

5. CHIRAL TECHNOLOGY - DEVELOPMENT VS ACQUISITION 25

In-House Creation & Development 25

Acquisition of Technology 25

"Economics" of Chiral Technology 26

6. CHIRAL ANALYSIS 27

Chiral Analysis: A Primer 27

Chiral Analysis Products 27

Chiral Analytical Chromatography 27

Chiral Liquid Chromatography 27

Supercritical Fluid Chromatography - Substitute to LC for

Enantiomer Separations 28

Chiral Gas Chromatography 28

Chiral Simulated Moving Bed Chromatography 28

Partition Chromatography 28

Adsorption Chromatography 29

Computer Assisted Resolution 29

Chiral Polarimetry 29

Other Chiral Analytical Techniques 30

Calorimetry 30

Differential Scanning Calorimetry (DSC) 30

Enzymatic Assay 30

Immunoassay 30

Isotope Dilution 31

Nuclear Magnetic Resonance (NMR) 31

X-Ray Crystallography 31

7. APPLICATION MARKETS 32

Pharmaceuticals - The Largest Market 32

Changing Face of the Pharmaceutical Industry: A Review 32

Analysis of Chiral Drugs 32

Select Companies Involved in Chiral Technology Market 33

Table 3: Single-Enantiomer Drugs Market Worldwide (2006- A

Recent past Perspective): Sales of Select Leading Brands

(In US$ Billion) (includes corresponding Graph/Chart) 34

Drugs Built on Chiral Technology 34

Analgesics 34

Anesthetics 35

Anti-Infective Products 35

Cardiovascular System (CVS) Products 35

Angiotensin-Converting Enzyme (ACE) Inhibitors 35

Beta-Blockers 35

Calcium Channel Blockers 36

Diuretics 36

Vasodilators 36

Central Nervous System (CNS) Agents 36

Anticonvulsants 36

Sedatives and Tranquilizers 36

Stimulants and Antidepressants 36

Oncogenic (Cancer-Treatment) Products 37

Biochemicals 37

Oligonucleotides 37

Oxyacids 38

Amino Acids 38

Sugars and Other Oligosaccharides 39

Vitamins 39

Peptides 40

Pesticides - A Thriving Market 41

Herbicides 41

Insecticides 41

Fungicides 42

Other Products 42

Liquid Crystals 42

Flavor and Aroma Chemicals 43

8. CHIRAL ISOMERISM 44

Organic Chemical Isomerism Types 44

Structural Isomerism 44

Chain Isomerism 44

Position Isomerism 44

Functional Group Isomerism 44

Stereoisomerism 44

Dynamic Isomerism (Tautomerism) 45

Patents 45

9. REGULATORY & ENVIRONMENTAL ISSUES- A REVIEW 46

10. PRODUCT INTRODUCTIONS/INNOVATIONS 47

Phenomenex Introduces Chiral Screening Service 47

AminoLogics Develops a Novel Chiral Converting Molecule for

Amino Acids 47

Chiral Technologies Worldwide to Display 3-im and Protein-

based Reversed Phase Columns 47

Chiral Technologies Introduces 3µm Chiral Stationary Phases

for Rapid Analysis 48

Chiral Technologies Introduces 5µm Versions of Polysaccharide

-Based Chiral Stationary 48

Semba Launches Semba Octave™ Chromatography System 48

Modular SFC to Launch Chiral Centrifugal Fraction Collector

and Sample Concentration System 49

Chiral Technologies Introduces New Versions of Immobilized IC

and IA Chiral Phases 49

PDR-Chiral Develops AutoMDS for Automated Screening of Chiral

and Achiral Substances 50

Waters Introduces New Products Under the UPLC Line 50

11. PRODUCT INTRODUCTIONS/INNOVATIONS IN THE RECENT PAST- A

PERSPECTIVE BUILDER 51

Sigma-Aldrich/Supelco Introduces Astec CHIROBIOTIC™ Chiral

HPLC Columns 51

Sigma-Aldrich/Supelco Introduces Astec CYCLOBOND™ Chiral HPLC

Columns 51

Chiral Technologies Introduces CHIRALPAK® IC Columns Under

Polysaccharide Product Range 51

Degussa Develops Novel Processes to Synthesize (S) CAP 52

Regis Technologies, Inc. Launches RegisPack Chiral Columns 52

Sigma-Aldrich Introduces ChiroSolv™ Kits 52

Sigma-Aldrich Launches Ascentis Express HPLC Columns 53

Evolved Nanomaterial Releases Revolutionary Analytical Chiral

Column 53

BASF Develops Novel Process to Produce Chiral Intermediates 53

Sepiatech Launches Sepmatix Parallel HPLC system 53

MACHEREY-NAGEL Launches Novel NUCLEOCEL CSP Columns 54

Eksigent to Launch Express™ HPLC System 54

Chiral Quest Launches C3 TunePhos 55

12. RECENT INDUSTRY ACTIVITY 56

WR Grace Takes Over Synthetech 56

Daicel Chiral to Start a New Branch in Beijing 56

Saltigo Concludes Process Development Agreement with Reuter

Chemische 56

Chiral Technologies Europe Inks Global Licensing Agreement

with University of Vienna 56

Shasun Announces Change of Name 57

CT Worldwide Announces the Launch of a Novel Microsite 57

Chiral Technologies Partners with Vanderbilt University's

Program in Drug Discovery 57

DSM Renews Co-Operation Agreement with Fudan University 57

Chiral Technologies Europe Inks Distribution Agreement with

HICHROM 58

Dow Sells Dowpharma Small Molecules Business 58

Daicel Chemical Establishes New Subsidiary in China 59

Chiral Technologies Europe Takes Over ChromTech 59

Cambrex to Buy ProSyntest AS 59

13. CORPORATE ACTIVITY IN THE RECENT PAST- A PERSPECTIVE BUILDER 60

Johnson Matthey and X-Zyme Sign Licensing Agreement 60

Chiral Quest Starts a New Production Facility 60

Chiral Quest Completes Reverse Merger with Surg II 60

DSM and IEP Extend Partnership 60

Shasun Chemicals Acquires Rhodia Pharma Solutions 60

Sigma-Aldrich Corp Acquires Astec 61

Solvias Receives License for MeOBIPHEP Catalyst Technology 61

Codexis Acquires Juelich Fine Chemicals 61

ChiroBlock Exits from Chiral Compounds Business 61

Chiral Quest Opens New Facility in China 61

Chiral Quest to Supply C3 TunePhos to Phoenix Chemicals 61

Lonza and Codexis Sign Agreement for Biocatalysis Process 62

DSM Signs Licensing Agreement with Chiral Quest 62

Chiral Quest Signs Distribution Agreement with Aldrich Chemical 62

BASF and Solvias to Collaborate on Chiral Molecule Development 62

Chiral Quest and Avantium Enter into Partnership 62

14. FOCUS ON SELECT PLAYERS 63

Albemarle Corporation (USA) 63

BASF SE (Germany) 63

Cambrex Corp. (USA) 63

Chiral Quest Inc. (US) 64

Dalco ChromTech AB (Sweden) 64

Daicel Chemical Industries Ltd. (Japan) 64

Chiral Technologies Worldwide 65

Chiral Technologies, Inc. (USA) 65

Chiral Technologies Europe (France) 65

DSM Pharmaceutical Products (The Netherlands) 65

Johnson Matthey PLC (UK) 66

Regis Technologies, Inc. (USA) 66

Shasun Pharmaceuticals Limited (India) 66

Solvias (Switzerland) 67

Sigma Aldrich Corp. (USA) 67

Suven Life Sciences Ltd. (USA) 67

15. GLOBAL MARKET PERSPECTIVE 69

Table 4: World Recent Past, Current & Future Analysis for

Chiral Technology Enabling Products by Geographic Region - US,

Japan, Europe, and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 69

Table 5: World Historic Review for Chiral Technology Enabling

Products by Geographic Region - US, Japan, Europe, and Rest of

World Markets Independently Analyzed with Annual Sales Figures

in US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 70

Table 6: World 11-Year Perspective for Chiral Technology

Enabling Products by Geographic Region - Percentage Breakdown

of Value Sales for US, Japan, Europe, and Rest of World

Markets for Years 2005, 2010 & 2015 (includes corresponding

Graph/Chart) 71

Table 7: World Recent Past, Current & Future Analysis for

Chiral Intermediates by Geographic Region - US, Japan, Europe,

and Rest of World Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2007 through 2015

(includes corresponding Graph/Chart) 72

Table 8: World Historic Review for Chiral Intermediates by

Geographic Region - US, Japan, Europe, and Rest of World

Markets Independently Analyzed with Annual Sales Figures in

US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 73

Table 9: World 11-Year Perspective for Chiral Intermediates by

Geographic Region - Percentage Breakdown of Value Sales for

US, Japan, Europe, and Rest of World Markets for Years 2005,

2010 & 2015 (includes corresponding Graph/Chart) 74

Table 10: World Recent Past, Current & Future Analysis for

Chiral Analytical Products by Geographic Region - US, Japan,

Europe, and Rest of World Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2007 through

2015 (includes corresponding Graph/Chart) 75

Table 11: World Historic Review for Chiral Analytical Products

by Geographic Region - US, Japan, Europe, and Rest of World

Markets Independently Analyzed with Annual Sales Figures in

US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 76

Table 12: World 11-Year Perspective for Chiral Analytical

Products by Geographic Region - Percentage Breakdown of Value

Sales for US, Japan, Europe, and Rest of World Markets for

Years 2005, 2010 & 2015 (includes corresponding Graph/Chart) 77

Table 13: World Recent Past, Current & Future Analysis for

Other Chiral Technology Enabling Products by Geographic Region

- US, Japan, Europe, and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 78

Table 14: World Historic Review for Other Chiral Technology

Enabling Products by Geographic Region - US, Japan, Europe,

and Rest of World Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2000 through 2006

(includes corresponding Graph/Chart) 79

Table 15: World 11-Year Perspective for Other Chiral

Technology Enabling Products by Geographic Region - Percentage

Breakdown of Value Sales for US, Japan, Europe, and Rest of

World Markets for Years 2005, 2010 & 2015 (includes

corresponding Graph/Chart) 80

Table 16: World Recent Past, Current & Future Analysis for

Chiral Technology in Pharmaceuticals by Geographic Region -

US, Japan, Europe, and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 81

Table 17: World Historic Review for Chiral Technology in

Pharmaceuticals by Geographic Region - US, Japan, Europe, and

Rest of World Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 82

Table 18: World 11-Year Perspective for Chiral Technology in

Pharmaceuticals by Geographic Region - Percentage Breakdown of

Value Sales for US, Japan, Europe, and Rest of World Markets

for Years 2005, 2010 & 2015 (includes corresponding

Graph/Chart) 83

Table 19: World Recent Past, Current & Future Analysis for

Chiral Technology in Agrochemicals by Geographic Region - US,

Japan, Europe, and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 84

Table 20: World Historic Review for Chiral Technology in

Agrochemicals by Geographic Region - US, Japan, Europe, and

Rest of World Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 85

Table 21: World 11-Year Perspective for Chiral Technology in

Agrochemicals by Geographic Region - Percentage Breakdown of

Value Sales for US, Japan, Europe, and Rest of World Markets

for Years 2005, 2010 & 2015 (includes corresponding

Graph/Chart) 86

16. THE UNITED STATES 87

A.Market Analysis 87

Overview 87

B.Market Analytics 88

Table 22: US Recent Past, Current and Future Analysis for

Chiral Technology Enabling Products by Product Segment -

Intermediates, Analytical, and Other Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 88

Table 23: US Historic Review for Chiral Technology Enabling

Products by Product Segment - Intermediates, Analytical, and

Other Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2006 (includes

corresponding Graph/Chart) 89

Table 24: US 11-Year Perspective for Chiral Technology

Enabling Products by Product Segment - Percentage Breakdown

of Value Sales for Intermediates, Analytical, and Other

Markets for Years 2005, 2010 & 2015 (includes corresponding

Graph/Chart) 90

Table 25: US Recent Past, Current & Future Analysis for

Chiral Technology by End-Use Segment - Pharmaceuticals, and

Agrochemicals Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2007 through 2015

(includes corresponding Graph/Chart) 91

Table 26: US Historic Review for Chiral Technology by

End-Use Segment - Pharmaceuticals, and Agrochemicals Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2000 through 2006 (includes corresponding

Graph/Chart) 92

Table 27: US 11-Year Perspective for Chiral Technology by

End-Use Segment - Percentage Breakdown of Value Sales for

Pharmaceuticals, and Agrochemicals Markets for Years 2005,

2010 & 2015 92

17. JAPAN 93

A.Market Analysis 93

Outlook 93

B.Market Analytics 93

Table 28: Japanese Recent Past, Current & Future Analysis

for Chiral Technology Enabling Products by Product Segment -

Intermediates, Analytical, and Other Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 93

Table 29: Japanese Historic Review for Chiral Technology

Enabling Products by Product Segment - Intermediates,

Analytical, and Other Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2000 through

2006 (includes corresponding Graph/Chart) 94

Table 30: Japanese 11-Year Perspective for Chiral Technology

Enabling Products by Product Segment - Percentage Breakdown

of Value Sales for Intermediates, Analytical, and Other

Markets for Years 2005, 2005 & 2015 (includes corresponding

Graph/Chart) 95

Table 31: Japanese Recent Past, Current & Future Analysis

for Chiral Technology by End-Use Segment - Pharmaceuticals,

and Agrochemicals Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2007 through 2015

(includes corresponding Graph/Chart) 96

Table 32: Japanese Historic Review for Chiral Technology by

End-Use Segment - Pharmaceuticals, and Agrochemicals Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart) 97

Table 33: Japanese 11-Year Perspective for Chiral Technology

by End-Use Segment - Percentage Breakdown of Value Sales for

Pharmaceuticals and Agrochemicals Markets for Years 2005,

2005 & 2015 97

18. EUROPE 98

A.Market Analysis 98

Overview 98

B.Market Analytics 99

Table 34: European Recent Past, Current & Future Analysis

for Chiral Technology Enabling Products by Product Segment -

Intermediates, Analytical, and Other Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 99

Table 35: European Historic Review for Chiral Technology

Enabling Products by Product Segment - Intermediates,

Analytical, and Other Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2000 through

2006 (includes corresponding Graph/Chart) 100

Table 36: European 11-Year Perspective for Chiral Technology

Enabling Products by Product Segment - Percentage Breakdown

of Value Sales for Intermediates, Analytical, and Other

Markets for Years 2005, 2010 & 2015 (includes corresponding

Graph/Chart) 101

Table 37: European Recent Past, Current and Future Analysis

for Chiral Technology by End-Use Segment - Pharmaceuticals,

and Agrochemicals Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2007 through 2015

(includes corresponding Graph/Chart) 102

Table 38: European Historic Review for Chiral Technology by

End-Use Segment - Pharmaceuticals, and Agrochemicals Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2000 through 2006 (includes corresponding

Graph/Chart) 103

Table 39: European 11-Year Perspective for Chiral Technology

by End-Use Segment - Percentage Breakdown of Value Sales for

Pharmaceuticals, and Agrochemicals Markets for Years 2005,

2010 & 2015 103

19. REST OF WORLD 104

A.Market Analysis 104

Outlook 104

India 104

Chiral Drugs in the Indian Market 104

China-A Hub for Pharmaceutical Manufacturing 104

B.Market Analytics 105

Table 40: Rest of World Recent Past, Current & Future

Analysis for Chiral Technology Enabling Products by Product

Segment - Intermediates, Analytical, and Other Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2007 through 2015 (includes corresponding

Graph/Chart) 105

Table 41: Rest of World Historic Review for Chiral

Technology Enabling Products by Product Segment -

Intermediates, Analytical, and Other Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2006 (includes corresponding Graph/Chart) 106

Table 42: Rest of World 11-Year Perspective for Chiral

Technology Enabling Products by Product Segment - Percentage

Breakdown of Value Sales for Intermediates, Analytical, and

Other Markets for Years 2005, 2010 & 2015 (includes

corresponding Graph/Chart) 107

Table 43: Rest of World Recent Past, Current & Future

Analysis for Chiral Technology by End-Use Segment -

Pharmaceuticals, and Agrochemicals Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2007 through 2015 (includes corresponding Graph/Chart) 108

Table 44: Rest of World Historic Review for Chiral

Technology by End-Use Segment - Pharmaceuticals, and

Agrochemicals Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2000 through 2006

(includes corresponding Graph/Chart) 109

Table 45: Rest of World 11-Year Perspective for Chiral

Technology by End-Use Segment - Percentage Breakdown of

Value Sales for Pharmaceuticals, and Agrochemicals Markets

for Years 2005, 2010 & 2015 109

COMPETITIVE LANDSCAPE

Total Companies Profiled: 38 (including Divisions/Subsidiaries - 48)

------------------------------------------

Region/Country Players

------------------------------------------

The United States 29

Canada 1

Japan 2

Europe 12

France 4

Germany 1

The United Kingdom 2

Italy 1

Rest of Europe 4

Asia-Pacific (Excluding Japan) 4

------------------------------------------

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Nicolas Bombourg
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